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The map label for this gene is zitB [H]

Identifier: 187928668

GI number: 187928668

Start: 1674338

End: 1675642

Strand: Direct

Name: zitB [H]

Synonym: Rpic_1585

Alternate gene names: 187928668

Gene position: 1674338-1675642 (Clockwise)

Preceding gene: 187928667

Following gene: 187928669

Centisome position: 42.47

GC content: 62.61

Gene sequence:

>1305_bases
ATGAGCAATTTCTACGACACGCCGTTCGGCGCGAGCCATGACCACGTGTTCCTGGGCGAGGGACACGAAAAGAACGAGCG
CAAAACCTGGGCCGTGATCGTGCTCTGCACGCTCATGATGGCCGCCGAGATCATCGGCGGAAGCATGTTTGGCTCGCTGG
CACTGGTGGCCGATGGGTTGCATATGTCGACGCACGCAGGCGCCATGCTGATCGCGGCACTGGCCTACACCTATGCGCGA
CGTCATGCGAACGACCCGCGCTTCGTGTTCGGGACGGGCAAGCTTGGTGATCTGGCCGGCTTCACCAGCGCCATCATCCT
GGCGATGATCGCGCTGTTGATCGGCTACGAAGCGGTGGTGCGGTTCCTCTCGCCGGTGCCCATCCACTTTAGTGAGGCGA
TCCCGATTGCGATCGTCGGTTTGCTGGTGAATATCGCCAGCGCCTGGCTGCTGAGCGGTGGCGACCACGGTGGTCACAGC
CATGGCCACAGTCATCACCATGGTCACGCCCACGGACACGATCACGACGCAGCCGGACTTGGCGACACGCATCCGCATGG
CAAGGAAGTGCAGCACATCGACGCGCCCGCGGGCGTGTTCGCACTGTCGATCTTTGAAGAAGGCGTACCGCCAGTGTTCC
GCCTGGCTGGAGAAACTGCTCCGCTGCCCGGCGATGTGGCGACGGTGACCACGTTCCGGCCGGACGGAAGCCGCCAGGAA
TTCCTGCTGGTCCGCAAGGCAAACTATCTGGAATCCACCACAGAGATTCCGGAGCCACATGCCTTCACTGCGGTGCTCGG
CATCGGTGGTCAGGAATACAGCGTGGATTTCGAAGAGCATGACCACGACCACGCCGACGGACACGGGGCACACCATCGCG
ACCACAACATGCGCGCAGCTTATGTGCACGTTCTGGCCGACGCCGCCGTCTCTGTGCTAGCCATTGTTGGGCTGTTGTTA
GCAAGAGCTTTCGGCTGGCTGTGGATGGACCCCCTTGCAGGCGTCGTCGGTGCGTTGGTCATCGCCAACTGGGCGTACGG
ATTGATGCGCGACACGGGCGGCATCCTGGTCGACATGACCCCAGACAAACATATCGGCAGGCGCATCAAGACGGCGCTGG
AGTCCGATGGCGACACGCTGCTCGACCTGCACGTGTGGCGCATCGGCCCTGGCCACCTGGGCGCGGTGGTCTCGGTGAGC
ACAGGCCAAGCGCATCGCGGGCCGCAGTTTTATCACCAACGGTTGCGGCGACTTCAGGCACTCTCGCATATCACGGTGGA
GGTTCACGCGTTGCCAGGCAACTAG

Upstream 100 bases:

>100_bases
ACCCACCTGACCGAGGTGGATGACGAACATGAGCACGCCGACGGCAGCGCCAAGGAGCAGCTGATCGAGGTCGTGCATAG
CTATTTCAAGTGAGTCGGCT

Downstream 100 bases:

>100_bases
CCTAACGGCCGACTCGGACATTTCCTCCGCATCCCCAAACATGGGGCGCGGCACCCTGCCAGGTGTGCCGCATCTGCCCG
ACCACAACAAAAACATTCGC

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MSNFYDTPFGASHDHVFLGEGHEKNERKTWAVIVLCTLMMAAEIIGGSMFGSLALVADGLHMSTHAGAMLIAALAYTYAR
RHANDPRFVFGTGKLGDLAGFTSAIILAMIALLIGYEAVVRFLSPVPIHFSEAIPIAIVGLLVNIASAWLLSGGDHGGHS
HGHSHHHGHAHGHDHDAAGLGDTHPHGKEVQHIDAPAGVFALSIFEEGVPPVFRLAGETAPLPGDVATVTTFRPDGSRQE
FLLVRKANYLESTTEIPEPHAFTAVLGIGGQEYSVDFEEHDHDHADGHGAHHRDHNMRAAYVHVLADAAVSVLAIVGLLL
ARAFGWLWMDPLAGVVGALVIANWAYGLMRDTGGILVDMTPDKHIGRRIKTALESDGDTLLDLHVWRIGPGHLGAVVSVS
TGQAHRGPQFYHQRLRRLQALSHITVEVHALPGN

Sequences:

>Translated_434_residues
MSNFYDTPFGASHDHVFLGEGHEKNERKTWAVIVLCTLMMAAEIIGGSMFGSLALVADGLHMSTHAGAMLIAALAYTYAR
RHANDPRFVFGTGKLGDLAGFTSAIILAMIALLIGYEAVVRFLSPVPIHFSEAIPIAIVGLLVNIASAWLLSGGDHGGHS
HGHSHHHGHAHGHDHDAAGLGDTHPHGKEVQHIDAPAGVFALSIFEEGVPPVFRLAGETAPLPGDVATVTTFRPDGSRQE
FLLVRKANYLESTTEIPEPHAFTAVLGIGGQEYSVDFEEHDHDHADGHGAHHRDHNMRAAYVHVLADAAVSVLAIVGLLL
ARAFGWLWMDPLAGVVGALVIANWAYGLMRDTGGILVDMTPDKHIGRRIKTALESDGDTLLDLHVWRIGPGHLGAVVSVS
TGQAHRGPQFYHQRLRRLQALSHITVEVHALPGN
>Mature_433_residues
SNFYDTPFGASHDHVFLGEGHEKNERKTWAVIVLCTLMMAAEIIGGSMFGSLALVADGLHMSTHAGAMLIAALAYTYARR
HANDPRFVFGTGKLGDLAGFTSAIILAMIALLIGYEAVVRFLSPVPIHFSEAIPIAIVGLLVNIASAWLLSGGDHGGHSH
GHSHHHGHAHGHDHDAAGLGDTHPHGKEVQHIDAPAGVFALSIFEEGVPPVFRLAGETAPLPGDVATVTTFRPDGSRQEF
LLVRKANYLESTTEIPEPHAFTAVLGIGGQEYSVDFEEHDHDHADGHGAHHRDHNMRAAYVHVLADAAVSVLAIVGLLLA
RAFGWLWMDPLAGVVGALVIANWAYGLMRDTGGILVDMTPDKHIGRRIKTALESDGDTLLDLHVWRIGPGHLGAVVSVST
GQAHRGPQFYHQRLRRLQALSHITVEVHALPGN

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=150, Percent_Identity=28, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786966, Length=133, Percent_Identity=40.6015037593985, Blast_Score=79, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6323899, Length=371, Percent_Identity=24.7978436657682, Blast_Score=80, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6324892, Length=391, Percent_Identity=21.9948849104859, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320411, Length=150, Percent_Identity=29.3333333333333, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 46574; Mature: 46442

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNFYDTPFGASHDHVFLGEGHEKNERKTWAVIVLCTLMMAAEIIGGSMFGSLALVADGL
CCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCC
HMSTHAGAMLIAALAYTYARRHANDPRFVFGTGKLGDLAGFTSAIILAMIALLIGYEAVV
CCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RFLSPVPIHFSEAIPIAIVGLLVNIASAWLLSGGDHGGHSHGHSHHHGHAHGHDHDAAGL
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GDTHPHGKEVQHIDAPAGVFALSIFEEGVPPVFRLAGETAPLPGDVATVTTFRPDGSRQE
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCEEEEEECCCCCCCE
FLLVRKANYLESTTEIPEPHAFTAVLGIGGQEYSVDFEEHDHDHADGHGAHHRDHNMRAA
EEEEEHHHHHHHHCCCCCCCCEEEEEECCCCEEEECHHHCCCCCCCCCCCCCCCCCCHHH
YVHVLADAAVSVLAIVGLLLARAFGWLWMDPLAGVVGALVIANWAYGLMRDTGGILVDMT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
PDKHIGRRIKTALESDGDTLLDLHVWRIGPGHLGAVVSVSTGQAHRGPQFYHQRLRRLQA
CCHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
LSHITVEVHALPGN
HHEEEEEEEECCCC
>Mature Secondary Structure 
SNFYDTPFGASHDHVFLGEGHEKNERKTWAVIVLCTLMMAAEIIGGSMFGSLALVADGL
CCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCC
HMSTHAGAMLIAALAYTYARRHANDPRFVFGTGKLGDLAGFTSAIILAMIALLIGYEAVV
CCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RFLSPVPIHFSEAIPIAIVGLLVNIASAWLLSGGDHGGHSHGHSHHHGHAHGHDHDAAGL
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GDTHPHGKEVQHIDAPAGVFALSIFEEGVPPVFRLAGETAPLPGDVATVTTFRPDGSRQE
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCEEEEEECCCCCCCE
FLLVRKANYLESTTEIPEPHAFTAVLGIGGQEYSVDFEEHDHDHADGHGAHHRDHNMRAA
EEEEEHHHHHHHHCCCCCCCCEEEEEECCCCEEEECHHHCCCCCCCCCCCCCCCCCCHHH
YVHVLADAAVSVLAIVGLLLARAFGWLWMDPLAGVVGALVIANWAYGLMRDTGGILVDMT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
PDKHIGRRIKTALESDGDTLLDLHVWRIGPGHLGAVVSVSTGQAHRGPQFYHQRLRRLQA
CCHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
LSHITVEVHALPGN
HHEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]