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The map label for this gene is uvrC [H]

Identifier: 187928031

GI number: 187928031

Start: 988937

End: 990910

Strand: Direct

Name: uvrC [H]

Synonym: Rpic_0936

Alternate gene names: 187928031

Gene position: 988937-990910 (Clockwise)

Preceding gene: 187928028

Following gene: 187928032

Centisome position: 25.08

GC content: 64.74

Gene sequence:

>1974_bases
ATGTCGTCCGACCCCACGCAACCCCAGCCCCCCGAGACGCCCGAGAGCGTCAAGCCCAGCGCGCCAGCGGATGTGCCCGA
GTTCGATGCGAAAGCACACATCGCACGCCTGCCGAACCTGCCGGGCGTGTATCGCTACTTTGATGCGCAGGGCAACGTGC
TCTATGTGGGCAAAGCGCGCGACCTCAAGAAGCGCGTGTCGAGCTACTTCAACAAGACGCTGCTTTCGCCGCGCATCGCA
ATGATGGTGGCGAAGATCGCGCGCATCGACACCACGGTCGTGCGCAACGAGGCCGAAGCGCTGCTGCTCGAAAACAACCT
GATCAAGGCGCTGGCGCCGCGCTACAACATCCTGTTTCGCGACGACAAGTCGTATCCGTATCTCAAGCTCACGCAGCACG
CGTATCCGCGCATGGCGTATTACCGCGGCGCGACCGATCGCAGGCATCAGTACTTCGGCCCATTCCCGAGCGCGCATGCC
GTGCGAGAGAGCATGCAGATCCTGCAGAAGGTGTTCCAGCTACGCACGTGCGAAGACACCGTCTTCAATAACCGCACGCG
GCCGTGCCTGCTGCATCAGATTCATCGTTGCAGTGGCCCGTGCGTCCAGGCGATCGGCGCAGAGGATTACGCGCGCGACG
TCGCCAACGCGGCCGGTTTCCTGCAGGGCCGGCAGGACGAGGTCATGCAGACGCTTCAGGACAAGATGCAGCGCTACGCC
GAGTCGCTGGAGTTCGAGCAGGCTGCCATCGTGCGCGACCAGATCGGTGCATTGTCGACGGTGCTCAAGCAGCAGTCGGT
GGAAGAAGTCGGCCACGCCAGCGACATCGACATCCTGGCGGTTGCCATCAAGGGCGGCCACGCCTGCGTGAACCTCGCGA
TGGTGCGCGGCGGGCGCCATCTGGGCGACAAGGCTTACTTTCCCACGCACGTGGAAGAGGGCGCCGCCATTGTCGGCGTG
GATGTGGAAGCCGACGGTGAGGCTGCGGCAGAAACATCACGCGATGCCGAACGCATGGCCAGCGACATCCTCGAAGCCTT
CGTCGCGCAGCACTATCTCGATCAGTTTGTGCCGCCGGTGCTGGTGGTCAGCCATCAGATTCACGCAACCGAGTTGATCA
ACGCGCTGGCCGAGCAGGCCGGGCGCCGCGTTTCGGTTGTGCGCCAGCCGCAGGGCGGGCGCCGCGCGTGGCTGGAGATG
GCGGAGAAGGGCGCCGAGCTGTCGCTGATGCGTCGCCTTTCCGAGCAAGGCAGCCAGCAGGCCCGCACACTTGCGCTGGC
CGAGACCATCGGCATTGACCTGGAAGACCTTGCCGCGCTGCGCGTCGAGTGCTTCGACATCAGCCACACCGCCGGCGAGG
CCACGCAAGCCTCGTGCGTGGTTTTTCACAGCCACGCCATGCAAAACAGCGAATACCGCCGCTACAACATCCAGGACATC
ACCCCCGGCGACGACTACGCGGCCATGCGGCAAGTCCTCACGCGCCGCTACCAGAAGATCGTCGAGCAGGCAGGCGAAGA
CGCGCCCAACATGCCGACCATCGTGCTGATCGACGGCGGCAAGGGGCAGGTGGAAGTCGCTCGCCAGGTTTTTGAGGAAC
TGGGGTTGGATATTGGATTGCTCGTCGGTGTGGCCAAGGGCGAGGGGCGCAAGGTGGGCCTCGAAACGCTGGTCTTCGCC
GATGGCCGGCCGTCACTGGAGCTAGGGCAGGGCAGCGCCGCGCTGATGCTCGTCGCGCAAATTCGCGACGAAGCGCACCG
CTTTGCCATCACCGGTATGCGCGCCAAGCGCGCCAAAGCGCGCAACACGTCGCGGCTGGAAGAGATCGAAGGCATCGGCG
CCAAGCGCCGGCAGCGGTTGCTGGCGCGCTTTGGCGGCCTGCGCGGTGTGATGGCCGCGAGCGTCGCCGAACTCGCCACG
GTGGAAGGCATCTCCCAGACCCTCGCCGAAGAAATCTACCGTCAGTTGCATTGA

Upstream 100 bases:

>100_bases
GTGCGCATGCAGGAAGGCGAGTCGGGCAGCGAAGAAGGGCGGGCCGACATTGTAGTCGGCAGCTTGTTCTACACTGACGG
CCTCTGATCCAGCGAACGCC

Downstream 100 bases:

>100_bases
TCGGCGACAATGCCCCATCTTGTCGCGTGGGGTCGAGCTTGCGCGGCGGTTGTCCTCTCGATTTGCCATGCCTTTCAACT
TCCCGATCCTCCTGACCTGG

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 657; Mature: 656

Protein sequence:

>657_residues
MSSDPTQPQPPETPESVKPSAPADVPEFDAKAHIARLPNLPGVYRYFDAQGNVLYVGKARDLKKRVSSYFNKTLLSPRIA
MMVAKIARIDTTVVRNEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTQHAYPRMAYYRGATDRRHQYFGPFPSAHA
VRESMQILQKVFQLRTCEDTVFNNRTRPCLLHQIHRCSGPCVQAIGAEDYARDVANAAGFLQGRQDEVMQTLQDKMQRYA
ESLEFEQAAIVRDQIGALSTVLKQQSVEEVGHASDIDILAVAIKGGHACVNLAMVRGGRHLGDKAYFPTHVEEGAAIVGV
DVEADGEAAAETSRDAERMASDILEAFVAQHYLDQFVPPVLVVSHQIHATELINALAEQAGRRVSVVRQPQGGRRAWLEM
AEKGAELSLMRRLSEQGSQQARTLALAETIGIDLEDLAALRVECFDISHTAGEATQASCVVFHSHAMQNSEYRRYNIQDI
TPGDDYAAMRQVLTRRYQKIVEQAGEDAPNMPTIVLIDGGKGQVEVARQVFEELGLDIGLLVGVAKGEGRKVGLETLVFA
DGRPSLELGQGSAALMLVAQIRDEAHRFAITGMRAKRAKARNTSRLEEIEGIGAKRRQRLLARFGGLRGVMAASVAELAT
VEGISQTLAEEIYRQLH

Sequences:

>Translated_657_residues
MSSDPTQPQPPETPESVKPSAPADVPEFDAKAHIARLPNLPGVYRYFDAQGNVLYVGKARDLKKRVSSYFNKTLLSPRIA
MMVAKIARIDTTVVRNEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTQHAYPRMAYYRGATDRRHQYFGPFPSAHA
VRESMQILQKVFQLRTCEDTVFNNRTRPCLLHQIHRCSGPCVQAIGAEDYARDVANAAGFLQGRQDEVMQTLQDKMQRYA
ESLEFEQAAIVRDQIGALSTVLKQQSVEEVGHASDIDILAVAIKGGHACVNLAMVRGGRHLGDKAYFPTHVEEGAAIVGV
DVEADGEAAAETSRDAERMASDILEAFVAQHYLDQFVPPVLVVSHQIHATELINALAEQAGRRVSVVRQPQGGRRAWLEM
AEKGAELSLMRRLSEQGSQQARTLALAETIGIDLEDLAALRVECFDISHTAGEATQASCVVFHSHAMQNSEYRRYNIQDI
TPGDDYAAMRQVLTRRYQKIVEQAGEDAPNMPTIVLIDGGKGQVEVARQVFEELGLDIGLLVGVAKGEGRKVGLETLVFA
DGRPSLELGQGSAALMLVAQIRDEAHRFAITGMRAKRAKARNTSRLEEIEGIGAKRRQRLLARFGGLRGVMAASVAELAT
VEGISQTLAEEIYRQLH
>Mature_656_residues
SSDPTQPQPPETPESVKPSAPADVPEFDAKAHIARLPNLPGVYRYFDAQGNVLYVGKARDLKKRVSSYFNKTLLSPRIAM
MVAKIARIDTTVVRNEAEALLLENNLIKALAPRYNILFRDDKSYPYLKLTQHAYPRMAYYRGATDRRHQYFGPFPSAHAV
RESMQILQKVFQLRTCEDTVFNNRTRPCLLHQIHRCSGPCVQAIGAEDYARDVANAAGFLQGRQDEVMQTLQDKMQRYAE
SLEFEQAAIVRDQIGALSTVLKQQSVEEVGHASDIDILAVAIKGGHACVNLAMVRGGRHLGDKAYFPTHVEEGAAIVGVD
VEADGEAAAETSRDAERMASDILEAFVAQHYLDQFVPPVLVVSHQIHATELINALAEQAGRRVSVVRQPQGGRRAWLEMA
EKGAELSLMRRLSEQGSQQARTLALAETIGIDLEDLAALRVECFDISHTAGEATQASCVVFHSHAMQNSEYRRYNIQDIT
PGDDYAAMRQVLTRRYQKIVEQAGEDAPNMPTIVLIDGGKGQVEVARQVFEELGLDIGLLVGVAKGEGRKVGLETLVFAD
GRPSLELGQGSAALMLVAQIRDEAHRFAITGMRAKRAKARNTSRLEEIEGIGAKRRQRLLARFGGLRGVMAASVAELATV
EGISQTLAEEIYRQLH

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=640, Percent_Identity=45.9375, Blast_Score=544, Evalue=1e-156,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 72545; Mature: 72413

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDPTQPQPPETPESVKPSAPADVPEFDAKAHIARLPNLPGVYRYFDAQGNVLYVGKAR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCHHEEEECCCCEEEEECCH
DLKKRVSSYFNKTLLSPRIAMMVAKIARIDTTVVRNEAEALLLENNLIKALAPRYNILFR
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEE
DDKSYPYLKLTQHAYPRMAYYRGATDRRHQYFGPFPSAHAVRESMQILQKVFQLRTCEDT
CCCCCCEEEEHHHCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VFNNRTRPCLLHQIHRCSGPCVQAIGAEDYARDVANAAGFLQGRQDEVMQTLQDKMQRYA
HHCCCCCHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
ESLEFEQAAIVRDQIGALSTVLKQQSVEEVGHASDIDILAVAIKGGHACVNLAMVRGGRH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHCCCC
LGDKAYFPTHVEEGAAIVGVDVEADGEAAAETSRDAERMASDILEAFVAQHYLDQFVPPV
CCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LVVSHQIHATELINALAEQAGRRVSVVRQPQGGRRAWLEMAEKGAELSLMRRLSEQGSQQ
HHHHCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
ARTLALAETIGIDLEDLAALRVECFDISHTAGEATQASCVVFHSHAMQNSEYRRYNIQDI
HHHHHHHHHHCCCHHHHHHHHHHHEECCCCCCCCCCCCEEEEEHHHHCCCCCCEECCCCC
TPGDDYAAMRQVLTRRYQKIVEQAGEDAPNMPTIVLIDGGKGQVEVARQVFEELGLDIGL
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEE
LVGVAKGEGRKVGLETLVFADGRPSLELGQGSAALMLVAQIRDEAHRFAITGMRAKRAKA
EEEEECCCCCEECCEEEEEECCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
RNTSRLEEIEGIGAKRRQRLLARFGGLRGVMAASVAELATVEGISQTLAEEIYRQLH
CCHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSDPTQPQPPETPESVKPSAPADVPEFDAKAHIARLPNLPGVYRYFDAQGNVLYVGKAR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCHHEEEECCCCEEEEECCH
DLKKRVSSYFNKTLLSPRIAMMVAKIARIDTTVVRNEAEALLLENNLIKALAPRYNILFR
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEE
DDKSYPYLKLTQHAYPRMAYYRGATDRRHQYFGPFPSAHAVRESMQILQKVFQLRTCEDT
CCCCCCEEEEHHHCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VFNNRTRPCLLHQIHRCSGPCVQAIGAEDYARDVANAAGFLQGRQDEVMQTLQDKMQRYA
HHCCCCCHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
ESLEFEQAAIVRDQIGALSTVLKQQSVEEVGHASDIDILAVAIKGGHACVNLAMVRGGRH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHCCCC
LGDKAYFPTHVEEGAAIVGVDVEADGEAAAETSRDAERMASDILEAFVAQHYLDQFVPPV
CCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LVVSHQIHATELINALAEQAGRRVSVVRQPQGGRRAWLEMAEKGAELSLMRRLSEQGSQQ
HHHHCHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
ARTLALAETIGIDLEDLAALRVECFDISHTAGEATQASCVVFHSHAMQNSEYRRYNIQDI
HHHHHHHHHHCCCHHHHHHHHHHHEECCCCCCCCCCCCEEEEEHHHHCCCCCCEECCCCC
TPGDDYAAMRQVLTRRYQKIVEQAGEDAPNMPTIVLIDGGKGQVEVARQVFEELGLDIGL
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCCEEE
LVGVAKGEGRKVGLETLVFADGRPSLELGQGSAALMLVAQIRDEAHRFAITGMRAKRAKA
EEEEECCCCCEECCEEEEEECCCCCCEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHH
RNTSRLEEIEGIGAKRRQRLLARFGGLRGVMAASVAELATVEGISQTLAEEIYRQLH
CCHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]