Click here to switch to the map view.

The map label for this gene is maeB [H]

Identifier: 187930081

GI number: 187930081

Start: 3141120

End: 3143465

Strand: Reverse

Name: maeB [H]

Synonym: Rpic_3013

Alternate gene names: 187930081

Gene position: 3143465-3141120 (Counterclockwise)

Preceding gene: 187930085

Following gene: 187930080

Centisome position: 79.73

GC content: 62.87

Gene sequence:

>2346_bases
ATGACCACGGTGGATACCCAGCCTCAGCAGCCCGCCCGCACGGATGAAGAACTCAAGGCGCAGCAGCGCGCCGCCTTGCG
CAAGGCCGCGCTGGAGTACCACGAGTTTCCGACCCCGGGCAAGATTTCCGTCACGCCGACCAAGCCGCTGTCGAACCAGC
GCGACCTCGCCCTGGCGTATTCACCGGGTGTTGCCGCCGCCTGTGAAGAGATCGTCGAAGACGTTACCAACTCGTTCCGC
TACACCGCCCGCGGCAACCTCGTCGGCGTGGTGACCAACGGTACGGCCGTGCTCGGCCTGGGCGATATCGGCCCGGAAGC
CTCGAAGCCGGTCATGGAAGGCAAGGCGGGCCTGTTCAAGAAATTCGCTGGTATCGATGTGTTTGATATCGAGATCAACG
AAAAAGACCCCCAAAAGCTTGTCGATATCATCGCCTCGCTGGAGCCGACCTTCGGCGGCATCAACCTCGAAGATATCAAG
GCACCGGAGTGCTTCTTCGTCGAGCGCGAACTGCGCAAGCGCATGAAGATCCCCGTCTTCCATGATGACCAGCACGGCAC
CGCCATCGTCGTGGGCGCAGGCATCACCAATGCGCTCAAGGTGGTCGGCAAGGACATCAAGAAGGTCAAGCTGGTGGCGT
CGGGCGCGGGCGCTGCGGCGCTGGCCTGCCTGGACTTGCTGGTCGACCTCGGCCTGCCGCGCGAAAACATCTGGGTGACG
GACTTGGCCGGTGTGGTCTACGAAGGCCGTACCGAACTGATGGATCCGGACAAGGCGCACTTCGCACAGAAGACCGATCT
GCGTACGTTGGCCGAAGTCATCGATGGCGCTGACATTTTCCTGGGCCTGTCCGCCGCCGGCGTGCTTAAGCAGGACATGG
TCAAGAAGATGGCCGACAAGCCGATCATCTTCGCGCTGGCCAATCCGAACCCGGAAATCCTGCCGGAACTGGCCAAGGAA
GTGCGCCCGGACGTCATCATGGGCACCGGCCGCACGGATTACCCGAACCAGGTCAACAACGTCCTGTGCTTCCCGTTCAT
CTTCCGCGGCGCGCTGGATGTGGGCGCGACCACCATCACGCGTGAGATGGAAGTTGCCGCCGTGCACGCCGTGGCTGAAC
TGGCTCGCCAGGAGCAAAGCGACATCGTCGCTTCCGCCTACGGCATCCAGGACTTGTCGTTCGGCCCCGAATACCTGATC
CCGAAGCCCTTCGACCCGCGCCTGATTGTCAAGATCGCGCCGGCCGTGGCGCAGGCGGCCATGCTCTCGGGCGTGGCGCA
GCGTCCGATCGAAGACATGGACGCCTACCGCCAGCACCTGCAGCAATTCGTCTACCACTCGGGCACGCTGATGAAGCCGA
TCTTCTCGGCCGCCCGCAAGGTGCCGATGGAGAACAAGCGCATCATCTTTGCCGAAGGCGAAGAAGAGCGCGTGCTGCGT
GCCGTGCAGATCGTTGTGGATGAAAAGCTCGCCAGCCCGATCCTGATCGGCCGCCCGAGCGTGATTGCCCACCGCATCGA
ACGCTTCGGCCTGCGTCTGCGTGAAGGCGTGGATTTCACCGTGGTGAACCCCGAGCACGACGAGCGCTTCCGCGACTACT
GGGAAACGTACTACAAGCTGATGGCGCGCAAGGGCGTGACGCCGCAGTACGCGAAGCTGGAAGTGCGCCGCCGTTCGACG
CTGATCGGCGCCGTCATGATCCACAAGGGCGAAGCCGACGGCATGATTTGCGGCACGGTCAGCACCACCGCTGCGCACCT
GCGCTACATCGACCAGGTCATCGGTGGCACGAACTGCGTGTACGCCGCCATGAACGGTCTGGTCCTGCCTGGCCGTCAGA
TCTTCTTGACAGATACGCACGTCAATATCGACCCCACTGCCGAGCAACTGGCCGAGATCACCATCATGGCCGCCGAGGAA
CTGTGCCGCTTCGGCATCAAGCCAAAGGTTGCGCTGATGTCGCACTCGAACTTCGGTTCGTCGGAGGCGCCTTCTGCCGT
CAAGATGCGCGAAACGCTGGCTATCCTGCGCGAACGCGCCCCGAACCTGGAAGTGGACGGTGAGATGCATGGCGACGCCG
CGCTCGACGAGAAGCTGCGGGACTCGCTGGTGCCGGATTCGACGCTCAAGGGCGAAGCCAACCTGTTGGTCATGCCGAAT
ATCGATGCCGCCAACATCGCCTATAACCTGCTGAAGGCGGCCGCCGGCAACAACATCGCCATCGGCCCGATCCTGCTGGG
CGCAAAAAAGCCGGTGCACATCCTCACGCCGTCGGCAACGGTGCGACGTATCCTCAACATGACGGCCCTGACCGTTGTGG
ATGCCGCTGCACAAGCGCAACGCTGA

Upstream 100 bases:

>100_bases
AGGAGGCGGACCGTATTCCCGTGGCGCTCGTGAGGGTATCCCGGTGGCCCGCTAGATGCGACGGCCGGCGCGCGCGCTGG
CCACCCGATACGAGAGACCC

Downstream 100 bases:

>100_bases
TCGCCACTGCACTGGAAAAGGGAGCGCACGATGCTGCGCTCCCTTTTTTAATTCACTAAGTTTGCGTGTGCTTACATTTC
TTAAGACGTAATAGCCATAT

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 781; Mature: 780

Protein sequence:

>781_residues
MTTVDTQPQQPARTDEELKAQQRAALRKAALEYHEFPTPGKISVTPTKPLSNQRDLALAYSPGVAAACEEIVEDVTNSFR
YTARGNLVGVVTNGTAVLGLGDIGPEASKPVMEGKAGLFKKFAGIDVFDIEINEKDPQKLVDIIASLEPTFGGINLEDIK
APECFFVERELRKRMKIPVFHDDQHGTAIVVGAGITNALKVVGKDIKKVKLVASGAGAAALACLDLLVDLGLPRENIWVT
DLAGVVYEGRTELMDPDKAHFAQKTDLRTLAEVIDGADIFLGLSAAGVLKQDMVKKMADKPIIFALANPNPEILPELAKE
VRPDVIMGTGRTDYPNQVNNVLCFPFIFRGALDVGATTITREMEVAAVHAVAELARQEQSDIVASAYGIQDLSFGPEYLI
PKPFDPRLIVKIAPAVAQAAMLSGVAQRPIEDMDAYRQHLQQFVYHSGTLMKPIFSAARKVPMENKRIIFAEGEEERVLR
AVQIVVDEKLASPILIGRPSVIAHRIERFGLRLREGVDFTVVNPEHDERFRDYWETYYKLMARKGVTPQYAKLEVRRRST
LIGAVMIHKGEADGMICGTVSTTAAHLRYIDQVIGGTNCVYAAMNGLVLPGRQIFLTDTHVNIDPTAEQLAEITIMAAEE
LCRFGIKPKVALMSHSNFGSSEAPSAVKMRETLAILRERAPNLEVDGEMHGDAALDEKLRDSLVPDSTLKGEANLLVMPN
IDAANIAYNLLKAAAGNNIAIGPILLGAKKPVHILTPSATVRRILNMTALTVVDAAAQAQR

Sequences:

>Translated_781_residues
MTTVDTQPQQPARTDEELKAQQRAALRKAALEYHEFPTPGKISVTPTKPLSNQRDLALAYSPGVAAACEEIVEDVTNSFR
YTARGNLVGVVTNGTAVLGLGDIGPEASKPVMEGKAGLFKKFAGIDVFDIEINEKDPQKLVDIIASLEPTFGGINLEDIK
APECFFVERELRKRMKIPVFHDDQHGTAIVVGAGITNALKVVGKDIKKVKLVASGAGAAALACLDLLVDLGLPRENIWVT
DLAGVVYEGRTELMDPDKAHFAQKTDLRTLAEVIDGADIFLGLSAAGVLKQDMVKKMADKPIIFALANPNPEILPELAKE
VRPDVIMGTGRTDYPNQVNNVLCFPFIFRGALDVGATTITREMEVAAVHAVAELARQEQSDIVASAYGIQDLSFGPEYLI
PKPFDPRLIVKIAPAVAQAAMLSGVAQRPIEDMDAYRQHLQQFVYHSGTLMKPIFSAARKVPMENKRIIFAEGEEERVLR
AVQIVVDEKLASPILIGRPSVIAHRIERFGLRLREGVDFTVVNPEHDERFRDYWETYYKLMARKGVTPQYAKLEVRRRST
LIGAVMIHKGEADGMICGTVSTTAAHLRYIDQVIGGTNCVYAAMNGLVLPGRQIFLTDTHVNIDPTAEQLAEITIMAAEE
LCRFGIKPKVALMSHSNFGSSEAPSAVKMRETLAILRERAPNLEVDGEMHGDAALDEKLRDSLVPDSTLKGEANLLVMPN
IDAANIAYNLLKAAAGNNIAIGPILLGAKKPVHILTPSATVRRILNMTALTVVDAAAQAQR
>Mature_780_residues
TTVDTQPQQPARTDEELKAQQRAALRKAALEYHEFPTPGKISVTPTKPLSNQRDLALAYSPGVAAACEEIVEDVTNSFRY
TARGNLVGVVTNGTAVLGLGDIGPEASKPVMEGKAGLFKKFAGIDVFDIEINEKDPQKLVDIIASLEPTFGGINLEDIKA
PECFFVERELRKRMKIPVFHDDQHGTAIVVGAGITNALKVVGKDIKKVKLVASGAGAAALACLDLLVDLGLPRENIWVTD
LAGVVYEGRTELMDPDKAHFAQKTDLRTLAEVIDGADIFLGLSAAGVLKQDMVKKMADKPIIFALANPNPEILPELAKEV
RPDVIMGTGRTDYPNQVNNVLCFPFIFRGALDVGATTITREMEVAAVHAVAELARQEQSDIVASAYGIQDLSFGPEYLIP
KPFDPRLIVKIAPAVAQAAMLSGVAQRPIEDMDAYRQHLQQFVYHSGTLMKPIFSAARKVPMENKRIIFAEGEEERVLRA
VQIVVDEKLASPILIGRPSVIAHRIERFGLRLREGVDFTVVNPEHDERFRDYWETYYKLMARKGVTPQYAKLEVRRRSTL
IGAVMIHKGEADGMICGTVSTTAAHLRYIDQVIGGTNCVYAAMNGLVLPGRQIFLTDTHVNIDPTAEQLAEITIMAAEEL
CRFGIKPKVALMSHSNFGSSEAPSAVKMRETLAILRERAPNLEVDGEMHGDAALDEKLRDSLVPDSTLKGEANLLVMPNI
DAANIAYNLLKAAAGNNIAIGPILLGAKKPVHILTPSATVRRILNMTALTVVDAAAQAQR

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=344, Percent_Identity=27.6162790697674, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI62420882, Length=353, Percent_Identity=28.8951841359773, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI62420880, Length=353, Percent_Identity=28.8951841359773, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI239049447, Length=353, Percent_Identity=28.8951841359773, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI4505145, Length=319, Percent_Identity=30.4075235109718, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI270265879, Length=319, Percent_Identity=30.4075235109718, Blast_Score=70, Evalue=6e-12,
Organism=Escherichia coli, GI1788806, Length=756, Percent_Identity=62.8306878306878, Blast_Score=978, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=316, Percent_Identity=33.2278481012658, Blast_Score=161, Evalue=2e-40,
Organism=Escherichia coli, GI1788800, Length=321, Percent_Identity=31.7757009345794, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI87081919, Length=409, Percent_Identity=24.2053789731051, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17537199, Length=421, Percent_Identity=26.3657957244656, Blast_Score=75, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322823, Length=239, Percent_Identity=30.9623430962343, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI281362672, Length=404, Percent_Identity=28.4653465346535, Blast_Score=98, Evalue=3e-20,
Organism=Drosophila melanogaster, GI281362674, Length=404, Percent_Identity=28.4653465346535, Blast_Score=98, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21356279, Length=404, Percent_Identity=28.4653465346535, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24646388, Length=350, Percent_Identity=30, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24646386, Length=350, Percent_Identity=30, Blast_Score=91, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 85043; Mature: 84912

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVDTQPQQPARTDEELKAQQRAALRKAALEYHEFPTPGKISVTPTKPLSNQRDLALAY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEE
SPGVAAACEEIVEDVTNSFRYTARGNLVGVVTNGTAVLGLGDIGPEASKPVMEGKAGLFK
CCCHHHHHHHHHHHHHHCEEEEECCCEEEEEECCEEEEEECCCCCCCCCCHHHCCHHHHH
KFAGIDVFDIEINEKDPQKLVDIIASLEPTFGGINLEDIKAPECFFVERELRKRMKIPVF
HHCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEE
HDDQHGTAIVVGAGITNALKVVGKDIKKVKLVASGAGAAALACLDLLVDLGLPRENIWVT
ECCCCCCEEEEECCHHHHHHHHHCCHHEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEE
DLAGVVYEGRTELMDPDKAHFAQKTDLRTLAEVIDGADIFLGLSAAGVLKQDMVKKMADK
HHHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCC
PIIFALANPNPEILPELAKEVRPDVIMGTGRTDYPNQVNNVLCFPFIFRGALDVGATTIT
CEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCCHHHH
REMEVAAVHAVAELARQEQSDIVASAYGIQDLSFGPEYLIPKPFDPRLIVKIAPAVAQAA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHH
MLSGVAQRPIEDMDAYRQHLQQFVYHSGTLMKPIFSAARKVPMENKRIIFAEGEEERVLR
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHH
AVQIVVDEKLASPILIGRPSVIAHRIERFGLRLREGVDFTVVNPEHDERFRDYWETYYKL
HHHHHHHHHHCCCEEECCCHHHHHHHHHHCHHHHCCCCEEEECCCHHHHHHHHHHHHHHH
MARKGVTPQYAKLEVRRRSTLIGAVMIHKGEADGMICGTVSTTAAHLRYIDQVIGGTNCV
HHHCCCCCHHHHHHHHHHHHEEEEEEEEECCCCCEEEECHHHHHHHHHHHHHHHCCCHHH
YAAMNGLVLPGRQIFLTDTHVNIDPTAEQLAEITIMAAEELCRFGIKPKVALMSHSNFGS
HHHHCCEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCC
SEAPSAVKMRETLAILRERAPNLEVDGEMHGDAALDEKLRDSLVPDSTLKGEANLLVMPN
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECC
IDAANIAYNLLKAAAGNNIAIGPILLGAKKPVHILTPSATVRRILNMTALTVVDAAAQAQ
CCHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCC
R
C
>Mature Secondary Structure 
TTVDTQPQQPARTDEELKAQQRAALRKAALEYHEFPTPGKISVTPTKPLSNQRDLALAY
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEE
SPGVAAACEEIVEDVTNSFRYTARGNLVGVVTNGTAVLGLGDIGPEASKPVMEGKAGLFK
CCCHHHHHHHHHHHHHHCEEEEECCCEEEEEECCEEEEEECCCCCCCCCCHHHCCHHHHH
KFAGIDVFDIEINEKDPQKLVDIIASLEPTFGGINLEDIKAPECFFVERELRKRMKIPVF
HHCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEE
HDDQHGTAIVVGAGITNALKVVGKDIKKVKLVASGAGAAALACLDLLVDLGLPRENIWVT
ECCCCCCEEEEECCHHHHHHHHHCCHHEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEE
DLAGVVYEGRTELMDPDKAHFAQKTDLRTLAEVIDGADIFLGLSAAGVLKQDMVKKMADK
HHHHHHCCCCHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHCCC
PIIFALANPNPEILPELAKEVRPDVIMGTGRTDYPNQVNNVLCFPFIFRGALDVGATTIT
CEEEEECCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCCHHHH
REMEVAAVHAVAELARQEQSDIVASAYGIQDLSFGPEYLIPKPFDPRLIVKIAPAVAQAA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHH
MLSGVAQRPIEDMDAYRQHLQQFVYHSGTLMKPIFSAARKVPMENKRIIFAEGEEERVLR
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHH
AVQIVVDEKLASPILIGRPSVIAHRIERFGLRLREGVDFTVVNPEHDERFRDYWETYYKL
HHHHHHHHHHCCCEEECCCHHHHHHHHHHCHHHHCCCCEEEECCCHHHHHHHHHHHHHHH
MARKGVTPQYAKLEVRRRSTLIGAVMIHKGEADGMICGTVSTTAAHLRYIDQVIGGTNCV
HHHCCCCCHHHHHHHHHHHHEEEEEEEEECCCCCEEEECHHHHHHHHHHHHHHHCCCHHH
YAAMNGLVLPGRQIFLTDTHVNIDPTAEQLAEITIMAAEELCRFGIKPKVALMSHSNFGS
HHHHCCEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCC
SEAPSAVKMRETLAILRERAPNLEVDGEMHGDAALDEKLRDSLVPDSTLKGEANLLVMPN
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECC
IDAANIAYNLLKAAAGNNIAIGPILLGAKKPVHILTPSATVRRILNMTALTVVDAAAQAQ
CCHHHHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]