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The map label for this gene is hisC2 [H]

Identifier: 187927871

GI number: 187927871

Start: 820893

End: 822017

Strand: Direct

Name: hisC2 [H]

Synonym: Rpic_0775

Alternate gene names: 187927871

Gene position: 820893-822017 (Clockwise)

Preceding gene: 187927870

Following gene: 187927872

Centisome position: 20.82

GC content: 63.38

Gene sequence:

>1125_bases
ATGTCTTTGCAGTTCGGCCCCGAGTATGTCCGCGCCATCGCCCCTTATGTGGCCGGCAAGCCGATTTCCGAAGTGGCACG
CGAATTCGGCCTGGATGCCGCGCGCATCGTCAAGCTGGCGTCCAACGAAAACCCGCTGGGCATGCCGAAGTCAGCCAAGA
ACGCGATGGCCTCGGCCATTAATGAACTGGCGCGCTATCCGGATGCCAACGGCTTCAGCCTGAAGGCCGCGCTGCATGCC
AAGTTTGGCGTGCCGGAAACATGGATCACGCTCGGCAACGGCAGCAATGACATCCTCGAACTGGCCGCTCGCGCGCTGGT
GTCGCCTGGGCAGGCTGTGATGTATGCGCAGCACTCGTTTGCCGTGTATGCGCTGGCCGCGCAGGAGGTGGGCGCGCGTG
CGATCGAGGTGCCGGCCCGCGATTACGGCCACGATCTTGACGCGATGGCCGCTGCAATCACGCCGGACACCCGCCTGATC
TACATCGCCAACCCAAACAACCCGACTGGCACGTTCCTGCCGGCCGATGCGATTGCGGCGTTCCTGGCGAAGGTGCCGCC
GACGGTGGTCGTCGTGCTGGACGAGGCGTACAACGAATTCCTCAAGCCGGAGCAGCAGTACGACTCCACCGCGTGGGTGC
GCCAATACCCGAACCTGCTGGTGTCGCGGACGTTCTCCAAGGCGTACGGGCTGGCTGGCTTGCGTGTGGGTTATGGCATT
GCGCAACCGCAGTTGACCGATCTGCTCAACCGCATCCGTCAGCCGTTCAACGTCAACAGCTTGGCGCAGGCGGCCGCGGT
GGCAGCGCTCAATGATGCGGAATTCCTGTGTCAATCGGCTGAACTGAACGCTGCCGGCTACGTGCAGTTGACGGACGCGT
TCGATCGGCTGGGCCTTGAATACGTGCCGTCATCGGGCAATTTTGTCTTGGTGCGTGTGGGTGACGATAACGGCGCCGGT
GCGCGCGTGAACGTTGCGTTGCTCAAGCAAGGTGTGATCGTGCGCCCGGTCGGCAACTACGGCTTGCCGCAATGGCTGCG
CATCAGCATCGGCTTGCCGGAAGAGAACGCCACGTTCATCGGCGCACTGGAGTCGGCGCTGGCGCGGGAAAAAGCCGCCG
CGTAA

Upstream 100 bases:

>100_bases
GACGCGGCGTATTTCAAAGTGTTGGGGTCCTATCCCTCAGCACATTGAGGGATTCAAGGCGCTCTGCACGGGCAGAGCGT
CGATAACGGAGGAGCACCCC

Downstream 100 bases:

>100_bases
CTTCAGCCGCAACCGCCACAGCGCCCCGCATCAGGCATCGGGCGCCGCGTACATCGGGCTACAATGCCGCTTTGCTTTTT
TCTGGCAGGACGGTGTTGTG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase 2 [H]

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MSLQFGPEYVRAIAPYVAGKPISEVAREFGLDAARIVKLASNENPLGMPKSAKNAMASAINELARYPDANGFSLKAALHA
KFGVPETWITLGNGSNDILELAARALVSPGQAVMYAQHSFAVYALAAQEVGARAIEVPARDYGHDLDAMAAAITPDTRLI
YIANPNNPTGTFLPADAIAAFLAKVPPTVVVVLDEAYNEFLKPEQQYDSTAWVRQYPNLLVSRTFSKAYGLAGLRVGYGI
AQPQLTDLLNRIRQPFNVNSLAQAAAVAALNDAEFLCQSAELNAAGYVQLTDAFDRLGLEYVPSSGNFVLVRVGDDNGAG
ARVNVALLKQGVIVRPVGNYGLPQWLRISIGLPEENATFIGALESALAREKAAA

Sequences:

>Translated_374_residues
MSLQFGPEYVRAIAPYVAGKPISEVAREFGLDAARIVKLASNENPLGMPKSAKNAMASAINELARYPDANGFSLKAALHA
KFGVPETWITLGNGSNDILELAARALVSPGQAVMYAQHSFAVYALAAQEVGARAIEVPARDYGHDLDAMAAAITPDTRLI
YIANPNNPTGTFLPADAIAAFLAKVPPTVVVVLDEAYNEFLKPEQQYDSTAWVRQYPNLLVSRTFSKAYGLAGLRVGYGI
AQPQLTDLLNRIRQPFNVNSLAQAAAVAALNDAEFLCQSAELNAAGYVQLTDAFDRLGLEYVPSSGNFVLVRVGDDNGAG
ARVNVALLKQGVIVRPVGNYGLPQWLRISIGLPEENATFIGALESALAREKAAA
>Mature_373_residues
SLQFGPEYVRAIAPYVAGKPISEVAREFGLDAARIVKLASNENPLGMPKSAKNAMASAINELARYPDANGFSLKAALHAK
FGVPETWITLGNGSNDILELAARALVSPGQAVMYAQHSFAVYALAAQEVGARAIEVPARDYGHDLDAMAAAITPDTRLIY
IANPNNPTGTFLPADAIAAFLAKVPPTVVVVLDEAYNEFLKPEQQYDSTAWVRQYPNLLVSRTFSKAYGLAGLRVGYGIA
QPQLTDLLNRIRQPFNVNSLAQAAAVAALNDAEFLCQSAELNAAGYVQLTDAFDRLGLEYVPSSGNFVLVRVGDDNGAGA
RVNVALLKQGVIVRPVGNYGLPQWLRISIGLPEENATFIGALESALAREKAAA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=370, Percent_Identity=27.027027027027, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1788627, Length=159, Percent_Identity=29.559748427673, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=337, Percent_Identity=28.1899109792285, Blast_Score=119, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 39888; Mature: 39757

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLQFGPEYVRAIAPYVAGKPISEVAREFGLDAARIVKLASNENPLGMPKSAKNAMASAI
CCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHH
NELARYPDANGFSLKAALHAKFGVPETWITLGNGSNDILELAARALVSPGQAVMYAQHSF
HHHHHCCCCCCEEEEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCE
AVYALAAQEVGARAIEVPARDYGHDLDAMAAAITPDTRLIYIANPNNPTGTFLPADAIAA
EEEEEEHHHHCCEEEECCCHHHCCCHHHHHHEECCCCEEEEEECCCCCCCCCCCHHHHHH
FLAKVPPTVVVVLDEAYNEFLKPEQQYDSTAWVRQYPNLLVSRTFSKAYGLAGLRVGYGI
HHHHCCCEEEEEEEHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCC
AQPQLTDLLNRIRQPFNVNSLAQAAAVAALNDAEFLCQSAELNAAGYVQLTDAFDRLGLE
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCCEEEEEHHHHHCCCE
YVPSSGNFVLVRVGDDNGAGARVNVALLKQGVIVRPVGNYGLPQWLRISIGLPEENATFI
EECCCCCEEEEEECCCCCCCCEEEEEEHHCCEEEEECCCCCCCCEEEEEECCCCCCCHHH
GALESALAREKAAA
HHHHHHHHHHHCCC
>Mature Secondary Structure 
SLQFGPEYVRAIAPYVAGKPISEVAREFGLDAARIVKLASNENPLGMPKSAKNAMASAI
CCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHH
NELARYPDANGFSLKAALHAKFGVPETWITLGNGSNDILELAARALVSPGQAVMYAQHSF
HHHHHCCCCCCEEEEEEEEECCCCCCEEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCE
AVYALAAQEVGARAIEVPARDYGHDLDAMAAAITPDTRLIYIANPNNPTGTFLPADAIAA
EEEEEEHHHHCCEEEECCCHHHCCCHHHHHHEECCCCEEEEEECCCCCCCCCCCHHHHHH
FLAKVPPTVVVVLDEAYNEFLKPEQQYDSTAWVRQYPNLLVSRTFSKAYGLAGLRVGYGI
HHHHCCCEEEEEEEHHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCC
AQPQLTDLLNRIRQPFNVNSLAQAAAVAALNDAEFLCQSAELNAAGYVQLTDAFDRLGLE
CCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHCCCCCCCCEEEEEHHHHHCCCE
YVPSSGNFVLVRVGDDNGAGARVNVALLKQGVIVRPVGNYGLPQWLRISIGLPEENATFI
EECCCCCEEEEEECCCCCCCCEEEEEEHHCCEEEEECCCCCCCCEEEEEECCCCCCCHHH
GALESALAREKAAA
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]