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The map label for this gene is trpS [H]

Identifier: 187928078

GI number: 187928078

Start: 1040373

End: 1041575

Strand: Direct

Name: trpS [H]

Synonym: Rpic_0985

Alternate gene names: 187928078

Gene position: 1040373-1041575 (Clockwise)

Preceding gene: 187928077

Following gene: 187928079

Centisome position: 26.39

GC content: 63.51

Gene sequence:

>1203_bases
ATGTTTCCTGACCGCGTTCTCTCTGGCATGCGTCCGACCGGTGCTCTGCACCTGGGGCATTACCACGGCGTCCTGAAAAA
CTGGGTCCGGCTGCAAGCCGAATACCCGTGCTTCTTCTTCGTCGCCGACTGGCATGCGCTGACCACGCACTACGAGTCGC
CCGAGGTGATCGAGGAATCGGTGTGGGAAATGCTGATCGACTGGCTCGCTGCCGGTGTCGATCCGACGCAGTCCACGCTG
TTCATCCAGAGCCGTGTGCCCGAGCACGCGGAGCTGTTCCTACTGCTCTCGATGGGCACGCCGCTGGGCTGGCTCGAACG
CGTGCCGACATACAAGGACCAAATCGAGAAGCTCAAGGAGAAGGACCTCTCCACCTACGGCTTCCTCGGTTACCCGCTGC
TGCAAGCCGCCGACATCCTGATCTACCGCGCCGGCTTCGTGCCGGTGGGCGAAGACCAGGTGCCGCACGTCGAGATGACG
CGCGAAGTCGCCCGCCGCTTCAACTACCTCTATGGCCGCGAACCAGGTTTCGAAGAGAAGGCGCTGGAAGCGGCCAAGAA
GCTCGGGGGCAAGCGCGCCAAGCTGTATCTGGAGCTGCGCACTGCCTACCAGGAGCGTGGTGAAGACGAGGCCCTGGAGC
AGGCCCGCGCGCTGCTGGCCGAATCGCAGAGCCTGTCCATGGGCGACCGCGAACGCCTGTTCGGCTATCTGGAAGGCGCC
CGCAAGATCATCCTGCCCGAACCGCAGGTGCTGCTGACCGAGGCATCGCGCATGCCGGGTCTTGATGGCCAGAAGATGTC
CAAGTCGTACGGCAACACGATCCGCATGCGCGAGGACAAGGAAACCGTCGAGAAAAAGGTTCGCACCATGCCGACCGATC
CGGCTCGCGTGCGCCGCACCGATCCGGGCGACCCGGACAAGTGCCCGGTCTGGCAGTTGCATCAGGTCTACTCTGATGCC
GACACGAAAGAGTGGGTGCAAAAGGGTTGCCGCAGCGCCGGCATTGGCTGCCTGGAGTGCAAGCAGCCCGTGATCGAGGG
CATCCTGCGGGAGCAGCAGCCGATGCTTGAGCGCGCCCAGAAATACATCGACGATCCGTCACTGCTGCGCGCCATCATTG
CTGATGGCTGCGACAACGCCCGCAAGGTTACGCAGGAGACCATGCGCGAGGTGCGCGAGGCGATGGGTCTGTCGTACAGC
TGA

Upstream 100 bases:

>100_bases
CTGGATGCGCCCGATCATGGCGCTGCTGTTTCAACTGCTGCAGTGGATTCTGAGTCCGCTGCAGATGCTGTTTTCCTGAG
TCTTCAACCCCATTTCCCAC

Downstream 100 bases:

>100_bases
TGGGCTGTTGATGTCTGCTGTCGCGTCTGATTCACACACGTTCGCTGCGCCCTCGCCGTGGGTGGTGCGTTGGGCGGCTG
GACTGCCGGCTGGCGCCTCC

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 400; Mature: 400

Protein sequence:

>400_residues
MFPDRVLSGMRPTGALHLGHYHGVLKNWVRLQAEYPCFFFVADWHALTTHYESPEVIEESVWEMLIDWLAAGVDPTQSTL
FIQSRVPEHAELFLLLSMGTPLGWLERVPTYKDQIEKLKEKDLSTYGFLGYPLLQAADILIYRAGFVPVGEDQVPHVEMT
REVARRFNYLYGREPGFEEKALEAAKKLGGKRAKLYLELRTAYQERGEDEALEQARALLAESQSLSMGDRERLFGYLEGA
RKIILPEPQVLLTEASRMPGLDGQKMSKSYGNTIRMREDKETVEKKVRTMPTDPARVRRTDPGDPDKCPVWQLHQVYSDA
DTKEWVQKGCRSAGIGCLECKQPVIEGILREQQPMLERAQKYIDDPSLLRAIIADGCDNARKVTQETMREVREAMGLSYS

Sequences:

>Translated_400_residues
MFPDRVLSGMRPTGALHLGHYHGVLKNWVRLQAEYPCFFFVADWHALTTHYESPEVIEESVWEMLIDWLAAGVDPTQSTL
FIQSRVPEHAELFLLLSMGTPLGWLERVPTYKDQIEKLKEKDLSTYGFLGYPLLQAADILIYRAGFVPVGEDQVPHVEMT
REVARRFNYLYGREPGFEEKALEAAKKLGGKRAKLYLELRTAYQERGEDEALEQARALLAESQSLSMGDRERLFGYLEGA
RKIILPEPQVLLTEASRMPGLDGQKMSKSYGNTIRMREDKETVEKKVRTMPTDPARVRRTDPGDPDKCPVWQLHQVYSDA
DTKEWVQKGCRSAGIGCLECKQPVIEGILREQQPMLERAQKYIDDPSLLRAIIADGCDNARKVTQETMREVREAMGLSYS
>Mature_400_residues
MFPDRVLSGMRPTGALHLGHYHGVLKNWVRLQAEYPCFFFVADWHALTTHYESPEVIEESVWEMLIDWLAAGVDPTQSTL
FIQSRVPEHAELFLLLSMGTPLGWLERVPTYKDQIEKLKEKDLSTYGFLGYPLLQAADILIYRAGFVPVGEDQVPHVEMT
REVARRFNYLYGREPGFEEKALEAAKKLGGKRAKLYLELRTAYQERGEDEALEQARALLAESQSLSMGDRERLFGYLEGA
RKIILPEPQVLLTEASRMPGLDGQKMSKSYGNTIRMREDKETVEKKVRTMPTDPARVRRTDPGDPDKCPVWQLHQVYSDA
DTKEWVQKGCRSAGIGCLECKQPVIEGILREQQPMLERAQKYIDDPSLLRAIIADGCDNARKVTQETMREVREAMGLSYS

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=189, Percent_Identity=42.3280423280423, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI41352700, Length=169, Percent_Identity=44.3786982248521, Blast_Score=142, Evalue=7e-34,
Organism=Escherichia coli, GI1789786, Length=167, Percent_Identity=42.5149700598802, Blast_Score=151, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI71982800, Length=176, Percent_Identity=35.7954545454545, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71982793, Length=176, Percent_Identity=35.7954545454545, Blast_Score=111, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6320474, Length=185, Percent_Identity=36.7567567567568, Blast_Score=122, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24666151, Length=172, Percent_Identity=41.2790697674419, Blast_Score=144, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 45658; Mature: 45658

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPDRVLSGMRPTGALHLGHYHGVLKNWVRLQAEYPCFFFVADWHALTTHYESPEVIEES
CCCHHHHCCCCCCCEEECHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHCCCCHHHHHHH
VWEMLIDWLAAGVDPTQSTLFIQSRVPEHAELFLLLSMGTPLGWLERVPTYKDQIEKLKE
HHHHHHHHHHCCCCCCCCEEEECCCCCCHHHEEEEEECCCCHHHHHHCCCHHHHHHHHHH
KDLSTYGFLGYPLLQAADILIYRAGFVPVGEDQVPHVEMTREVARRFNYLYGREPGFEEK
HCCCHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHH
ALEAAKKLGGKRAKLYLELRTAYQERGEDEALEQARALLAESQSLSMGDRERLFGYLEGA
HHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
RKIILPEPQVLLTEASRMPGLDGQKMSKSYGNTIRMREDKETVEKKVRTMPTDPARVRRT
CEEECCCCHHHHHHHHCCCCCCCHHHHHHHCCEEEECCHHHHHHHHHHCCCCCHHHCCCC
DPGDPDKCPVWQLHQVYSDADTKEWVQKGCRSAGIGCLECKQPVIEGILREQQPMLERAQ
CCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KYIDDPSLLRAIIADGCDNARKVTQETMREVREAMGLSYS
HHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFPDRVLSGMRPTGALHLGHYHGVLKNWVRLQAEYPCFFFVADWHALTTHYESPEVIEES
CCCHHHHCCCCCCCEEECHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHCCCCHHHHHHH
VWEMLIDWLAAGVDPTQSTLFIQSRVPEHAELFLLLSMGTPLGWLERVPTYKDQIEKLKE
HHHHHHHHHHCCCCCCCCEEEECCCCCCHHHEEEEEECCCCHHHHHHCCCHHHHHHHHHH
KDLSTYGFLGYPLLQAADILIYRAGFVPVGEDQVPHVEMTREVARRFNYLYGREPGFEEK
HCCCHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHH
ALEAAKKLGGKRAKLYLELRTAYQERGEDEALEQARALLAESQSLSMGDRERLFGYLEGA
HHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCC
RKIILPEPQVLLTEASRMPGLDGQKMSKSYGNTIRMREDKETVEKKVRTMPTDPARVRRT
CEEECCCCHHHHHHHHCCCCCCCHHHHHHHCCEEEECCHHHHHHHHHHCCCCCHHHCCCC
DPGDPDKCPVWQLHQVYSDADTKEWVQKGCRSAGIGCLECKQPVIEGILREQQPMLERAQ
CCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
KYIDDPSLLRAIIADGCDNARKVTQETMREVREAMGLSYS
HHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]