Definition Ralstonia pickettii 12J chromosome chromosome 1, complete sequence.
Accession NC_010682
Length 3,942,557

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The map label for this gene is serC

Identifier: 187927869

GI number: 187927869

Start: 818501

End: 819637

Strand: Direct

Name: serC

Synonym: Rpic_0773

Alternate gene names: 187927869

Gene position: 818501-819637 (Clockwise)

Preceding gene: 187927868

Following gene: 187927870

Centisome position: 20.76

GC content: 62.36

Gene sequence:

>1137_bases
ATGAACCAAGCGGATCGAGCCCTCCAAGCCAGCCAGGCGCGTGTGTACAACTTTTCGGCAGGGCCGGCAGTGCTGCCGCT
CGAGGTGCTGGAACAGGCGAAGGAGGAGATGGTGTCCTGGCACGGCAGCGGCATGAGCGTGATGGAAATGAGCCATCGCG
GGCGGGAATTTGAAAACATTCTGGCGGCAGCGTTCAGCGATTTGCGGCAGTTGCTGGCCGTGCCGGACAACTACGAAATT
CTCTTCCTGCAAGGCGGCGCCATCGCCGAGAACGCCATCGTTCCGCTGAACCTGATGCGTCGGCTCTCGGCCGATGCTCC
GAAGGCTGACTACGTCGTCACCGGTACGTGGTCGGTCAAGTCGCAGCAGGAGGCGCGCAAGTACGGCGAGGTGAACATCG
CCGCCACCAGCGAGACCGAGCGCTTCCACAAGATCCCGGATGTGTCGAGCTGGAAGCTGTCCTCGGACGCGGCCTACGTG
CACCTGTGCACGAACGAGACCATTGTCGGCGTTGAATATCAGGAGACGCCTGACGTCGGTCAGGCGCACGGGCGAGTGGT
GGTGTCTGATGTGTCGAGCCACATCCTTTCGCGGCCGATCGACTGGAACGGCTACCAGGTCCTGTACGGCGGCGCGCAGA
AAAACATCGGCCCTGCCGGCCTGACGATTGCCATCGTCCGCAAGGACCTTCTGGGTCATGCGCACCCTCTGTGCCCGTCG
GCATTCAACTGGCGCCTCGTGGCCGAGAACGGCTCGATGTACAACACGCCGCCCACTTACGCCATCTACATCGCGGGGCT
TGTGTTCCAGTGGATCAAGCGCCAAGGTGGCGTGGAAGCGCTGGAGACGCGCAACATCATCAAGTCGAAGATGCTGTACG
ACTTCATCGACGCCAGCAGCTTCTACCGCAATGAAATCCATCCAACGTGCCGGTCGCGCATGAACGTGCCGTTCTTCCTC
AACGACGAGTCCCGCAGCGAGGCGTTCCTCGCGCAGGCGCGCGAGCGGGGGCTGGTGCAGCTCAAGGGCCACAAGTCCGT
GGGCGGCATGCGGGCGAGCATCTACAACGCGATGCCGCTGGAGGGTGTTGAGGCGCTGGTCGACTTCATGCGCGAGTTTG
AAAGAGTGTCCGCGTAA

Upstream 100 bases:

>100_bases
GCAGACGATCGGGGCACAATCCCCCTCGGGCTGTCAGTTGGTAGATAATGGCTGCTCGGGTTTGCGCCCAGACAGCCATT
TTTCTTTTGCCCTTCGTCCT

Downstream 100 bases:

>100_bases
GGCTGACCCTCAATCACGGCAGAACATTGCGTGAAGCGCCCGCTTCGCGCGGCAATTTGCAATCCGTTGCCGAACCCGAT
TCCTACAATGACCAGTCAGT

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MNQADRALQASQARVYNFSAGPAVLPLEVLEQAKEEMVSWHGSGMSVMEMSHRGREFENILAAAFSDLRQLLAVPDNYEI
LFLQGGAIAENAIVPLNLMRRLSADAPKADYVVTGTWSVKSQQEARKYGEVNIAATSETERFHKIPDVSSWKLSSDAAYV
HLCTNETIVGVEYQETPDVGQAHGRVVVSDVSSHILSRPIDWNGYQVLYGGAQKNIGPAGLTIAIVRKDLLGHAHPLCPS
AFNWRLVAENGSMYNTPPTYAIYIAGLVFQWIKRQGGVEALETRNIIKSKMLYDFIDASSFYRNEIHPTCRSRMNVPFFL
NDESRSEAFLAQARERGLVQLKGHKSVGGMRASIYNAMPLEGVEALVDFMREFERVSA

Sequences:

>Translated_378_residues
MNQADRALQASQARVYNFSAGPAVLPLEVLEQAKEEMVSWHGSGMSVMEMSHRGREFENILAAAFSDLRQLLAVPDNYEI
LFLQGGAIAENAIVPLNLMRRLSADAPKADYVVTGTWSVKSQQEARKYGEVNIAATSETERFHKIPDVSSWKLSSDAAYV
HLCTNETIVGVEYQETPDVGQAHGRVVVSDVSSHILSRPIDWNGYQVLYGGAQKNIGPAGLTIAIVRKDLLGHAHPLCPS
AFNWRLVAENGSMYNTPPTYAIYIAGLVFQWIKRQGGVEALETRNIIKSKMLYDFIDASSFYRNEIHPTCRSRMNVPFFL
NDESRSEAFLAQARERGLVQLKGHKSVGGMRASIYNAMPLEGVEALVDFMREFERVSA
>Mature_378_residues
MNQADRALQASQARVYNFSAGPAVLPLEVLEQAKEEMVSWHGSGMSVMEMSHRGREFENILAAAFSDLRQLLAVPDNYEI
LFLQGGAIAENAIVPLNLMRRLSADAPKADYVVTGTWSVKSQQEARKYGEVNIAATSETERFHKIPDVSSWKLSSDAAYV
HLCTNETIVGVEYQETPDVGQAHGRVVVSDVSSHILSRPIDWNGYQVLYGGAQKNIGPAGLTIAIVRKDLLGHAHPLCPS
AFNWRLVAENGSMYNTPPTYAIYIAGLVFQWIKRQGGVEALETRNIIKSKMLYDFIDASSFYRNEIHPTCRSRMNVPFFL
NDESRSEAFLAQARERGLVQLKGHKSVGGMRASIYNAMPLEGVEALVDFMREFERVSA

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=365, Percent_Identity=46.5753424657534, Blast_Score=346, Evalue=2e-95,
Organism=Homo sapiens, GI10863955, Length=360, Percent_Identity=42.5, Blast_Score=295, Evalue=4e-80,
Organism=Escherichia coli, GI1787136, Length=364, Percent_Identity=52.4725274725275, Blast_Score=384, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17506897, Length=374, Percent_Identity=44.9197860962567, Blast_Score=324, Evalue=4e-89,
Organism=Saccharomyces cerevisiae, GI6324758, Length=387, Percent_Identity=41.0852713178295, Blast_Score=276, Evalue=3e-75,
Organism=Drosophila melanogaster, GI21356589, Length=366, Percent_Identity=46.9945355191257, Blast_Score=341, Evalue=6e-94,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_RALPJ (B2U882)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001898356.1
- ProteinModelPortal:   B2U882
- SMR:   B2U882
- GeneID:   6287962
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_0773
- HOGENOM:   HBG289982
- OMA:   TFAWYLA
- ProtClustDB:   PRK05355
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01364

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 42017; Mature: 42017

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 53-53 BINDING 117-117 BINDING 167-167 BINDING 190-190 BINDING 213-213

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MNQADRALQASQARVYNFSAGPAVLPLEVLEQAKEEMVSWHGSGMSVMEMSHRGREFENI
CCHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHH
LAAAFSDLRQLLAVPDNYEILFLQGGAIAENAIVPLNLMRRLSADAPKADYVVTGTWSVK
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCEEEEEEECCC
SQQEARKYGEVNIAATSETERFHKIPDVSSWKLSSDAAYVHLCTNETIVGVEYQETPDVG
CHHHHHHCCCEEEEECCCHHHHHCCCCCCCCEECCCCEEEEEECCCEEEEEEECCCCCCC
QAHGRVVVSDVSSHILSRPIDWNGYQVLYGGAQKNIGPAGLTIAIVRKDLLGHAHPLCPS
CCCCEEEEHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEEEEHHHHHHCCCCCCCCC
AFNWRLVAENGSMYNTPPTYAIYIAGLVFQWIKRQGGVEALETRNIIKSKMLYDFIDASS
CCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
FYRNEIHPTCRSRMNVPFFLNDESRSEAFLAQARERGLVQLKGHKSVGGMRASIYNAMPL
HHHHCCCHHHHHCCCCCEEECCCCHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHCCCCH
EGVEALVDFMREFERVSA
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNQADRALQASQARVYNFSAGPAVLPLEVLEQAKEEMVSWHGSGMSVMEMSHRGREFENI
CCHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHH
LAAAFSDLRQLLAVPDNYEILFLQGGAIAENAIVPLNLMRRLSADAPKADYVVTGTWSVK
HHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCEEEEEEECCC
SQQEARKYGEVNIAATSETERFHKIPDVSSWKLSSDAAYVHLCTNETIVGVEYQETPDVG
CHHHHHHCCCEEEEECCCHHHHHCCCCCCCCEECCCCEEEEEECCCEEEEEEECCCCCCC
QAHGRVVVSDVSSHILSRPIDWNGYQVLYGGAQKNIGPAGLTIAIVRKDLLGHAHPLCPS
CCCCEEEEHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCEEEEHHHHHHCCCCCCCCC
AFNWRLVAENGSMYNTPPTYAIYIAGLVFQWIKRQGGVEALETRNIIKSKMLYDFIDASS
CCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
FYRNEIHPTCRSRMNVPFFLNDESRSEAFLAQARERGLVQLKGHKSVGGMRASIYNAMPL
HHHHCCCHHHHHCCCCCEEECCCCHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHCCCCH
EGVEALVDFMREFERVSA
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA