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The map label for this gene is lpxB [H]

Identifier: 187928380

GI number: 187928380

Start: 1386949

End: 1388082

Strand: Direct

Name: lpxB [H]

Synonym: Rpic_1291

Alternate gene names: 187928380

Gene position: 1386949-1388082 (Clockwise)

Preceding gene: 187928379

Following gene: 187928381

Centisome position: 35.18

GC content: 63.93

Gene sequence:

>1134_bases
ATGGTGGCCGGCGAGGCTTCCGGCGATTTGCTGGCCTCGCTGCTGCTGAAGGGGCTGCGCGCACAACTGCCTGCCGACAT
CGCCTACAACGGCATTGGCGGTGCGCGCATGACGGAGCAGGGTTTCCAGTCGAACTGGCCGATGCACAAGCTGTCGGTCA
ACGGCTACGTGGAAGTGCTCGGCCAGTTGCGCGAAATCCTTGCGATCCGCAAGGAACTCAAGCAGGACCTGCTGGCCCAG
CCGCCGCTGGCCTTCATCGGCGTGGATGCGCCCGACTTCAATTTCAACGTCGAGATCGCCATGCGGCAGGCGGGAGTGCC
GGTGGTGCACTTCGTGAGCCCGTCGATCTGGGCATGGCGAGCCGGCCGTATCAAGACGATCGCCCGCGCGGTCGACCATA
TCCTTTGCCTGTTCCCGTTCGAGCCCGAAATTTACGCCAAGGCCGGCATTCCGGCCACGTACGTCGGGCATCCGCTTGCG
GATGAGATTCCGCTGGTGCCGGACGTGGAGGGTGCACGCACGCGCCTTGGCCTGCCGTTGGGCCGCAAGGTCGTTGCGGT
GCTGCCCGGCAGCCGCAATTCCGAAGTGAAGCATCTCGGGCCGACGCTGTTTGCGGCGATGTCACGCATGCAGGCGGTCG
AACCGGATCTGGCCTTCGTGCTGCCGGCGGCCAATGCGACGTTGCGCGAGCGGATCGATGCCATGCGCGCGGAGCACCCA
GGACTGCATCTGTGGGTGGTCGATGGTCAGTCGCACACAGCCATGGAAGCGGCTGACGTGATCCTGCTGGCCAGCGGCAC
GGCCACGCTGGAAGCGGCGCTGTACAAGAAGCCGATGGTCATCACCTACAAGGTGCCCTGGCTGACCGCGCAGATCATGA
AGCGCAAAGGCTATCTGCCGTACGTTGGGCTGCCGAACATCCTGTCCGGCCGCTTTGTCGTGCCGGAATTGCTGCAGGAT
GACGCGACCCCCGAGGCACTCGCGCGCGAAACGCTGCTGCAACTGAGCGACCATGGCAACGCCACGTTCCTGCGTGAACA
CTTCACGCAGATGCACCTGACGCTCAAGCAGAATATGGCGGAGATCGGCGCGAAAGTCGTGGTCGATCTGCTACGCAGTC
GCGGTAAGCTTTAA

Upstream 100 bases:

>100_bases
AGGTGTTGACCGCGTTTGCCGATTTCATTGCCGCCACCAAGCGCGGCATCGTCCGTTGAGCGAGCAGCTTCAGAACGCCG
CGCCGGTGCGCCGCATCGGC

Downstream 100 bases:

>100_bases
GCCCATGGCTTCCCGCAAACCCAATCCGGACCAGCTTGGCCTGCTCCTCTCGCAGGAGCCGGCGGCCAAGCGCGCGCGTC
GCATTCTCTGTGGCGTGGAT

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MVAGEASGDLLASLLLKGLRAQLPADIAYNGIGGARMTEQGFQSNWPMHKLSVNGYVEVLGQLREILAIRKELKQDLLAQ
PPLAFIGVDAPDFNFNVEIAMRQAGVPVVHFVSPSIWAWRAGRIKTIARAVDHILCLFPFEPEIYAKAGIPATYVGHPLA
DEIPLVPDVEGARTRLGLPLGRKVVAVLPGSRNSEVKHLGPTLFAAMSRMQAVEPDLAFVLPAANATLRERIDAMRAEHP
GLHLWVVDGQSHTAMEAADVILLASGTATLEAALYKKPMVITYKVPWLTAQIMKRKGYLPYVGLPNILSGRFVVPELLQD
DATPEALARETLLQLSDHGNATFLREHFTQMHLTLKQNMAEIGAKVVVDLLRSRGKL

Sequences:

>Translated_377_residues
MVAGEASGDLLASLLLKGLRAQLPADIAYNGIGGARMTEQGFQSNWPMHKLSVNGYVEVLGQLREILAIRKELKQDLLAQ
PPLAFIGVDAPDFNFNVEIAMRQAGVPVVHFVSPSIWAWRAGRIKTIARAVDHILCLFPFEPEIYAKAGIPATYVGHPLA
DEIPLVPDVEGARTRLGLPLGRKVVAVLPGSRNSEVKHLGPTLFAAMSRMQAVEPDLAFVLPAANATLRERIDAMRAEHP
GLHLWVVDGQSHTAMEAADVILLASGTATLEAALYKKPMVITYKVPWLTAQIMKRKGYLPYVGLPNILSGRFVVPELLQD
DATPEALARETLLQLSDHGNATFLREHFTQMHLTLKQNMAEIGAKVVVDLLRSRGKL
>Mature_377_residues
MVAGEASGDLLASLLLKGLRAQLPADIAYNGIGGARMTEQGFQSNWPMHKLSVNGYVEVLGQLREILAIRKELKQDLLAQ
PPLAFIGVDAPDFNFNVEIAMRQAGVPVVHFVSPSIWAWRAGRIKTIARAVDHILCLFPFEPEIYAKAGIPATYVGHPLA
DEIPLVPDVEGARTRLGLPLGRKVVAVLPGSRNSEVKHLGPTLFAAMSRMQAVEPDLAFVLPAANATLRERIDAMRAEHP
GLHLWVVDGQSHTAMEAADVILLASGTATLEAALYKKPMVITYKVPWLTAQIMKRKGYLPYVGLPNILSGRFVVPELLQD
DATPEALARETLLQLSDHGNATFLREHFTQMHLTLKQNMAEIGAKVVVDLLRSRGKL

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=371, Percent_Identity=39.622641509434, Blast_Score=276, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 41195; Mature: 41195

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAGEASGDLLASLLLKGLRAQLPADIAYNGIGGARMTEQGFQSNWPMHKLSVNGYVEVL
CCCCCCCHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHCCCCCEEEEEHHHHHHHH
GQLREILAIRKELKQDLLAQPPLAFIGVDAPDFNFNVEIAMRQAGVPVVHFVSPSIWAWR
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEECCCCCEEEECCCCCEEEC
AGRIKTIARAVDHILCLFPFEPEIYAKAGIPATYVGHPLADEIPLVPDVEGARTRLGLPL
CCHHHHHHHHHHHEEEEECCCCCCEEECCCCHHHCCCCCCCCCCCCCCCCCCHHHCCCCC
GRKVVAVLPGSRNSEVKHLGPTLFAAMSRMQAVEPDLAFVLPAANATLRERIDAMRAEHP
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCC
GLHLWVVDGQSHTAMEAADVILLASGTATLEAALYKKPMVITYKVPWLTAQIMKRKGYLP
CEEEEEEECCCCCHHHHCCEEEEECCCHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCC
YVGLPNILSGRFVVPELLQDDATPEALARETLLQLSDHGNATFLREHFTQMHLTLKQNMA
CCCCCHHHCCCEECHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EIGAKVVVDLLRSRGKL
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVAGEASGDLLASLLLKGLRAQLPADIAYNGIGGARMTEQGFQSNWPMHKLSVNGYVEVL
CCCCCCCHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHCCCCCEEEEEHHHHHHHH
GQLREILAIRKELKQDLLAQPPLAFIGVDAPDFNFNVEIAMRQAGVPVVHFVSPSIWAWR
HHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEECCCCCEEEECCCCCEEEC
AGRIKTIARAVDHILCLFPFEPEIYAKAGIPATYVGHPLADEIPLVPDVEGARTRLGLPL
CCHHHHHHHHHHHEEEEECCCCCCEEECCCCHHHCCCCCCCCCCCCCCCCCCHHHCCCCC
GRKVVAVLPGSRNSEVKHLGPTLFAAMSRMQAVEPDLAFVLPAANATLRERIDAMRAEHP
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHCCCC
GLHLWVVDGQSHTAMEAADVILLASGTATLEAALYKKPMVITYKVPWLTAQIMKRKGYLP
CEEEEEEECCCCCHHHHCCEEEEECCCHHHHHHHHCCCEEEEEECCHHHHHHHHHCCCCC
YVGLPNILSGRFVVPELLQDDATPEALARETLLQLSDHGNATFLREHFTQMHLTLKQNMA
CCCCCHHHCCCEECHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
EIGAKVVVDLLRSRGKL
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]