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The map label for this gene is prs [H]

Identifier: 187928793

GI number: 187928793

Start: 1802371

End: 1803276

Strand: Direct

Name: prs [H]

Synonym: Rpic_1710

Alternate gene names: 187928793

Gene position: 1802371-1803276 (Clockwise)

Preceding gene: 187928792

Following gene: 187928794

Centisome position: 45.72

GC content: 64.24

Gene sequence:

>906_bases
ATGACGCCACTGATTTTTGCCATGCCGGGCAATGAAGCGATGGCAGAGAAGCTGGCTTCGGCGTTGGGCGCAGAGCGCGG
GACTACGACGGTGCGGCGCTTTCCGGATGGAGAGTCGTATGTGCGGGTGGAGTCTGCCGTGGAGGGGCGGCGGGTCGCCA
TCGTCTGCACGCTAGACCGGCCGGACGACAAGCTGATTCCGTTGCTGCTGTTGGCGGCGGCCGCCCGGGAGAACGGTGCG
ACCGACGTTGGTCTGGTCGCACCTTACCTCGCCTACATGCGACAGGATAGTTGCTTCCAGCCGGGTGAGACGGTGAGTGC
ACGGCATTTTGCAGCCTGGTTGTCGCGTGGATTTGATTGGCTGGCAACAGTCGATCCCCACTTGCACCGCATCACCAAGT
TGTCGCAGGTCTATGTAATCCCAACGCGTCACGTCCACGCGGCGCCGGCTGTGGCGGCATGGCTGCGCGCCCATGTGACA
CGCCCGGCGCTTGTGGGCCCTGACGAGGAGAGCAACCAATGGGTGGCCGATGTCGCAAGCAGGGCGGACGCGCCCATGGT
GGTGCTGCACAAGGTCCGCAAAGGTGACCGGGATGTCGAGGTTTCGGTGCCGGATGTGGAGCGCTGGCGCGACCACACGC
CGGTGCTGGTCGATGACATTGTCTCCACCGGTCGCACGATGGCCGAGACCATTGGTCATCTGCGGCGCGCGGGCTTGGCC
GCGCCTGTGTGCATCGCGATTCACGCGGTGTTTTCAGGCAACGCGGTTCAGGATTTGGAGTCCACTGGGGCCGGGCTGGT
GGTGAGCTGCGACACGGTTGTCCATCCCACCAATGGAATCTCCGTTGCCCCGGACCTAGCGTCCGCGGTTCGTGAACTCA
TGCAAGACCCCGGGGGTGCCACATGA

Upstream 100 bases:

>100_bases
GTATGCCGCTGTTCACCGTGCATGCCGAAGCGCTCGGCGAGTTGGACTACGCGTTCGACTACCTGGAGGCTCACCCGCTG
ATCGATGTGGGAGATTCGAG

Downstream 100 bases:

>100_bases
GTGCCAAGACTCCGCACGTTCACTTCGAGATAGATCTGGCCGGATTTTGCAAAGCCGCGATTCCGATGTCGGGTTGGCGC
TTCATCGTGTCAATTGGCGG

Product: phosphoribosylpyrophosphate synthetase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MTPLIFAMPGNEAMAEKLASALGAERGTTTVRRFPDGESYVRVESAVEGRRVAIVCTLDRPDDKLIPLLLLAAAARENGA
TDVGLVAPYLAYMRQDSCFQPGETVSARHFAAWLSRGFDWLATVDPHLHRITKLSQVYVIPTRHVHAAPAVAAWLRAHVT
RPALVGPDEESNQWVADVASRADAPMVVLHKVRKGDRDVEVSVPDVERWRDHTPVLVDDIVSTGRTMAETIGHLRRAGLA
APVCIAIHAVFSGNAVQDLESTGAGLVVSCDTVVHPTNGISVAPDLASAVRELMQDPGGAT

Sequences:

>Translated_301_residues
MTPLIFAMPGNEAMAEKLASALGAERGTTTVRRFPDGESYVRVESAVEGRRVAIVCTLDRPDDKLIPLLLLAAAARENGA
TDVGLVAPYLAYMRQDSCFQPGETVSARHFAAWLSRGFDWLATVDPHLHRITKLSQVYVIPTRHVHAAPAVAAWLRAHVT
RPALVGPDEESNQWVADVASRADAPMVVLHKVRKGDRDVEVSVPDVERWRDHTPVLVDDIVSTGRTMAETIGHLRRAGLA
APVCIAIHAVFSGNAVQDLESTGAGLVVSCDTVVHPTNGISVAPDLASAVRELMQDPGGAT
>Mature_300_residues
TPLIFAMPGNEAMAEKLASALGAERGTTTVRRFPDGESYVRVESAVEGRRVAIVCTLDRPDDKLIPLLLLAAAARENGAT
DVGLVAPYLAYMRQDSCFQPGETVSARHFAAWLSRGFDWLATVDPHLHRITKLSQVYVIPTRHVHAAPAVAAWLRAHVTR
PALVGPDEESNQWVADVASRADAPMVVLHKVRKGDRDVEVSVPDVERWRDHTPVLVDDIVSTGRTMAETIGHLRRAGLAA
PVCIAIHAVFSGNAVQDLESTGAGLVVSCDTVVHPTNGISVAPDLASAVRELMQDPGGAT

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=276, Percent_Identity=29.7101449275362, Blast_Score=111, Evalue=9e-25,
Organism=Homo sapiens, GI84875539, Length=280, Percent_Identity=28.5714285714286, Blast_Score=109, Evalue=3e-24,
Organism=Homo sapiens, GI4506129, Length=277, Percent_Identity=28.158844765343, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI28557709, Length=276, Percent_Identity=28.9855072463768, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1787458, Length=276, Percent_Identity=28.9855072463768, Blast_Score=96, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17554704, Length=304, Percent_Identity=25, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI25149168, Length=300, Percent_Identity=24.6666666666667, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17554702, Length=300, Percent_Identity=24.6666666666667, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71989924, Length=300, Percent_Identity=24.6666666666667, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319403, Length=294, Percent_Identity=27.2108843537415, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6321776, Length=267, Percent_Identity=25.0936329588015, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6320946, Length=307, Percent_Identity=25.0814332247557, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355239, Length=282, Percent_Identity=28.3687943262411, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI45551540, Length=305, Percent_Identity=26.5573770491803, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 32321; Mature: 32190

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLIFAMPGNEAMAEKLASALGAERGTTTVRRFPDGESYVRVESAVEGRRVAIVCTLDR
CCCEEEEECCCHHHHHHHHHHHCCCCCCCCEEECCCCCCEEEEHHHCCCCEEEEEEEECC
PDDKLIPLLLLAAAARENGATDVGLVAPYLAYMRQDSCFQPGETVSARHFAAWLSRGFDW
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCE
LATVDPHLHRITKLSQVYVIPTRHVHAAPAVAAWLRAHVTRPALVGPDEESNQWVADVAS
EEECCHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHH
RADAPMVVLHKVRKGDRDVEVSVPDVERWRDHTPVLVDDIVSTGRTMAETIGHLRRAGLA
CCCCCHHHHHHHHCCCCCEEEECCCHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCC
APVCIAIHAVFSGNAVQDLESTGAGLVVSCDTVVHPTNGISVAPDLASAVRELMQDPGGA
CHHHHHHHHHHCCCHHHHHHHCCCCEEEEECEEEECCCCCEECHHHHHHHHHHHHCCCCC
T
C
>Mature Secondary Structure 
TPLIFAMPGNEAMAEKLASALGAERGTTTVRRFPDGESYVRVESAVEGRRVAIVCTLDR
CCEEEEECCCHHHHHHHHHHHCCCCCCCCEEECCCCCCEEEEHHHCCCCEEEEEEEECC
PDDKLIPLLLLAAAARENGATDVGLVAPYLAYMRQDSCFQPGETVSARHFAAWLSRGFDW
CCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCE
LATVDPHLHRITKLSQVYVIPTRHVHAAPAVAAWLRAHVTRPALVGPDEESNQWVADVAS
EEECCHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHH
RADAPMVVLHKVRKGDRDVEVSVPDVERWRDHTPVLVDDIVSTGRTMAETIGHLRRAGLA
CCCCCHHHHHHHHCCCCCEEEECCCHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCC
APVCIAIHAVFSGNAVQDLESTGAGLVVSCDTVVHPTNGISVAPDLASAVRELMQDPGGA
CHHHHHHHHHHCCCHHHHHHHCCCCEEEEECEEEECCCCCEECHHHHHHHHHHHHCCCCC
T
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]