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The map label for this gene is icd [H]

Identifier: 187929821

GI number: 187929821

Start: 2863905

End: 2865155

Strand: Reverse

Name: icd [H]

Synonym: Rpic_2752

Alternate gene names: 187929821

Gene position: 2865155-2863905 (Counterclockwise)

Preceding gene: 187929822

Following gene: 187929820

Centisome position: 72.67

GC content: 59.79

Gene sequence:

>1251_bases
ATGTATCAACACATCAAGGTCCCGGCCGGCGAGAAGATCACCGTCAACCAAGACTTCTCCCTCAACGTTCCGAACAACCC
GATCATTCCTTACATCGAAGGTGACGGCACCGGCTTCGACATCACCCCGGTGATGATCAAGGTGGTCGACGCAGCGGTTG
AGAAGGCTTACAAGGGCGAGCGCAAGATTTCCTGGATGGAAATCTACGCCGGCGAGAAGTCGACCAAGGTGTACGGCCCG
GACGTGTGGCTGCCGGAAGAAACCCTGCAAGTCCTGAAGGACTACGTGGTGTCCATCAAGGGCCCGCTGACGACGCCGGT
GGGCGGCGGCATCCGTTCGCTGAACGTGGCGCTGCGCCAGGAGCTGGACCTCTACGTCTGCCTGCGCCCGGTGCGCTACT
TCAAGGGCGTGCCTTCGCCGGTCAAAGAGCCGGAGAAGACCGACATGGTCATCTTCCGCGAGAACTCGGAAGACATCTAC
GCCGGTATCGAATTCGAAGCCCAGAGCGACAAGGCCAAGAAGCTGATCAAGATTCTGCAAGACGAATTCGGCGTCAAGAA
GATTCGCTTCCCGGAAACGTCGGGCATCGGCGTGAAGCCGGTTTCGCGCGAAGGCACCGAGCGTCTGGTGCGCAAGGCCA
TTCAGTACGCGATCGACAACGACAAGCCGTCGGTCACGATCGTGCACAAGGGCAACATCATGAAGTTCACGGAAGGTGGC
TTCCGTGACTGGGCCTACGCGCTGGCACAGAAGGAATTCGGCGCCGAGCTGATCGACGGCGGCCCGTGGTGCAAGTTCAA
GAACCCGAAGACGGGCAAGGAAATCATCGTCAAGGACGCGATTGCCGACGCCTTCCTGCAGCAGATCCTGCTGCGTCCGG
CCGAGTACTCGGTGGTGGCAACGCTGAACCTGAACGGCGACTACATCTCCGACGCTCTGGCTGCGCAAGTCGGCGGTATC
GGCATCGCCCCGGGCGCGAACCTGAGCGACTCCGTTGCCATGTTCGAAGCCACCCACGGCACGGCACCGAAGTACGCAGG
CAAGGATTACGTGAACCCCGGTTCGGAAATCCTGTCGGCCGAAATGATGCTGCGTCACATGGGCTGGACGGAAGCCGCTG
ACCTGATCATCTCGTCGATCGAAAAATCGATCCTGTCGAAGAAGGTCACGTATGACTTCGCCCGTCTGCTGGAAGGCGCG
ACCCAAGTGTCGTGCTCGGGCTTCGGTCAGGTGATGATCGACAACATGTAA

Upstream 100 bases:

>100_bases
TTCACTGCAGCGCGCCACGCCGGCCAACCCGTGAGCGGCGCGCTGTGCTGTCAATCCCCACCGTCCACCCGCTAACCTGC
GGTCTGCACTGGAGTCGTCC

Downstream 100 bases:

>100_bases
ACTGATCCGGAGTGTTCCGGAAAAGTCCAGAAAACCCCGGTGTACACTTAGTGTCGCCGGGGTTTTTTGTCTCTAGAGTT
CCAGAAAGATTGAGTACGAT

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MYQHIKVPAGEKITVNQDFSLNVPNNPIIPYIEGDGTGFDITPVMIKVVDAAVEKAYKGERKISWMEIYAGEKSTKVYGP
DVWLPEETLQVLKDYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFKGVPSPVKEPEKTDMVIFRENSEDIY
AGIEFEAQSDKAKKLIKILQDEFGVKKIRFPETSGIGVKPVSREGTERLVRKAIQYAIDNDKPSVTIVHKGNIMKFTEGG
FRDWAYALAQKEFGAELIDGGPWCKFKNPKTGKEIIVKDAIADAFLQQILLRPAEYSVVATLNLNGDYISDALAAQVGGI
GIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADLIISSIEKSILSKKVTYDFARLLEGA
TQVSCSGFGQVMIDNM

Sequences:

>Translated_416_residues
MYQHIKVPAGEKITVNQDFSLNVPNNPIIPYIEGDGTGFDITPVMIKVVDAAVEKAYKGERKISWMEIYAGEKSTKVYGP
DVWLPEETLQVLKDYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFKGVPSPVKEPEKTDMVIFRENSEDIY
AGIEFEAQSDKAKKLIKILQDEFGVKKIRFPETSGIGVKPVSREGTERLVRKAIQYAIDNDKPSVTIVHKGNIMKFTEGG
FRDWAYALAQKEFGAELIDGGPWCKFKNPKTGKEIIVKDAIADAFLQQILLRPAEYSVVATLNLNGDYISDALAAQVGGI
GIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADLIISSIEKSILSKKVTYDFARLLEGA
TQVSCSGFGQVMIDNM
>Mature_416_residues
MYQHIKVPAGEKITVNQDFSLNVPNNPIIPYIEGDGTGFDITPVMIKVVDAAVEKAYKGERKISWMEIYAGEKSTKVYGP
DVWLPEETLQVLKDYVVSIKGPLTTPVGGGIRSLNVALRQELDLYVCLRPVRYFKGVPSPVKEPEKTDMVIFRENSEDIY
AGIEFEAQSDKAKKLIKILQDEFGVKKIRFPETSGIGVKPVSREGTERLVRKAIQYAIDNDKPSVTIVHKGNIMKFTEGG
FRDWAYALAQKEFGAELIDGGPWCKFKNPKTGKEIIVKDAIADAFLQQILLRPAEYSVVATLNLNGDYISDALAAQVGGI
GIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADLIISSIEKSILSKKVTYDFARLLEGA
TQVSCSGFGQVMIDNM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=398, Percent_Identity=30.4020100502513, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI28178816, Length=352, Percent_Identity=28.6931818181818, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI28178821, Length=352, Percent_Identity=28.6931818181818, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI4758582, Length=276, Percent_Identity=28.2608695652174, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI28178838, Length=276, Percent_Identity=28.2608695652174, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI28178819, Length=181, Percent_Identity=33.1491712707182, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1787381, Length=417, Percent_Identity=75.0599520383693, Blast_Score=652, Evalue=0.0,
Organism=Escherichia coli, GI1788101, Length=378, Percent_Identity=27.5132275132275, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI87081683, Length=406, Percent_Identity=24.384236453202, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI71986051, Length=374, Percent_Identity=31.283422459893, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI25144293, Length=305, Percent_Identity=30.1639344262295, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17505779, Length=301, Percent_Identity=29.5681063122924, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17550882, Length=364, Percent_Identity=24.1758241758242, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324709, Length=391, Percent_Identity=29.156010230179, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6322097, Length=366, Percent_Identity=28.1420765027322, Blast_Score=126, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6324291, Length=367, Percent_Identity=28.6103542234332, Blast_Score=126, Evalue=7e-30,
Organism=Saccharomyces cerevisiae, GI6319830, Length=361, Percent_Identity=24.3767313019391, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24643270, Length=350, Percent_Identity=34, Blast_Score=179, Evalue=3e-45,
Organism=Drosophila melanogaster, GI24643268, Length=350, Percent_Identity=34, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24661184, Length=389, Percent_Identity=29.8200514138817, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI161078635, Length=278, Percent_Identity=28.4172661870504, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI161078639, Length=278, Percent_Identity=28.4172661870504, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI161078633, Length=278, Percent_Identity=28.4172661870504, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24650122, Length=278, Percent_Identity=28.4172661870504, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI161078637, Length=278, Percent_Identity=28.4172661870504, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI20130355, Length=296, Percent_Identity=24.6621621621622, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI281362242, Length=336, Percent_Identity=27.6785714285714, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24648872, Length=336, Percent_Identity=27.6785714285714, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45784; Mature: 45784

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQHIKVPAGEKITVNQDFSLNVPNNPIIPYIEGDGTGFDITPVMIKVVDAAVEKAYKGE
CCCEEECCCCCEEEECCCEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCC
RKISWMEIYAGEKSTKVYGPDVWLPEETLQVLKDYVVSIKGPLTTPVGGGIRSLNVALRQ
CCEEEEEEECCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
ELDLYVCLRPVRYFKGVPSPVKEPEKTDMVIFRENSEDIYAGIEFEAQSDKAKKLIKILQ
CCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCHHHHHHHHHHH
DEFGVKKIRFPETSGIGVKPVSREGTERLVRKAIQYAIDNDKPSVTIVHKGNIMKFTEGG
HHCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCC
FRDWAYALAQKEFGAELIDGGPWCKFKNPKTGKEIIVKDAIADAFLQQILLRPAEYSVVA
HHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEE
TLNLNGDYISDALAAQVGGIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSA
EEECCCHHHHHHHHHHHCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHH
EMMLRHMGWTEAADLIISSIEKSILSKKVTYDFARLLEGATQVSCSGFGQVMIDNM
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEECCC
>Mature Secondary Structure
MYQHIKVPAGEKITVNQDFSLNVPNNPIIPYIEGDGTGFDITPVMIKVVDAAVEKAYKGE
CCCEEECCCCCEEEECCCEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCC
RKISWMEIYAGEKSTKVYGPDVWLPEETLQVLKDYVVSIKGPLTTPVGGGIRSLNVALRQ
CCEEEEEEECCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
ELDLYVCLRPVRYFKGVPSPVKEPEKTDMVIFRENSEDIYAGIEFEAQSDKAKKLIKILQ
CCCHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCHHHHHHHHHHH
DEFGVKKIRFPETSGIGVKPVSREGTERLVRKAIQYAIDNDKPSVTIVHKGNIMKFTEGG
HHCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCC
FRDWAYALAQKEFGAELIDGGPWCKFKNPKTGKEIIVKDAIADAFLQQILLRPAEYSVVA
HHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEE
TLNLNGDYISDALAAQVGGIGIAPGANLSDSVAMFEATHGTAPKYAGKDYVNPGSEILSA
EEECCCHHHHHHHHHHHCCEECCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHH
EMMLRHMGWTEAADLIISSIEKSILSKKVTYDFARLLEGATQVSCSGFGQVMIDNM
HHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3112144; 8905232; 9278503; 9352899; 9298646; 2204109; 2682654; 10623532 [H]