Click here to switch to the map view.

The map label for this gene is hldE [H]

Identifier: 187927880

GI number: 187927880

Start: 830627

End: 831559

Strand: Direct

Name: hldE [H]

Synonym: Rpic_0784

Alternate gene names: 187927880

Gene position: 830627-831559 (Clockwise)

Preceding gene: 187927879

Following gene: 187927881

Centisome position: 21.07

GC content: 65.17

Gene sequence:

>933_bases
ATGACCACGCTCGCTTCCGAACAGATCCACGCCGCCCGTATCCTCGTGGTCGGCGACATGATGCTCGACCGCTACTGGTT
TGGAGACGTCGATCGGATTTCGCCCGAAGCGCCGGTACCGGTCGTGCAGATCAAGCGCCAGGACGAACGTCTCGGCGGTG
CCGCCAACGTGGCGCGCAACGTGGCGGCGCTCGGTGCGCAGGCAGCCATGCTCGGTGTGGTCGGCGACGACGAGCCGGGC
CGCAGCATCGAAACGCTGCTCGGCGAAAGCCACGTCACCGGTCACCTGCATCGTGATCCGGCAGTCAACACGACGATCAA
ACTGCGCGTGCTGGCTCGTCAGCAGCAATTGATTCGCGTCGATTTCGAGAACGCGCCCACGCACGAAGTGCTGATGTCGG
TGCTCGATCGTTTCGCCACGCTGGTGCCGCAGCACGACGTGGTGGTGCTGTCGGACTACGGCAAGGGCGGTCTCACGCAT
GTCGGCAAGATGATTGAGGCGTCGCGCCAGGCAGGCCGCCGCGTGCTGGTCGACCCGAAGGGCGACGACTACTCGCGCTA
CAGGGGCGCCACCATGATCACGCCCAATCGCGCTGAAATGCGCCAGGTGGTGGGCTCGTGGAAGTCGGAGCAGGACCTGA
CCATCCGGGCACAGAATCTGCGCCGGGAGCTGCAGCTCGAAGCGTTGCTGCTCACACGCTCCGAAGAAGGCATGACGCTC
TACACCGAGCACGAGGTGCTGCACGTGTCAGCGCAGGCGCGAGAGGTGTTCGACGTCTCGGGCGCGGGCGATACGGTGAT
CGCTACGCTGGCCACGCTGCTGGGCGCAGGCGCCAACATCAAGGAAGCCGTGCAGTACGCGAATCGCGCAGGCGGCATCG
TGGTCGGCAAGCTGGGCACGGCTGTCGTCACCCACGCAGAACTCTTCAACTGA

Upstream 100 bases:

>100_bases
GCCGCAAGCCATGCGCGATGCGGGCTTTGAATATCAGGCCATCGGGCGCTCCACCCAATCGTAATCACCGACCCACCGGC
CGCTGCCGACGCCCAGACTC

Downstream 100 bases:

>100_bases
TCACCTGATCAACGGATCATGACCATCATCGTCACTGGCGCGGCCGGCTTTATCGGCGCCAACATCGTCAAGGGCCTAAA
CGAGCGCGGCGAGACCGACA

Product: bifunctional protein RfaE

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MTTLASEQIHAARILVVGDMMLDRYWFGDVDRISPEAPVPVVQIKRQDERLGGAANVARNVAALGAQAAMLGVVGDDEPG
RSIETLLGESHVTGHLHRDPAVNTTIKLRVLARQQQLIRVDFENAPTHEVLMSVLDRFATLVPQHDVVVLSDYGKGGLTH
VGKMIEASRQAGRRVLVDPKGDDYSRYRGATMITPNRAEMRQVVGSWKSEQDLTIRAQNLRRELQLEALLLTRSEEGMTL
YTEHEVLHVSAQAREVFDVSGAGDTVIATLATLLGAGANIKEAVQYANRAGGIVVGKLGTAVVTHAELFN

Sequences:

>Translated_310_residues
MTTLASEQIHAARILVVGDMMLDRYWFGDVDRISPEAPVPVVQIKRQDERLGGAANVARNVAALGAQAAMLGVVGDDEPG
RSIETLLGESHVTGHLHRDPAVNTTIKLRVLARQQQLIRVDFENAPTHEVLMSVLDRFATLVPQHDVVVLSDYGKGGLTH
VGKMIEASRQAGRRVLVDPKGDDYSRYRGATMITPNRAEMRQVVGSWKSEQDLTIRAQNLRRELQLEALLLTRSEEGMTL
YTEHEVLHVSAQAREVFDVSGAGDTVIATLATLLGAGANIKEAVQYANRAGGIVVGKLGTAVVTHAELFN
>Mature_309_residues
TTLASEQIHAARILVVGDMMLDRYWFGDVDRISPEAPVPVVQIKRQDERLGGAANVARNVAALGAQAAMLGVVGDDEPGR
SIETLLGESHVTGHLHRDPAVNTTIKLRVLARQQQLIRVDFENAPTHEVLMSVLDRFATLVPQHDVVVLSDYGKGGLTHV
GKMIEASRQAGRRVLVDPKGDDYSRYRGATMITPNRAEMRQVVGSWKSEQDLTIRAQNLRRELQLEALLLTRSEEGMTLY
TEHEVLHVSAQAREVFDVSGAGDTVIATLATLLGAGANIKEAVQYANRAGGIVVGKLGTAVVTHAELFN

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=311, Percent_Identity=48.5530546623794, Blast_Score=284, Evalue=5e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.-

Molecular weight: Translated: 33738; Mature: 33607

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00583 PFKB_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLASEQIHAARILVVGDMMLDRYWFGDVDRISPEAPVPVVQIKRQDERLGGAANVARN
CCCCCCCCHHHEEEEEEHHHHHHHHHCCCHHCCCCCCCCCEEEEECHHHHCCCHHHHHHH
VAALGAQAAMLGVVGDDEPGRSIETLLGESHVTGHLHRDPAVNTTIKLRVLARQQQLIRV
HHHHCHHHHEEEEECCCCCCCHHHHHHCCCCCCCEEECCCCCCCEEEEEEEECCCCEEEE
DFENAPTHEVLMSVLDRFATLVPQHDVVVLSDYGKGGLTHVGKMIEASRQAGRRVLVDPK
ECCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEECCC
GDDYSRYRGATMITPNRAEMRQVVGSWKSEQDLTIRAQNLRRELQLEALLLTRSEEGMTL
CCCHHHHCCCEEECCCHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHEEEECCCCCEE
YTEHEVLHVSAQAREVFDVSGAGDTVIATLATLLGAGANIKEAVQYANRAGGIVVGKLGT
EECCEEEEEEHHHHHHEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEECCCH
AVVTHAELFN
HHHHHHHHCC
>Mature Secondary Structure 
TTLASEQIHAARILVVGDMMLDRYWFGDVDRISPEAPVPVVQIKRQDERLGGAANVARN
CCCCCCCHHHEEEEEEHHHHHHHHHCCCHHCCCCCCCCCEEEEECHHHHCCCHHHHHHH
VAALGAQAAMLGVVGDDEPGRSIETLLGESHVTGHLHRDPAVNTTIKLRVLARQQQLIRV
HHHHCHHHHEEEEECCCCCCCHHHHHHCCCCCCCEEECCCCCCCEEEEEEEECCCCEEEE
DFENAPTHEVLMSVLDRFATLVPQHDVVVLSDYGKGGLTHVGKMIEASRQAGRRVLVDPK
ECCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEECCC
GDDYSRYRGATMITPNRAEMRQVVGSWKSEQDLTIRAQNLRRELQLEALLLTRSEEGMTL
CCCHHHHCCCEEECCCHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHEEEECCCCCEE
YTEHEVLHVSAQAREVFDVSGAGDTVIATLATLLGAGANIKEAVQYANRAGGIVVGKLGT
EECCEEEEEEHHHHHHEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEECCCH
AVVTHAELFN
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA