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The map label for this gene is dppA [H]

Identifier: 187929166

GI number: 187929166

Start: 2196417

End: 2197985

Strand: Direct

Name: dppA [H]

Synonym: Rpic_2087

Alternate gene names: 187929166

Gene position: 2196417-2197985 (Clockwise)

Preceding gene: 187929165

Following gene: 187929167

Centisome position: 55.71

GC content: 63.73

Gene sequence:

>1569_bases
GTGAAACGCCTCCTAGCCTCGTCGCTTGCCGTCGCGCTGTTTGCCGCTGCCGGCGCTGCCGGCGCGCAGACGCTGAACAT
TGCCTTTGCCGATCCGCTGTCGTCGCTCGACCCGCAGTTGAACAATCACGCAGGCGACCGCTCCGTCGACGTGCACTTCT
GGGATCTGCTGGTCGAGAACAAGTGGAACCAGCTGCAGCCCGGCCTGGCGCTGTCGTGGAGGACGCTGGACCCGAAGACG
TGGGAATTCAAGCTGCGCCCGAACGTGAAATGGCACGACGGCCAGCCGTTCACGGCGGATGACGTCATCTTCTCGTACCA
GCGCGCGCGCAGCGTGCCGGGCAGCGTGGCAACGTTCGCGGGCTATCTGCGCACGGTGGAGTCCGTCACGGCCAAAGACC
CGCTGACGCTGATCATCAAGACGAACATCCCGAACCCGGACTTGCCGCTGAACCTCGCGTCCGTGCACATCGTCAGCAAG
CATGTGGGTGAGAAGTCGTCGACTGAGGACTACAACGCGGGCCGCGCCGTGGTGGGCACCGGCCCCTACAAGTTCGTCTC
GTATGTGCCGGGCGATCGCGTGGTGATGGCGCGCAACGACAACTACTGGGGCGGCAAACAGCTCTGGGAGAAGGTCAACT
ACCGCTACATCAACAATGCTGCCGCGCGCACGGCCAACCTGCTCTCAGGCGAGGTGGATGTCATCGACAAGGTGTCGGTG
TCTGACCTGGCGCGCCTGCGCCAGTCGCCCAACGTGAAGGTGTTTTCCTATCCGGGCTTGCGTGTGATGCTGTTGCAACC
GAGCTTCCGCAAGGGGCCGAACGATTACGTCACCGGCAACGACGGCAAGCCGCTGCCGAACAATCCGCTGCTGGATGTGC
GCGTGCGCCGTGCGCTGTCGCTGGCCATCGACCGCAAGGCCATTGTCGACCGCATCCTGCAAGGCGCCGCCACTGTCGCC
AACCAGTGGATGCCGTCGAACACGTACGGCTACAACCCCGACGTGAAGGATATCGCCTACGACCCGGCGCAGGCCAAGAA
GCTGCTGGCCGATGCGGGCTTTCCGCAGGGCTTCAACCTCGTGATGCACGTGCCGAATGATCGCTACCCGCAAGGCCCCG
AAACGGCGCAGGCGGTGGCGCAGTTCTGGACGCGCATCGGCGTGAAGGCGCGCGTGGAAGTGGTGCCCTGGTCGGTCTAC
TCGGGCCGCGCCAACAAGAATGAATATGCGATGAGCATGCTGGCGTGGGGCAACGGCACGGGCGAAGCAAGCTACGCGCT
TGTCAACGTGCTGGCCACCGTCGATACCAAGAAGGGTCTGGGCGCATCCAACTGGGGCCACTACAGCAACGCGGCTGTCG
ACAACGCGTTGAACGCCTCCACCGAGGAATTCAACGTGGAAAAGCGCGCGGCCATTCTTCGCCACTCCGTCAAGCTGGTC
TCGGATGACGTGGGCGTGATGCCGCTGTACCACTACCAGAACGTGTGGGCCGCCAAAAAAGGCCTGAAGGTGACGCCGAT
GACGAGCGATCGCACCGCGGCCCAGATGGTCACCAAGGACGGCAAGTAA

Upstream 100 bases:

>100_bases
GCATTGCGGTCAACCACATCAGCGCGTGCCACCTGAACGACGCGACCTGAACGACATTCAATAAGCCAACGATTCCAAAA
ACAGGAAAAAGGGAACCCAC

Downstream 100 bases:

>100_bases
GCGCCATGGGAACCTTCGCGCTCAGCGTGACGCCGGCGGATGACCTGATCGACGTATCGCGCGGCATCGTCGTGACGGGG
CTCGCGCCTGGCACACAAGT

Product: family 5 extracellular solute-binding protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Dipeptide-binding protein; DBP [H]

Number of amino acids: Translated: 522; Mature: 522

Protein sequence:

>522_residues
MKRLLASSLAVALFAAAGAAGAQTLNIAFADPLSSLDPQLNNHAGDRSVDVHFWDLLVENKWNQLQPGLALSWRTLDPKT
WEFKLRPNVKWHDGQPFTADDVIFSYQRARSVPGSVATFAGYLRTVESVTAKDPLTLIIKTNIPNPDLPLNLASVHIVSK
HVGEKSSTEDYNAGRAVVGTGPYKFVSYVPGDRVVMARNDNYWGGKQLWEKVNYRYINNAAARTANLLSGEVDVIDKVSV
SDLARLRQSPNVKVFSYPGLRVMLLQPSFRKGPNDYVTGNDGKPLPNNPLLDVRVRRALSLAIDRKAIVDRILQGAATVA
NQWMPSNTYGYNPDVKDIAYDPAQAKKLLADAGFPQGFNLVMHVPNDRYPQGPETAQAVAQFWTRIGVKARVEVVPWSVY
SGRANKNEYAMSMLAWGNGTGEASYALVNVLATVDTKKGLGASNWGHYSNAAVDNALNASTEEFNVEKRAAILRHSVKLV
SDDVGVMPLYHYQNVWAAKKGLKVTPMTSDRTAAQMVTKDGK

Sequences:

>Translated_522_residues
MKRLLASSLAVALFAAAGAAGAQTLNIAFADPLSSLDPQLNNHAGDRSVDVHFWDLLVENKWNQLQPGLALSWRTLDPKT
WEFKLRPNVKWHDGQPFTADDVIFSYQRARSVPGSVATFAGYLRTVESVTAKDPLTLIIKTNIPNPDLPLNLASVHIVSK
HVGEKSSTEDYNAGRAVVGTGPYKFVSYVPGDRVVMARNDNYWGGKQLWEKVNYRYINNAAARTANLLSGEVDVIDKVSV
SDLARLRQSPNVKVFSYPGLRVMLLQPSFRKGPNDYVTGNDGKPLPNNPLLDVRVRRALSLAIDRKAIVDRILQGAATVA
NQWMPSNTYGYNPDVKDIAYDPAQAKKLLADAGFPQGFNLVMHVPNDRYPQGPETAQAVAQFWTRIGVKARVEVVPWSVY
SGRANKNEYAMSMLAWGNGTGEASYALVNVLATVDTKKGLGASNWGHYSNAAVDNALNASTEEFNVEKRAAILRHSVKLV
SDDVGVMPLYHYQNVWAAKKGLKVTPMTSDRTAAQMVTKDGK
>Mature_522_residues
MKRLLASSLAVALFAAAGAAGAQTLNIAFADPLSSLDPQLNNHAGDRSVDVHFWDLLVENKWNQLQPGLALSWRTLDPKT
WEFKLRPNVKWHDGQPFTADDVIFSYQRARSVPGSVATFAGYLRTVESVTAKDPLTLIIKTNIPNPDLPLNLASVHIVSK
HVGEKSSTEDYNAGRAVVGTGPYKFVSYVPGDRVVMARNDNYWGGKQLWEKVNYRYINNAAARTANLLSGEVDVIDKVSV
SDLARLRQSPNVKVFSYPGLRVMLLQPSFRKGPNDYVTGNDGKPLPNNPLLDVRVRRALSLAIDRKAIVDRILQGAATVA
NQWMPSNTYGYNPDVKDIAYDPAQAKKLLADAGFPQGFNLVMHVPNDRYPQGPETAQAVAQFWTRIGVKARVEVVPWSVY
SGRANKNEYAMSMLAWGNGTGEASYALVNVLATVDTKKGLGASNWGHYSNAAVDNALNASTEEFNVEKRAAILRHSVKLV
SDDVGVMPLYHYQNVWAAKKGLKVTPMTSDRTAAQMVTKDGK

Specific function: Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis [H]

COG id: COG0747

COG function: function code E; ABC-type dipeptide transport system, periplasmic component

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=537, Percent_Identity=26.4432029795158, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI87081878, Length=546, Percent_Identity=26.007326007326, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1789397, Length=497, Percent_Identity=27.1629778672032, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1787495, Length=530, Percent_Identity=25.8490566037736, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI1787551, Length=489, Percent_Identity=25.3578732106339, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI1787762, Length=512, Percent_Identity=25.5859375, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1787052, Length=513, Percent_Identity=26.1208576998051, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1789887, Length=369, Percent_Identity=24.6612466124661, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 57338; Mature: 57338

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLLASSLAVALFAAAGAAGAQTLNIAFADPLSSLDPQLNNHAGDRSVDVHFWDLLVEN
CCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHCCCCCCCCCCCCEEEEEEEEEHHHC
KWNQLQPGLALSWRTLDPKTWEFKLRPNVKWHDGQPFTADDVIFSYQRARSVPGSVATFA
CCCCCCCCCEEEEEECCCCCEEEEECCCCEECCCCCCCHHHHHHHHHHHHCCCCHHHHHH
GYLRTVESVTAKDPLTLIIKTNIPNPDLPLNLASVHIVSKHVGEKSSTEDYNAGRAVVGT
HHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEC
GPYKFVSYVPGDRVVMARNDNYWGGKQLWEKVNYRYINNAAARTANLLSGEVDVIDKVSV
CCHHEEEECCCCEEEEECCCCCCCHHHHHHHCCCEEECCHHHHHHHHHCCCCCCEECCCH
SDLARLRQSPNVKVFSYPGLRVMLLQPSFRKGPNDYVTGNDGKPLPNNPLLDVRVRRALS
HHHHHHHCCCCEEEEECCCEEEEEECCCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHH
LAIDRKAIVDRILQGAATVANQWMPSNTYGYNPDVKDIAYDPAQAKKLLADAGFPQGFNL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCEE
VMHVPNDRYPQGPETAQAVAQFWTRIGVKARVEVVPWSVYSGRANKNEYAMSMLAWGNGT
EEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCCCCHHEEEEEEECCCC
GEASYALVNVLATVDTKKGLGASNWGHYSNAAVDNALNASTEEFNVEKRAAILRHSVKLV
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHCHHHHHHHHHHHHHHH
SDDVGVMPLYHYQNVWAAKKGLKVTPMTSDRTAAQMVTKDGK
CCCCCCEEEHHHHHHHHHHCCCEEECCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MKRLLASSLAVALFAAAGAAGAQTLNIAFADPLSSLDPQLNNHAGDRSVDVHFWDLLVEN
CCHHHHHHHHHHHHHHCCCCCCEEEEEEECCCHHHCCCCCCCCCCCCEEEEEEEEEHHHC
KWNQLQPGLALSWRTLDPKTWEFKLRPNVKWHDGQPFTADDVIFSYQRARSVPGSVATFA
CCCCCCCCCEEEEEECCCCCEEEEECCCCEECCCCCCCHHHHHHHHHHHHCCCCHHHHHH
GYLRTVESVTAKDPLTLIIKTNIPNPDLPLNLASVHIVSKHVGEKSSTEDYNAGRAVVGT
HHHHHHHHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCEEEEC
GPYKFVSYVPGDRVVMARNDNYWGGKQLWEKVNYRYINNAAARTANLLSGEVDVIDKVSV
CCHHEEEECCCCEEEEECCCCCCCHHHHHHHCCCEEECCHHHHHHHHHCCCCCCEECCCH
SDLARLRQSPNVKVFSYPGLRVMLLQPSFRKGPNDYVTGNDGKPLPNNPLLDVRVRRALS
HHHHHHHCCCCEEEEECCCEEEEEECCCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHH
LAIDRKAIVDRILQGAATVANQWMPSNTYGYNPDVKDIAYDPAQAKKLLADAGFPQGFNL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCEE
VMHVPNDRYPQGPETAQAVAQFWTRIGVKARVEVVPWSVYSGRANKNEYAMSMLAWGNGT
EEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEEEEEECCCCCCCHHEEEEEEECCCC
GEASYALVNVLATVDTKKGLGASNWGHYSNAAVDNALNASTEEFNVEKRAAILRHSVKLV
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHCHHHHHHHHHHHHHHH
SDDVGVMPLYHYQNVWAAKKGLKVTPMTSDRTAAQMVTKDGK
CCCCCCEEEHHHHHHHHHHCCCEEECCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1702779; 1956284; 7536291; 8041620; 9278503; 9298646; 9600841; 8563629; 8527431 [H]