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The map label for this gene is nadA

Identifier: 187929787

GI number: 187929787

Start: 2829947

End: 2831095

Strand: Reverse

Name: nadA

Synonym: Rpic_2717

Alternate gene names: 187929787

Gene position: 2831095-2829947 (Counterclockwise)

Preceding gene: 187929788

Following gene: 187929786

Centisome position: 71.81

GC content: 63.45

Gene sequence:

>1149_bases
ATGGAAACCCACATCAAGACGGTTGAATTCGAGCGCCCGGATATGCTTTCCGAGGCGCAATCCGGCGCCAGTTGCGTGGC
TCACGCCTGGGCCAAGGTGCCGCCGGTGCTGTCGCGTGAGGAACGCGACGAACTGAAGGCCCGCATCAAGCGCCTGCTCA
AGGAACGCGAGGCCGTGCTGGTCGCGCACTACTACGTTGACGCCGACCTTCAGGATCTGGCCGAGGAGACCGGTGGCTGC
GTGTCCGATTCGCTGGAGATGGCGCGCTTTGGCCGCGACCATTCGGCTAAGACATTGATCGTGGCGGGCGTGCGCTTCAT
GGGCGAGACCGCCAAGATTCTGAGTCCTGAAAAGACCGTGCTGATGCCTGATCTGGATGCGACCTGCTCGTTGGATCTGG
GTTGCCCGCCGGATGAGTTCGCCGCCTTCTGCGACGCGCATCCGGATCGCACCGTGGTCGTCTATGCCAATACCAGCGCC
GCCGTGAAGGCGCGCGCGGACTGGATGGTGACGTCTTCCATCGGCCTGAAGATCGTGCAGCACCTGCACGCGCAGGGAAA
GAAGATCCTGTGGGCACCCGATCGCCATCTCGGCAGCTACATTCAGAAGCAGACCGGCGCCGACATGCTGATGTGGCAGG
GCTCGTGCTTGGTGCACGACGAATTCAAGGGCGTGGAGCTTGACCTGCTGCGTGCCGAGCACCCGAACGCGAAGATTCTC
GTGCATCCGGAATCGCCGGAATCGGTCGTGGCCCAGGCCGATGTCGTGGGTTCGACTTCGCAGCTGATTGCCGCAGCGCA
GTCATTGTCGGCGCAGGAATTTATTGTCGCGACCGACAACGGCATCCTGCACAAGATGCGCATGGCCGCCCCGGGCAAGC
GCTTCATCGAGGCGCCGACCGCCGGCAACGCTGCCACCTGCAAGAGCTGCGCGCATTGCCCCTGGATGGCGATGAACGCG
CTGACCAATCTGGCCGAGGTGCTGGAAACCGGTCGCAACGAGATCCACGTCGATCCGGCCATCGGGCGGCAAGCCGTGGT
CTGCATCGATCGCATGCTGGACTTTGCCGCGCGCGAGAAAGCCACGGTTCGCCCGCAAGGCGACCTGGCCGCGAACGCAC
AACTCTTTCAAGGAATCGGCCCGGCATGA

Upstream 100 bases:

>100_bases
GACAATGTATCGCGGTGCCAGTCCTCCTCACACGCCGTCCGTTTCATTGCCGCGCCAGCTTCTTGGCGCTTTCACAGCGC
GAATGGACGCGGAGACCACC

Downstream 100 bases:

>100_bases
CGGCAACACAGATGAACACGACGCGTCTCGCCCCTGCGGCTGAGGCAATTTTCGATGGCTTTGGCCCGGCACTGCGCGAG
GCGTTGTCCGCGAATGTGGC

Product: quinolinate synthetase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
METHIKTVEFERPDMLSEAQSGASCVAHAWAKVPPVLSREERDELKARIKRLLKEREAVLVAHYYVDADLQDLAEETGGC
VSDSLEMARFGRDHSAKTLIVAGVRFMGETAKILSPEKTVLMPDLDATCSLDLGCPPDEFAAFCDAHPDRTVVVYANTSA
AVKARADWMVTSSIGLKIVQHLHAQGKKILWAPDRHLGSYIQKQTGADMLMWQGSCLVHDEFKGVELDLLRAEHPNAKIL
VHPESPESVVAQADVVGSTSQLIAAAQSLSAQEFIVATDNGILHKMRMAAPGKRFIEAPTAGNAATCKSCAHCPWMAMNA
LTNLAEVLETGRNEIHVDPAIGRQAVVCIDRMLDFAAREKATVRPQGDLAANAQLFQGIGPA

Sequences:

>Translated_382_residues
METHIKTVEFERPDMLSEAQSGASCVAHAWAKVPPVLSREERDELKARIKRLLKEREAVLVAHYYVDADLQDLAEETGGC
VSDSLEMARFGRDHSAKTLIVAGVRFMGETAKILSPEKTVLMPDLDATCSLDLGCPPDEFAAFCDAHPDRTVVVYANTSA
AVKARADWMVTSSIGLKIVQHLHAQGKKILWAPDRHLGSYIQKQTGADMLMWQGSCLVHDEFKGVELDLLRAEHPNAKIL
VHPESPESVVAQADVVGSTSQLIAAAQSLSAQEFIVATDNGILHKMRMAAPGKRFIEAPTAGNAATCKSCAHCPWMAMNA
LTNLAEVLETGRNEIHVDPAIGRQAVVCIDRMLDFAAREKATVRPQGDLAANAQLFQGIGPA
>Mature_382_residues
METHIKTVEFERPDMLSEAQSGASCVAHAWAKVPPVLSREERDELKARIKRLLKEREAVLVAHYYVDADLQDLAEETGGC
VSDSLEMARFGRDHSAKTLIVAGVRFMGETAKILSPEKTVLMPDLDATCSLDLGCPPDEFAAFCDAHPDRTVVVYANTSA
AVKARADWMVTSSIGLKIVQHLHAQGKKILWAPDRHLGSYIQKQTGADMLMWQGSCLVHDEFKGVELDLLRAEHPNAKIL
VHPESPESVVAQADVVGSTSQLIAAAQSLSAQEFIVATDNGILHKMRMAAPGKRFIEAPTAGNAATCKSCAHCPWMAMNA
LTNLAEVLETGRNEIHVDPAIGRQAVVCIDRMLDFAAREKATVRPQGDLAANAQLFQGIGPA

Specific function: Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate

COG id: COG0379

COG function: function code H; Quinolinate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the quinolinate synthase A family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1786964, Length=326, Percent_Identity=67.4846625766871, Blast_Score=459, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NADA_RALPJ (B2UAP5)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001900274.1
- GeneID:   6289101
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_2717
- HOGENOM:   HBG291157
- OMA:   IAHPECE
- ProtClustDB:   PRK09375
- GO:   GO:0005737
- HAMAP:   MF_00567
- InterPro:   IPR003473
- TIGRFAMs:   TIGR00550

Pfam domain/function: PF02445 NadA

EC number: =2.5.1.72

Molecular weight: Translated: 41479; Mature: 41479

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: BINDING 63-63 BINDING 84-84 BINDING 155-155 BINDING 172-172 BINDING 242-242 BINDING 259-259

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METHIKTVEFERPDMLSEAQSGASCVAHAWAKVPPVLSREERDELKARIKRLLKEREAVL
CCCCEEEEECCCCCHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCEEE
VAHYYVDADLQDLAEETGGCVSDSLEMARFGRDHSAKTLIVAGVRFMGETAKILSPEKTV
EEEEEECCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEHHHHHCCHHHHCCCCCEE
LMPDLDATCSLDLGCPPDEFAAFCDAHPDRTVVVYANTSAAVKARADWMVTSSIGLKIVQ
EECCCCCCEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCEEEECCCEEEEHHHHHHHHH
HLHAQGKKILWAPDRHLGSYIQKQTGADMLMWQGSCLVHDEFKGVELDLLRAEHPNAKIL
HHHHCCCEEEECCCHHHHHHHHHHCCCCEEEECCCEEEECCCCCCEEEEEECCCCCCEEE
VHPESPESVVAQADVVGSTSQLIAAAQSLSAQEFIVATDNGILHKMRMAAPGKRFIEAPT
EECCCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCCEEECCC
AGNAATCKSCAHCPWMAMNALTNLAEVLETGRNEIHVDPAIGRQAVVCIDRMLDFAAREK
CCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHCC
ATVRPQGDLAANAQLFQGIGPA
CCCCCCCCCHHCHHHHHCCCCC
>Mature Secondary Structure
METHIKTVEFERPDMLSEAQSGASCVAHAWAKVPPVLSREERDELKARIKRLLKEREAVL
CCCCEEEEECCCCCHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCEEE
VAHYYVDADLQDLAEETGGCVSDSLEMARFGRDHSAKTLIVAGVRFMGETAKILSPEKTV
EEEEEECCCHHHHHHHHCCCHHHHHHHHHCCCCCCCCEEEEEHHHHHCCHHHHCCCCCEE
LMPDLDATCSLDLGCPPDEFAAFCDAHPDRTVVVYANTSAAVKARADWMVTSSIGLKIVQ
EECCCCCCEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCEEEECCCEEEEHHHHHHHHH
HLHAQGKKILWAPDRHLGSYIQKQTGADMLMWQGSCLVHDEFKGVELDLLRAEHPNAKIL
HHHHCCCEEEECCCHHHHHHHHHHCCCCEEEECCCEEEECCCCCCEEEEEECCCCCCEEE
VHPESPESVVAQADVVGSTSQLIAAAQSLSAQEFIVATDNGILHKMRMAAPGKRFIEAPT
EECCCCHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHHCCCCCCEEECCC
AGNAATCKSCAHCPWMAMNALTNLAEVLETGRNEIHVDPAIGRQAVVCIDRMLDFAAREK
CCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHCC
ATVRPQGDLAANAQLFQGIGPA
CCCCCCCCCHHCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA