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The map label for this gene is lysC [H]

Identifier: 187928105

GI number: 187928105

Start: 1069483

End: 1070733

Strand: Direct

Name: lysC [H]

Synonym: Rpic_1012

Alternate gene names: 187928105

Gene position: 1069483-1070733 (Clockwise)

Preceding gene: 187928104

Following gene: 187928107

Centisome position: 27.13

GC content: 61.63

Gene sequence:

>1251_bases
ATGGCTCTCATCGTTCACAAATACGGTGGCACCTCGATGGGTTCGGTTGAACGCATCAAGAATGTCGCCAAGCGCGTTGC
CAAGTGGCACCGTGCAGGTCACCAGATCGTGGTCGTTCCGTCGGCCATGTCTGGCGAAACCAACCGCCTGCTGGGTATGG
CCAAAGAGATTTCGGCCCAACCCGACCCGCGTGAACTCGACATGATTGCCTCGACTGGCGAGCAGGTGAGTGTGGGTCTG
CTGGCCATTGCTCTGCATGCTGAAGGCATCGATGCCCGCAGCTACACCGGCTGGCAAGTGCCGGTGAAGACCGATTCGGC
CTACACAAAGGCGCGCATCCAGTCGATCGACGACGAGCGTGTGCGCGCCGATCTCGACGCCGGTCGTGTGGTGGTCATCA
CGGGCTTCCAGGGCATCGACAGCGAAGGCCATATCACCACGCTGGGCCGTGGTGGCTCGGATACCTCGGCCGTGGCGGTT
GCCGCCGCGCTCGAAGCCGAGGAATGCCTGATCTACACCGACGTCGACGGTGTCTACACCACCGACCCGCGCGTGGTGGA
CGACGCTCGCCGGCTGGACAAGATCACCTTCGAAGAGATGCTGGAAATGGCCAGCCTTGGCTCGAAGGTGCTGCAGATTC
GCTCGGTGGAGTTTGCCGGCAAGTACCGCGTGAAGACGCGCGTGCTGTCGTCGCTGACCGACCCGCTGATGCCGCTCGAC
ATTGAGATGAACTCGGGCACGCTGATTACTTTTGAGGAAGATTCGAACATGGAAGCCGCCGCCATTTCCGGCATCGCCTT
TGCCCGCGACGAAGCCAAGATCACCGTGATCGGTGTGCCGGACAAGCCTGGCATCGCTTATCAGATCCTGGGCCCGGTCG
CCGACGCCAACATCGACGTCGACATGATCATCCAGAACCAGTCGGTGGAAGGCAAGACGGACTTCACCTTCACCGTGCCG
CGCGGCGAATACCAACGCGCCTTGGCGATCCTGAACGACAGCGTGAAGGCGCACATCGGCGCGGCCAGCGTGTCGGGCGA
CCCGAAGGTGTCGAAGGTGTCGGTGGTGGGTGTGGGCATGCGCTCGCACGTGGGCATCGCCAGCAAGATGTTCCGCACGC
TGTCGGAAGAGGGCATCAACATCCAGATGATCTCCACCTCGGAAATCAAGATCTCGGTGCTGATCGATGAGAAGTACATG
GAGCTGGCCGTGCGCGCGCTCCACAAGGCGTTCGAGCTGGATCAGGCGTAA

Upstream 100 bases:

>100_bases
GTGATACGCATCGTCACCGGCGGATTGCTTGCCGATCGATGCAAATTGCTGTATTTTCAAAAGCTTTTGCACCGCTCCGC
CTCCTCCTGATCTTTCCAAG

Downstream 100 bases:

>100_bases
TCGGCTGAACTGGCACTGTATGGCCGGGGTGGCGCCCCCCGGGGGCCACAGATTCTCACCGCGTGTCATGCAGTTGTCGT
TGACCGGGTGGGGTGAAGTG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MALIVHKYGGTSMGSVERIKNVAKRVAKWHRAGHQIVVVPSAMSGETNRLLGMAKEISAQPDPRELDMIASTGEQVSVGL
LAIALHAEGIDARSYTGWQVPVKTDSAYTKARIQSIDDERVRADLDAGRVVVITGFQGIDSEGHITTLGRGGSDTSAVAV
AAALEAEECLIYTDVDGVYTTDPRVVDDARRLDKITFEEMLEMASLGSKVLQIRSVEFAGKYRVKTRVLSSLTDPLMPLD
IEMNSGTLITFEEDSNMEAAAISGIAFARDEAKITVIGVPDKPGIAYQILGPVADANIDVDMIIQNQSVEGKTDFTFTVP
RGEYQRALAILNDSVKAHIGAASVSGDPKVSKVSVVGVGMRSHVGIASKMFRTLSEEGINIQMISTSEIKISVLIDEKYM
ELAVRALHKAFELDQA

Sequences:

>Translated_416_residues
MALIVHKYGGTSMGSVERIKNVAKRVAKWHRAGHQIVVVPSAMSGETNRLLGMAKEISAQPDPRELDMIASTGEQVSVGL
LAIALHAEGIDARSYTGWQVPVKTDSAYTKARIQSIDDERVRADLDAGRVVVITGFQGIDSEGHITTLGRGGSDTSAVAV
AAALEAEECLIYTDVDGVYTTDPRVVDDARRLDKITFEEMLEMASLGSKVLQIRSVEFAGKYRVKTRVLSSLTDPLMPLD
IEMNSGTLITFEEDSNMEAAAISGIAFARDEAKITVIGVPDKPGIAYQILGPVADANIDVDMIIQNQSVEGKTDFTFTVP
RGEYQRALAILNDSVKAHIGAASVSGDPKVSKVSVVGVGMRSHVGIASKMFRTLSEEGINIQMISTSEIKISVLIDEKYM
ELAVRALHKAFELDQA
>Mature_415_residues
ALIVHKYGGTSMGSVERIKNVAKRVAKWHRAGHQIVVVPSAMSGETNRLLGMAKEISAQPDPRELDMIASTGEQVSVGLL
AIALHAEGIDARSYTGWQVPVKTDSAYTKARIQSIDDERVRADLDAGRVVVITGFQGIDSEGHITTLGRGGSDTSAVAVA
AALEAEECLIYTDVDGVYTTDPRVVDDARRLDKITFEEMLEMASLGSKVLQIRSVEFAGKYRVKTRVLSSLTDPLMPLDI
EMNSGTLITFEEDSNMEAAAISGIAFARDEAKITVIGVPDKPGIAYQILGPVADANIDVDMIIQNQSVEGKTDFTFTVPR
GEYQRALAILNDSVKAHIGAASVSGDPKVSKVSVVGVGMRSHVGIASKMFRTLSEEGINIQMISTSEIKISVLIDEKYME
LAVRALHKAFELDQA

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=359, Percent_Identity=30.3621169916435, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1790455, Length=383, Percent_Identity=27.9373368146214, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790376, Length=90, Percent_Identity=38.8888888888889, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320893, Length=406, Percent_Identity=26.6009852216749, Blast_Score=116, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44837; Mature: 44706

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIVHKYGGTSMGSVERIKNVAKRVAKWHRAGHQIVVVPSAMSGETNRLLGMAKEISAQ
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCC
PDPRELDMIASTGEQVSVGLLAIALHAEGIDARSYTGWQVPVKTDSAYTKARIQSIDDER
CCCHHHHHHHCCCCCEEEEEEEEEEECCCCCCCCCCCCEEEECCCCHHHHHHHHCCCHHH
VRADLDAGRVVVITGFQGIDSEGHITTLGRGGSDTSAVAVAAALEAEECLIYTDVDGVYT
HHEECCCCCEEEEECCCCCCCCCCEEEECCCCCCCHHEEEEEEECCCCEEEEEECCCEEE
TDPRVVDDARRLDKITFEEMLEMASLGSKVLQIRSVEFAGKYRVKTRVLSSLTDPLMPLD
CCCCHHHHHHHHHHCCHHHHHHHHHCCHHEEEEEEEEECCCCHHHHHHHHHHCCCCCEEE
IEMNSGTLITFEEDSNMEAAAISGIAFARDEAKITVIGVPDKPGIAYQILGPVADANIDV
EEECCCEEEEEECCCCCCHHHCCCEEEECCCCEEEEEECCCCCCEEEEEECCCCCCCCCE
DMIIQNQSVEGKTDFTFTVPRGEYQRALAILNDSVKAHIGAASVSGDPKVSKVSVVGVGM
EEEEECCCCCCCCCEEEECCCCHHHHHHHHHCCCHHEEEEEEECCCCCCCEEEEEEEECH
RSHVGIASKMFRTLSEEGINIQMISTSEIKISVLIDEKYMELAVRALHKAFELDQA
HHHCHHHHHHHHHHHHCCCEEEEEECCCEEEEEEECHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ALIVHKYGGTSMGSVERIKNVAKRVAKWHRAGHQIVVVPSAMSGETNRLLGMAKEISAQ
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHCCC
PDPRELDMIASTGEQVSVGLLAIALHAEGIDARSYTGWQVPVKTDSAYTKARIQSIDDER
CCCHHHHHHHCCCCCEEEEEEEEEEECCCCCCCCCCCCEEEECCCCHHHHHHHHCCCHHH
VRADLDAGRVVVITGFQGIDSEGHITTLGRGGSDTSAVAVAAALEAEECLIYTDVDGVYT
HHEECCCCCEEEEECCCCCCCCCCEEEECCCCCCCHHEEEEEEECCCCEEEEEECCCEEE
TDPRVVDDARRLDKITFEEMLEMASLGSKVLQIRSVEFAGKYRVKTRVLSSLTDPLMPLD
CCCCHHHHHHHHHHCCHHHHHHHHHCCHHEEEEEEEEECCCCHHHHHHHHHHCCCCCEEE
IEMNSGTLITFEEDSNMEAAAISGIAFARDEAKITVIGVPDKPGIAYQILGPVADANIDV
EEECCCEEEEEECCCCCCHHHCCCEEEECCCCEEEEEECCCCCCEEEEEECCCCCCCCCE
DMIIQNQSVEGKTDFTFTVPRGEYQRALAILNDSVKAHIGAASVSGDPKVSKVSVVGVGM
EEEEECCCCCCCCCEEEECCCCHHHHHHHHHCCCHHEEEEEEECCCCCCCEEEEEEEECH
RSHVGIASKMFRTLSEEGINIQMISTSEIKISVLIDEKYMELAVRALHKAFELDQA
HHHCHHHHHHHHHHHHCCCEEEEEECCCEEEEEEECHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]