Click here to switch to the map view.

The map label for this gene is lysP [H]

Identifier: 187928535

GI number: 187928535

Start: 1539448

End: 1540971

Strand: Direct

Name: lysP [H]

Synonym: Rpic_1449

Alternate gene names: 187928535

Gene position: 1539448-1540971 (Clockwise)

Preceding gene: 187928534

Following gene: 187928542

Centisome position: 39.05

GC content: 62.2

Gene sequence:

>1524_bases
ATGCATACACCCATCACCCCCACCGGGCTCGAAGCCCAATCCGAACTGCGCCGACGCCTGCGCTCGCGCCACCTGATGAT
GATCGCCCTGGGCGGCGCCATCGGCACGGGGCTGTTCGTCGCGTCCGGCGCGTCCATTGCCCAGGCCGGCCCCGGCGGCG
CACTGCTGACCTACACGCTGATCGGCGTGATGGTCTATTGCCTGATGACGAGTCTTGGCGAGCTGGCGGTACATCTGCCC
GTCTCGGGTTCGTTCGTGACTTACAGCCGCCTGTATGTCGAAGAAGGCTTTGGCTTTGCGCTGGGATGGAACTACTGGTT
TGCACTGGCCGTGTCCGTTGCGGTGGAATTGGCGGCCGCGCAACTCGTGATGAAGTACTGGTTCCCGGGCATCTCGGGCA
TGGTCTGGAGCGCCGCATTCCTGCTGCTGATGTTTGGCCTCAACGCCTTCTCCGTGCGCGGCTTCGGCGAGGCGGAATAC
TGGTTCTCGATGATCAAGGTGGTGACCATCATCGTGTTCCTGCTGATCGGCCTGGCGATGATCTTCGGCATCATGCACGG
CGGCCCACAGTCGGGTTGGCAGAACTTCACCGTGGGTGATGCGCCGTTCGTGGGCGGTGTGCCTGCCATGGTGGGTGTGG
CGATGATTGCCGGGTTCTCGTTCCAGGGTGTCGAAACCATCGGCGTGGCCGCCGGCGAGGCGGAGAACCCCTCCCGCACG
ATCCCCCGCGCCATCCGCCAGACGTTCTGGCGCATTCTGCTGTTCTATGTGCTGGCGATCCTGATCATTGGCGTGCTGCT
GCCATACACCGACCCGAACCTGCTGCGCAATGAAGCGACGGACGTCGGCGTCAGCCCGTTTGCGCTGGTGTTCCAGCACG
CGGGCCTCGCGTTTGCGGCCGGTATGATGAATGCGGTGGTGCTGACCGCGCTGCTGTCGTCCGGCACGTCGAGCCTCTAT
GTGTCGACGCGGATTCTGTACGATTTGGCGCTCGAAGGCCAAGCGCCGCGCTGGTTTGCCAAGGTATCTACCAATGGCGT
GCCGCATCGCGCGCTGCTTTCCACGTCCGCTGTTGGCGCGCTGTGCTTCTTCAGCTCTTTGTTTGGCGATCAGGTGGTCT
ACCTGTGGCTGCTGAATACATCTGCGGTGACATGCTTCATCGCCTGGTTCGGCATTGCGCTGGCGCACTACCGGTTCCGC
AAGGGGTTCACGAGCCAGGGCCATTCAGTGGAGCAACTGGCGTATCGGTCGCCGTTCTTCCCATTCGGGCCGATCATGGT
GGCGATCCTGTGCGCGGTGATCATCCTTGGGCAGAACACCAAGGCACTGTTTGCACCGGTGGACAACTTCGGCGCCTTCA
TCGCAACGTACTGCGGTGTGATTCTGTTCGTGGCGATCTGGCTGGCTTACCGCTGGAAATTCAAGACGCGATTCGTGAAG
TACACCGAGATGCAGTTCAGCCCGGCGCATCTGCAACAACCCGAACCTACCAACGCCACTGCGACGGGCGTGGTTGCCAA
CTAG

Upstream 100 bases:

>100_bases
TGGCAAACAGTACACAGTAACCATCCCCCCGCTCCGCCAGCCGTTTGCACAGCATCCGGCCGGCGCTTTTATTGGGGCGC
CCGCTCCGGCGCTACCGGCT

Downstream 100 bases:

>100_bases
GCAAATCAAAAAAGGCCCGCACAGTTGTCCATGCGGGCCATCTTTTCAGTGTGGTTAAACGTCCGGCCTTTACACCTCCA
GCCACTCCTGCCGGACTTTC

Product: amino acid permease-associated protein

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MHTPITPTGLEAQSELRRRLRSRHLMMIALGGAIGTGLFVASGASIAQAGPGGALLTYTLIGVMVYCLMTSLGELAVHLP
VSGSFVTYSRLYVEEGFGFALGWNYWFALAVSVAVELAAAQLVMKYWFPGISGMVWSAAFLLLMFGLNAFSVRGFGEAEY
WFSMIKVVTIIVFLLIGLAMIFGIMHGGPQSGWQNFTVGDAPFVGGVPAMVGVAMIAGFSFQGVETIGVAAGEAENPSRT
IPRAIRQTFWRILLFYVLAILIIGVLLPYTDPNLLRNEATDVGVSPFALVFQHAGLAFAAGMMNAVVLTALLSSGTSSLY
VSTRILYDLALEGQAPRWFAKVSTNGVPHRALLSTSAVGALCFFSSLFGDQVVYLWLLNTSAVTCFIAWFGIALAHYRFR
KGFTSQGHSVEQLAYRSPFFPFGPIMVAILCAVIILGQNTKALFAPVDNFGAFIATYCGVILFVAIWLAYRWKFKTRFVK
YTEMQFSPAHLQQPEPTNATATGVVAN

Sequences:

>Translated_507_residues
MHTPITPTGLEAQSELRRRLRSRHLMMIALGGAIGTGLFVASGASIAQAGPGGALLTYTLIGVMVYCLMTSLGELAVHLP
VSGSFVTYSRLYVEEGFGFALGWNYWFALAVSVAVELAAAQLVMKYWFPGISGMVWSAAFLLLMFGLNAFSVRGFGEAEY
WFSMIKVVTIIVFLLIGLAMIFGIMHGGPQSGWQNFTVGDAPFVGGVPAMVGVAMIAGFSFQGVETIGVAAGEAENPSRT
IPRAIRQTFWRILLFYVLAILIIGVLLPYTDPNLLRNEATDVGVSPFALVFQHAGLAFAAGMMNAVVLTALLSSGTSSLY
VSTRILYDLALEGQAPRWFAKVSTNGVPHRALLSTSAVGALCFFSSLFGDQVVYLWLLNTSAVTCFIAWFGIALAHYRFR
KGFTSQGHSVEQLAYRSPFFPFGPIMVAILCAVIILGQNTKALFAPVDNFGAFIATYCGVILFVAIWLAYRWKFKTRFVK
YTEMQFSPAHLQQPEPTNATATGVVAN
>Mature_507_residues
MHTPITPTGLEAQSELRRRLRSRHLMMIALGGAIGTGLFVASGASIAQAGPGGALLTYTLIGVMVYCLMTSLGELAVHLP
VSGSFVTYSRLYVEEGFGFALGWNYWFALAVSVAVELAAAQLVMKYWFPGISGMVWSAAFLLLMFGLNAFSVRGFGEAEY
WFSMIKVVTIIVFLLIGLAMIFGIMHGGPQSGWQNFTVGDAPFVGGVPAMVGVAMIAGFSFQGVETIGVAAGEAENPSRT
IPRAIRQTFWRILLFYVLAILIIGVLLPYTDPNLLRNEATDVGVSPFALVFQHAGLAFAAGMMNAVVLTALLSSGTSSLY
VSTRILYDLALEGQAPRWFAKVSTNGVPHRALLSTSAVGALCFFSSLFGDQVVYLWLLNTSAVTCFIAWFGIALAHYRFR
KGFTSQGHSVEQLAYRSPFFPFGPIMVAILCAVIILGQNTKALFAPVDNFGAFIATYCGVILFVAIWLAYRWKFKTRFVK
YTEMQFSPAHLQQPEPTNATATGVVAN

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI258645169, Length=398, Percent_Identity=24.3718592964824, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1788480, Length=482, Percent_Identity=62.2406639004149, Blast_Score=627, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=453, Percent_Identity=37.5275938189845, Blast_Score=305, Evalue=4e-84,
Organism=Escherichia coli, GI1786789, Length=429, Percent_Identity=34.7319347319347, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1786302, Length=471, Percent_Identity=34.1825902335456, Blast_Score=255, Evalue=4e-69,
Organism=Escherichia coli, GI48994972, Length=430, Percent_Identity=37.2093023255814, Blast_Score=243, Evalue=1e-65,
Organism=Escherichia coli, GI87081915, Length=418, Percent_Identity=35.1674641148325, Blast_Score=225, Evalue=5e-60,
Organism=Escherichia coli, GI1786602, Length=410, Percent_Identity=34.1463414634146, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1790653, Length=414, Percent_Identity=33.5748792270531, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1789017, Length=476, Percent_Identity=27.9411764705882, Blast_Score=207, Evalue=2e-54,
Organism=Escherichia coli, GI87081869, Length=415, Percent_Identity=23.1325301204819, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320772, Length=483, Percent_Identity=35.6107660455487, Blast_Score=316, Evalue=6e-87,
Organism=Saccharomyces cerevisiae, GI6324061, Length=520, Percent_Identity=33.8461538461538, Blast_Score=298, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6324059, Length=507, Percent_Identity=33.7278106508876, Blast_Score=285, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6324990, Length=512, Percent_Identity=31.0546875, Blast_Score=275, Evalue=9e-75,
Organism=Saccharomyces cerevisiae, GI6322892, Length=478, Percent_Identity=33.0543933054393, Blast_Score=268, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6324553, Length=427, Percent_Identity=33.4894613583138, Blast_Score=254, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6321629, Length=414, Percent_Identity=32.8502415458937, Blast_Score=242, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6322967, Length=501, Percent_Identity=32.1357285429142, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6320717, Length=477, Percent_Identity=28.9308176100629, Blast_Score=236, Evalue=8e-63,
Organism=Saccharomyces cerevisiae, GI6324924, Length=492, Percent_Identity=31.7073170731707, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6321053, Length=476, Percent_Identity=31.0924369747899, Blast_Score=229, Evalue=6e-61,
Organism=Saccharomyces cerevisiae, GI6324981, Length=489, Percent_Identity=33.7423312883436, Blast_Score=227, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6319824, Length=490, Percent_Identity=29.1836734693878, Blast_Score=226, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6319543, Length=487, Percent_Identity=29.5687885010267, Blast_Score=219, Evalue=7e-58,
Organism=Saccharomyces cerevisiae, GI6319542, Length=512, Percent_Identity=27.1484375, Blast_Score=217, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6320251, Length=515, Percent_Identity=26.2135922330097, Blast_Score=213, Evalue=7e-56,
Organism=Saccharomyces cerevisiae, GI6319608, Length=494, Percent_Identity=27.7327935222672, Blast_Score=212, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6320364, Length=537, Percent_Identity=27.9329608938547, Blast_Score=171, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 54883; Mature: 54883

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTPITPTGLEAQSELRRRLRSRHLMMIALGGAIGTGLFVASGASIAQAGPGGALLTYTL
CCCCCCCCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCCHHCCCCCCHHHHHHH
IGVMVYCLMTSLGELAVHLPVSGSFVTYSRLYVEEGFGFALGWNYWFALAVSVAVELAAA
HHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHH
QLVMKYWFPGISGMVWSAAFLLLMFGLNAFSVRGFGEAEYWFSMIKVVTIIVFLLIGLAM
HHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
IFGIMHGGPQSGWQNFTVGDAPFVGGVPAMVGVAMIAGFSFQGVETIGVAAGEAENPSRT
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHEEECCCCCCCCHH
IPRAIRQTFWRILLFYVLAILIIGVLLPYTDPNLLRNEATDVGVSPFALVFQHAGLAFAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
GMMNAVVLTALLSSGTSSLYVSTRILYDLALEGQAPRWFAKVSTNGVPHRALLSTSAVGA
HHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHH
LCFFSSLFGDQVVYLWLLNTSAVTCFIAWFGIALAHYRFRKGFTSQGHSVEQLAYRSPFF
HHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCC
PFGPIMVAILCAVIILGQNTKALFAPVDNFGAFIATYCGVILFVAIWLAYRWKFKTRFVK
CHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
YTEMQFSPAHLQQPEPTNATATGVVAN
EEECCCCHHHCCCCCCCCCCCCCEECC
>Mature Secondary Structure
MHTPITPTGLEAQSELRRRLRSRHLMMIALGGAIGTGLFVASGASIAQAGPGGALLTYTL
CCCCCCCCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCCHHCCCCCCHHHHHHH
IGVMVYCLMTSLGELAVHLPVSGSFVTYSRLYVEEGFGFALGWNYWFALAVSVAVELAAA
HHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHH
QLVMKYWFPGISGMVWSAAFLLLMFGLNAFSVRGFGEAEYWFSMIKVVTIIVFLLIGLAM
HHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
IFGIMHGGPQSGWQNFTVGDAPFVGGVPAMVGVAMIAGFSFQGVETIGVAAGEAENPSRT
HHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHEEECCCCCCCCHH
IPRAIRQTFWRILLFYVLAILIIGVLLPYTDPNLLRNEATDVGVSPFALVFQHAGLAFAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
GMMNAVVLTALLSSGTSSLYVSTRILYDLALEGQAPRWFAKVSTNGVPHRALLSTSAVGA
HHHHHHHHHHHHHCCCCCEEEHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHH
LCFFSSLFGDQVVYLWLLNTSAVTCFIAWFGIALAHYRFRKGFTSQGHSVEQLAYRSPFF
HHHHHHHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCC
PFGPIMVAILCAVIILGQNTKALFAPVDNFGAFIATYCGVILFVAIWLAYRWKFKTRFVK
CHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
YTEMQFSPAHLQQPEPTNATATGVVAN
EEECCCCHHHCCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]