Click here to switch to the map view.

The map label for this gene is uvrD [H]

Identifier: 187929519

GI number: 187929519

Start: 2547460

End: 2549820

Strand: Reverse

Name: uvrD [H]

Synonym: Rpic_2440

Alternate gene names: 187929519

Gene position: 2549820-2547460 (Counterclockwise)

Preceding gene: 187929522

Following gene: 187929514

Centisome position: 64.67

GC content: 63.15

Gene sequence:

>2361_bases
ATGTCCGACCTGCTCGCCAATCTGAACCCCGAACAACGCGCTGCCATCACGCTTCCCGATGAATCGGCGCTGATCCTGGC
GGGCGCAGGCAGCGGCAAAACGCGCGTGTTGACCACCCGCATCGCGTGGCTGATCCAAAGCGCGCGGGTGTCGCCGTCGG
GTGTGCTGGCCGTCACGTTTACGAACAAGGCAGCCAAGGAAATGACGGCCCGCCTGCAGGCCATGCTGCCGATCAACACG
CGCGCCATGTGGATCGGCACGTTCCACGGTCTGTGCAACCGGTTGCTGCGCGCGCATTACCGCGATGCCGGCCTGCCGCA
GACGTTCCAGATTCTGGATACGCAAGACCAGCTCTCCGCCGTCAAGCGCCTGCTCAAGTCGCTCAATATCGACGACGAGA
AATTCCCGCCCAAGAACGTCCAGTACTTCATCAACGGGGCCAAGGAGCAGGGCCTGCGCGCGGGCGATCTGGAAATCGCC
AACGAGTACGACCGGCGCATGGCCGATCTCTACGCCGCTTACGACGCGCAATGCCAGCGCGAAGGCGTGGTCGATTTTGC
CGAGCTGCTGCTGCGCTGCTACGAACTGCTGCGCTACAACGACGCCATCCGTGCGCACTACCAACGGCGTTTCAAGCACA
TCCTGGTGGACGAGTTCCAGGATACGAACAAGCTGCAATATGCGTGGCTGAAGATTCTGGCCGGCCTGGGCGAGCCCGGC
GTCACGCCCAACGCCATCTTTGCCGTGGGCGACGATGACCAGAGCATCTACGCGTTTCGTGGTGCCAATGTCGGCAACAT
GGTCGACTTTGAACGCGAATTCCGCGTCGAGCACCGGATCAAGCTGGAGCAGAACTACCGCTCGCATGGCCATATCCTCG
ATACCGCCAACCACCTGATCTCGCACAACACGCGTCGGCTGGGCAAGAACCTGCGCACGGACGCCGGCCACGGTGAGCCG
GTGCGCGTCTATCAGGCCGCGACGGACGGGCAGGAGGCGGGCTGGATTGTCGATGAGATCCGCGACCGTATTGCGACCGG
CATGTCGCGCTCGGAAATCGCCATCCTGTATCGCAGCAACGCGCAGTCGCGGGTGATCGAACACGCGCTGTTCTCGGCAG
GCATCCCGTACAAGGTGTACGGCGGCCTGCGCTTTTTCGAGCGTGCGGAAATCAAGCACGCGCTGGCGTATCTTCAGCTT
CTTGAGAATCCCGACAATGACGCGGCGTTTGGTCGCGTGGTGAATTTCCCGGCGCGTGGCGTCGGGGCTCGTTCGCTCGA
GCAGTTGCAGGATGCGGCGCGGCTGTATGGCATTTCGCTCGCAGCGGCGGTGCCGTACCTCACGGGGGCAGCAGGCACCA
AGCTGTCGGCGTTTGTGCGTCTGATCGAACAGATGCGTGCCGACACGCGCCAGATGACGCTGCCCGAAATCGTTCAGCAC
GTCATTCACGCCAGCGGGCTGATCACGCATTACCAGGGTGAAAAGGAAGGCCAGGACCGCATCGAGAACTTGCAGGAACT
GGTGACAGCCGCCCAAGCTTTCGTTGCTGAAGAAGGCTACGGCGTGGATGCGATTGCGACCGCGCTGCCCGTGCGCCACG
ATGCCATGCTGCGCATCGAAGGCGGCGAGATCGATACCGCTTCTGAACTCGTCACCGACGAAACGCCTGCAGAGATGACG
CCGCTCGTCGCGTTTCTGACGCATGCCTCGCTGGAGGCTGGCGACAACCAGGCCCAGGCCGGCCAGGATGCCGTGCAAAT
GATGACCGTGCATGCGGCCAAGGGGCTGGAATTCCACGTCGTCTTCATCACCGGGCTGGAAGAGGGCTTGTTCCCGCACG
AAAACAGCCAGATGGAGAAGGACGGCCTGGAGGAAGAGCGCCGCCTGATGTACGTGGCGATCACGCGTGCGCGTGAGCGG
TTGTATCTATCGTTCGCGCAAAGCCGCGTGCTGCACGGGCAGGTCCGCTACCACATTCGCTCACGCTTCTTTGACGAACT
GCCCGAAGACACATTGAAGTGGCTGACGCCGCAGCACTCGGGCTACCAGGCGACGCGTCGTGTGCAAGGCGATACCGCAT
GGGGCAAGGATTGGTTCAAGCGCCCAGAGCGTGGCGATGACGACGCCTACACCGGCCGCCCGACCGGCGGCATGGACACC
GGCAAGAACTACGCCGACGCCAAGCGCGCAGAGGCCACCGGCTTCCGCGTCGGCCAGTCGGTGTTCCATAACAAGTTCGG
GGAAGGCGTCATCACGACGCTGGAAGGCGAGGGCGCCGAGGCGCGCGCCCAGATCAAGTTCAACCGCCACGGGGTGAAGA
CGCTGGCGCTGGGCATCGCCAAGCTGGACCCGATCAACTGA

Upstream 100 bases:

>100_bases
GGGCGAAAGCTTGGAATTATACGGCGTGTCGATGTCCGGCACGGGCGAAGCGGCGAATGCGGCCGGTATAATTTCAGGAT
TCTGCCGAGGCTCCTCCCGC

Downstream 100 bases:

>100_bases
GCGTCGACCGGGCCATCGTGCCGGTCAGACCGCCTTGTCAGCCGTCTGGCCGGCCGCTTGCGTCACGTTGAAGCAGCCGC
GGTAGGTGGCGTAGAACGAG

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 786; Mature: 785

Protein sequence:

>786_residues
MSDLLANLNPEQRAAITLPDESALILAGAGSGKTRVLTTRIAWLIQSARVSPSGVLAVTFTNKAAKEMTARLQAMLPINT
RAMWIGTFHGLCNRLLRAHYRDAGLPQTFQILDTQDQLSAVKRLLKSLNIDDEKFPPKNVQYFINGAKEQGLRAGDLEIA
NEYDRRMADLYAAYDAQCQREGVVDFAELLLRCYELLRYNDAIRAHYQRRFKHILVDEFQDTNKLQYAWLKILAGLGEPG
VTPNAIFAVGDDDQSIYAFRGANVGNMVDFEREFRVEHRIKLEQNYRSHGHILDTANHLISHNTRRLGKNLRTDAGHGEP
VRVYQAATDGQEAGWIVDEIRDRIATGMSRSEIAILYRSNAQSRVIEHALFSAGIPYKVYGGLRFFERAEIKHALAYLQL
LENPDNDAAFGRVVNFPARGVGARSLEQLQDAARLYGISLAAAVPYLTGAAGTKLSAFVRLIEQMRADTRQMTLPEIVQH
VIHASGLITHYQGEKEGQDRIENLQELVTAAQAFVAEEGYGVDAIATALPVRHDAMLRIEGGEIDTASELVTDETPAEMT
PLVAFLTHASLEAGDNQAQAGQDAVQMMTVHAAKGLEFHVVFITGLEEGLFPHENSQMEKDGLEEERRLMYVAITRARER
LYLSFAQSRVLHGQVRYHIRSRFFDELPEDTLKWLTPQHSGYQATRRVQGDTAWGKDWFKRPERGDDDAYTGRPTGGMDT
GKNYADAKRAEATGFRVGQSVFHNKFGEGVITTLEGEGAEARAQIKFNRHGVKTLALGIAKLDPIN

Sequences:

>Translated_786_residues
MSDLLANLNPEQRAAITLPDESALILAGAGSGKTRVLTTRIAWLIQSARVSPSGVLAVTFTNKAAKEMTARLQAMLPINT
RAMWIGTFHGLCNRLLRAHYRDAGLPQTFQILDTQDQLSAVKRLLKSLNIDDEKFPPKNVQYFINGAKEQGLRAGDLEIA
NEYDRRMADLYAAYDAQCQREGVVDFAELLLRCYELLRYNDAIRAHYQRRFKHILVDEFQDTNKLQYAWLKILAGLGEPG
VTPNAIFAVGDDDQSIYAFRGANVGNMVDFEREFRVEHRIKLEQNYRSHGHILDTANHLISHNTRRLGKNLRTDAGHGEP
VRVYQAATDGQEAGWIVDEIRDRIATGMSRSEIAILYRSNAQSRVIEHALFSAGIPYKVYGGLRFFERAEIKHALAYLQL
LENPDNDAAFGRVVNFPARGVGARSLEQLQDAARLYGISLAAAVPYLTGAAGTKLSAFVRLIEQMRADTRQMTLPEIVQH
VIHASGLITHYQGEKEGQDRIENLQELVTAAQAFVAEEGYGVDAIATALPVRHDAMLRIEGGEIDTASELVTDETPAEMT
PLVAFLTHASLEAGDNQAQAGQDAVQMMTVHAAKGLEFHVVFITGLEEGLFPHENSQMEKDGLEEERRLMYVAITRARER
LYLSFAQSRVLHGQVRYHIRSRFFDELPEDTLKWLTPQHSGYQATRRVQGDTAWGKDWFKRPERGDDDAYTGRPTGGMDT
GKNYADAKRAEATGFRVGQSVFHNKFGEGVITTLEGEGAEARAQIKFNRHGVKTLALGIAKLDPIN
>Mature_785_residues
SDLLANLNPEQRAAITLPDESALILAGAGSGKTRVLTTRIAWLIQSARVSPSGVLAVTFTNKAAKEMTARLQAMLPINTR
AMWIGTFHGLCNRLLRAHYRDAGLPQTFQILDTQDQLSAVKRLLKSLNIDDEKFPPKNVQYFINGAKEQGLRAGDLEIAN
EYDRRMADLYAAYDAQCQREGVVDFAELLLRCYELLRYNDAIRAHYQRRFKHILVDEFQDTNKLQYAWLKILAGLGEPGV
TPNAIFAVGDDDQSIYAFRGANVGNMVDFEREFRVEHRIKLEQNYRSHGHILDTANHLISHNTRRLGKNLRTDAGHGEPV
RVYQAATDGQEAGWIVDEIRDRIATGMSRSEIAILYRSNAQSRVIEHALFSAGIPYKVYGGLRFFERAEIKHALAYLQLL
ENPDNDAAFGRVVNFPARGVGARSLEQLQDAARLYGISLAAAVPYLTGAAGTKLSAFVRLIEQMRADTRQMTLPEIVQHV
IHASGLITHYQGEKEGQDRIENLQELVTAAQAFVAEEGYGVDAIATALPVRHDAMLRIEGGEIDTASELVTDETPAEMTP
LVAFLTHASLEAGDNQAQAGQDAVQMMTVHAAKGLEFHVVFITGLEEGLFPHENSQMEKDGLEEERRLMYVAITRARERL
YLSFAQSRVLHGQVRYHIRSRFFDELPEDTLKWLTPQHSGYQATRRVQGDTAWGKDWFKRPERGDDDAYTGRPTGGMDTG
KNYADAKRAEATGFRVGQSVFHNKFGEGVITTLEGEGAEARAQIKFNRHGVKTLALGIAKLDPIN

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=794, Percent_Identity=43.7027707808564, Blast_Score=625, Evalue=1e-180,
Organism=Escherichia coli, GI48994965, Length=682, Percent_Identity=35.9237536656891, Blast_Score=355, Evalue=6e-99,
Organism=Escherichia coli, GI1787196, Length=344, Percent_Identity=29.3604651162791, Blast_Score=118, Evalue=2e-27,
Organism=Escherichia coli, GI1789183, Length=311, Percent_Identity=24.1157556270096, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322369, Length=805, Percent_Identity=27.8260869565217, Blast_Score=224, Evalue=6e-59,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 87730; Mature: 87599

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLLANLNPEQRAAITLPDESALILAGAGSGKTRVLTTRIAWLIQSARVSPSGVLAVTF
CCCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCEEHHHHHHHHHHHCCCCCCCEEEEEE
TNKAAKEMTARLQAMLPINTRAMWIGTFHGLCNRLLRAHYRDAGLPQTFQILDTQDQLSA
CCHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHH
VKRLLKSLNIDDEKFPPKNVQYFINGAKEQGLRAGDLEIANEYDRRMADLYAAYDAQCQR
HHHHHHHCCCCCCCCCCCCCEEEEECHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EGVVDFAELLLRCYELLRYNDAIRAHYQRRFKHILVDEFQDTNKLQYAWLKILAGLGEPG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCC
VTPNAIFAVGDDDQSIYAFRGANVGNMVDFEREFRVEHRIKLEQNYRSHGHILDTANHLI
CCCCEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHEEEHHCCCCCCCCHHHHHHHH
SHNTRRLGKNLRTDAGHGEPVRVYQAATDGQEAGWIVDEIRDRIATGMSRSEIAILYRSN
HCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECC
AQSRVIEHALFSAGIPYKVYGGLRFFERAEIKHALAYLQLLENPDNDAAFGRVVNFPARG
CHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEECCCCCC
VGARSLEQLQDAARLYGISLAAAVPYLTGAAGTKLSAFVRLIEQMRADTRQMTLPEIVQH
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
VIHASGLITHYQGEKEGQDRIENLQELVTAAQAFVAEEGYGVDAIATALPVRHDAMLRIE
HHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEEE
GGEIDTASELVTDETPAEMTPLVAFLTHASLEAGDNQAQAGQDAVQMMTVHAAKGLEFHV
CCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEE
VFITGLEEGLFPHENSQMEKDGLEEERRLMYVAITRARERLYLSFAQSRVLHGQVRYHIR
EEEECCCCCCCCCCCCCCCCCCCHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRFFDELPEDTLKWLTPQHSGYQATRRVQGDTAWGKDWFKRPERGDDDAYTGRPTGGMDT
HHHHHHCCHHHHHHCCCCCCCCHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCC
GKNYADAKRAEATGFRVGQSVFHNKFGEGVITTLEGEGAEARAQIKFNRHGVKTLALGIA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCHHHHHHHHH
KLDPIN
HCCCCC
>Mature Secondary Structure 
SDLLANLNPEQRAAITLPDESALILAGAGSGKTRVLTTRIAWLIQSARVSPSGVLAVTF
CCCCCCCCCCCCEEEECCCCCEEEEEECCCCCCEEHHHHHHHHHHHCCCCCCCEEEEEE
TNKAAKEMTARLQAMLPINTRAMWIGTFHGLCNRLLRAHYRDAGLPQTFQILDTQDQLSA
CCHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHH
VKRLLKSLNIDDEKFPPKNVQYFINGAKEQGLRAGDLEIANEYDRRMADLYAAYDAQCQR
HHHHHHHCCCCCCCCCCCCCEEEEECHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EGVVDFAELLLRCYELLRYNDAIRAHYQRRFKHILVDEFQDTNKLQYAWLKILAGLGEPG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCC
VTPNAIFAVGDDDQSIYAFRGANVGNMVDFEREFRVEHRIKLEQNYRSHGHILDTANHLI
CCCCEEEEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHEEEHHCCCCCCCCHHHHHHHH
SHNTRRLGKNLRTDAGHGEPVRVYQAATDGQEAGWIVDEIRDRIATGMSRSEIAILYRSN
HCCHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECC
AQSRVIEHALFSAGIPYKVYGGLRFFERAEIKHALAYLQLLENPDNDAAFGRVVNFPARG
CHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHEECCCCCC
VGARSLEQLQDAARLYGISLAAAVPYLTGAAGTKLSAFVRLIEQMRADTRQMTLPEIVQH
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
VIHASGLITHYQGEKEGQDRIENLQELVTAAQAFVAEEGYGVDAIATALPVRHDAMLRIE
HHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEEEE
GGEIDTASELVTDETPAEMTPLVAFLTHASLEAGDNQAQAGQDAVQMMTVHAAKGLEFHV
CCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCEEEE
VFITGLEEGLFPHENSQMEKDGLEEERRLMYVAITRARERLYLSFAQSRVLHGQVRYHIR
EEEECCCCCCCCCCCCCCCCCCCHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRFFDELPEDTLKWLTPQHSGYQATRRVQGDTAWGKDWFKRPERGDDDAYTGRPTGGMDT
HHHHHHCCHHHHHHCCCCCCCCHHHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCC
GKNYADAKRAEATGFRVGQSVFHNKFGEGVITTLEGEGAEARAQIKFNRHGVKTLALGIA
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEECCCCHHHHHHHHH
KLDPIN
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]