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The map label for this gene is aroA [H]

Identifier: 187927873

GI number: 187927873

Start: 823050

End: 824354

Strand: Direct

Name: aroA [H]

Synonym: Rpic_0777

Alternate gene names: 187927873

Gene position: 823050-824354 (Clockwise)

Preceding gene: 187927872

Following gene: 187927874

Centisome position: 20.88

GC content: 66.36

Gene sequence:

>1305_bases
ATGGAACATCTCGACGTCGGCCCGCTGAAGACGGCGCGCGGCACCATCAAGCTGCCGGGCTCGAAGAGCATCTCCAACCG
CGTGCTGCTGCTGGCTGCACTCGCGCAGGGCGAGACGGTGGTGCGCGACCTGCTTGACTCCGACGACACGCGCGTCATGC
TCGACGCGCTTGGCAAGCTGGGCGTCTCGGTCGAAGGCCAGGGCGAGAACGCATACCGCGTCACCGGCACCGGCGGCCGC
TTCCCGAACACGTCGGCCGATCTGTTCATGGGCAACGCCGGCACAGCCATCCGTCCGCTGACAGCCGCGCTGGCGCTGCA
AGGTGGCGAGTACACGCTGCACGGCGTGCCGCGCATGCACGAGCGTCCGATCGGCGATCTGGTCGACGGCCTGCGCCAGG
TCGGTGCGCGCATCGACTACACGGGCAATGAGGGTTATCCGCCGCTGGCGATCCACGCCGCGCCGGTCAAGATCGACGCA
CCGATCCGCGTGCGCGGCGATGTGTCGAGCCAGTTCCTGACGGCATTGCTGATGGCGCTGCCGCTCGTCGAGTCTGCCGG
CAACGTCACCATCGAAGTGGTTGGCGAGTTGATTTCCAAGCCTTACATCGAAATCACGCTGAACCTGATGGCGCGCTTCG
GCGTGCAGGTCGCGCGAGATGGCTGGTCGTCGTTCACCGTGCCGACCGGCGTGGCTTACACGGCGCCGGGAGAGATCTTT
GTGGAGGGCGATGCTTCCTCCGCGTCGTACTTCCTGGCCGCTGGTGCGCTCGGCGGCGGGCCGGTGCGTGTGGAGGGCGT
CGGCATGTCCAGCATCCAGGGTGATGTCCGCTTTGCCGACGCGCTGAATCGCATGGGCGCCAACGTGATGGCCGGCGGCA
ACTGGATCGAAGTGCGCGGCGCCGAACGCGACGACGGCAAGCTGCACGCTGTCGAGTTGGATTGCAACCACATTCCAGAT
GCGGCCATGACGCTGGCGGTGGCTGCGTTGTTTGCTGACGGCACGACTACCTTGACGAACATCGCAAGCTGGCGCGTCAA
GGAAACCGACCGCCTGAGCGCCATGGCCACCGAACTGCGCAAGCTTGGCGCCGAGGTTGAAGAGGGCGCGGACTACATTC
GCGTGACGCCTCCGTCGCAATGGACGCCGCCGGCCGGTGGCATCGACACCTACGATGACCATCGCATGGCGATGGCTTTC
TCGCTGGCAGCGTTCGGCCCGGTGCCGGTCCGTATCAACGACCCGCGCTGCGTCGCCAAGACGTTCCCGGAATATTTCAC
GGCGTTCGGCGGCATCACCGCCTGA

Upstream 100 bases:

>100_bases
GTGCCAGCGAAGCGCGTCTGGCGTGGCCGCAACGCGTGGCGCCAGGAAATGCCGCCGGCGCACAATCCGAATAACGTTTT
GTTTTGAACTGAGTGGATTC

Downstream 100 bases:

>100_bases
ACCGCAATTAACTGCACGCACTTCATCATGTCCGACACCGCTGCTTCCATGCCGTACCCGGTCATCACCATCGACGGTCC
GACCGCATCTGGCAAGGGCA

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MEHLDVGPLKTARGTIKLPGSKSISNRVLLLAALAQGETVVRDLLDSDDTRVMLDALGKLGVSVEGQGENAYRVTGTGGR
FPNTSADLFMGNAGTAIRPLTAALALQGGEYTLHGVPRMHERPIGDLVDGLRQVGARIDYTGNEGYPPLAIHAAPVKIDA
PIRVRGDVSSQFLTALLMALPLVESAGNVTIEVVGELISKPYIEITLNLMARFGVQVARDGWSSFTVPTGVAYTAPGEIF
VEGDASSASYFLAAGALGGGPVRVEGVGMSSIQGDVRFADALNRMGANVMAGGNWIEVRGAERDDGKLHAVELDCNHIPD
AAMTLAVAALFADGTTTLTNIASWRVKETDRLSAMATELRKLGAEVEEGADYIRVTPPSQWTPPAGGIDTYDDHRMAMAF
SLAAFGPVPVRINDPRCVAKTFPEYFTAFGGITA

Sequences:

>Translated_434_residues
MEHLDVGPLKTARGTIKLPGSKSISNRVLLLAALAQGETVVRDLLDSDDTRVMLDALGKLGVSVEGQGENAYRVTGTGGR
FPNTSADLFMGNAGTAIRPLTAALALQGGEYTLHGVPRMHERPIGDLVDGLRQVGARIDYTGNEGYPPLAIHAAPVKIDA
PIRVRGDVSSQFLTALLMALPLVESAGNVTIEVVGELISKPYIEITLNLMARFGVQVARDGWSSFTVPTGVAYTAPGEIF
VEGDASSASYFLAAGALGGGPVRVEGVGMSSIQGDVRFADALNRMGANVMAGGNWIEVRGAERDDGKLHAVELDCNHIPD
AAMTLAVAALFADGTTTLTNIASWRVKETDRLSAMATELRKLGAEVEEGADYIRVTPPSQWTPPAGGIDTYDDHRMAMAF
SLAAFGPVPVRINDPRCVAKTFPEYFTAFGGITA
>Mature_434_residues
MEHLDVGPLKTARGTIKLPGSKSISNRVLLLAALAQGETVVRDLLDSDDTRVMLDALGKLGVSVEGQGENAYRVTGTGGR
FPNTSADLFMGNAGTAIRPLTAALALQGGEYTLHGVPRMHERPIGDLVDGLRQVGARIDYTGNEGYPPLAIHAAPVKIDA
PIRVRGDVSSQFLTALLMALPLVESAGNVTIEVVGELISKPYIEITLNLMARFGVQVARDGWSSFTVPTGVAYTAPGEIF
VEGDASSASYFLAAGALGGGPVRVEGVGMSSIQGDVRFADALNRMGANVMAGGNWIEVRGAERDDGKLHAVELDCNHIPD
AAMTLAVAALFADGTTTLTNIASWRVKETDRLSAMATELRKLGAEVEEGADYIRVTPPSQWTPPAGGIDTYDDHRMAMAF
SLAAFGPVPVRINDPRCVAKTFPEYFTAFGGITA

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1787137, Length=435, Percent_Identity=55.4022988505747, Blast_Score=436, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6320332, Length=449, Percent_Identity=39.8663697104677, Blast_Score=245, Evalue=9e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792 [H]

Pfam domain/function: PF00275 EPSP_synthase [H]

EC number: =2.5.1.19 [H]

Molecular weight: Translated: 45809; Mature: 45809

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00104 EPSP_SYNTHASE_1 ; PS00885 EPSP_SYNTHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHLDVGPLKTARGTIKLPGSKSISNRVLLLAALAQGETVVRDLLDSDDTRVMLDALGKL
CCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEEHHCCHHHHHHHHCCCCCEEHHHHHHHC
GVSVEGQGENAYRVTGTGGRFPNTSADLFMGNAGTAIRPLTAALALQGGEYTLHGVPRMH
CCEEECCCCCEEEEEECCCCCCCCCCCEEECCCCCCHHHHHHHHEECCCCEEEECCCCHH
ERPIGDLVDGLRQVGARIDYTGNEGYPPLAIHAAPVKIDAPIRVRGDVSSQFLTALLMAL
CCCHHHHHHHHHHHCCEEEECCCCCCCCEEEEECCEEECCCEEEECCCHHHHHHHHHHHH
PLVESAGNVTIEVVGELISKPYIEITLNLMARFGVQVARDGWSSFTVPTGVAYTAPGEIF
HHHHCCCCEEHEEHHHHHCCCEEEEHHHHHHHHCHHEECCCCCCCCCCCCEEEECCCEEE
VEGDASSASYFLAAGALGGGPVRVEGVGMSSIQGDVRFADALNRMGANVMAGGNWIEVRG
EECCCCCCEEEEEECCCCCCCEEEEECCHHHCCCCHHHHHHHHHCCCEEEECCCEEEEEC
AERDDGKLHAVELDCNHIPDAAMTLAVAALFADGTTTLTNIASWRVKETDRLSAMATELR
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHEEECCHHHHHHHHHHHH
KLGAEVEEGADYIRVTPPSQWTPPAGGIDTYDDHRMAMAFSLAAFGPVPVRINDPRCVAK
HHCCHHHCCCCEEEECCCCCCCCCCCCCCCCCCCHHEEEEHHHHCCCEEEEECCCHHHHH
TFPEYFTAFGGITA
HHHHHHHHHCCCCC
>Mature Secondary Structure
MEHLDVGPLKTARGTIKLPGSKSISNRVLLLAALAQGETVVRDLLDSDDTRVMLDALGKL
CCCCCCCCCCCCCCEEECCCCCCCCCCEEEEEEHHCCHHHHHHHHCCCCCEEHHHHHHHC
GVSVEGQGENAYRVTGTGGRFPNTSADLFMGNAGTAIRPLTAALALQGGEYTLHGVPRMH
CCEEECCCCCEEEEEECCCCCCCCCCCEEECCCCCCHHHHHHHHEECCCCEEEECCCCHH
ERPIGDLVDGLRQVGARIDYTGNEGYPPLAIHAAPVKIDAPIRVRGDVSSQFLTALLMAL
CCCHHHHHHHHHHHCCEEEECCCCCCCCEEEEECCEEECCCEEEECCCHHHHHHHHHHHH
PLVESAGNVTIEVVGELISKPYIEITLNLMARFGVQVARDGWSSFTVPTGVAYTAPGEIF
HHHHCCCCEEHEEHHHHHCCCEEEEHHHHHHHHCHHEECCCCCCCCCCCCEEEECCCEEE
VEGDASSASYFLAAGALGGGPVRVEGVGMSSIQGDVRFADALNRMGANVMAGGNWIEVRG
EECCCCCCEEEEEECCCCCCCEEEEECCHHHCCCCHHHHHHHHHCCCEEEECCCEEEEEC
AERDDGKLHAVELDCNHIPDAAMTLAVAALFADGTTTLTNIASWRVKETDRLSAMATELR
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHEEECCHHHHHHHHHHHH
KLGAEVEEGADYIRVTPPSQWTPPAGGIDTYDDHRMAMAFSLAAFGPVPVRINDPRCVAK
HHCCHHHCCCCEEEECCCCCCCCCCCCCCCCCCCHHEEEEHHHHCCCEEEEECCCHHHHH
TFPEYFTAFGGITA
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]