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The map label for this gene is lolC [H]

Identifier: 187928053

GI number: 187928053

Start: 1016355

End: 1017605

Strand: Direct

Name: lolC [H]

Synonym: Rpic_0960

Alternate gene names: 187928053

Gene position: 1016355-1017605 (Clockwise)

Preceding gene: 187928048

Following gene: 187928054

Centisome position: 25.78

GC content: 62.27

Gene sequence:

>1251_bases
TTGAAACTTCCATACGAATGGCAGATCGGCTGGCGGTATACGCGCGCAAGCAAGCGCGCCAGCCGCAATAGCTTCATCTC
TTTCATTTCGCTCATCTCCATGCTCGGCATTGCGCTGGGGGTGGCGGCGCTGATCATCGTGCTTTCGGTCATGAACGGCT
TCCAGAAGGAAGTGCGAGACCGCATGCTGTCGGTGCTGGCGCATATCGAAGTGATGGCGCCGAACAGCCTGCCGGACTGG
CAGCGTACCGCCAATGAGGCGATGCAGAACAAGGAAGTCATCGGCGCGGCGCCCTACGTGGGCGCACAGGCCATGATCAC
GCGCGACGAGGCGGTGCGCGGCGTGCTGCTGCGCGGCGTGTCGCCGGCGGACGAGCCGAAGGTGTCGGACATTGCCAAGG
ATTTCAAATCGGGCTCGATCGACGATCTGAAACCCGGCGAATTCGGCATCGCCCTGGGCAGCCAGCTGGCCAACGGCCTG
GGCGTGCATCAGGGAGACAAGGTCACGCTGGTGGCGCCGCAGGGCACCATCACGCCGGCGGGCGTGTTGCCGCGCCTGAA
GCAGTTCACGGTGACGGGCATCTTCGAGTCGGGCCACTACGAGTTCGACAGCTCCCTCGCACTCGTCAACATGGAAGACG
CCGAACGACTGTTCCGCCTCGATGGCCCGACCGGCGTGCGTCTGAAGCTGGTCGACATGGACCGCGCCCCGCAGGTGGCC
GAAGCGCTGTCGCGCACGTTGTCCGGCGAGCTGTACATCCGCGACTGGTCGCGCCAGAACCGCAACTGGTTTGCCGCCGT
GAAGACCGAGAAGAAGATGATGTTCATCATCCTCACGCTGATCATCGCCGTGGCCGCGTTCAACCTGGTGTCAACGCTGG
TGATGACGGTGACGGACAAGCAGGCCGACATCGCCATCCTGCGCACCATGGGCGCACAACCCGCGTCGATCATGAAGATC
TTCATCGTGCAGGGCGTTGCGATCGGGTTCATCGGCACATTGCTGGGGGTCGGCTTCGGCACGCTCATCGCTTACAACAT
CGACGTGATCGTCCCTTTCATCGAGCGTCTTTTCCACGTGCAATTCCTGCCGCGTGACATCTATTTCATCAGCGAACTGC
CCTCGGACCCCCGCGTGAACGACATTGCAACCATTGGCGTCATTTCCTTCATCCTCGCGTCGGTGGCGACGCTGTATCCA
AGCTGGCACGCTTCGCGCGTGAATCCGGCGGAGGCACTGCGCTATGAGTGA

Upstream 100 bases:

>100_bases
GGGACAATCAGGGTGAGTTCAGGAATCATGGCTCCGAGATTGTAAACTTCCGGCTTGTCGGCCAGTGAGCTGGACAAATC
ACACCCACGGGGAACCCCCT

Downstream 100 bases:

>100_bases
GGCCGTCATGACTTCGATGGAAGCGCCTGCCGCGGCGCCGCAGGGTGGGGTGGTGCAAGCCGAAGGGCTGTCCAAGTCGT
TCCGCCAGGGCGGGTTGAAC

Product: lipoprotein releasing system, transmembrane protein, LolC/E family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MKLPYEWQIGWRYTRASKRASRNSFISFISLISMLGIALGVAALIIVLSVMNGFQKEVRDRMLSVLAHIEVMAPNSLPDW
QRTANEAMQNKEVIGAAPYVGAQAMITRDEAVRGVLLRGVSPADEPKVSDIAKDFKSGSIDDLKPGEFGIALGSQLANGL
GVHQGDKVTLVAPQGTITPAGVLPRLKQFTVTGIFESGHYEFDSSLALVNMEDAERLFRLDGPTGVRLKLVDMDRAPQVA
EALSRTLSGELYIRDWSRQNRNWFAAVKTEKKMMFIILTLIIAVAAFNLVSTLVMTVTDKQADIAILRTMGAQPASIMKI
FIVQGVAIGFIGTLLGVGFGTLIAYNIDVIVPFIERLFHVQFLPRDIYFISELPSDPRVNDIATIGVISFILASVATLYP
SWHASRVNPAEALRYE

Sequences:

>Translated_416_residues
MKLPYEWQIGWRYTRASKRASRNSFISFISLISMLGIALGVAALIIVLSVMNGFQKEVRDRMLSVLAHIEVMAPNSLPDW
QRTANEAMQNKEVIGAAPYVGAQAMITRDEAVRGVLLRGVSPADEPKVSDIAKDFKSGSIDDLKPGEFGIALGSQLANGL
GVHQGDKVTLVAPQGTITPAGVLPRLKQFTVTGIFESGHYEFDSSLALVNMEDAERLFRLDGPTGVRLKLVDMDRAPQVA
EALSRTLSGELYIRDWSRQNRNWFAAVKTEKKMMFIILTLIIAVAAFNLVSTLVMTVTDKQADIAILRTMGAQPASIMKI
FIVQGVAIGFIGTLLGVGFGTLIAYNIDVIVPFIERLFHVQFLPRDIYFISELPSDPRVNDIATIGVISFILASVATLYP
SWHASRVNPAEALRYE
>Mature_416_residues
MKLPYEWQIGWRYTRASKRASRNSFISFISLISMLGIALGVAALIIVLSVMNGFQKEVRDRMLSVLAHIEVMAPNSLPDW
QRTANEAMQNKEVIGAAPYVGAQAMITRDEAVRGVLLRGVSPADEPKVSDIAKDFKSGSIDDLKPGEFGIALGSQLANGL
GVHQGDKVTLVAPQGTITPAGVLPRLKQFTVTGIFESGHYEFDSSLALVNMEDAERLFRLDGPTGVRLKLVDMDRAPQVA
EALSRTLSGELYIRDWSRQNRNWFAAVKTEKKMMFIILTLIIAVAAFNLVSTLVMTVTDKQADIAILRTMGAQPASIMKI
FIVQGVAIGFIGTLLGVGFGTLIAYNIDVIVPFIERLFHVQFLPRDIYFISELPSDPRVNDIATIGVISFILASVATLYP
SWHASRVNPAEALRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=416, Percent_Identity=33.1730769230769, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1787360, Length=419, Percent_Identity=35.0835322195704, Blast_Score=202, Evalue=3e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 45699; Mature: 45699

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLPYEWQIGWRYTRASKRASRNSFISFISLISMLGIALGVAALIIVLSVMNGFQKEVRD
CCCCCEEECCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMLSVLAHIEVMAPNSLPDWQRTANEAMQNKEVIGAAPYVGAQAMITRDEAVRGVLLRGV
HHHHHHHHHHEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHEEEHHHHHHHHHHCCC
SPADEPKVSDIAKDFKSGSIDDLKPGEFGIALGSQLANGLGVHQGDKVTLVAPQGTITPA
CCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHH
GVLPRLKQFTVTGIFESGHYEFDSSLALVNMEDAERLFRLDGPTGVRLKLVDMDRAPQVA
HHHHHHHHHEEEEEEECCCEEECCCEEEEEHHHHHHHHCCCCCCCCEEEEEECCCCCHHH
EALSRTLSGELYIRDWSRQNRNWFAAVKTEKKMMFIILTLIIAVAAFNLVSTLVMTVTDK
HHHHHHHCCCEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QADIAILRTMGAQPASIMKIFIVQGVAIGFIGTLLGVGFGTLIAYNIDVIVPFIERLFHV
CHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFLPRDIYFISELPSDPRVNDIATIGVISFILASVATLYPSWHASRVNPAEALRYE
HHCCCHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCC
>Mature Secondary Structure
MKLPYEWQIGWRYTRASKRASRNSFISFISLISMLGIALGVAALIIVLSVMNGFQKEVRD
CCCCCEEECCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RMLSVLAHIEVMAPNSLPDWQRTANEAMQNKEVIGAAPYVGAQAMITRDEAVRGVLLRGV
HHHHHHHHHHEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHEEEHHHHHHHHHHCCC
SPADEPKVSDIAKDFKSGSIDDLKPGEFGIALGSQLANGLGVHQGDKVTLVAPQGTITPA
CCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHH
GVLPRLKQFTVTGIFESGHYEFDSSLALVNMEDAERLFRLDGPTGVRLKLVDMDRAPQVA
HHHHHHHHHEEEEEEECCCEEECCCEEEEEHHHHHHHHCCCCCCCCEEEEEECCCCCHHH
EALSRTLSGELYIRDWSRQNRNWFAAVKTEKKMMFIILTLIIAVAAFNLVSTLVMTVTDK
HHHHHHHCCCEEEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QADIAILRTMGAQPASIMKIFIVQGVAIGFIGTLLGVGFGTLIAYNIDVIVPFIERLFHV
CHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QFLPRDIYFISELPSDPRVNDIATIGVISFILASVATLYPSWHASRVNPAEALRYE
HHCCCHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]