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The map label for this gene is pncB

Identifier: 187927991

GI number: 187927991

Start: 948839

End: 950008

Strand: Direct

Name: pncB

Synonym: Rpic_0896

Alternate gene names: 187927991

Gene position: 948839-950008 (Clockwise)

Preceding gene: 187927990

Following gene: 187927992

Centisome position: 24.07

GC content: 60.34

Gene sequence:

>1170_bases
ATGATCATCCGCTCGTTGCTCGATACCGATCTGTACAAATTCACGATGATGCAGGTGGTGCTGCATCACTTTCCTGGCGC
GCACGTCGAATACCGCTTTAAGTGCCGTAACGCGGGCGTCGATCTGGTGCCGTTCATTGAAGAGATCCGCGCGGAAATCC
GCCATCTCTGCACCCTGCGCTTTACCGATACGGAACTTGATTACCTGCGCGGCATGCGCTTCATCAAGAGCGATTTCGTC
GATTTTCTCGGCCTGTTCCATCTCAACGAGAAGTACATCGACGTGCGCCCGGCGCCGAGCAACGATGGGCAGATCGAGAT
CGTCATCGCGGGGCCGTGGCTGCACACGATCATGTTCGAGGTGCCCGTTCTGGCCATCGTCAACGAGGTGTTCTTCAGCC
GCACGCAGACGCACCCGCAGTGGGAGGAGGGCAAGCGCCGCCTGACCGACAAGCTGGCATCGCTGAAGCGCCCCGGCCTG
GAAGACTGCCGCATTGCCGACTACGGCACCCGCCGCCGTTTTTCGCACACTTGGCATGAGCATGTGCTGCTGGAGACGCA
TGCGCAACTCGGCGCCCAGTACGCGGGCACGAGCAACGTCTACTTCGCCATGAAGCACGGCATGACGCCGCTGGGCACCA
TGGCGCATGAATACCTTCAGGCCTGCCAAGCGCTGGGTCCGCGCCTGCGCGATTCCCAGACCTTTGCGCTGGAAACCTGG
GCCAAGGAATATCGCGGCGACCTCGGCATCGCGCTGTCGGATACCTACGGCTTTGACGCCTTCCTGCGCGATTTCGACAT
GTTCTTCTGCAAGCTCTTCGACGGCGTTCGCCATGATTCTGGCGACCCGTTCGAGTGGGGCGAGCGCATGCTCAAGCATT
ACGACGACATGCGCGCCGAGCCGAAGTCCAAGGCGCTGATCTTCTCCGACAGCCTCGACATGCCCAAGGTCATCGGCCTG
TATGAGCGCTTTCATGGCCGCTGCAAGCTGGCGTTTGGCGTGGGGACCAATCTGACAAACGACCTGGGCTACACGCCGCT
GCAGATCGTCATCAAGATAGTCCGCTGCAATGGCCAGCCGGTGGCCAAACTGTCGGACGCGCCGGAGAAGACGATGTGCG
ACGATCCAGCGTACCTCACGTACCTGAAGCAGGTATTTGGCGTGCAATAA

Upstream 100 bases:

>100_bases
TTTTCCGCGGTGCGCGGCGGGATTTATGTGACTGCCACAGGCGTCCCGCCTGGCTTCGGTTAGCATGGCGGCCAGTCCAT
ATGGCTTTTGGCGCTGTCCG

Downstream 100 bases:

>100_bases
GGCTCACGCCGACGCCGAATAAGTTTCAACGGCGGGGGCGGATCGTGCAGGAAGCGGCTCGTATAATCGATCGATCTTTC
GGAGCCGCCATGGAATCACA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MIIRSLLDTDLYKFTMMQVVLHHFPGAHVEYRFKCRNAGVDLVPFIEEIRAEIRHLCTLRFTDTELDYLRGMRFIKSDFV
DFLGLFHLNEKYIDVRPAPSNDGQIEIVIAGPWLHTIMFEVPVLAIVNEVFFSRTQTHPQWEEGKRRLTDKLASLKRPGL
EDCRIADYGTRRRFSHTWHEHVLLETHAQLGAQYAGTSNVYFAMKHGMTPLGTMAHEYLQACQALGPRLRDSQTFALETW
AKEYRGDLGIALSDTYGFDAFLRDFDMFFCKLFDGVRHDSGDPFEWGERMLKHYDDMRAEPKSKALIFSDSLDMPKVIGL
YERFHGRCKLAFGVGTNLTNDLGYTPLQIVIKIVRCNGQPVAKLSDAPEKTMCDDPAYLTYLKQVFGVQ

Sequences:

>Translated_389_residues
MIIRSLLDTDLYKFTMMQVVLHHFPGAHVEYRFKCRNAGVDLVPFIEEIRAEIRHLCTLRFTDTELDYLRGMRFIKSDFV
DFLGLFHLNEKYIDVRPAPSNDGQIEIVIAGPWLHTIMFEVPVLAIVNEVFFSRTQTHPQWEEGKRRLTDKLASLKRPGL
EDCRIADYGTRRRFSHTWHEHVLLETHAQLGAQYAGTSNVYFAMKHGMTPLGTMAHEYLQACQALGPRLRDSQTFALETW
AKEYRGDLGIALSDTYGFDAFLRDFDMFFCKLFDGVRHDSGDPFEWGERMLKHYDDMRAEPKSKALIFSDSLDMPKVIGL
YERFHGRCKLAFGVGTNLTNDLGYTPLQIVIKIVRCNGQPVAKLSDAPEKTMCDDPAYLTYLKQVFGVQ
>Mature_389_residues
MIIRSLLDTDLYKFTMMQVVLHHFPGAHVEYRFKCRNAGVDLVPFIEEIRAEIRHLCTLRFTDTELDYLRGMRFIKSDFV
DFLGLFHLNEKYIDVRPAPSNDGQIEIVIAGPWLHTIMFEVPVLAIVNEVFFSRTQTHPQWEEGKRRLTDKLASLKRPGL
EDCRIADYGTRRRFSHTWHEHVLLETHAQLGAQYAGTSNVYFAMKHGMTPLGTMAHEYLQACQALGPRLRDSQTFALETW
AKEYRGDLGIALSDTYGFDAFLRDFDMFFCKLFDGVRHDSGDPFEWGERMLKHYDDMRAEPKSKALIFSDSLDMPKVIGL
YERFHGRCKLAFGVGTNLTNDLGYTPLQIVIKIVRCNGQPVAKLSDAPEKTMCDDPAYLTYLKQVFGVQ

Specific function: NAD biosynthesis; nicotinamide to NaMN; second step. [C]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family

Homologues:

Organism=Escherichia coli, GI1787162, Length=394, Percent_Identity=42.1319796954315, Blast_Score=310, Evalue=9e-86,
Organism=Saccharomyces cerevisiae, GI6324783, Length=414, Percent_Identity=30.6763285024155, Blast_Score=200, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PNCB_RALPJ (B2U8V2)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001898478.1
- GeneID:   6287448
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_0896
- HOGENOM:   HBG325503
- OMA:   GNTFYGK
- ProtClustDB:   PRK05321
- GO:   GO:0005737
- HAMAP:   MF_00570
- InterPro:   IPR006406
- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR002638
- PANTHER:   PTHR11098:SF1
- PIRSF:   PIRSF000484
- TIGRFAMs:   TIGR01514

Pfam domain/function: PF04095 NAPRTase; SSF51690 Q_phspho_trans

EC number: =2.4.2.11

Molecular weight: Translated: 44841; Mature: 44841

Theoretical pI: Translated: 6.83; Mature: 6.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIRSLLDTDLYKFTMMQVVLHHFPGAHVEYRFKCRNAGVDLVPFIEEIRAEIRHLCTLR
CCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHEE
FTDTELDYLRGMRFIKSDFVDFLGLFHLNEKYIDVRPAPSNDGQIEIVIAGPWLHTIMFE
ECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCHHHHHHHH
VPVLAIVNEVFFSRTQTHPQWEEGKRRLTDKLASLKRPGLEDCRIADYGTRRRFSHTWHE
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHH
HVLLETHAQLGAQYAGTSNVYFAMKHGMTPLGTMAHEYLQACQALGPRLRDSQTFALETW
HHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
AKEYRGDLGIALSDTYGFDAFLRDFDMFFCKLFDGVRHDSGDPFEWGERMLKHYDDMRAE
HHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
PKSKALIFSDSLDMPKVIGLYERFHGRCKLAFGVGTNLTNDLGYTPLQIVIKIVRCNGQP
CCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCC
VAKLSDAPEKTMCDDPAYLTYLKQVFGVQ
CHHCCCCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MIIRSLLDTDLYKFTMMQVVLHHFPGAHVEYRFKCRNAGVDLVPFIEEIRAEIRHLCTLR
CCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHEE
FTDTELDYLRGMRFIKSDFVDFLGLFHLNEKYIDVRPAPSNDGQIEIVIAGPWLHTIMFE
ECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCHHHHHHHH
VPVLAIVNEVFFSRTQTHPQWEEGKRRLTDKLASLKRPGLEDCRIADYGTRRRFSHTWHE
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHHHHH
HVLLETHAQLGAQYAGTSNVYFAMKHGMTPLGTMAHEYLQACQALGPRLRDSQTFALETW
HHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
AKEYRGDLGIALSDTYGFDAFLRDFDMFFCKLFDGVRHDSGDPFEWGERMLKHYDDMRAE
HHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
PKSKALIFSDSLDMPKVIGLYERFHGRCKLAFGVGTNLTNDLGYTPLQIVIKIVRCNGQP
CCCCEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCC
VAKLSDAPEKTMCDDPAYLTYLKQVFGVQ
CHHCCCCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA