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The map label for this gene is cobQ [H]

Identifier: 187929727

GI number: 187929727

Start: 2770055

End: 2771551

Strand: Reverse

Name: cobQ [H]

Synonym: Rpic_2656

Alternate gene names: 187929727

Gene position: 2771551-2770055 (Counterclockwise)

Preceding gene: 187929732

Following gene: 187929726

Centisome position: 70.3

GC content: 67.47

Gene sequence:

>1497_bases
ATGTCGAAAGCTCCATTTTCTGTGCCGCCGGACTCGCTTCGGGGCACGCTGATGATCCAGGGCGCCACGTCCGATGCCGG
CAAGAGCACGCTGGTCGCCGGCCTGTGCCGTGTCGCGCATCGCGCCGGTGTGCGCGTGGCGCCGTTCAAGCCGCAGAACA
TGGCGCTCAACAGCGCCGTCACCGCAGACGGCGGCGAGATCGGCCGCGCGCAGGCGTTGCAGGCGCAGGCGGCGGGCGTC
GTGCCCACGGTCGACATGAACCCCGTCCTGCTCAAGCCCAACAGCGACACCGGCGCACAGATCATCATCCACGGTCAGCC
GCGCTGCGACCTCGACGCCCGTGCGTACCACGACTACAAGCCCACCGCCATGGCCGCTGTGCTCGAATCGCACACGCGGC
TGCGTGGGCAGTACGACCTCGTGCTGGTAGAGGGCGCCGGCAGCCCGGCGGAGATCAACCTGCGCGACCGCGACATCGCC
AACATGGGCTTTGCCGAAGCCGTCGATTGTCCCGTCGTGCTCGTCGCCGACATTGATCGCGGCGGCGTGTTCGCGCACCT
TGTTGGCACGCTCGCCTGCTTGTCTGACAGCGAACGCGCGCGCGTGACGGGCTTCATCATCAACCGGTTCCGCGGCGACA
TTTCATTGCTGACGCCGGGGCTCGACTGGCTGACCGCGCAGACGGGCAAGCCGGTGTTTGGCGTGCTGCCATATCTGCCC
GGCCTCCATCTCGACGCAGAAGACGCGGTGCAGACGGCGCAGCGTGCAGCCTCGCCCGATGCGCTGCGCGTCGTTATTCC
GGTGTTGCCGCGTGTGTCCAACCACACCGATTTCGATGCGCTGCGCGCGCATCCGCAGGTGGACGTTCGACTGGTCGGCC
CTGGCCAGCCGATTCCGCCCGCCGACCTCATCATCCTGCCCGGCAGCAAGAGCGTGCAGGCGGATCTCGCCTGGCTGCGC
GCCAATGGCTGGGAAGCGGCCATCGCGCGACATCTGCGCTATGGCGGCAAGCTGATCGGCATCTGCGGCGGCATGCAAAT
GTTGGGGCGGTGGTTGCATGATCCGCTAGGGCTTGAGGGCGCGCCCGGTAGCGTCAAGGGACTCGGCTATCTCGATTTCG
AGACCACGCTGGAGACCAGCAAGAAGTTGCGTCAGGTGCGCGGCAGCCTGGCGGAAGGCGGTGCGGCCGTCGCCGGCTAC
GAAATCCACATGGGCGTGACTGCGGGGCCAGCCTTGGCATGCCCCGCCGTGTTGCTCGATGATGGCCACGCAGATGGCGC
GATCTCGGCCGATGGGCAGATCTTCGCCACGTATCTGCATGGTCTGTTCGATGCGCCACAGGCGTGCTGCGCGCTGCTAG
CCTGGGCCGGCGTGGGTGATGCGCAGGCGCAGGACTACGCCGCATTGCGTGAGGCTTCGCTCGAGCGTCTGGCCGACACC
TGCGAAGCGCATCTCGACCTTGCCGCGTTGCTGCGAACGCCGCCACGTGCAGGCTGA

Upstream 100 bases:

>100_bases
GCGGGCACCACCGAGGACAAGTGTGAGACGGCGTGACATTCCCGCATTTTAGCGAGGGCGCGGCAGCCAGGCATAACAAG
GTGGGTGCGATAATCCGCGC

Downstream 100 bases:

>100_bases
GCCATAATTACCGATGGACAGATCTGTCGAGTGATCAAATCGACACATGATTCAACGAGCGCAAGGAGGCGGGCATGCCG
GTGGCCGTTGTAGCGAATCC

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MSKAPFSVPPDSLRGTLMIQGATSDAGKSTLVAGLCRVAHRAGVRVAPFKPQNMALNSAVTADGGEIGRAQALQAQAAGV
VPTVDMNPVLLKPNSDTGAQIIIHGQPRCDLDARAYHDYKPTAMAAVLESHTRLRGQYDLVLVEGAGSPAEINLRDRDIA
NMGFAEAVDCPVVLVADIDRGGVFAHLVGTLACLSDSERARVTGFIINRFRGDISLLTPGLDWLTAQTGKPVFGVLPYLP
GLHLDAEDAVQTAQRAASPDALRVVIPVLPRVSNHTDFDALRAHPQVDVRLVGPGQPIPPADLIILPGSKSVQADLAWLR
ANGWEAAIARHLRYGGKLIGICGGMQMLGRWLHDPLGLEGAPGSVKGLGYLDFETTLETSKKLRQVRGSLAEGGAAVAGY
EIHMGVTAGPALACPAVLLDDGHADGAISADGQIFATYLHGLFDAPQACCALLAWAGVGDAQAQDYAALREASLERLADT
CEAHLDLAALLRTPPRAG

Sequences:

>Translated_498_residues
MSKAPFSVPPDSLRGTLMIQGATSDAGKSTLVAGLCRVAHRAGVRVAPFKPQNMALNSAVTADGGEIGRAQALQAQAAGV
VPTVDMNPVLLKPNSDTGAQIIIHGQPRCDLDARAYHDYKPTAMAAVLESHTRLRGQYDLVLVEGAGSPAEINLRDRDIA
NMGFAEAVDCPVVLVADIDRGGVFAHLVGTLACLSDSERARVTGFIINRFRGDISLLTPGLDWLTAQTGKPVFGVLPYLP
GLHLDAEDAVQTAQRAASPDALRVVIPVLPRVSNHTDFDALRAHPQVDVRLVGPGQPIPPADLIILPGSKSVQADLAWLR
ANGWEAAIARHLRYGGKLIGICGGMQMLGRWLHDPLGLEGAPGSVKGLGYLDFETTLETSKKLRQVRGSLAEGGAAVAGY
EIHMGVTAGPALACPAVLLDDGHADGAISADGQIFATYLHGLFDAPQACCALLAWAGVGDAQAQDYAALREASLERLADT
CEAHLDLAALLRTPPRAG
>Mature_497_residues
SKAPFSVPPDSLRGTLMIQGATSDAGKSTLVAGLCRVAHRAGVRVAPFKPQNMALNSAVTADGGEIGRAQALQAQAAGVV
PTVDMNPVLLKPNSDTGAQIIIHGQPRCDLDARAYHDYKPTAMAAVLESHTRLRGQYDLVLVEGAGSPAEINLRDRDIAN
MGFAEAVDCPVVLVADIDRGGVFAHLVGTLACLSDSERARVTGFIINRFRGDISLLTPGLDWLTAQTGKPVFGVLPYLPG
LHLDAEDAVQTAQRAASPDALRVVIPVLPRVSNHTDFDALRAHPQVDVRLVGPGQPIPPADLIILPGSKSVQADLAWLRA
NGWEAAIARHLRYGGKLIGICGGMQMLGRWLHDPLGLEGAPGSVKGLGYLDFETTLETSKKLRQVRGSLAEGGAAVAGYE
IHMGVTAGPALACPAVLLDDGHADGAISADGQIFATYLHGLFDAPQACCALLAWAGVGDAQAQDYAALREASLERLADTC
EAHLDLAALLRTPPRAG

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: 6.3.5.10

Molecular weight: Translated: 52224; Mature: 52093

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAPFSVPPDSLRGTLMIQGATSDAGKSTLVAGLCRVAHRAGVRVAPFKPQNMALNSAV
CCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCEECCEE
TADGGEIGRAQALQAQAAGVVPTVDMNPVLLKPNSDTGAQIIIHGQPRCDLDARAYHDYK
ECCCCCCCHHHHHHHHHCCCCEECCCCCEEECCCCCCCCEEEEECCCCCCCCCCCCCCCC
PTAMAAVLESHTRLRGQYDLVLVEGAGSPAEINLRDRDIANMGFAEAVDCPVVLVADIDR
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEECCCCCCCCCCHHHCCCCEEEEEECCC
GGVFAHLVGTLACLSDSERARVTGFIINRFRGDISLLTPGLDWLTAQTGKPVFGVLPYLP
CCHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCEEEECCCCHHEECCCCCCCEEHHHCCC
GLHLDAEDAVQTAQRAASPDALRVVIPVLPRVSNHTDFDALRAHPQVDVRLVGPGQPIPP
CCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCC
ADLIILPGSKSVQADLAWLRANGWEAAIARHLRYGGKLIGICGGMQMLGRWLHDPLGLEG
CCEEEECCCCCCHHHEEEEECCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHCCCCCCCC
APGSVKGLGYLDFETTLETSKKLRQVRGSLAEGGAAVAGYEIHMGVTAGPALACPAVLLD
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHCCEEEEE
DGHADGAISADGQIFATYLHGLFDAPQACCALLAWAGVGDAQAQDYAALREASLERLADT
CCCCCCEECCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
CEAHLDLAALLRTPPRAG
HHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SKAPFSVPPDSLRGTLMIQGATSDAGKSTLVAGLCRVAHRAGVRVAPFKPQNMALNSAV
CCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCEECCEE
TADGGEIGRAQALQAQAAGVVPTVDMNPVLLKPNSDTGAQIIIHGQPRCDLDARAYHDYK
ECCCCCCCHHHHHHHHHCCCCEECCCCCEEECCCCCCCCEEEEECCCCCCCCCCCCCCCC
PTAMAAVLESHTRLRGQYDLVLVEGAGSPAEINLRDRDIANMGFAEAVDCPVVLVADIDR
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEECCCCCCCCCCHHHCCCCEEEEEECCC
GGVFAHLVGTLACLSDSERARVTGFIINRFRGDISLLTPGLDWLTAQTGKPVFGVLPYLP
CCHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCEEEECCCCHHEECCCCCCCEEHHHCCC
GLHLDAEDAVQTAQRAASPDALRVVIPVLPRVSNHTDFDALRAHPQVDVRLVGPGQPIPP
CCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCC
ADLIILPGSKSVQADLAWLRANGWEAAIARHLRYGGKLIGICGGMQMLGRWLHDPLGLEG
CCEEEECCCCCCHHHEEEEECCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHCCCCCCCC
APGSVKGLGYLDFETTLETSKKLRQVRGSLAEGGAAVAGYEIHMGVTAGPALACPAVLLD
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCHHHCCEEEEE
DGHADGAISADGQIFATYLHGLFDAPQACCALLAWAGVGDAQAQDYAALREASLERLADT
CCCCCCEECCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
CEAHLDLAALLRTPPRAG
HHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]