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The map label for this gene is lysP [H]

Identifier: 187928534

GI number: 187928534

Start: 1537832

End: 1539367

Strand: Direct

Name: lysP [H]

Synonym: Rpic_1448

Alternate gene names: 187928534

Gene position: 1537832-1539367 (Clockwise)

Preceding gene: 187928521

Following gene: 187928535

Centisome position: 39.01

GC content: 63.61

Gene sequence:

>1536_bases
ATGTCAGAACACGCTACCCCGTCTTCAGAGACGCCGGGCTTGCGCCGCACCTTGCGCGCGCGCCATCTCACCATGATCGC
CATCGGCGGGTCGATCGGCACCGGGCTCTTCGTGGCCTCGGGGGCGTCGGTCTCGCAGGCCGGCCCCGGAGGCGCCCTCG
CCGCTTACATCCTGATCGGGGCGATGGTCTACTTTCTGATGACCAGCCTGGGCGAACTTGCCGCCTATATGCCGGTTTCC
GGGTCCTTCGCCACCTACGGCGCGCTGTACGTGGACGAAGGCTTCGGCTTCGCGCTCGGCTGGAACTATTGGTACAACTG
GGCCGTAACGATTGCCGTTGAACTGGCCGCCGCACAGCTCGTCATGCATTACTGGTTTCCCGATGTGCCGGGCGTGCTGT
GGAGCGCCGTGTTCCTCGCCATCATGTTCCTGCTCAACGCCATCTCGGTGCGCGGCTTTGGCGAGGCGGAATACTGGTTC
GCGCTCATCAAGGTCGTTACGGTCATCTTCTTTATCGGCATTGGCCTGGCGATGATCTTCGGGATCATGAAGGGCGGTCC
GCAATCGGGCCTGCAGAACCTGACGATCGGTGATGCGCCGTTCGTGGGTGGGCTGCCGGCGATGATCGGCGTGGCGATGA
TCGCCGGGTTCTCGTTCCAGGGGACGGAGCTGATTGGCGTGGCGGCCGGCGAATCGGCCGACCCGGCGCGCACCATTCCA
CGTGCGGTCAAACAGGTGTTCTGGCGGATCCTGCTGTTCTACGTGCTGGCGATCTTCATCATCGGCCTGCTGGTGCCGTA
CACCGATCCGAATCTGTTGTCGACGGAAGTCACCAACATTGGCGTGAGCCCGTTCACGCTGGTGTTCAAGCATGCTGGCC
TGGCCTTTGCCGCCGGGCTGATGAATGCGGTGATCCTGACCGCGGTGCTGTCGGCGGGCAACTCGGGCATGTATGCATCC
ACGCGCATGCTCTACAACCTGGCCACTGAGGGCCGCGCGCCGCGTATCTTTGCGCGACTCACCCAGAACGGTGTGCCGCG
CAATGCACTACTGGCCACGACCGCCGTTGGCGCGCTATGTTTCCTGAGTTCGCTGTTTGGCGACAAGACGGTCTACCTGT
GGCTGCTGAACACCTCTGGCATGACCGGCTTCGTGGCGTGGCTTGGGATTGCCGTGAGCCACTATCGCTTCCGCAAGGGA
CTCGTGGCGCAGGGGCACGATCCGGCGCAGTTGCCGTACCGCTCCAGGTTCTTCCCATATGGCCCGTTGTTCGCGTTCGG
GTTGTGCCTGGTCATCACGCTGGGCCAGAACTACCAGGCGTTCACCAGCGGCACCGTCGATTGGCCGGCGGTGATCGCCA
CGTACATCGGCATCCCGGTCTTCTTCCTGATCTGGATCGGCTACCGGCTGGTGCGTGGCGGCGGCATTGTCCGTTACCCG
GACATGCACTTCCCGCGCCCGCCCGTGTTGCGCGATTCGCTGGCCGGCCAAGACCCCGGCCCCGAATTGCCGATCGTGGC
AAACAGTACACAGTAA

Upstream 100 bases:

>100_bases
CGCGCATTTCGTTTGCCGGGTGCCCATCAGGCGCGGGAACGTCTCGTCACATTTCGTCGATTTGATTCGCGATCCGAGCA
AAATCGACCACTCTGTATCC

Downstream 100 bases:

>100_bases
CCATCCCCCCGCTCCGCCAGCCGTTTGCACAGCATCCGGCCGGCGCTTTTATTGGGGCGCCCGCTCCGGCGCTACCGGCT
ATGCATACACCCATCACCCC

Product: amino acid permease-associated protein

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MSEHATPSSETPGLRRTLRARHLTMIAIGGSIGTGLFVASGASVSQAGPGGALAAYILIGAMVYFLMTSLGELAAYMPVS
GSFATYGALYVDEGFGFALGWNYWYNWAVTIAVELAAAQLVMHYWFPDVPGVLWSAVFLAIMFLLNAISVRGFGEAEYWF
ALIKVVTVIFFIGIGLAMIFGIMKGGPQSGLQNLTIGDAPFVGGLPAMIGVAMIAGFSFQGTELIGVAAGESADPARTIP
RAVKQVFWRILLFYVLAIFIIGLLVPYTDPNLLSTEVTNIGVSPFTLVFKHAGLAFAAGLMNAVILTAVLSAGNSGMYAS
TRMLYNLATEGRAPRIFARLTQNGVPRNALLATTAVGALCFLSSLFGDKTVYLWLLNTSGMTGFVAWLGIAVSHYRFRKG
LVAQGHDPAQLPYRSRFFPYGPLFAFGLCLVITLGQNYQAFTSGTVDWPAVIATYIGIPVFFLIWIGYRLVRGGGIVRYP
DMHFPRPPVLRDSLAGQDPGPELPIVANSTQ

Sequences:

>Translated_511_residues
MSEHATPSSETPGLRRTLRARHLTMIAIGGSIGTGLFVASGASVSQAGPGGALAAYILIGAMVYFLMTSLGELAAYMPVS
GSFATYGALYVDEGFGFALGWNYWYNWAVTIAVELAAAQLVMHYWFPDVPGVLWSAVFLAIMFLLNAISVRGFGEAEYWF
ALIKVVTVIFFIGIGLAMIFGIMKGGPQSGLQNLTIGDAPFVGGLPAMIGVAMIAGFSFQGTELIGVAAGESADPARTIP
RAVKQVFWRILLFYVLAIFIIGLLVPYTDPNLLSTEVTNIGVSPFTLVFKHAGLAFAAGLMNAVILTAVLSAGNSGMYAS
TRMLYNLATEGRAPRIFARLTQNGVPRNALLATTAVGALCFLSSLFGDKTVYLWLLNTSGMTGFVAWLGIAVSHYRFRKG
LVAQGHDPAQLPYRSRFFPYGPLFAFGLCLVITLGQNYQAFTSGTVDWPAVIATYIGIPVFFLIWIGYRLVRGGGIVRYP
DMHFPRPPVLRDSLAGQDPGPELPIVANSTQ
>Mature_510_residues
SEHATPSSETPGLRRTLRARHLTMIAIGGSIGTGLFVASGASVSQAGPGGALAAYILIGAMVYFLMTSLGELAAYMPVSG
SFATYGALYVDEGFGFALGWNYWYNWAVTIAVELAAAQLVMHYWFPDVPGVLWSAVFLAIMFLLNAISVRGFGEAEYWFA
LIKVVTVIFFIGIGLAMIFGIMKGGPQSGLQNLTIGDAPFVGGLPAMIGVAMIAGFSFQGTELIGVAAGESADPARTIPR
AVKQVFWRILLFYVLAIFIIGLLVPYTDPNLLSTEVTNIGVSPFTLVFKHAGLAFAAGLMNAVILTAVLSAGNSGMYAST
RMLYNLATEGRAPRIFARLTQNGVPRNALLATTAVGALCFLSSLFGDKTVYLWLLNTSGMTGFVAWLGIAVSHYRFRKGL
VAQGHDPAQLPYRSRFFPYGPLFAFGLCLVITLGQNYQAFTSGTVDWPAVIATYIGIPVFFLIWIGYRLVRGGGIVRYPD
MHFPRPPVLRDSLAGQDPGPELPIVANSTQ

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=481, Percent_Identity=74.6361746361746, Blast_Score=740, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=477, Percent_Identity=39.4129979035639, Blast_Score=334, Evalue=7e-93,
Organism=Escherichia coli, GI1786789, Length=419, Percent_Identity=37.4701670644391, Blast_Score=275, Evalue=5e-75,
Organism=Escherichia coli, GI48994972, Length=456, Percent_Identity=37.9385964912281, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1786302, Length=392, Percent_Identity=36.2244897959184, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI1789017, Length=443, Percent_Identity=32.7313769751693, Blast_Score=237, Evalue=2e-63,
Organism=Escherichia coli, GI87081915, Length=510, Percent_Identity=32.3529411764706, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1790653, Length=409, Percent_Identity=33.2518337408313, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1786602, Length=390, Percent_Identity=35.3846153846154, Blast_Score=204, Evalue=8e-54,
Organism=Escherichia coli, GI87081869, Length=403, Percent_Identity=24.5657568238213, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI87082023, Length=347, Percent_Identity=24.207492795389, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=386, Percent_Identity=24.6113989637306, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=506, Percent_Identity=34.7826086956522, Blast_Score=324, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6324061, Length=514, Percent_Identity=35.2140077821012, Blast_Score=323, Evalue=4e-89,
Organism=Saccharomyces cerevisiae, GI6324990, Length=493, Percent_Identity=33.2657200811359, Blast_Score=303, Evalue=5e-83,
Organism=Saccharomyces cerevisiae, GI6324059, Length=484, Percent_Identity=35.5371900826446, Blast_Score=288, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6322892, Length=519, Percent_Identity=35.4527938342967, Blast_Score=286, Evalue=5e-78,
Organism=Saccharomyces cerevisiae, GI6324553, Length=471, Percent_Identity=34.8195329087049, Blast_Score=275, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6324924, Length=483, Percent_Identity=32.9192546583851, Blast_Score=273, Evalue=7e-74,
Organism=Saccharomyces cerevisiae, GI6321629, Length=472, Percent_Identity=32.4152542372881, Blast_Score=261, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6322967, Length=469, Percent_Identity=35.181236673774, Blast_Score=259, Evalue=9e-70,
Organism=Saccharomyces cerevisiae, GI6320717, Length=475, Percent_Identity=28.6315789473684, Blast_Score=242, Evalue=9e-65,
Organism=Saccharomyces cerevisiae, GI6319824, Length=477, Percent_Identity=28.5115303983228, Blast_Score=239, Evalue=6e-64,
Organism=Saccharomyces cerevisiae, GI6321053, Length=508, Percent_Identity=29.7244094488189, Blast_Score=226, Evalue=9e-60,
Organism=Saccharomyces cerevisiae, GI6324981, Length=469, Percent_Identity=34.1151385927505, Blast_Score=224, Evalue=2e-59,
Organism=Saccharomyces cerevisiae, GI6320251, Length=514, Percent_Identity=26.6536964980545, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6319542, Length=511, Percent_Identity=26.027397260274, Blast_Score=222, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6319543, Length=470, Percent_Identity=28.936170212766, Blast_Score=214, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6319608, Length=489, Percent_Identity=27.6073619631902, Blast_Score=208, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6320364, Length=557, Percent_Identity=25.673249551167, Blast_Score=171, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 54772; Mature: 54641

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHATPSSETPGLRRTLRARHLTMIAIGGSIGTGLFVASGASVSQAGPGGALAAYILIG
CCCCCCCCCCCCHHHHHHHHHHEEEEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHH
AMVYFLMTSLGELAAYMPVSGSFATYGALYVDEGFGFALGWNYWYNWAVTIAVELAAAQL
HHHHHHHHHHHHHHHHCCCCCCCHHHCEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHH
VMHYWFPDVPGVLWSAVFLAIMFLLNAISVRGFGEAEYWFALIKVVTVIFFIGIGLAMIF
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GIMKGGPQSGLQNLTIGDAPFVGGLPAMIGVAMIAGFSFQGTELIGVAAGESADPARTIP
HHHCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHH
RAVKQVFWRILLFYVLAIFIIGLLVPYTDPNLLSTEVTNIGVSPFTLVFKHAGLAFAAGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
MNAVILTAVLSAGNSGMYASTRMLYNLATEGRAPRIFARLTQNGVPRNALLATTAVGALC
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
FLSSLFGDKTVYLWLLNTSGMTGFVAWLGIAVSHYRFRKGLVAQGHDPAQLPYRSRFFPY
HHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GPLFAFGLCLVITLGQNYQAFTSGTVDWPAVIATYIGIPVFFLIWIGYRLVRGGGIVRYP
CHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECC
DMHFPRPPVLRDSLAGQDPGPELPIVANSTQ
CCCCCCCCCHHHHCCCCCCCCCCCEEECCCC
>Mature Secondary Structure 
SEHATPSSETPGLRRTLRARHLTMIAIGGSIGTGLFVASGASVSQAGPGGALAAYILIG
CCCCCCCCCCCHHHHHHHHHHEEEEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHH
AMVYFLMTSLGELAAYMPVSGSFATYGALYVDEGFGFALGWNYWYNWAVTIAVELAAAQL
HHHHHHHHHHHHHHHHCCCCCCCHHHCEEEEECCCCEEEECHHHHHHHHHHHHHHHHHHH
VMHYWFPDVPGVLWSAVFLAIMFLLNAISVRGFGEAEYWFALIKVVTVIFFIGIGLAMIF
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
GIMKGGPQSGLQNLTIGDAPFVGGLPAMIGVAMIAGFSFQGTELIGVAAGESADPARTIP
HHHCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHH
RAVKQVFWRILLFYVLAIFIIGLLVPYTDPNLLSTEVTNIGVSPFTLVFKHAGLAFAAGL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHH
MNAVILTAVLSAGNSGMYASTRMLYNLATEGRAPRIFARLTQNGVPRNALLATTAVGALC
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
FLSSLFGDKTVYLWLLNTSGMTGFVAWLGIAVSHYRFRKGLVAQGHDPAQLPYRSRFFPY
HHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GPLFAFGLCLVITLGQNYQAFTSGTVDWPAVIATYIGIPVFFLIWIGYRLVRGGGIVRYP
CHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECC
DMHFPRPPVLRDSLAGQDPGPELPIVANSTQ
CCCCCCCCCHHHHCCCCCCCCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]