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The map label for this gene is envZ [H]

Identifier: 187928979

GI number: 187928979

Start: 2001149

End: 2002510

Strand: Direct

Name: envZ [H]

Synonym: Rpic_1899

Alternate gene names: 187928979

Gene position: 2001149-2002510 (Clockwise)

Preceding gene: 187928978

Following gene: 187928980

Centisome position: 50.76

GC content: 64.9

Gene sequence:

>1362_bases
TTGCGCATCCCGCGTCCGGCCGCGTTGCGGCATCTGCTGATCAGTGTGTTTGGTTCGCTGTTCTGGCGAACCTTCATGCT
GATCGCATTGCTCATCGCGATTTCTCTGGGCGTGTGGTTCCAGAGCTTCCGTATTTTCGAGCGTGAACCGCGCGCGCAGC
AGATCGCCATGCAGGTGGTCAGCGTGGTCAAGCTCACGCGGGCGGCGCTGCTGTATTCGGATCCGTCGAGACGCCGCTTC
CTGCTGCTCGATCTCGTGCAGAACGAGGGCATCAAGGTCTACCCACGCGAGAAGGAAGACGAATACCGGGAGCCGCACAC
CAACCCTTACCTGACGCAGCTTGTCCAGCAGGAGATCCGCAACCGGCTCGGGGCCGACGCGGTGATCGCCACGGCCGTCA
ACGACATCCCGGGCGTGTGGGTGAGCTTCCAGATCGAGGGCGACGACTACTGGGTCGCCATCAGCCCGGACCGTTTCGAG
CACGTGCCGGGGTTGCAATGGCTGTGGTGGTCGATGGCGGCGCTGGTGCTGTCGGTGCTGGGCGCGGCGTTCATTACGTC
ACGCGTGAACCAGCCGCTCAAGCGCCTGGCCGATACAGCGCGCGCCATCAGCGCCGGAGACGACCCGAAGGCATTGCCCG
AAGGCGGCGGCACCGAAGTGGCGCAGGCGAATCACAGCTTCAACCAGATGGTGCGCGACCTCAAGCAGCTCGAGGCCGAT
CGCGCCGTCATGCTGGCCGGCATCTCGCACGACCTGCGCACGCCCCTTACGCGCCTGCGCCTGGAAACCGAGATGAGCCC
CGTCGACGAGCAGACGCGCGAACTGATGGTGGCCGACATCGAACAGATGGACGCGATCATCGGCCAGTTCCTGGACTACG
CGCGCCCCAGCGGGGAGATGCTCGAGGACGTGGACCTGACCGAACTCGTGCGCGACACGGCGCCCGTCTACTCTGCGCAT
GACGATATCGACCTGACACTCAAGCTCGCGCCCGAGGCCATCGCCCGCTGCAACCGCATGGAAACACAGCGCATTCTCGA
CAACCTGATCGAAAACGCACGCCGCTACGGCAAGACCCCCGGCACGAACCGCGCAGAGATCACCGTCAGCACGTTCCTGC
AAGGCAACGAGGTTGTATTGTGCGTGGCCGATCGCGGTACAGGTGTGCCGGCCAACCAGCTTGCATTGCTCACCCGGCCG
TTCTACCGCCTTGAATCGGCACGCAGCGAAGCCAAGGGCGCCGGGCTGGGCATGTCGATCGTCAATCGCATCCTGCAGCG
CAGCGGCGGCCGCCTCGTGCTTGAGAACCGCACACCGCCCGAAACGGGACTGCTCGTCAGCGCCTGCTACGCGCGCGCCT
GA

Upstream 100 bases:

>100_bases
CAACCCGCGCTTCATTCAGACCGTGTGGGGCCTGGGCTACGTGTTCATTCCCGACGGCGCCAAGTAAGCACCCGAGCAAC
CTTTCTCTTCCGCATCCGAC

Downstream 100 bases:

>100_bases
TCCGGCACACTGCGCGGCCTCTCCCGGGCATATCCCCTGCTTCCCACGCCTGTCATGCGTCGCCGATAAGGTGCGGCGGC
GGGCAGCGCTATGGCTGGCG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MRIPRPAALRHLLISVFGSLFWRTFMLIALLIAISLGVWFQSFRIFEREPRAQQIAMQVVSVVKLTRAALLYSDPSRRRF
LLLDLVQNEGIKVYPREKEDEYREPHTNPYLTQLVQQEIRNRLGADAVIATAVNDIPGVWVSFQIEGDDYWVAISPDRFE
HVPGLQWLWWSMAALVLSVLGAAFITSRVNQPLKRLADTARAISAGDDPKALPEGGGTEVAQANHSFNQMVRDLKQLEAD
RAVMLAGISHDLRTPLTRLRLETEMSPVDEQTRELMVADIEQMDAIIGQFLDYARPSGEMLEDVDLTELVRDTAPVYSAH
DDIDLTLKLAPEAIARCNRMETQRILDNLIENARRYGKTPGTNRAEITVSTFLQGNEVVLCVADRGTGVPANQLALLTRP
FYRLESARSEAKGAGLGMSIVNRILQRSGGRLVLENRTPPETGLLVSACYARA

Sequences:

>Translated_453_residues
MRIPRPAALRHLLISVFGSLFWRTFMLIALLIAISLGVWFQSFRIFEREPRAQQIAMQVVSVVKLTRAALLYSDPSRRRF
LLLDLVQNEGIKVYPREKEDEYREPHTNPYLTQLVQQEIRNRLGADAVIATAVNDIPGVWVSFQIEGDDYWVAISPDRFE
HVPGLQWLWWSMAALVLSVLGAAFITSRVNQPLKRLADTARAISAGDDPKALPEGGGTEVAQANHSFNQMVRDLKQLEAD
RAVMLAGISHDLRTPLTRLRLETEMSPVDEQTRELMVADIEQMDAIIGQFLDYARPSGEMLEDVDLTELVRDTAPVYSAH
DDIDLTLKLAPEAIARCNRMETQRILDNLIENARRYGKTPGTNRAEITVSTFLQGNEVVLCVADRGTGVPANQLALLTRP
FYRLESARSEAKGAGLGMSIVNRILQRSGGRLVLENRTPPETGLLVSACYARA
>Mature_453_residues
MRIPRPAALRHLLISVFGSLFWRTFMLIALLIAISLGVWFQSFRIFEREPRAQQIAMQVVSVVKLTRAALLYSDPSRRRF
LLLDLVQNEGIKVYPREKEDEYREPHTNPYLTQLVQQEIRNRLGADAVIATAVNDIPGVWVSFQIEGDDYWVAISPDRFE
HVPGLQWLWWSMAALVLSVLGAAFITSRVNQPLKRLADTARAISAGDDPKALPEGGGTEVAQANHSFNQMVRDLKQLEAD
RAVMLAGISHDLRTPLTRLRLETEMSPVDEQTRELMVADIEQMDAIIGQFLDYARPSGEMLEDVDLTELVRDTAPVYSAH
DDIDLTLKLAPEAIARCNRMETQRILDNLIENARRYGKTPGTNRAEITVSTFLQGNEVVLCVADRGTGVPANQLALLTRP
FYRLESARSEAKGAGLGMSIVNRILQRSGGRLVLENRTPPETGLLVSACYARA

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=442, Percent_Identity=30.9954751131222, Blast_Score=159, Evalue=5e-40,
Organism=Escherichia coli, GI1787894, Length=268, Percent_Identity=30.5970149253731, Blast_Score=98, Evalue=9e-22,
Organism=Escherichia coli, GI87082128, Length=287, Percent_Identity=26.8292682926829, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790346, Length=262, Percent_Identity=29.0076335877863, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1788393, Length=257, Percent_Identity=26.8482490272374, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790551, Length=301, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1786600, Length=220, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786912, Length=236, Percent_Identity=30.0847457627119, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1790436, Length=202, Percent_Identity=24.7524752475248, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786783, Length=303, Percent_Identity=24.0924092409241, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50742; Mature: 50742

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIPRPAALRHLLISVFGSLFWRTFMLIALLIAISLGVWFQSFRIFEREPRAQQIAMQVV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SVVKLTRAALLYSDPSRRRFLLLDLVQNEGIKVYPREKEDEYREPHTNPYLTQLVQQEIR
HHHHHHHHHHHCCCCCCCEEEEEEHHHCCCEEECCCCCCHHHCCCCCCHHHHHHHHHHHH
NRLGADAVIATAVNDIPGVWVSFQIEGDDYWVAISPDRFEHVPGLQWLWWSMAALVLSVL
HHHCCCHHHHHHHHCCCCCEEEEEEECCEEEEEECCCHHHCCCCHHHHHHHHHHHHHHHH
GAAFITSRVNQPLKRLADTARAISAGDDPKALPEGGGTEVAQANHSFNQMVRDLKQLEAD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHC
RAVMLAGISHDLRTPLTRLRLETEMSPVDEQTRELMVADIEQMDAIIGQFLDYARPSGEM
CEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
LEDVDLTELVRDTAPVYSAHDDIDLTLKLAPEAIARCNRMETQRILDNLIENARRYGKTP
HHCCCHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GTNRAEITVSTFLQGNEVVLCVADRGTGVPANQLALLTRPFYRLESARSEAKGAGLGMSI
CCCCEEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
VNRILQRSGGRLVLENRTPPETGLLVSACYARA
HHHHHHCCCCEEEECCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MRIPRPAALRHLLISVFGSLFWRTFMLIALLIAISLGVWFQSFRIFEREPRAQQIAMQVV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
SVVKLTRAALLYSDPSRRRFLLLDLVQNEGIKVYPREKEDEYREPHTNPYLTQLVQQEIR
HHHHHHHHHHHCCCCCCCEEEEEEHHHCCCEEECCCCCCHHHCCCCCCHHHHHHHHHHHH
NRLGADAVIATAVNDIPGVWVSFQIEGDDYWVAISPDRFEHVPGLQWLWWSMAALVLSVL
HHHCCCHHHHHHHHCCCCCEEEEEEECCEEEEEECCCHHHCCCCHHHHHHHHHHHHHHHH
GAAFITSRVNQPLKRLADTARAISAGDDPKALPEGGGTEVAQANHSFNQMVRDLKQLEAD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHC
RAVMLAGISHDLRTPLTRLRLETEMSPVDEQTRELMVADIEQMDAIIGQFLDYARPSGEM
CEEEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
LEDVDLTELVRDTAPVYSAHDDIDLTLKLAPEAIARCNRMETQRILDNLIENARRYGKTP
HHCCCHHHHHHHCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GTNRAEITVSTFLQGNEVVLCVADRGTGVPANQLALLTRPFYRLESARSEAKGAGLGMSI
CCCCEEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
VNRILQRSGGRLVLENRTPPETGLLVSACYARA
HHHHHHCCCCEEEECCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]