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The map label for this gene is rnc [H]

Identifier: 187928023

GI number: 187928023

Start: 982039

End: 982809

Strand: Direct

Name: rnc [H]

Synonym: Rpic_0928

Alternate gene names: 187928023

Gene position: 982039-982809 (Clockwise)

Preceding gene: 187928022

Following gene: 187928024

Centisome position: 24.91

GC content: 62.91

Gene sequence:

>771_bases
ATGAGTTTGGATGCGCTACAGCAACGTCTTGGCTACCGCTTCAGCAAACCGGAGTTGCTGCAGCAGGCGCTCACCCATCG
CAGCCACAGCGCGATGCATAACGAGCGCCTGGAATTTCTTGGCGATTCGATCCTGAATTGCGCCGTCGCTGACATGCTCT
ACGGCATGTTCGGCAAGCTGGACGAGGGCGATCTGTCGCGCGTGCGGGCCAATCTGGTCAAGCAACAGGCGCTGTACGAG
ATCGCGCAGATGCTGCAGTTGCCCGATGCCCTGCGTTTGGGCGAAGGCGAGTTGAAAAGCGGAGGTTTCCGCCGCCCATC
TATCCTGGCCGATGCGCTGGAAGCGATTTTCGGGGCGGTGTTTCTCGACGGTGGCTTCGATGCAGCCCGCACGCTGATTC
GCAAGCTGTACATCCCCATCCTCGAGCAGGTGGACCCGCGCACGCTCGGCAAGGACGCCAAGACGCTGTTGCAGGAGTAC
CTCCAAGGTCACAAGATCGCGTTGCCGCTGTACACGGTGGTGGCCACCCACGGCGCGGCGCATAATCAGCAATTCGAGGT
CGAGTGCTCGATTCCCAAGCTGGAGATTCGCGTCTCCGGCAGCGGGGCATCGCGGCGCGCGGCCGAACAGTCGGCGGCCA
AGCTGGCCCTGGATGAAGCGCATCGCCTGGTGCCGCAGCTCGTCAAGCGCAGCCGCGCCGAGCGCACCGGCAAGACGCGC
AAGCAGGCCACGCCGCCCGATCCGCAGTTGTCTCTCAGGTTGAAGGAATAA

Upstream 100 bases:

>100_bases
GGTGGCTCCATCCAGGCGGTGCGTTTCTCGTACAAGCGCGAGATCCCCTTGTATGGCCCCATCGGTCTGGTGATCACCTA
TTCGGGGACCCAGCGTTGAC

Downstream 100 bases:

>100_bases
TCAGGTAAATGAGCGACACCCCATTGCAGCCTCCGCAGCCAGAATCTGGCGTGCCGGAGGGGTTCCGCTGCGGCATGGTC
GCCATTGTTGGGCGGCCGAA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MSLDALQQRLGYRFSKPELLQQALTHRSHSAMHNERLEFLGDSILNCAVADMLYGMFGKLDEGDLSRVRANLVKQQALYE
IAQMLQLPDALRLGEGELKSGGFRRPSILADALEAIFGAVFLDGGFDAARTLIRKLYIPILEQVDPRTLGKDAKTLLQEY
LQGHKIALPLYTVVATHGAAHNQQFEVECSIPKLEIRVSGSGASRRAAEQSAAKLALDEAHRLVPQLVKRSRAERTGKTR
KQATPPDPQLSLRLKE

Sequences:

>Translated_256_residues
MSLDALQQRLGYRFSKPELLQQALTHRSHSAMHNERLEFLGDSILNCAVADMLYGMFGKLDEGDLSRVRANLVKQQALYE
IAQMLQLPDALRLGEGELKSGGFRRPSILADALEAIFGAVFLDGGFDAARTLIRKLYIPILEQVDPRTLGKDAKTLLQEY
LQGHKIALPLYTVVATHGAAHNQQFEVECSIPKLEIRVSGSGASRRAAEQSAAKLALDEAHRLVPQLVKRSRAERTGKTR
KQATPPDPQLSLRLKE
>Mature_255_residues
SLDALQQRLGYRFSKPELLQQALTHRSHSAMHNERLEFLGDSILNCAVADMLYGMFGKLDEGDLSRVRANLVKQQALYEI
AQMLQLPDALRLGEGELKSGGFRRPSILADALEAIFGAVFLDGGFDAARTLIRKLYIPILEQVDPRTLGKDAKTLLQEYL
QGHKIALPLYTVVATHGAAHNQQFEVECSIPKLEIRVSGSGASRRAAEQSAAKLALDEAHRLVPQLVKRSRAERTGKTRK
QATPPDPQLSLRLKE

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=240, Percent_Identity=27.9166666666667, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI155030236, Length=240, Percent_Identity=27.9166666666667, Blast_Score=82, Evalue=5e-16,
Organism=Escherichia coli, GI1788920, Length=206, Percent_Identity=52.9126213592233, Blast_Score=216, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17506883, Length=231, Percent_Identity=30.3030303030303, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193202651, Length=231, Percent_Identity=30.3030303030303, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323895, Length=201, Percent_Identity=29.3532338308458, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI17137682, Length=244, Percent_Identity=29.0983606557377, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 28405; Mature: 28274

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDALQQRLGYRFSKPELLQQALTHRSHSAMHNERLEFLGDSILNCAVADMLYGMFGKL
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DEGDLSRVRANLVKQQALYEIAQMLQLPDALRLGEGELKSGGFRRPSILADALEAIFGAV
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FLDGGFDAARTLIRKLYIPILEQVDPRTLGKDAKTLLQEYLQGHKIALPLYTVVATHGAA
HHCCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
HNQQFEVECSIPKLEIRVSGSGASRRAAEQSAAKLALDEAHRLVPQLVKRSRAERTGKTR
CCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KQATPPDPQLSLRLKE
CCCCCCCCCEEEEECC
>Mature Secondary Structure 
SLDALQQRLGYRFSKPELLQQALTHRSHSAMHNERLEFLGDSILNCAVADMLYGMFGKL
CHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DEGDLSRVRANLVKQQALYEIAQMLQLPDALRLGEGELKSGGFRRPSILADALEAIFGAV
CCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FLDGGFDAARTLIRKLYIPILEQVDPRTLGKDAKTLLQEYLQGHKIALPLYTVVATHGAA
HHCCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
HNQQFEVECSIPKLEIRVSGSGASRRAAEQSAAKLALDEAHRLVPQLVKRSRAERTGKTR
CCCCEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KQATPPDPQLSLRLKE
CCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]