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The map label for this gene is fcbA1 [H]

Identifier: 187929134

GI number: 187929134

Start: 2167156

End: 2168574

Strand: Direct

Name: fcbA1 [H]

Synonym: Rpic_2055

Alternate gene names: 187929134

Gene position: 2167156-2168574 (Clockwise)

Preceding gene: 187929133

Following gene: 187929135

Centisome position: 54.97

GC content: 63.28

Gene sequence:

>1419_bases
ATGCTTGATCTCGGCCGCACATTCCTGCAGAGCGTGGAGCGCAGCCCCCACGCTCTCGCCATAGTCGACGGGGACCTGAA
ACTATCCTATGCGCAATGGCTAACGCGCATCCAGAGCGTGGCCGCAGGCCTGCTTGACCTTGGCCTGCGCCCTGGCGAAC
GCCTGCTTGCCATCCTGCAGAACCGCTGGGAGATGGCGACCCTTCACTGGGCTTGCCAGTTCACCGGGATCGTCATCGTC
CCGCTGAATTGGCGCGCCAAGCCGGACGAGCTCGACTATTGCGTACGTGACGCAGACGCAAAAGCACTGATCTTCGAGCC
AGTCAGTGCAGACGCCGTTCTCGGCAGTCCCGCTGCGCTGAAAATCCTCCGCATCGCACTGGACGGCGCACCACACTCTT
CGCTGTCATTTGACACCCTGATGGGCGCCGCGCCGCGGCCAGACAGCGTCCTGCCCGAAGCTGATGACGTCTCGCTCATG
TTGTACACCTCGGGCACAACTGGACGGCCAAAGGGCGTGCCCCGCCGCCACAGGCAGGAGCGCGCTGCTGCGTTGGCGCA
CGTCGCTCAGAACCTGTACCGGCGAGGCGAGCGTACGCTCGGGGTGATGCCGCTGTATCACACGATGGGCGTGCGCTCCT
TGCTGGCGATGGCACTGGTGGACGGTCTTTTCGTCTGCGTGCGGCGCTGGAGTCCGTCTCAGACGCTGCAAGCTATCGCT
GATCATCGCGTGAGCTGTCTCTACCTCGTCCCCACGCTCTACCACGACCTGCTGGCCGATCCGGGCTTTGACGCGTTACG
CGTGCGCTCAGTCACCAAGCTCGGCTTCGCCGGTGCCGCCATGAATGATGGTCTGCTGAAGCGGCTGGAGCAGGCGTTCC
ACCCAGAGCTGTTCGTTAACCACTACGGCTCGTCCGAGGTCTACACGTTCAGTGTCGAACAGCGCGCGGCGGGCAAGCCT
GGCAGCGCGGGTCGCGCTGGGTTCAATACACGACTGCGCCTAGTCCGCTTGGACACCAACTCGCCGGATGCGGTGGTGGC
CCCTGGCGAAGAAGGGCAGATCATCGTCGAACTGCGCGGCGACGAAGCCTTTGAGGGGTACTGGAATCGCGACGATGCCA
ACGCGAAGTCCCTGCGCCAGGGCTGGTACTTCACCGGTGACACCGGCTACTTCGACGCAGAGGGGGATCTATTCGTCAGT
GGCCGCGTGGACGACATGATCATCAGCGGAGGCGAGAACATCTCGCCTGCTGATATCGAGTCGGTCCTCTCCCTGCACCC
TGCCGTGGATGAGGTCGCCGTAGCCGGTTTGCCGGACCCGCGCTGGGGCCAAAAAGTCGTCGCTTTCGTCAAGCCGCACG
ACGACGTAGAGCAGCGAGGAAAATCATCATGCCAGCAGACAAGCTCGGTCAGTACATGA

Upstream 100 bases:

>100_bases
TGTACCGGCTACACACCGATCGTTGCCGCCGTCCTTGACGTCGCCGCCAGCCGCGCAGGGGCACGCCCGATTTCAGCGCC
GGTTTCCGAGGAGACCAGCA

Downstream 100 bases:

>100_bases
CGAGCCCAGAGTTTCTCAGGCGAGCCAACGAAGCCGTGGCTAGAGCGGTGCGCGAACTGGAGGCAAAGGGCATCAAGCCC
GTCTATGTCACGCGCCAGCG

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: 4-CBA:CoA ligase [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MLDLGRTFLQSVERSPHALAIVDGDLKLSYAQWLTRIQSVAAGLLDLGLRPGERLLAILQNRWEMATLHWACQFTGIVIV
PLNWRAKPDELDYCVRDADAKALIFEPVSADAVLGSPAALKILRIALDGAPHSSLSFDTLMGAAPRPDSVLPEADDVSLM
LYTSGTTGRPKGVPRRHRQERAAALAHVAQNLYRRGERTLGVMPLYHTMGVRSLLAMALVDGLFVCVRRWSPSQTLQAIA
DHRVSCLYLVPTLYHDLLADPGFDALRVRSVTKLGFAGAAMNDGLLKRLEQAFHPELFVNHYGSSEVYTFSVEQRAAGKP
GSAGRAGFNTRLRLVRLDTNSPDAVVAPGEEGQIIVELRGDEAFEGYWNRDDANAKSLRQGWYFTGDTGYFDAEGDLFVS
GRVDDMIISGGENISPADIESVLSLHPAVDEVAVAGLPDPRWGQKVVAFVKPHDDVEQRGKSSCQQTSSVST

Sequences:

>Translated_472_residues
MLDLGRTFLQSVERSPHALAIVDGDLKLSYAQWLTRIQSVAAGLLDLGLRPGERLLAILQNRWEMATLHWACQFTGIVIV
PLNWRAKPDELDYCVRDADAKALIFEPVSADAVLGSPAALKILRIALDGAPHSSLSFDTLMGAAPRPDSVLPEADDVSLM
LYTSGTTGRPKGVPRRHRQERAAALAHVAQNLYRRGERTLGVMPLYHTMGVRSLLAMALVDGLFVCVRRWSPSQTLQAIA
DHRVSCLYLVPTLYHDLLADPGFDALRVRSVTKLGFAGAAMNDGLLKRLEQAFHPELFVNHYGSSEVYTFSVEQRAAGKP
GSAGRAGFNTRLRLVRLDTNSPDAVVAPGEEGQIIVELRGDEAFEGYWNRDDANAKSLRQGWYFTGDTGYFDAEGDLFVS
GRVDDMIISGGENISPADIESVLSLHPAVDEVAVAGLPDPRWGQKVVAFVKPHDDVEQRGKSSCQQTSSVST
>Mature_472_residues
MLDLGRTFLQSVERSPHALAIVDGDLKLSYAQWLTRIQSVAAGLLDLGLRPGERLLAILQNRWEMATLHWACQFTGIVIV
PLNWRAKPDELDYCVRDADAKALIFEPVSADAVLGSPAALKILRIALDGAPHSSLSFDTLMGAAPRPDSVLPEADDVSLM
LYTSGTTGRPKGVPRRHRQERAAALAHVAQNLYRRGERTLGVMPLYHTMGVRSLLAMALVDGLFVCVRRWSPSQTLQAIA
DHRVSCLYLVPTLYHDLLADPGFDALRVRSVTKLGFAGAAMNDGLLKRLEQAFHPELFVNHYGSSEVYTFSVEQRAAGKP
GSAGRAGFNTRLRLVRLDTNSPDAVVAPGEEGQIIVELRGDEAFEGYWNRDDANAKSLRQGWYFTGDTGYFDAEGDLFVS
GRVDDMIISGGENISPADIESVLSLHPAVDEVAVAGLPDPRWGQKVVAFVKPHDDVEQRGKSSCQQTSSVST

Specific function: Catalyzes the formation of chlorobenzoyl-CoA via a 2 step reaction. First 4-chlorobenzoate is adenylated by ATP, followed by acyl transfer from the 4-chlorobenzoyl-AMP intermediate to CoA. Benzoate, 4-bromobenzoate, 4- iodobenzoate and 4-fluorobenzoate al

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=505, Percent_Identity=27.3267326732673, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI187761345, Length=439, Percent_Identity=28.9293849658314, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI187761343, Length=439, Percent_Identity=28.9293849658314, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI38505220, Length=475, Percent_Identity=27.3684210526316, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI122937307, Length=452, Percent_Identity=27.8761061946903, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI40807357, Length=493, Percent_Identity=26.5720081135903, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI42544132, Length=434, Percent_Identity=25.3456221198157, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI38524616, Length=475, Percent_Identity=25.8947368421053, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI115511026, Length=453, Percent_Identity=25.1655629139073, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI58082049, Length=446, Percent_Identity=24.2152466367713, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI157311624, Length=443, Percent_Identity=24.6049661399549, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI157311622, Length=443, Percent_Identity=24.6049661399549, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI227499619, Length=504, Percent_Identity=24.2063492063492, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI13375727, Length=352, Percent_Identity=28.9772727272727, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI13236579, Length=458, Percent_Identity=24.235807860262, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI13325057, Length=315, Percent_Identity=27.6190476190476, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI221142682, Length=442, Percent_Identity=27.3755656108597, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI1788107, Length=490, Percent_Identity=26.530612244898, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI145693145, Length=465, Percent_Identity=25.3763440860215, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786810, Length=464, Percent_Identity=24.7844827586207, Blast_Score=99, Evalue=9e-22,
Organism=Escherichia coli, GI1790505, Length=325, Percent_Identity=27.6923076923077, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1788595, Length=303, Percent_Identity=28.0528052805281, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789201, Length=327, Percent_Identity=27.217125382263, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1786529, Length=512, Percent_Identity=24.609375, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71994694, Length=476, Percent_Identity=27.5210084033613, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71994690, Length=476, Percent_Identity=27.5210084033613, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI71994703, Length=476, Percent_Identity=27.5210084033613, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17559526, Length=471, Percent_Identity=26.3269639065817, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17558820, Length=450, Percent_Identity=26.4444444444444, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17560308, Length=505, Percent_Identity=25.9405940594059, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17531443, Length=472, Percent_Identity=23.728813559322, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI32563687, Length=457, Percent_Identity=26.0393873085339, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17557194, Length=465, Percent_Identity=24.9462365591398, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17538037, Length=338, Percent_Identity=27.2189349112426, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17560140, Length=453, Percent_Identity=22.9580573951435, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI115534440, Length=499, Percent_Identity=23.0460921843687, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71985884, Length=298, Percent_Identity=24.8322147651007, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25147511, Length=247, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=403, Percent_Identity=28.0397022332506, Blast_Score=131, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6319264, Length=315, Percent_Identity=27.6190476190476, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323182, Length=343, Percent_Identity=25.3644314868805, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24581924, Length=500, Percent_Identity=27, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI21355181, Length=434, Percent_Identity=25.8064516129032, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI19922652, Length=437, Percent_Identity=28.604118993135, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI18859661, Length=480, Percent_Identity=24.1666666666667, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24648257, Length=449, Percent_Identity=24.0534521158129, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24648253, Length=464, Percent_Identity=22.6293103448276, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24648255, Length=469, Percent_Identity=23.6673773987207, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI281366413, Length=490, Percent_Identity=25.9183673469388, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24666501, Length=490, Percent_Identity=25.9183673469388, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24666497, Length=490, Percent_Identity=25.9183673469388, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24656500, Length=443, Percent_Identity=27.313769751693, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI20130357, Length=466, Percent_Identity=22.1030042918455, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI21356441, Length=478, Percent_Identity=22.1757322175732, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21358303, Length=465, Percent_Identity=21.9354838709677, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24648260, Length=308, Percent_Identity=26.2987012987013, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI62472339, Length=502, Percent_Identity=25.0996015936255, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356947, Length=462, Percent_Identity=21.8614718614719, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667955, Length=502, Percent_Identity=25.4980079681275, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI281365686, Length=297, Percent_Identity=25.2525252525253, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24653035, Length=311, Percent_Identity=23.1511254019293, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24667959, Length=339, Percent_Identity=26.5486725663717, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI21355225, Length=353, Percent_Identity=24.6458923512748, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI161076582, Length=295, Percent_Identity=22.3728813559322, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: =6.2.1.33 [H]

Molecular weight: Translated: 51586; Mature: 51586

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLGRTFLQSVERSPHALAIVDGDLKLSYAQWLTRIQSVAAGLLDLGLRPGERLLAILQ
CCCCHHHHHHHHCCCCCEEEEEECCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
NRWEMATLHWACQFTGIVIVPLNWRAKPDELDYCVRDADAKALIFEPVSADAVLGSPAAL
CCCCEEEEEEEEEECCEEEEEECCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCHHHH
KILRIALDGAPHSSLSFDTLMGAAPRPDSVLPEADDVSLMLYTSGTTGRPKGVPRRHRQE
HEEHEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHH
RAAALAHVAQNLYRRGERTLGVMPLYHTMGVRSLLAMALVDGLFVCVRRWSPSQTLQAIA
HHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DHRVSCLYLVPTLYHDLLADPGFDALRVRSVTKLGFAGAAMNDGLLKRLEQAFHPELFVN
HCCCEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEE
HYGSSEVYTFSVEQRAAGKPGSAGRAGFNTRLRLVRLDTNSPDAVVAPGEEGQIIVELRG
CCCCCCEEEEEEHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEECCCCCEEEEEECC
DEAFEGYWNRDDANAKSLRQGWYFTGDTGYFDAEGDLFVSGRVDDMIISGGENISPADIE
CCCCCCCCCCCCCCHHHHHCCCEEECCCCEECCCCCEEEECCCCEEEEECCCCCCHHHHH
SVLSLHPAVDEVAVAGLPDPRWGQKVVAFVKPHDDVEQRGKSSCQQTSSVST
HHHHHCCCHHHHEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLDLGRTFLQSVERSPHALAIVDGDLKLSYAQWLTRIQSVAAGLLDLGLRPGERLLAILQ
CCCCHHHHHHHHCCCCCEEEEEECCCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
NRWEMATLHWACQFTGIVIVPLNWRAKPDELDYCVRDADAKALIFEPVSADAVLGSPAAL
CCCCEEEEEEEEEECCEEEEEECCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCCHHHH
KILRIALDGAPHSSLSFDTLMGAAPRPDSVLPEADDVSLMLYTSGTTGRPKGVPRRHRQE
HEEHEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHH
RAAALAHVAQNLYRRGERTLGVMPLYHTMGVRSLLAMALVDGLFVCVRRWSPSQTLQAIA
HHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DHRVSCLYLVPTLYHDLLADPGFDALRVRSVTKLGFAGAAMNDGLLKRLEQAFHPELFVN
HCCCEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEE
HYGSSEVYTFSVEQRAAGKPGSAGRAGFNTRLRLVRLDTNSPDAVVAPGEEGQIIVELRG
CCCCCCEEEEEEHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEECCCCCEEEEEECC
DEAFEGYWNRDDANAKSLRQGWYFTGDTGYFDAEGDLFVSGRVDDMIISGGENISPADIE
CCCCCCCCCCCCCCHHHHHCCCEEECCCCEECCCCCEEEECCCCEEEEECCCCCCHHHHH
SVLSLHPAVDEVAVAGLPDPRWGQKVVAFVKPHDDVEQRGKSSCQQTSSVST
HHHHHCCCHHHHEECCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA