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The map label for this gene is hldD

Identifier: 187927881

GI number: 187927881

Start: 831578

End: 832573

Strand: Direct

Name: hldD

Synonym: Rpic_0785

Alternate gene names: 187927881

Gene position: 831578-832573 (Clockwise)

Preceding gene: 187927880

Following gene: 187927882

Centisome position: 21.09

GC content: 60.84

Gene sequence:

>996_bases
ATGACCATCATCGTCACTGGCGCGGCCGGCTTTATCGGCGCCAACATCGTCAAGGGCCTAAACGAGCGCGGCGAGACCGA
CATCATCGCCGTCGACAACCTCACGCGGGCCGACAAGTTCAAGAACATCGTCGACTGCCAGATCAGCGACTACCTGGACA
AGACCGATTTTGTCGAACGCTTTGCGCGCGGCGAGTTCGGCAAGGTTCGCGCGATCTTCCATGAAGGCGCCTGCTCCGAC
ACCATGGAGACCGATGGCCGCTACATGATGGACAACAATTACCGTTACTCGCTGGCGGTGATGCGCGCGTGTCTGGACCA
AGGCGTGCAGTTCCTCTATGCCTCGTCGGCAGCCACGTACGGCGCGTCGGAAACGTTCCGCGAAGAGCCCGAGTTCGAGC
GGCCGCTGAACGTGTATGGCTACTCCAAGCTGCTGTTCGACCAAGTTGTGCGCCGTGTCATGCTGACCGCGCTGTCGCAG
ATCGTCGGCTTCCGCTACTTCAACGTCTACGGCCCGCGCGAGCAGCACAAAGGCCGCATGGCGTCGGTGGCGTTCCACAA
CTTCAACCAGTTCCGCTCGGAAGGTACCGTCAAGCTGTTCGGCGAGTACAACGGCTACCCGCAAGGCGGCCAGATGCGCG
ATTTCGTGTCGGTGGAAGATGTGGTCAAGGTCAACCTCTTCTTCTTCGACAATCCGGACAAGTCGGGCATCTTCAATCTC
GGCACGGGCCGCGCGCAGCCGTTCAACGACATCGCCACGACGGTGATGAACACGTTGCGCGGAGCCGAAGGCAAGCCGGC
GCTTTCTACCGAGGAACTGGCTCAGGAAGGCCTGATCGAGTACGTGAAATTTCCCGATGCGTTGCGTGGCAAGTACCAGT
GCTTCACCCAGGCTGATCAATCGCGCCTGCGTGCGGCGGGCTACACGGCGCCGTTCCTCACGGTGCAGGAAGGTGTGGAG
CGCTACTGCCAGTGGCTGTTGAAGCAACCGGTCTGA

Upstream 100 bases:

>100_bases
GCAGTACGCGAATCGCGCAGGCGGCATCGTGGTCGGCAAGCTGGGCACGGCTGTCGTCACCCACGCAGAACTCTTCAACT
GATCACCTGATCAACGGATC

Downstream 100 bases:

>100_bases
TCGCCCAGCGCTCCAACAATCAGACAGCGTGTGAATTTTTGTCCGTTCGCTGCGGCGTTGCCAGATCGCTCTTTAAGATG
TGTCGAAACCGCCACCTCAT

Product: ADP-L-glycero-D-manno-heptose-6-epimerase

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MTIIVTGAAGFIGANIVKGLNERGETDIIAVDNLTRADKFKNIVDCQISDYLDKTDFVERFARGEFGKVRAIFHEGACSD
TMETDGRYMMDNNYRYSLAVMRACLDQGVQFLYASSAATYGASETFREEPEFERPLNVYGYSKLLFDQVVRRVMLTALSQ
IVGFRYFNVYGPREQHKGRMASVAFHNFNQFRSEGTVKLFGEYNGYPQGGQMRDFVSVEDVVKVNLFFFDNPDKSGIFNL
GTGRAQPFNDIATTVMNTLRGAEGKPALSTEELAQEGLIEYVKFPDALRGKYQCFTQADQSRLRAAGYTAPFLTVQEGVE
RYCQWLLKQPV

Sequences:

>Translated_331_residues
MTIIVTGAAGFIGANIVKGLNERGETDIIAVDNLTRADKFKNIVDCQISDYLDKTDFVERFARGEFGKVRAIFHEGACSD
TMETDGRYMMDNNYRYSLAVMRACLDQGVQFLYASSAATYGASETFREEPEFERPLNVYGYSKLLFDQVVRRVMLTALSQ
IVGFRYFNVYGPREQHKGRMASVAFHNFNQFRSEGTVKLFGEYNGYPQGGQMRDFVSVEDVVKVNLFFFDNPDKSGIFNL
GTGRAQPFNDIATTVMNTLRGAEGKPALSTEELAQEGLIEYVKFPDALRGKYQCFTQADQSRLRAAGYTAPFLTVQEGVE
RYCQWLLKQPV
>Mature_330_residues
TIIVTGAAGFIGANIVKGLNERGETDIIAVDNLTRADKFKNIVDCQISDYLDKTDFVERFARGEFGKVRAIFHEGACSDT
METDGRYMMDNNYRYSLAVMRACLDQGVQFLYASSAATYGASETFREEPEFERPLNVYGYSKLLFDQVVRRVMLTALSQI
VGFRYFNVYGPREQHKGRMASVAFHNFNQFRSEGTVKLFGEYNGYPQGGQMRDFVSVEDVVKVNLFFFDNPDKSGIFNLG
TGRAQPFNDIATTVMNTLRGAEGKPALSTEELAQEGLIEYVKFPDALRGKYQCFTQADQSRLRAAGYTAPFLTVQEGVER
YCQWLLKQPV

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily

Homologues:

Organism=Escherichia coli, GI1790049, Length=326, Percent_Identity=56.1349693251534, Blast_Score=344, Evalue=4e-96,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): HLDD_RALPJ (B2U894)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001898368.1
- ProteinModelPortal:   B2U894
- SMR:   B2U894
- GeneID:   6286838
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_0785
- HOGENOM:   HBG755066
- OMA:   GFIGSAM
- ProtClustDB:   CLSK896740
- HAMAP:   MF_01601
- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10366:SF29
- TIGRFAMs:   TIGR02197

Pfam domain/function: PF01370 Epimerase

EC number: =5.1.3.20

Molecular weight: Translated: 37357; Mature: 37225

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: ACT_SITE 139-139 ACT_SITE 177-177 BINDING 39-39 BINDING 54-54 BINDING 92-92 BINDING 143-143 BINDING 168-168 BINDING 169-169 BINDING 177-177 BINDING 179-179 BINDING 186-186 BINDING 213-213 BINDING 292-292

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIIVTGAAGFIGANIVKGLNERGETDIIAVDNLTRADKFKNIVDCQISDYLDKTDFVER
CEEEEECCCHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHCCHHHHHCCHHHHHHH
FARGEFGKVRAIFHEGACSDTMETDGRYMMDNNYRYSLAVMRACLDQGVQFLYASSAATY
HHCCCCCHHHHHHCCCCCCCCHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
GASETFREEPEFERPLNVYGYSKLLFDQVVRRVMLTALSQIVGFRYFNVYGPREQHKGRM
CCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHCCCC
ASVAFHNFNQFRSEGTVKLFGEYNGYPQGGQMRDFVSVEDVVKVNLFFFDNPDKSGIFNL
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHEEEEEEEEEECCCCCCEEEC
GTGRAQPFNDIATTVMNTLRGAEGKPALSTEELAQEGLIEYVKFPDALRGKYQCFTQADQ
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHH
SRLRAAGYTAPFLTVQEGVERYCQWLLKQPV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TIIVTGAAGFIGANIVKGLNERGETDIIAVDNLTRADKFKNIVDCQISDYLDKTDFVER
EEEEECCCHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHCCHHHHHCCHHHHHHH
FARGEFGKVRAIFHEGACSDTMETDGRYMMDNNYRYSLAVMRACLDQGVQFLYASSAATY
HHCCCCCHHHHHHCCCCCCCCHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
GASETFREEPEFERPLNVYGYSKLLFDQVVRRVMLTALSQIVGFRYFNVYGPREQHKGRM
CCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHCCCC
ASVAFHNFNQFRSEGTVKLFGEYNGYPQGGQMRDFVSVEDVVKVNLFFFDNPDKSGIFNL
HHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHEEEEEEEEEECCCCCCEEEC
GTGRAQPFNDIATTVMNTLRGAEGKPALSTEELAQEGLIEYVKFPDALRGKYQCFTQADQ
CCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHH
SRLRAAGYTAPFLTVQEGVERYCQWLLKQPV
HHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA