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The map label for this gene is lepB [H]

Identifier: 187928021

GI number: 187928021

Start: 980713

End: 981606

Strand: Direct

Name: lepB [H]

Synonym: Rpic_0926

Alternate gene names: 187928021

Gene position: 980713-981606 (Clockwise)

Preceding gene: 187928020

Following gene: 187928022

Centisome position: 24.88

GC content: 58.72

Gene sequence:

>894_bases
ATGAACTTCGCCCTGATTCTGTTTGTTCTCGTCGTCCTCACTGGTATCGCGTGGGTGGCTGACAAGCTCGTGTTCCAGCG
CCAGCGTCAGGCGGCTGCGGCCACGGCGCTGGCTGAATTCGACGCTCGCGCGCAGGTGCAGGCGCAGTACGGCGGTGGCG
GCGACATCGGTGCCGCGCGTTTGCAACTGGCTGAAGACAAGTTGCGCCAGCCGTGGTGGCTCGAGTACACCGCCAGCTTC
TTCCCGGTGATCGCCGCGGTGTTCCTGCTGCGCTCGTTCGTGATCGAGCCGTTCAAGATTCCGTCGGGATCGATGATTCC
GACGCTGCAGATCGGCGATTTCATCCTGGTCAACAAGTACACGTATGGCATTCGTTTGCCGATCGTGAACAAGAAGATCG
TCGAACTCAATCAACCGCAACGTGGCGACGTGATGGTCTTTCGCTATCCGAAAGACGAGTCGATGGACTACATCAAGCGC
GTGATCGGCGTGCCCGGCGACGTGGTGAAGTATGACAACAAGCGCCTGACCGTGAACGGCCAGCCGGCAACCTACGCGCC
GCAGTCCGATTACCTTGATGGCGAGCGCCTGACGTACTCGAAGCAGTACCAGGAGACGCTGGGGAACGTGACGCACAACA
TCCTGAACGATGCCGACCGCCCGGCCTATGTCTCCGGTCCGGATGATTTTCCGTTCCGCGAAAACTGCACTTACAATCAG
ACCGGCTTCACCTGCAAGGTACCTGCAGGTCACTATTTTATGATGGGCGATAATCGCGACAACAGCGCGGACTCCCGCTA
TTGGGGCTTCGTGCCGGACAAGAACATCGTCGGGAAAGCGTTCTTCATCTGGATGAACCTGGGTGACCTGAAGCGGATCG
GTGGTTTCCATTGA

Upstream 100 bases:

>100_bases
GAAGCAGGTGGGTACCGTTGAAATTCCGCAAGAGGCCTTCCTGGCCATCCTGCGCGTCGAAGAAAAATAATCCAGACATC
GCTCGGACGATCTCTCATCC

Downstream 100 bases:

>100_bases
TCCCGTAAGTGAAGCAAAAATCTCTTATTGAAACTCGGCAATTGCAAAACGGGGGAAATGCAATGCGGATTCGTCAGGCC
GGTCTGAAACGCCCGTCGCG

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MNFALILFVLVVLTGIAWVADKLVFQRQRQAAAATALAEFDARAQVQAQYGGGGDIGAARLQLAEDKLRQPWWLEYTASF
FPVIAAVFLLRSFVIEPFKIPSGSMIPTLQIGDFILVNKYTYGIRLPIVNKKIVELNQPQRGDVMVFRYPKDESMDYIKR
VIGVPGDVVKYDNKRLTVNGQPATYAPQSDYLDGERLTYSKQYQETLGNVTHNILNDADRPAYVSGPDDFPFRENCTYNQ
TGFTCKVPAGHYFMMGDNRDNSADSRYWGFVPDKNIVGKAFFIWMNLGDLKRIGGFH

Sequences:

>Translated_297_residues
MNFALILFVLVVLTGIAWVADKLVFQRQRQAAAATALAEFDARAQVQAQYGGGGDIGAARLQLAEDKLRQPWWLEYTASF
FPVIAAVFLLRSFVIEPFKIPSGSMIPTLQIGDFILVNKYTYGIRLPIVNKKIVELNQPQRGDVMVFRYPKDESMDYIKR
VIGVPGDVVKYDNKRLTVNGQPATYAPQSDYLDGERLTYSKQYQETLGNVTHNILNDADRPAYVSGPDDFPFRENCTYNQ
TGFTCKVPAGHYFMMGDNRDNSADSRYWGFVPDKNIVGKAFFIWMNLGDLKRIGGFH
>Mature_297_residues
MNFALILFVLVVLTGIAWVADKLVFQRQRQAAAATALAEFDARAQVQAQYGGGGDIGAARLQLAEDKLRQPWWLEYTASF
FPVIAAVFLLRSFVIEPFKIPSGSMIPTLQIGDFILVNKYTYGIRLPIVNKKIVELNQPQRGDVMVFRYPKDESMDYIKR
VIGVPGDVVKYDNKRLTVNGQPATYAPQSDYLDGERLTYSKQYQETLGNVTHNILNDADRPAYVSGPDDFPFRENCTYNQ
TGFTCKVPAGHYFMMGDNRDNSADSRYWGFVPDKNIVGKAFFIWMNLGDLKRIGGFH

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=351, Percent_Identity=41.5954415954416, Blast_Score=225, Evalue=3e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 33552; Mature: 33552

Theoretical pI: Translated: 8.55; Mature: 8.55

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFALILFVLVVLTGIAWVADKLVFQRQRQAAAATALAEFDARAQVQAQYGGGGDIGAAR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHH
LQLAEDKLRQPWWLEYTASFFPVIAAVFLLRSFVIEPFKIPSGSMIPTLQIGDFILVNKY
HHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEECCCEEEEEEE
TYGIRLPIVNKKIVELNQPQRGDVMVFRYPKDESMDYIKRVIGVPGDVVKYDNKRLTVNG
EEEEEEEECCCEEEECCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEECCCEEEECC
QPATYAPQSDYLDGERLTYSKQYQETLGNVTHNILNDADRPAYVSGPDDFPFRENCTYNQ
CCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCC
TGFTCKVPAGHYFMMGDNRDNSADSRYWGFVPDKNIVGKAFFIWMNLGDLKRIGGFH
CCCEEECCCCEEEEEECCCCCCCCCCEECCCCCCCCCCEEEEEEECCCHHHHCCCCC
>Mature Secondary Structure
MNFALILFVLVVLTGIAWVADKLVFQRQRQAAAATALAEFDARAQVQAQYGGGGDIGAAR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHH
LQLAEDKLRQPWWLEYTASFFPVIAAVFLLRSFVIEPFKIPSGSMIPTLQIGDFILVNKY
HHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEEEECCCEEEEEEE
TYGIRLPIVNKKIVELNQPQRGDVMVFRYPKDESMDYIKRVIGVPGDVVKYDNKRLTVNG
EEEEEEEECCCEEEECCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEEECCCEEEECC
QPATYAPQSDYLDGERLTYSKQYQETLGNVTHNILNDADRPAYVSGPDDFPFRENCTYNQ
CCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCC
TGFTCKVPAGHYFMMGDNRDNSADSRYWGFVPDKNIVGKAFFIWMNLGDLKRIGGFH
CCCEEECCCCEEEEEECCCCCCCCCCEECCCCCCCCCCEEEEEEECCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1546969 [H]