Click here to switch to the map view.

The map label for this gene is map [H]

Identifier: 187928366

GI number: 187928366

Start: 1372475

End: 1373299

Strand: Reverse

Name: map [H]

Synonym: Rpic_1277

Alternate gene names: 187928366

Gene position: 1373299-1372475 (Counterclockwise)

Preceding gene: 187928386

Following gene: 187928365

Centisome position: 34.83

GC content: 63.64

Gene sequence:

>825_bases
ATGGCCGTTACCATTCACACTGCCGAAGACATTGCGCACATGCGCGTCGCCTGCCGGCTCGCGTCCGAAGTCCTGGATTA
CATCACGCCGTTCGTGACGCCCGGCGTGACCACGGGCAAGCTGAACGAGCTGTGCCACGCCTACATGCGTGACGTGCAAG
GCACTGTGCCGGCGCCATTGAACTATGCCCCGCCGGGCTATCCGCCCTTCCCGGCATCGATCTGCTCGTCGGTCAACGAC
GTGATCTGCCACGGCATTCCGGGCGACAAGGTGCTCAAAAGCGGCGACATCGTCAACCTCGACATCACCGTCATCACCAA
GGAAGGCTATTACGGCGACACCAGCCGCACCTTCGTCGTCGGCGAAGGGTCGATCCTGGCCAAACGCCTGACGCAGGTCA
CGTTCGAATGCATGTGGAAGGGCATTGCGGCCGTGCGTCCGGGCGCGCGCCTGGGCGACATCGGCCACGTGATCCAGCAG
CACGCCGAAGCCGCCGGCTACAGCGTGGTGCGCGAATATTGCGGCCACGGCATCGGCAAGAAATTCCACGAAGATCCGCA
GATCCTGCACTACGGCCGCCCGGGTACCGGGATGGAACTGAAGGCCGGCATGATCTTCACGATTGAACCGATGATCAACG
CGGGCAAGCGCGACATCCGCACGATGCCCGACCAGTGGACCGTCAAGACGCGTGATCGCAGCCTGTCGGCGCAGTGGGAA
CACACGCTTCTGGTGACGGAGACTGGCCACGAAGTGCTGACCGTGTCCGCCTTGACGCCACCGGCACCGGAATTCGTACA
CGAAGGCGCTCCGGCCACGGCCTGA

Upstream 100 bases:

>100_bases
CGAGCGCCCGAAAACCCCGGCCCGGGCGCTTTGGTGCGATAATTCACACTTTAGCCACGACGCGGCGCTTCGCGCGCTTG
CGTGCAGAAAGAGTCACAGC

Downstream 100 bases:

>100_bases
TCCTAACGGGCGAGCCGCACCGTCAGCGGCAGCAATGTCACGCTGATCTCGCCCCGCACCGGCTCAACCCCTGCAGCGAC
CGGCTCATTCCGGTCGCTGT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MAVTIHTAEDIAHMRVACRLASEVLDYITPFVTPGVTTGKLNELCHAYMRDVQGTVPAPLNYAPPGYPPFPASICSSVND
VICHGIPGDKVLKSGDIVNLDITVITKEGYYGDTSRTFVVGEGSILAKRLTQVTFECMWKGIAAVRPGARLGDIGHVIQQ
HAEAAGYSVVREYCGHGIGKKFHEDPQILHYGRPGTGMELKAGMIFTIEPMINAGKRDIRTMPDQWTVKTRDRSLSAQWE
HTLLVTETGHEVLTVSALTPPAPEFVHEGAPATA

Sequences:

>Translated_274_residues
MAVTIHTAEDIAHMRVACRLASEVLDYITPFVTPGVTTGKLNELCHAYMRDVQGTVPAPLNYAPPGYPPFPASICSSVND
VICHGIPGDKVLKSGDIVNLDITVITKEGYYGDTSRTFVVGEGSILAKRLTQVTFECMWKGIAAVRPGARLGDIGHVIQQ
HAEAAGYSVVREYCGHGIGKKFHEDPQILHYGRPGTGMELKAGMIFTIEPMINAGKRDIRTMPDQWTVKTRDRSLSAQWE
HTLLVTETGHEVLTVSALTPPAPEFVHEGAPATA
>Mature_273_residues
AVTIHTAEDIAHMRVACRLASEVLDYITPFVTPGVTTGKLNELCHAYMRDVQGTVPAPLNYAPPGYPPFPASICSSVNDV
ICHGIPGDKVLKSGDIVNLDITVITKEGYYGDTSRTFVVGEGSILAKRLTQVTFECMWKGIAAVRPGARLGDIGHVIQQH
AEAAGYSVVREYCGHGIGKKFHEDPQILHYGRPGTGMELKAGMIFTIEPMINAGKRDIRTMPDQWTVKTRDRSLSAQWEH
TLLVTETGHEVLTVSALTPPAPEFVHEGAPATA

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=266, Percent_Identity=47.7443609022556, Blast_Score=242, Evalue=3e-64,
Organism=Homo sapiens, GI40385867, Length=255, Percent_Identity=38.4313725490196, Blast_Score=179, Evalue=2e-45,
Organism=Escherichia coli, GI1786364, Length=256, Percent_Identity=56.25, Blast_Score=299, Evalue=1e-82,
Organism=Escherichia coli, GI1788728, Length=255, Percent_Identity=28.6274509803922, Blast_Score=86, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71996291, Length=255, Percent_Identity=46.2745098039216, Blast_Score=221, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6323273, Length=260, Percent_Identity=45.7692307692308, Blast_Score=220, Evalue=2e-58,
Organism=Drosophila melanogaster, GI21355531, Length=258, Percent_Identity=45.7364341085271, Blast_Score=211, Evalue=6e-55,
Organism=Drosophila melanogaster, GI24583427, Length=250, Percent_Identity=38.8, Blast_Score=180, Evalue=1e-45,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29731; Mature: 29600

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVTIHTAEDIAHMRVACRLASEVLDYITPFVTPGVTTGKLNELCHAYMRDVQGTVPAPL
CEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
NYAPPGYPPFPASICSSVNDVICHGIPGDKVLKSGDIVNLDITVITKEGYYGDTSRTFVV
CCCCCCCCCCHHHHHCCHHHHEECCCCCHHHCCCCCEEEEEEEEEEECCCCCCCCCEEEE
GEGSILAKRLTQVTFECMWKGIAAVRPGARLGDIGHVIQQHAEAAGYSVVREYCGHGIGK
ECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
KFHEDPQILHYGRPGTGMELKAGMIFTIEPMINAGKRDIRTMPDQWTVKTRDRSLSAQWE
HHCCCCCEEEECCCCCCCEEECCEEEEECCHHCCCCHHHHCCCCCEEEEECCCCCCCCCC
HTLLVTETGHEVLTVSALTPPAPEFVHEGAPATA
EEEEEEECCCEEEEEEECCCCCHHHHHCCCCCCC
>Mature Secondary Structure 
AVTIHTAEDIAHMRVACRLASEVLDYITPFVTPGVTTGKLNELCHAYMRDVQGTVPAPL
EEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCC
NYAPPGYPPFPASICSSVNDVICHGIPGDKVLKSGDIVNLDITVITKEGYYGDTSRTFVV
CCCCCCCCCCHHHHHCCHHHHEECCCCCHHHCCCCCEEEEEEEEEEECCCCCCCCCEEEE
GEGSILAKRLTQVTFECMWKGIAAVRPGARLGDIGHVIQQHAEAAGYSVVREYCGHGIGK
ECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
KFHEDPQILHYGRPGTGMELKAGMIFTIEPMINAGKRDIRTMPDQWTVKTRDRSLSAQWE
HHCCCCCEEEECCCCCCCEEECCEEEEECCHHCCCCHHHHCCCCCEEEEECCCCCCCCCC
HTLLVTETGHEVLTVSALTPPAPEFVHEGAPATA
EEEEEEECCCEEEEEEECCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]