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The map label for this gene is pcoA [H]

Identifier: 187928931

GI number: 187928931

Start: 1939838

End: 1941817

Strand: Direct

Name: pcoA [H]

Synonym: Rpic_1850

Alternate gene names: 187928931

Gene position: 1939838-1941817 (Clockwise)

Preceding gene: 187928925

Following gene: 187928934

Centisome position: 49.2

GC content: 57.93

Gene sequence:

>1980_bases
ATGCTGAACGACTGTCTCATGCTGAACGACTCCCCGGGGATTGCTATGGAGGTCCTCCTCGCGTTCGTGACGCAGGGGCA
CAACCTTCCAACGGGAGCAAGGATCGTGGGCGACAACACTTCAATCGACTTGGCGCTGCGGCGCAAATTTCTACGCCAAA
TGGCTGGGGCGGGCTTGGCGGCAACGGGGGCCGGTATCGGCACGCCTGCTTCGGGGCTGCAAAGCCAGGATCGTTCAACT
GACCTGTCCGGAACCGAATTCGCTCTGACAATTGGGCGCACACCCGTCAATTTCACGGGGCATTTACGGTACGCGCTTAC
GGTAAACGGATCAATTCCTGCGCCCATCCTGCGTTGGAAACAAGGTTCCGAGGTAACGCTGCGGGTCACCAACACACTGG
CCACGCAAACTTCGATCCACTGGCATGGCATCCTCGTTCCGTTTGCCATGGATGGCGTGCCTGGCGTGTCCTTTCCCGGC
ATTCCTGCTCACCAGACCTTCGTCTACAAATTCAAGGTCCGACAGGCCGGTACATACTGGTACCACAGCCACACCCGCTT
TCAGGAGCAACTCGGCCTCTATGGCCCATTGGTGATCGAGCCACAAAGGCCGGCCCCCATACCTAGCGACAGGGACTACG
TCGTTATGCTGAGTGATTGGACTGACGAAGATCCTGAAAACGTCTTCCTTCACTTGAAGCAGTCGAGTGATTTTTACAAT
TTCCAATTACCGACGGTCACTGATTTTGTGGCCGACGTCAGGGCGGCGGGCCTCTCAAAAGCACTGGCTCGACGGCGTAT
GTGGAACCAGATGCGCATGAATCCCACGGACCTCGCCGATGTCTCTGCTGCAACCTACTGCTACTTGGTCAATGGCGCCA
CACCCTTCACTAACTGGACAGCTATCGCGGAGGCAGGCGAATACGTACGTTTGCGCTTCATCAATGGATCGGCCACCACA
ACGTTTGATGTTCGCATCCCGGGCCTGACCATGCGAGTTTGTGCGGCGGACGGACAAGATGTCGAACCCGTGAACGTCGA
CGAGTTTCGGATTGGTGTAGCGGAGACCTACGATGTGTTGGTGCAGATGCCCCGGAATGAGGCATACACCATATTTGCAC
AGGCGATGGACCGCAGCGGATATGCACGTGCCACCCTCGCGCCGAAGCACGGCATGCGGGCCGCGATTCCTATTATGGAC
CCCAAAACCTGGCTGACCATGGCTGACATGGGCATGGACATGAACATGAACGGAATGTCTATGACCAGCGGGCCACCCAA
TGAAACGATGGAAACTCAGGACAACGGCATCCATTCCCCCCTCGGCCACTCTATGCAGGCGGGGGGCGAAACCGCGGCCG
ACGCCATGCCAGGCATGCGACTGCAGTCCGGCGATGAAGGCATGGCCGGCATGAAACCCTCCATGTCGATGTCCCACGAT
GGTAAGCCCGAGCATTCCCACCCAATGACGATGCTGGGTATGCACGGCGGCCCCGAAGTCGACATGCGGTCGATGAACCC
TTCCAAGTCGCTCGCAGACCCTGGGCCGAGATTGCGCCAAAATGGCCGGAGGGTTTTGACCTACGCAGACTTGCGAACGC
TGGGCCAGCCCTATGACGATCGGCCTCCGGGCCGCGAGATCGTGTTGCATCTGACCGGCAACATGCGACGGTTCATCTGG
GGATTCGATGGCAAAAGGTTCTCGGAGGCCGAGCCGATCCGTCTGTACTACGGCGAACGGCTGCGGATCACTCTCGTTAA
TGACACCATGATGAATCACCCTATGCACCTGCACGGGATGTTCAGCGAGCTTGAAAACACGGAGCGTCAAGCGCTCGTCC
GTAAGCACACCATCAACGTTCAACCATCCAAGCAGATCAGTTTCCTCGTAACTGCGGATGCCCCGGGCCAGTGGGCATTT
CATTGTCATCTGCTGTACCACATGGAAGCCGGTATGTTCCGCAAGGTGGTTGTGGCCTGA

Upstream 100 bases:

>100_bases
CGGTCCGCAATGACGGTATCAATGGATTCACAAGGGACGTGCTTCTGTGGCCACGAGCTTGGTCTGCGGTGCAGGTCCAT
GCGAATTCCGGGCACGTCTC

Downstream 100 bases:

>100_bases
CCCTTGGACAAAGGAGCGCGTCATGTTGCCAGGAGTGAAGGGACGGCTGCGTTTGGTTGCCGCAGCCTTATTGGGGTTCT
AAGCCAGAACCGCCGAAATT

Product: copper-resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 659; Mature: 659

Protein sequence:

>659_residues
MLNDCLMLNDSPGIAMEVLLAFVTQGHNLPTGARIVGDNTSIDLALRRKFLRQMAGAGLAATGAGIGTPASGLQSQDRST
DLSGTEFALTIGRTPVNFTGHLRYALTVNGSIPAPILRWKQGSEVTLRVTNTLATQTSIHWHGILVPFAMDGVPGVSFPG
IPAHQTFVYKFKVRQAGTYWYHSHTRFQEQLGLYGPLVIEPQRPAPIPSDRDYVVMLSDWTDEDPENVFLHLKQSSDFYN
FQLPTVTDFVADVRAAGLSKALARRRMWNQMRMNPTDLADVSAATYCYLVNGATPFTNWTAIAEAGEYVRLRFINGSATT
TFDVRIPGLTMRVCAADGQDVEPVNVDEFRIGVAETYDVLVQMPRNEAYTIFAQAMDRSGYARATLAPKHGMRAAIPIMD
PKTWLTMADMGMDMNMNGMSMTSGPPNETMETQDNGIHSPLGHSMQAGGETAADAMPGMRLQSGDEGMAGMKPSMSMSHD
GKPEHSHPMTMLGMHGGPEVDMRSMNPSKSLADPGPRLRQNGRRVLTYADLRTLGQPYDDRPPGREIVLHLTGNMRRFIW
GFDGKRFSEAEPIRLYYGERLRITLVNDTMMNHPMHLHGMFSELENTERQALVRKHTINVQPSKQISFLVTADAPGQWAF
HCHLLYHMEAGMFRKVVVA

Sequences:

>Translated_659_residues
MLNDCLMLNDSPGIAMEVLLAFVTQGHNLPTGARIVGDNTSIDLALRRKFLRQMAGAGLAATGAGIGTPASGLQSQDRST
DLSGTEFALTIGRTPVNFTGHLRYALTVNGSIPAPILRWKQGSEVTLRVTNTLATQTSIHWHGILVPFAMDGVPGVSFPG
IPAHQTFVYKFKVRQAGTYWYHSHTRFQEQLGLYGPLVIEPQRPAPIPSDRDYVVMLSDWTDEDPENVFLHLKQSSDFYN
FQLPTVTDFVADVRAAGLSKALARRRMWNQMRMNPTDLADVSAATYCYLVNGATPFTNWTAIAEAGEYVRLRFINGSATT
TFDVRIPGLTMRVCAADGQDVEPVNVDEFRIGVAETYDVLVQMPRNEAYTIFAQAMDRSGYARATLAPKHGMRAAIPIMD
PKTWLTMADMGMDMNMNGMSMTSGPPNETMETQDNGIHSPLGHSMQAGGETAADAMPGMRLQSGDEGMAGMKPSMSMSHD
GKPEHSHPMTMLGMHGGPEVDMRSMNPSKSLADPGPRLRQNGRRVLTYADLRTLGQPYDDRPPGREIVLHLTGNMRRFIW
GFDGKRFSEAEPIRLYYGERLRITLVNDTMMNHPMHLHGMFSELENTERQALVRKHTINVQPSKQISFLVTADAPGQWAF
HCHLLYHMEAGMFRKVVVA
>Mature_659_residues
MLNDCLMLNDSPGIAMEVLLAFVTQGHNLPTGARIVGDNTSIDLALRRKFLRQMAGAGLAATGAGIGTPASGLQSQDRST
DLSGTEFALTIGRTPVNFTGHLRYALTVNGSIPAPILRWKQGSEVTLRVTNTLATQTSIHWHGILVPFAMDGVPGVSFPG
IPAHQTFVYKFKVRQAGTYWYHSHTRFQEQLGLYGPLVIEPQRPAPIPSDRDYVVMLSDWTDEDPENVFLHLKQSSDFYN
FQLPTVTDFVADVRAAGLSKALARRRMWNQMRMNPTDLADVSAATYCYLVNGATPFTNWTAIAEAGEYVRLRFINGSATT
TFDVRIPGLTMRVCAADGQDVEPVNVDEFRIGVAETYDVLVQMPRNEAYTIFAQAMDRSGYARATLAPKHGMRAAIPIMD
PKTWLTMADMGMDMNMNGMSMTSGPPNETMETQDNGIHSPLGHSMQAGGETAADAMPGMRLQSGDEGMAGMKPSMSMSHD
GKPEHSHPMTMLGMHGGPEVDMRSMNPSKSLADPGPRLRQNGRRVLTYADLRTLGQPYDDRPPGREIVLHLTGNMRRFIW
GFDGKRFSEAEPIRLYYGERLRITLVNDTMMNHPMHLHGMFSELENTERQALVRKHTINVQPSKQISFLVTADAPGQWAF
HCHLLYHMEAGMFRKVVVA

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=635, Percent_Identity=24.8818897637795, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320714, Length=301, Percent_Identity=24.9169435215947, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323703, Length=122, Percent_Identity=36.0655737704918, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6321067, Length=138, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI18859919, Length=308, Percent_Identity=29.5454545454545, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28574104, Length=143, Percent_Identity=33.5664335664336, Blast_Score=76, Evalue=8e-14,
Organism=Drosophila melanogaster, GI281360167, Length=294, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24585842, Length=294, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI221330000, Length=294, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=8e-13,
Organism=Drosophila melanogaster, GI221329998, Length=294, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 72979; Mature: 72979

Theoretical pI: Translated: 7.04; Mature: 7.04

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNDCLMLNDSPGIAMEVLLAFVTQGHNLPTGARIVGDNTSIDLALRRKFLRQMAGAGLA
CCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCEEHHHHHHHHHHHHCCCEE
ATGAGIGTPASGLQSQDRSTDLSGTEFALTIGRTPVNFTGHLRYALTVNGSIPAPILRWK
ECCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEEEEECCCCCCCCEEEC
QGSEVTLRVTNTLATQTSIHWHGILVPFAMDGVPGVSFPGIPAHQTFVYKFKVRQAGTYW
CCCEEEEEEEEEEEECEEEEEEEEEEEEEECCCCCCCCCCCCCCCEEEEEEEEEECCEEE
YHSHTRFQEQLGLYGPLVIEPQRPAPIPSDRDYVVMLSDWTDEDPENVFLHLKQSSDFYN
EECHHHHHHHHCCCCCEEECCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCEEE
FQLPTVTDFVADVRAAGLSKALARRRMWNQMRMNPTDLADVSAATYCYLVNGATPFTNWT
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEEEEECCCCCCCCH
AIAEAGEYVRLRFINGSATTTFDVRIPGLTMRVCAADGQDVEPVNVDEFRIGVAETYDVL
HHHCCCCEEEEEEECCCCEEEEEEEECCEEEEEEECCCCCCCCCCHHHEEECHHHHEEHH
VQMPRNEAYTIFAQAMDRSGYARATLAPKHGMRAAIPIMDPKTWLTMADMGMDMNMNGMS
EECCCCCEEEEEEEHHCCCCCEEEEECCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCC
MTSGPPNETMETQDNGIHSPLGHSMQAGGETAADAMPGMRLQSGDEGMAGMKPSMSMSHD
CCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHCCCCCEECCCCCCCCCCCCCCCCCCC
GKPEHSHPMTMLGMHGGPEVDMRSMNPSKSLADPGPRLRQNGRRVLTYADLRTLGQPYDD
CCCCCCCCEEEEECCCCCCCEEECCCCCCCCCCCCHHHHHCCCEEEEEEHHHHHCCCCCC
RPPGREIVLHLTGNMRRFIWGFDGKRFSEAEPIRLYYGERLRITLVNDTMMNHPMHLHGM
CCCCCEEEEEECCCCEEEEEECCCCCCCCCCCEEEEECCEEEEEEECCHHHCCCCHHHHH
FSELENTERQALVRKHTINVQPSKQISFLVTADAPGQWAFHCHLLYHMEAGMFRKVVVA
HHHHHHHHHHHHHHHHEECCCCCCCEEEEEEECCCCCEEEEEEEEEECCCCCEEEEECC
>Mature Secondary Structure
MLNDCLMLNDSPGIAMEVLLAFVTQGHNLPTGARIVGDNTSIDLALRRKFLRQMAGAGLA
CCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCEEECCCCCEEHHHHHHHHHHHHCCCEE
ATGAGIGTPASGLQSQDRSTDLSGTEFALTIGRTPVNFTGHLRYALTVNGSIPAPILRWK
ECCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEEEEECCCCCCCCEEEC
QGSEVTLRVTNTLATQTSIHWHGILVPFAMDGVPGVSFPGIPAHQTFVYKFKVRQAGTYW
CCCEEEEEEEEEEEECEEEEEEEEEEEEEECCCCCCCCCCCCCCCEEEEEEEEEECCEEE
YHSHTRFQEQLGLYGPLVIEPQRPAPIPSDRDYVVMLSDWTDEDPENVFLHLKQSSDFYN
EECHHHHHHHHCCCCCEEECCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEECCCCEEE
FQLPTVTDFVADVRAAGLSKALARRRMWNQMRMNPTDLADVSAATYCYLVNGATPFTNWT
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEEEEEEECCCCCCCCH
AIAEAGEYVRLRFINGSATTTFDVRIPGLTMRVCAADGQDVEPVNVDEFRIGVAETYDVL
HHHCCCCEEEEEEECCCCEEEEEEEECCEEEEEEECCCCCCCCCCHHHEEECHHHHEEHH
VQMPRNEAYTIFAQAMDRSGYARATLAPKHGMRAAIPIMDPKTWLTMADMGMDMNMNGMS
EECCCCCEEEEEEEHHCCCCCEEEEECCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCC
MTSGPPNETMETQDNGIHSPLGHSMQAGGETAADAMPGMRLQSGDEGMAGMKPSMSMSHD
CCCCCCCCCCCCCCCCCCCCCCCCHHCCCCHHHHCCCCCEECCCCCCCCCCCCCCCCCCC
GKPEHSHPMTMLGMHGGPEVDMRSMNPSKSLADPGPRLRQNGRRVLTYADLRTLGQPYDD
CCCCCCCCEEEEECCCCCCCEEECCCCCCCCCCCCHHHHHCCCEEEEEEHHHHHCCCCCC
RPPGREIVLHLTGNMRRFIWGFDGKRFSEAEPIRLYYGERLRITLVNDTMMNHPMHLHGM
CCCCCEEEEEECCCCEEEEEECCCCCCCCCCCEEEEECCEEEEEEECCHHHCCCCHHHHH
FSELENTERQALVRKHTINVQPSKQISFLVTADAPGQWAFHCHLLYHMEAGMFRKVVVA
HHHHHHHHHHHHHHHHEECCCCCCCEEEEEEECCCCCEEEEEEEEEECCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]