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The map label for this gene is nrdB [H]

Identifier: 187930114

GI number: 187930114

Start: 3174893

End: 3176101

Strand: Reverse

Name: nrdB [H]

Synonym: Rpic_3046

Alternate gene names: 187930114

Gene position: 3176101-3174893 (Counterclockwise)

Preceding gene: 187930115

Following gene: 187930113

Centisome position: 80.56

GC content: 62.53

Gene sequence:

>1209_bases
ATGCTGAGCTGGGACGACGACGTCAAACCTGCCGCACAACCGCAAGCTGCGCCGCAGCCCGCGTACCAACCGCAGCCGCA
GCTGCAAACGGCCACCGCCGACCAGGGCGGCGTGCTGCCCCCGTCGGCCACGCAGGCCGCCGGCACGGGCATCCTTGGCA
ACAATCCGAACGCCGCTGCCGCACAGAGCAACCGCCGCGTGAACGCCGCCGACAAGCGCGTCATCAACGGCGCCACCGAC
GTCAACCAGCTGGTGCCGTTCAAGTACAAGTGGGCCTGGGAAAAGTACCTGGCCGGCTGCGCGAACCACTGGATGCCGCA
GGAAATCAACATGTCGCGCGACATCGCGACGTGGAAAGACCCGAACGGTCTGACCGAAGACGAGCGCCGCATCATCAAGC
GCAACCTGGGCTTCTTCGTGACGGCCGACTCGCTGGCCGCCAACAACATCGTGCTGGGCACGTACCGCCAGATCACCGCG
CCGGAATGCCGCCAGTACCTGCTGCGCCAGGCGTTTGAAGAGGCGATCCATACGCACGCGTATCAGTACATCGTTGAATC
GCTGGGCCTGAACGAGGCCGAGATCTTCAACGCGTACCACGAAGTGCAGTCGATCCGCGACAAGGACGAGTTCCTGATCC
CGTTCATCGACACGCTGACCGATCCGTCCTTCAAGACCGGCACGCCCGAGAACGACCAGAAGCTGCTGAAGTCGCTCATC
GTCTTCGCCTGCATCATGGAAGGCCTGTTCTTCTACGTCGGCTTCACGCAGATCCTGGCGATGGGCCGTCAGAACAAGAT
GACCGGCGCTGCGGAGCAGTACCAGTACATCCTGCGCGACGAGTCGCTGCACTGCAATTTCGGTATCGACCTGATCAACC
AGATCAAGCTGGAGAACCCGCACCTGTGGACGGCCGAGTTCAAGGCCGAGATCACGGAGCTGTTCAAGAAGGCCGTCGAC
CTGGAATATCGCTACGCAGAAGACACCATGCCGCGTGGCGTGCTGGGCCTGAACGCACCGATGTTCAAGGGCTACCTGCG
CTTCATCTGCAACCGTCGCTGCCAGCAGATCGGCCTGGACGCGCTGTTCCCGAACGAGGAAAACCCGTTCCCGTGGATGA
GCGAGATGATCGACCTGAAGAAGGAGCGCAACTTCTTCGAGACGCGCGTGATCGAGTACCAGACCGGCGGCGCGCTGTCC
TGGGAGTGA

Upstream 100 bases:

>100_bases
AGGTTGCTCCCGCGCAAGCGGGGGCGCCGTGACCTGCACGACACTGGACTCGCGCTCCGAAAGAGCGGGAGCGACGAGCA
AAGAATTAGGAGAAACACAT

Downstream 100 bases:

>100_bases
TCTGAGCCACCGGCTCGACACTCGGCTCGACCCCCGGCATCAATGTAGACAGGCGACGCACCATGCGTCGCCTGTTTGCA
TTTTGGGGTGGTCGATTCAC

Product: ribonucleotide-diphosphate reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit [H]

Number of amino acids: Translated: 402; Mature: 402

Protein sequence:

>402_residues
MLSWDDDVKPAAQPQAAPQPAYQPQPQLQTATADQGGVLPPSATQAAGTGILGNNPNAAAAQSNRRVNAADKRVINGATD
VNQLVPFKYKWAWEKYLAGCANHWMPQEINMSRDIATWKDPNGLTEDERRIIKRNLGFFVTADSLAANNIVLGTYRQITA
PECRQYLLRQAFEEAIHTHAYQYIVESLGLNEAEIFNAYHEVQSIRDKDEFLIPFIDTLTDPSFKTGTPENDQKLLKSLI
VFACIMEGLFFYVGFTQILAMGRQNKMTGAAEQYQYILRDESLHCNFGIDLINQIKLENPHLWTAEFKAEITELFKKAVD
LEYRYAEDTMPRGVLGLNAPMFKGYLRFICNRRCQQIGLDALFPNEENPFPWMSEMIDLKKERNFFETRVIEYQTGGALS
WE

Sequences:

>Translated_402_residues
MLSWDDDVKPAAQPQAAPQPAYQPQPQLQTATADQGGVLPPSATQAAGTGILGNNPNAAAAQSNRRVNAADKRVINGATD
VNQLVPFKYKWAWEKYLAGCANHWMPQEINMSRDIATWKDPNGLTEDERRIIKRNLGFFVTADSLAANNIVLGTYRQITA
PECRQYLLRQAFEEAIHTHAYQYIVESLGLNEAEIFNAYHEVQSIRDKDEFLIPFIDTLTDPSFKTGTPENDQKLLKSLI
VFACIMEGLFFYVGFTQILAMGRQNKMTGAAEQYQYILRDESLHCNFGIDLINQIKLENPHLWTAEFKAEITELFKKAVD
LEYRYAEDTMPRGVLGLNAPMFKGYLRFICNRRCQQIGLDALFPNEENPFPWMSEMIDLKKERNFFETRVIEYQTGGALS
WE
>Mature_402_residues
MLSWDDDVKPAAQPQAAPQPAYQPQPQLQTATADQGGVLPPSATQAAGTGILGNNPNAAAAQSNRRVNAADKRVINGATD
VNQLVPFKYKWAWEKYLAGCANHWMPQEINMSRDIATWKDPNGLTEDERRIIKRNLGFFVTADSLAANNIVLGTYRQITA
PECRQYLLRQAFEEAIHTHAYQYIVESLGLNEAEIFNAYHEVQSIRDKDEFLIPFIDTLTDPSFKTGTPENDQKLLKSLI
VFACIMEGLFFYVGFTQILAMGRQNKMTGAAEQYQYILRDESLHCNFGIDLINQIKLENPHLWTAEFKAEITELFKKAVD
LEYRYAEDTMPRGVLGLNAPMFKGYLRFICNRRCQQIGLDALFPNEENPFPWMSEMIDLKKERNFFETRVIEYQTGGALS
WE

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family [H]

Homologues:

Organism=Homo sapiens, GI42544136, Length=363, Percent_Identity=24.7933884297521, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI289177074, Length=320, Percent_Identity=26.5625, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI260064013, Length=320, Percent_Identity=26.875, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI4557845, Length=320, Percent_Identity=26.875, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI289177076, Length=300, Percent_Identity=28, Blast_Score=119, Evalue=6e-27,
Organism=Escherichia coli, GI1788567, Length=292, Percent_Identity=26.3698630136986, Blast_Score=101, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI17551968, Length=356, Percent_Identity=26.4044943820225, Blast_Score=131, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI193206379, Length=404, Percent_Identity=21.039603960396, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17567153, Length=224, Percent_Identity=25.4464285714286, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322434, Length=330, Percent_Identity=30.3030303030303, Blast_Score=149, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6321619, Length=320, Percent_Identity=22.5, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI18079279, Length=320, Percent_Identity=26.875, Blast_Score=139, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358 [H]

Pfam domain/function: PF00268 Ribonuc_red_sm [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 45726; Mature: 45726

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSWDDDVKPAAQPQAAPQPAYQPQPQLQTATADQGGVLPPSATQAAGTGILGNNPNAAA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCHHHCCCCCCCCCCCCHH
AQSNRRVNAADKRVINGATDVNQLVPFKYKWAWEKYLAGCANHWMPQEINMSRDIATWKD
HHCCCCCCHHHHHHHCCCCCHHHHCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
PNGLTEDERRIIKRNLGFFVTADSLAANNIVLGTYRQITAPECRQYLLRQAFEEAIHTHA
CCCCCHHHHHHHHHCCCEEEEECCCCCCCEEEECCHHCCCHHHHHHHHHHHHHHHHHHHH
YQYIVESLGLNEAEIFNAYHEVQSIRDKDEFLIPFIDTLTDPSFKTGTPENDQKLLKSLI
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCCCCCCCCCCHHHHHHHHH
VFACIMEGLFFYVGFTQILAMGRQNKMTGAAEQYQYILRDESLHCNFGIDLINQIKLENP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEECCCHHHHHHHCCCCC
HLWTAEFKAEITELFKKAVDLEYRYAEDTMPRGVLGLNAPMFKGYLRFICNRRCQQIGLD
CEEHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCC
ALFPNEENPFPWMSEMIDLKKERNFFETRVIEYQTGGALSWE
CCCCCCCCCCCHHHHHHHHHHHCCHHHHHEEEEECCCCCCCC
>Mature Secondary Structure
MLSWDDDVKPAAQPQAAPQPAYQPQPQLQTATADQGGVLPPSATQAAGTGILGNNPNAAA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCHHHCCCCCCCCCCCCHH
AQSNRRVNAADKRVINGATDVNQLVPFKYKWAWEKYLAGCANHWMPQEINMSRDIATWKD
HHCCCCCCHHHHHHHCCCCCHHHHCCCEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
PNGLTEDERRIIKRNLGFFVTADSLAANNIVLGTYRQITAPECRQYLLRQAFEEAIHTHA
CCCCCHHHHHHHHHCCCEEEEECCCCCCCEEEECCHHCCCHHHHHHHHHHHHHHHHHHHH
YQYIVESLGLNEAEIFNAYHEVQSIRDKDEFLIPFIDTLTDPSFKTGTPENDQKLLKSLI
HHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHCCCCCCCCCCCCCHHHHHHHHH
VFACIMEGLFFYVGFTQILAMGRQNKMTGAAEQYQYILRDESLHCNFGIDLINQIKLENP
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEECCCHHHHHHHCCCCC
HLWTAEFKAEITELFKKAVDLEYRYAEDTMPRGVLGLNAPMFKGYLRFICNRRCQQIGLD
CEEHHHHHHHHHHHHHHHHCCCEEECCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCC
ALFPNEENPFPWMSEMIDLKKERNFFETRVIEYQTGGALSWE
CCCCCCCCCCCHHHHHHHHHHHCCHHHHHEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]