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The map label for this gene is ybdL [H]

Identifier: 187929245

GI number: 187929245

Start: 2279141

End: 2280313

Strand: Direct

Name: ybdL [H]

Synonym: Rpic_2166

Alternate gene names: 187929245

Gene position: 2279141-2280313 (Clockwise)

Preceding gene: 187929244

Following gene: 187929247

Centisome position: 57.81

GC content: 64.71

Gene sequence:

>1173_bases
ATGACCACTGTTGAATCGCTCGCGCCCATCGCCCCGCCGCCGTCGCGGCTACCGAATGTCGGCACCACCATCTTCACCGT
GATGTCTGCGCTGGCCGTGGAAAAGCAGGCCGTCAACCTGGGCCAGGGCTTTCCTGATTTCGATTGCGATCCGCGCATCG
TCGATGCGGTGTCCGACGCCATGCGCGCCGGCCTGAACCAATACCCGCCGATGACCGGCGTGCCCGCCCTGCGCCAGGCC
ATCGCCGCGAAGATCGCCAATCTGTACGGCCACGCTTACGATGCCGACCGCGAGATCACCATCACCGCCGGCGCCACGCA
GGCGCTGCTGACCACCGTGCTGTGCTGCGTGCATCCGGGCGACGAAGTCATCGTCTTCGAGCCGACGTACGACAGCTACA
TCCCTTCGATTGAACTGGCGGGCGGCAAGGTTGTGCCGATCACGCTGAACGCGCCGGACTTCCGCATCCCGTTCGACACG
CTGGCCGCGGCCATCACGCCGCGCACGCGTCTGATCATGCTGAACACACCGCACAACCCGACCGGCACGGTCTGGCATGC
GGACGACATGCGCAAGCTCGCCGAGATCCTCGCGCCGACCAACGTGCTGCTGCTCTCCGATGAGGTGTACGAGCACATGG
TGTACGACGGCGTGCCGCATGCCTCGGTGGCGCGCATTCCCGAGCTGGCGCGGCGCGCCTTCGTGGTGTCGAGTTTCGGC
AAGACGTATCACGTGACAGGCTGGAAGGTCGGCTACGTGGCCGCGCCCGCCGCGCTCATGGCGGAATTCCGCAAGGTGCA
CCAGTTCAACGTGTTCACCGTCAATACGCCGATGCAGCACGGCCTGGCAAGCTACATGGCCGATCCGCGTCCATACCTGG
AGTTGCCGGCGTTCTATCAGCACAAGCGCGACCTGTTCCGCGCGGGGCTGGGGAAGACGCGCTTCAAGCTGCTGCCCTGT
CAGGGCACGTACTTCCAGTGCGTGGATTACAGCGCCATCTCCGATCTGCCCGAGGCCGAGTTCGCCAAGTGGCTGACGAG
CGAGATTGGCGTGGCGGCAATTCCCGTGTCGGCGTTCTACTCGCAGCCGCACGAATCGGGCGTGGTGCGCTTCTGCTTCG
CCAAGAAAGACGAAACGCTCCAGGTTGCCCTGGAGCGTTTGTCGAAGGTGTAA

Upstream 100 bases:

>100_bases
CGACGTGGCGGTGTTGCCACCCAAGCAGTTCGTCGCGCTGGTCCAGTTGGAAAACGCGTCCCTTGCTGCAATCCCAAATC
AAGCCTGAAGCCGTCTTGTC

Downstream 100 bases:

>100_bases
AACCGTAAGGCCGAGGCCGATCAGCGCTTGCTGGCGTAGTGCGCAAGCATCTGCTCGAGATTGGCCTTGCTGTCTGCCCG
CACTTTCTGCACGTTGGGAT

Product: putative aminotransferase

Products: oxaloacetate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MTTVESLAPIAPPPSRLPNVGTTIFTVMSALAVEKQAVNLGQGFPDFDCDPRIVDAVSDAMRAGLNQYPPMTGVPALRQA
IAAKIANLYGHAYDADREITITAGATQALLTTVLCCVHPGDEVIVFEPTYDSYIPSIELAGGKVVPITLNAPDFRIPFDT
LAAAITPRTRLIMLNTPHNPTGTVWHADDMRKLAEILAPTNVLLLSDEVYEHMVYDGVPHASVARIPELARRAFVVSSFG
KTYHVTGWKVGYVAAPAALMAEFRKVHQFNVFTVNTPMQHGLASYMADPRPYLELPAFYQHKRDLFRAGLGKTRFKLLPC
QGTYFQCVDYSAISDLPEAEFAKWLTSEIGVAAIPVSAFYSQPHESGVVRFCFAKKDETLQVALERLSKV

Sequences:

>Translated_390_residues
MTTVESLAPIAPPPSRLPNVGTTIFTVMSALAVEKQAVNLGQGFPDFDCDPRIVDAVSDAMRAGLNQYPPMTGVPALRQA
IAAKIANLYGHAYDADREITITAGATQALLTTVLCCVHPGDEVIVFEPTYDSYIPSIELAGGKVVPITLNAPDFRIPFDT
LAAAITPRTRLIMLNTPHNPTGTVWHADDMRKLAEILAPTNVLLLSDEVYEHMVYDGVPHASVARIPELARRAFVVSSFG
KTYHVTGWKVGYVAAPAALMAEFRKVHQFNVFTVNTPMQHGLASYMADPRPYLELPAFYQHKRDLFRAGLGKTRFKLLPC
QGTYFQCVDYSAISDLPEAEFAKWLTSEIGVAAIPVSAFYSQPHESGVVRFCFAKKDETLQVALERLSKV
>Mature_389_residues
TTVESLAPIAPPPSRLPNVGTTIFTVMSALAVEKQAVNLGQGFPDFDCDPRIVDAVSDAMRAGLNQYPPMTGVPALRQAI
AAKIANLYGHAYDADREITITAGATQALLTTVLCCVHPGDEVIVFEPTYDSYIPSIELAGGKVVPITLNAPDFRIPFDTL
AAAITPRTRLIMLNTPHNPTGTVWHADDMRKLAEILAPTNVLLLSDEVYEHMVYDGVPHASVARIPELARRAFVVSSFGK
TYHVTGWKVGYVAAPAALMAEFRKVHQFNVFTVNTPMQHGLASYMADPRPYLELPAFYQHKRDLFRAGLGKTRFKLLPCQ
GTYFQCVDYSAISDLPEAEFAKWLTSEIGVAAIPVSAFYSQPHESGVVRFCFAKKDETLQVALERLSKV

Specific function: Shows aminotransferase activity with methionine and histidine as substrates, and to a lesser extent also with phenylalanine [H]

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=409, Percent_Identity=35.4523227383863, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI169881279, Length=409, Percent_Identity=35.4523227383863, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI56713256, Length=401, Percent_Identity=34.4139650872818, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI56713254, Length=401, Percent_Identity=34.4139650872818, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI169881281, Length=408, Percent_Identity=31.3725490196078, Blast_Score=182, Evalue=4e-46,
Organism=Homo sapiens, GI4507369, Length=217, Percent_Identity=26.7281105990783, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1786816, Length=379, Percent_Identity=53.0343007915567, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI1788722, Length=370, Percent_Identity=25.6756756756757, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI1788627, Length=159, Percent_Identity=30.8176100628931, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787710, Length=281, Percent_Identity=27.7580071174377, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787909, Length=189, Percent_Identity=26.984126984127, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71994472, Length=420, Percent_Identity=34.0476190476191, Blast_Score=230, Evalue=9e-61,
Organism=Caenorhabditis elegans, GI71994476, Length=420, Percent_Identity=34.0476190476191, Blast_Score=230, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI17567369, Length=418, Percent_Identity=33.4928229665072, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI17567663, Length=349, Percent_Identity=22.0630372492837, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322401, Length=389, Percent_Identity=32.9048843187661, Blast_Score=204, Evalue=2e-53,
Organism=Drosophila melanogaster, GI28573069, Length=409, Percent_Identity=34.718826405868, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24646114, Length=409, Percent_Identity=34.718826405868, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI28573067, Length=409, Percent_Identity=34.718826405868, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI28573065, Length=409, Percent_Identity=34.718826405868, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI18859735, Length=250, Percent_Identity=25.2, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.1

Molecular weight: Translated: 42742; Mature: 42610

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVESLAPIAPPPSRLPNVGTTIFTVMSALAVEKQAVNLGQGFPDFDCDPRIVDAVSDA
CCCHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
MRAGLNQYPPMTGVPALRQAIAAKIANLYGHAYDADREITITAGATQALLTTVLCCVHPG
HHCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHCCCC
DEVIVFEPTYDSYIPSIELAGGKVVPITLNAPDFRIPFDTLAAAITPRTRLIMLNTPHNP
CEEEEECCCHHHHCCEEEECCCEEEEEEECCCCCCCCHHHHHHHCCCCEEEEEEECCCCC
TGTVWHADDMRKLAEILAPTNVLLLSDEVYEHMVYDGVPHASVARIPELARRAFVVSSFG
CCCEEEHHHHHHHHHHHCCCCEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
KTYHVTGWKVGYVAAPAALMAEFRKVHQFNVFTVNTPMQHGLASYMADPRPYLELPAFYQ
CEEEECCEEEHHHHCCHHHHHHHHHHHHEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHH
HKRDLFRAGLGKTRFKLLPCQGTYFQCVDYSAISDLPEAEFAKWLTSEIGVAAIPVSAFY
HHHHHHHHCCCCCEEEEECCCCCEEEEECCHHHHCCCHHHHHHHHHHHCCEEEEEHHHHH
SQPHESGVVRFCFAKKDETLQVALERLSKV
CCCCCCCEEEEEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TTVESLAPIAPPPSRLPNVGTTIFTVMSALAVEKQAVNLGQGFPDFDCDPRIVDAVSDA
CCHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
MRAGLNQYPPMTGVPALRQAIAAKIANLYGHAYDADREITITAGATQALLTTVLCCVHPG
HHCCHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHCCCC
DEVIVFEPTYDSYIPSIELAGGKVVPITLNAPDFRIPFDTLAAAITPRTRLIMLNTPHNP
CEEEEECCCHHHHCCEEEECCCEEEEEEECCCCCCCCHHHHHHHCCCCEEEEEEECCCCC
TGTVWHADDMRKLAEILAPTNVLLLSDEVYEHMVYDGVPHASVARIPELARRAFVVSSFG
CCCEEEHHHHHHHHHHHCCCCEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
KTYHVTGWKVGYVAAPAALMAEFRKVHQFNVFTVNTPMQHGLASYMADPRPYLELPAFYQ
CEEEECCEEEHHHHCCHHHHHHHHHHHHEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHH
HKRDLFRAGLGKTRFKLLPCQGTYFQCVDYSAISDLPEAEFAKWLTSEIGVAAIPVSAFY
HHHHHHHHCCCCCEEEEECCCCCEEEEECCHHHHCCCHHHHHHHHHHHCCEEEEEHHHHH
SQPHESGVVRFCFAKKDETLQVALERLSKV
CCCCCCCEEEEEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate; 2-oxoglutarate

Specific reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503 [H]