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The map label for this gene is fppS [H]

Identifier: 187929506

GI number: 187929506

Start: 2533008

End: 2533919

Strand: Reverse

Name: fppS [H]

Synonym: Rpic_2427

Alternate gene names: 187929506

Gene position: 2533919-2533008 (Counterclockwise)

Preceding gene: 187929507

Following gene: 187929505

Centisome position: 64.27

GC content: 66.34

Gene sequence:

>912_bases
ATGAGCGATTTCGCCCAATGGATGGCGTCTGTGGTCGCGCGGACGGAAGTTGCGCTCGAGCGCGCGCTGCCGGCCGAAAC
CGTCTCGCCACAACGTCTGCATGCCGCCATGCGGTACGCCACGCTGGGTGCGGGAAAGCGTGTGCGCCCATTGCTGGCAC
ATGCTGCCGGTGCGCTGGGCGACGCATCGCCGGAGGCGCTAGACGGCGTGAGTTGCGCGGTGGAGATGATCCACGCCTAT
TCGCTCGTCCACGACGACATGCCTTGCATGGACGACGACGATCTGCGCCGTGGCCGTCCCACCGTACATCGCGCCTATGA
TGAAGCGACGGCCCTTCTGGTAGGTGACGCCTTGCAAACGCAGGCGTTCATCGTGCTGGCAGAGCAGGGTGCGGTGCGCC
CGGCCACGCGTGCAGTGCTGATGGGCGAACTGGCGCGCGCCTCGGGTTCGCAGGGCATGGCAGGCGGCCAAGCGATCGAT
CTGCAGAGCGTTGGCATTGCGCTGTCGCAAGACGAACTGGAAGCGATGCACCGCATGAAGACCGGTGCGCTCCTGCGGGC
GAGCCTGCGGATGGGCGCGCTCTGTGCTGAGGTGAATGCCGCTGCCTTGGAGCATGTCGATGCTTATGCGGGTGCTGTCG
GCCTCGCGTTCCAGGTGGTCGACGACATTCTCGATGTGACGGCCGATACCGCCACGCTGGGCAAAACTGCGGGCAAGGAC
GAGGCCAACGACAAACCGACTTACGTGTCCATCCTTGGGTTGGACAAGGCCCGGGCACTGGCCGATGAGCTGCACGCCGC
GGCGGGAGCGGCGGTCGCGGAACTGGCCCGCGAGATCGGCTGTGAAGCGGGCCGAGCCCGTACCGTTCGATTGGCCGAGA
TGGCCGACCTGATCGTGCGGCGTGGCCACTGA

Upstream 100 bases:

>100_bases
AGCAGGTGCTAGAGCGCGTGGAGCAACAGGTGCGCGTGCTTGACGGCGATGCCCTGAAGCCGTTGGGCGACGATAGCAAC
ACGAACGAACAGGGCGACGC

Downstream 100 bases:

>100_bases
ACAACATTGCATCGACGTTAGAAGTCTTTGCCAAAACGCCTGAGCGGCGGTCCCACATGACGTACGAACTTCTGAACACC
ATCGACGATCCGGCCGACCT

Product: Polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MSDFAQWMASVVARTEVALERALPAETVSPQRLHAAMRYATLGAGKRVRPLLAHAAGALGDASPEALDGVSCAVEMIHAY
SLVHDDMPCMDDDDLRRGRPTVHRAYDEATALLVGDALQTQAFIVLAEQGAVRPATRAVLMGELARASGSQGMAGGQAID
LQSVGIALSQDELEAMHRMKTGALLRASLRMGALCAEVNAAALEHVDAYAGAVGLAFQVVDDILDVTADTATLGKTAGKD
EANDKPTYVSILGLDKARALADELHAAAGAAVAELAREIGCEAGRARTVRLAEMADLIVRRGH

Sequences:

>Translated_303_residues
MSDFAQWMASVVARTEVALERALPAETVSPQRLHAAMRYATLGAGKRVRPLLAHAAGALGDASPEALDGVSCAVEMIHAY
SLVHDDMPCMDDDDLRRGRPTVHRAYDEATALLVGDALQTQAFIVLAEQGAVRPATRAVLMGELARASGSQGMAGGQAID
LQSVGIALSQDELEAMHRMKTGALLRASLRMGALCAEVNAAALEHVDAYAGAVGLAFQVVDDILDVTADTATLGKTAGKD
EANDKPTYVSILGLDKARALADELHAAAGAAVAELAREIGCEAGRARTVRLAEMADLIVRRGH
>Mature_302_residues
SDFAQWMASVVARTEVALERALPAETVSPQRLHAAMRYATLGAGKRVRPLLAHAAGALGDASPEALDGVSCAVEMIHAYS
LVHDDMPCMDDDDLRRGRPTVHRAYDEATALLVGDALQTQAFIVLAEQGAVRPATRAVLMGELARASGSQGMAGGQAIDL
QSVGIALSQDELEAMHRMKTGALLRASLRMGALCAEVNAAALEHVDAYAGAVGLAFQVVDDILDVTADTATLGKTAGKDE
ANDKPTYVSILGLDKARALADELHAAAGAAVAELAREIGCEAGRARTVRLAEMADLIVRRGH

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=225, Percent_Identity=28.8888888888889, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786623, Length=303, Percent_Identity=45.8745874587459, Blast_Score=205, Evalue=2e-54,
Organism=Escherichia coli, GI1789578, Length=214, Percent_Identity=30.3738317757009, Blast_Score=94, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24651612, Length=215, Percent_Identity=28.3720930232558, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31728; Mature: 31596

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDFAQWMASVVARTEVALERALPAETVSPQRLHAAMRYATLGAGKRVRPLLAHAAGALG
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
DASPEALDGVSCAVEMIHAYSLVHDDMPCMDDDDLRRGRPTVHRAYDEATALLVGDALQT
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHH
QAFIVLAEQGAVRPATRAVLMGELARASGSQGMAGGQAIDLQSVGIALSQDELEAMHRMK
CEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHCCEECHHHHHHHHHHH
TGALLRASLRMGALCAEVNAAALEHVDAYAGAVGLAFQVVDDILDVTADTATLGKTAGKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCC
EANDKPTYVSILGLDKARALADELHAAAGAAVAELAREIGCEAGRARTVRLAEMADLIVR
CCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
RGH
CCC
>Mature Secondary Structure 
SDFAQWMASVVARTEVALERALPAETVSPQRLHAAMRYATLGAGKRVRPLLAHAAGALG
CHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
DASPEALDGVSCAVEMIHAYSLVHDDMPCMDDDDLRRGRPTVHRAYDEATALLVGDALQT
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHH
QAFIVLAEQGAVRPATRAVLMGELARASGSQGMAGGQAIDLQSVGIALSQDELEAMHRMK
CEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHCCEECHHHHHHHHHHH
TGALLRASLRMGALCAEVNAAALEHVDAYAGAVGLAFQVVDDILDVTADTATLGKTAGKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCC
EANDKPTYVSILGLDKARALADELHAAAGAAVAELAREIGCEAGRARTVRLAEMADLIVR
CCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
RGH
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9655913; 12597275 [H]