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The map label for this gene is cusR [H]

Identifier: 187928863

GI number: 187928863

Start: 1877879

End: 1878565

Strand: Direct

Name: cusR [H]

Synonym: Rpic_1780

Alternate gene names: 187928863

Gene position: 1877879-1878565 (Clockwise)

Preceding gene: 187928857

Following gene: 187928864

Centisome position: 47.63

GC content: 62.88

Gene sequence:

>687_bases
ATGAAGCTGTTAGTCGTCGAGGACGAACCCAAGACCGGAGAGTACCTGCAGCAAGGCCTGACTGAAGCCGGCTTCGTGGT
AGATCTGGCCTGCAACGGCACTGACGGCCGGCATCTGGCTATGACCGGTGAGTACGACTTACTGGTGCTGGATGTGATGT
TGCCGGACGTCGATGGTTGGCAGATCGTCCAATCGTTGCGAGCCTCGGAACAAGCAGTGCCGGTGCTGTTCCTGACCGCG
CGCGACAGCGTGGCAGACCGCGTCAAAGGACTCGAACTGGGTGCTGACGACTACCTGGTGAAGCCGTTCGCGTTTGCCGA
GCTGCTGGCGCGGGTTCGCACGCTGCTGCGCCGCGGAAACAGCGCGGTCACTGCCGACCGCATCCAGGTGGCCGATCTGG
TGCTGGATCTTGCCCGCCGCCGCGCGTCGCGCGGTGGCCAGAAAATCCCGCTGACGAGCAAGGAGTTCTCGCTGCTCGAG
CTGCTGGTTCGGCGCCGTGGCGAAGTCCTGCCGCGCTCGCTGATCGCCTCTCAGGTCTGGGACATGAACTTCGACAGCGA
CACCAACGTGATCGACGTCGCCATCCGCCGCCTGCGCGCAAAGATCGATGATCACTTCGAGCCGAAGCTGATCCAAACGG
TGCGCGGCATGGGTTATGTGCTCGAAGCACCCGAGGAAGTGGCTTGA

Upstream 100 bases:

>100_bases
CCTGACCGAAACATTACAAATCGGTCATCTTGGTGTGATGCGGCCCACAGCACGGTACTCTACAGCCCATACAAGCCATA
GAAAGTGATTCAGGCGAGAT

Downstream 100 bases:

>100_bases
TGGGTCGGTTCTCCCTCACGACGCGGCTGACCGCGTATTTCTCGCTGTGTTCGGCTGCCGTCTTGCTGGGGCTGGGTGTC
GTGATTGCGCTGGCTATGGA

Product: winged helix family two component heavy metal response transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKLLVVEDEPKTGEYLQQGLTEAGFVVDLACNGTDGRHLAMTGEYDLLVLDVMLPDVDGWQIVQSLRASEQAVPVLFLTA
RDSVADRVKGLELGADDYLVKPFAFAELLARVRTLLRRGNSAVTADRIQVADLVLDLARRRASRGGQKIPLTSKEFSLLE
LLVRRRGEVLPRSLIASQVWDMNFDSDTNVIDVAIRRLRAKIDDHFEPKLIQTVRGMGYVLEAPEEVA

Sequences:

>Translated_228_residues
MKLLVVEDEPKTGEYLQQGLTEAGFVVDLACNGTDGRHLAMTGEYDLLVLDVMLPDVDGWQIVQSLRASEQAVPVLFLTA
RDSVADRVKGLELGADDYLVKPFAFAELLARVRTLLRRGNSAVTADRIQVADLVLDLARRRASRGGQKIPLTSKEFSLLE
LLVRRRGEVLPRSLIASQVWDMNFDSDTNVIDVAIRRLRAKIDDHFEPKLIQTVRGMGYVLEAPEEVA
>Mature_228_residues
MKLLVVEDEPKTGEYLQQGLTEAGFVVDLACNGTDGRHLAMTGEYDLLVLDVMLPDVDGWQIVQSLRASEQAVPVLFLTA
RDSVADRVKGLELGADDYLVKPFAFAELLARVRTLLRRGNSAVTADRIQVADLVLDLARRRASRGGQKIPLTSKEFSLLE
LLVRRRGEVLPRSLIASQVWDMNFDSDTNVIDVAIRRLRAKIDDHFEPKLIQTVRGMGYVLEAPEEVA

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=70.6666666666667, Blast_Score=336, Evalue=6e-94,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=54.7085201793722, Blast_Score=249, Evalue=9e-68,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=40.2714932126697, Blast_Score=167, Evalue=7e-43,
Organism=Escherichia coli, GI1790552, Length=230, Percent_Identity=40.4347826086956, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1787375, Length=222, Percent_Identity=35.1351351351351, Blast_Score=139, Evalue=2e-34,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=37.8854625550661, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI1790860, Length=221, Percent_Identity=38.9140271493213, Blast_Score=127, Evalue=6e-31,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=36.8181818181818, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=34.5454545454545, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=33.1877729257642, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=38.5964912280702, Blast_Score=117, Evalue=4e-28,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=34.375, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI1790863, Length=232, Percent_Identity=31.4655172413793, Blast_Score=97, Evalue=7e-22,
Organism=Escherichia coli, GI145693140, Length=235, Percent_Identity=31.063829787234, Blast_Score=86, Evalue=1e-18,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=32.7102803738318, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788713, Length=115, Percent_Identity=31.304347826087, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790437, Length=134, Percent_Identity=33.5820895522388, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25386; Mature: 25386

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLVVEDEPKTGEYLQQGLTEAGFVVDLACNGTDGRHLAMTGEYDLLVLDVMLPDVDGW
CEEEEECCCCCCHHHHHHCCCCCCEEEEEEECCCCCCEEEEECCCCEEEEEEECCCCCHH
QIVQSLRASEQAVPVLFLTARDSVADRVKGLELGADDYLVKPFAFAELLARVRTLLRRGN
HHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHCCC
SAVTADRIQVADLVLDLARRRASRGGQKIPLTSKEFSLLELLVRRRGEVLPRSLIASQVW
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
DMNFDSDTNVIDVAIRRLRAKIDDHFEPKLIQTVRGMGYVLEAPEEVA
CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEECCCCCCC
>Mature Secondary Structure
MKLLVVEDEPKTGEYLQQGLTEAGFVVDLACNGTDGRHLAMTGEYDLLVLDVMLPDVDGW
CEEEEECCCCCCHHHHHHCCCCCCEEEEEEECCCCCCEEEEECCCCEEEEEEECCCCCHH
QIVQSLRASEQAVPVLFLTARDSVADRVKGLELGADDYLVKPFAFAELLARVRTLLRRGN
HHHHHHHHCCCCCCEEEEECCHHHHHHHHCCCCCCCCCEECHHHHHHHHHHHHHHHHCCC
SAVTADRIQVADLVLDLARRRASRGGQKIPLTSKEFSLLELLVRRRGEVLPRSLIASQVW
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
DMNFDSDTNVIDVAIRRLRAKIDDHFEPKLIQTVRGMGYVLEAPEEVA
CCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]