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The map label for this gene is trxA [H]

Identifier: 187927822

GI number: 187927822

Start: 760981

End: 761826

Strand: Reverse

Name: trxA [H]

Synonym: Rpic_0726

Alternate gene names: 187927822

Gene position: 761826-760981 (Counterclockwise)

Preceding gene: 187927824

Following gene: 187927821

Centisome position: 19.32

GC content: 64.3

Gene sequence:

>846_bases
ATGAGCGACATCACCTCGCAGAATTTCGCGCAGGAAGTGATCGAAACCTCTCGCCAAATACCGGTGCTGGTCGATTTCTG
GGCGCCATGGTGCGGCCCGTGCCGCACGTTGGGCCCGATGCTGGAAAAGCTGGAGGCCGAATTTGCCGGCAAATGGAAGC
TCGCCAAGATCAACTCCGACGAAAACCCCGAGCTTTCCGCCCAGTTCCACGTCCGCAGCATCCCGTACGTGGTGGCGTTC
GTGGATGGCAAGCCGGTCGACCAGTTCGTCGGCGTCTTGCCCGAAGCGCAATTGCGCGCGTTCCTCGACCGCGTGATTCC
GCAGCCCGCAGAAGTCGCCTATCGCGAAGGACTGGCAGCGAGCCAGGCCGGCGAAACCGCCCACGCGCGCGAAGCGTTCC
AGAACGCGCTGGCCTTCGACCCGGGCTTCGATGCCGCCCGCTTTGCGCTGGTGAACCTGCTGCTCGACAGCGGCGACGTG
CATGCCGCGCAAGACGAATTCGCATTGCTCTCGCCCAAGGCGCCGCAGGATGAGCGCTATGCCCCGCTGGAAACGCGCCT
GAGGGCCACCGAACGGGCCGATACGCTACCCGATGCCGGCGCCCTTCGCACGGTCGTGGAAGCGCAACCGGACAACCTGC
AGGCACGGCTCGACCTGGCACAGCAGTACATCGCGGCACAAGACTACGAAGCCGCCCTGGAGCAATTGCTCGCCATCGTC
GAGCGGGATCGCGCCTTCCGTGACGACATTGCGCGCAAGACGATGGTCTCGGTATTCGACATGATGCGCGACGCGCCGCA
GGCGGTATCGCATTGGCGCAGGCAGCTGGCGTCCAAACTGAATTGA

Upstream 100 bases:

>100_bases
AGACTGGCTGAAAACGGCTCGCCCCACCCGCAAGTAAAATGCACGATACCTCTCGCCGGCCCGTGTGCCGGCGCCATTGC
CCCTCAGGAGAATCCCGCCG

Downstream 100 bases:

>100_bases
GGAGCCGTCATGCGACTGATCTACGTGGCCGATCCGATGTGTTCCTGGTGCTACGGCTTTGGCCCGCAGCTGGCTGACCT
GCGCAAGCGGCTGGCCGAAA

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MSDITSQNFAQEVIETSRQIPVLVDFWAPWCGPCRTLGPMLEKLEAEFAGKWKLAKINSDENPELSAQFHVRSIPYVVAF
VDGKPVDQFVGVLPEAQLRAFLDRVIPQPAEVAYREGLAASQAGETAHAREAFQNALAFDPGFDAARFALVNLLLDSGDV
HAAQDEFALLSPKAPQDERYAPLETRLRATERADTLPDAGALRTVVEAQPDNLQARLDLAQQYIAAQDYEAALEQLLAIV
ERDRAFRDDIARKTMVSVFDMMRDAPQAVSHWRRQLASKLN

Sequences:

>Translated_281_residues
MSDITSQNFAQEVIETSRQIPVLVDFWAPWCGPCRTLGPMLEKLEAEFAGKWKLAKINSDENPELSAQFHVRSIPYVVAF
VDGKPVDQFVGVLPEAQLRAFLDRVIPQPAEVAYREGLAASQAGETAHAREAFQNALAFDPGFDAARFALVNLLLDSGDV
HAAQDEFALLSPKAPQDERYAPLETRLRATERADTLPDAGALRTVVEAQPDNLQARLDLAQQYIAAQDYEAALEQLLAIV
ERDRAFRDDIARKTMVSVFDMMRDAPQAVSHWRRQLASKLN
>Mature_280_residues
SDITSQNFAQEVIETSRQIPVLVDFWAPWCGPCRTLGPMLEKLEAEFAGKWKLAKINSDENPELSAQFHVRSIPYVVAFV
DGKPVDQFVGVLPEAQLRAFLDRVIPQPAEVAYREGLAASQAGETAHAREAFQNALAFDPGFDAARFALVNLLLDSGDVH
AAQDEFALLSPKAPQDERYAPLETRLRATERADTLPDAGALRTVVEAQPDNLQARLDLAQQYIAAQDYEAALEQLLAIVE
RDRAFRDDIARKTMVSVFDMMRDAPQAVSHWRRQLASKLN

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG3118

COG function: function code O; Thioredoxin domain-containing protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=99, Percent_Identity=43.4343434343434, Blast_Score=92, Evalue=5e-19,
Organism=Escherichia coli, GI87081747, Length=280, Percent_Identity=30, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1788936, Length=84, Percent_Identity=42.8571428571429, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI87082331, Length=107, Percent_Identity=39.2523364485981, Blast_Score=90, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI212646193, Length=105, Percent_Identity=42.8571428571429, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI28573567, Length=105, Percent_Identity=40, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21358065, Length=104, Percent_Identity=37.5, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24664269, Length=103, Percent_Identity=36.8932038834951, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24639068, Length=96, Percent_Identity=38.5416666666667, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24639826, Length=70, Percent_Identity=35.7142857142857, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 31290; Mature: 31158

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS50005 TPR ; PS50293 TPR_REGION ; PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDITSQNFAQEVIETSRQIPVLVDFWAPWCGPCRTLGPMLEKLEAEFAGKWKLAKINSD
CCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCC
ENPELSAQFHVRSIPYVVAFVDGKPVDQFVGVLPEAQLRAFLDRVIPQPAEVAYREGLAA
CCCCCCCEEEEECCCEEEEEECCCCHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHCCHH
SQAGETAHAREAFQNALAFDPGFDAARFALVNLLLDSGDVHAAQDEFALLSPKAPQDERY
HHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCC
APLETRLRATERADTLPDAGALRTVVEAQPDNLQARLDLAQQYIAAQDYEAALEQLLAIV
CCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ERDRAFRDDIARKTMVSVFDMMRDAPQAVSHWRRQLASKLN
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDITSQNFAQEVIETSRQIPVLVDFWAPWCGPCRTLGPMLEKLEAEFAGKWKLAKINSD
CCCCHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCC
ENPELSAQFHVRSIPYVVAFVDGKPVDQFVGVLPEAQLRAFLDRVIPQPAEVAYREGLAA
CCCCCCCEEEEECCCEEEEEECCCCHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHCCHH
SQAGETAHAREAFQNALAFDPGFDAARFALVNLLLDSGDVHAAQDEFALLSPKAPQDERY
HHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCC
APLETRLRATERADTLPDAGALRTVVEAQPDNLQARLDLAQQYIAAQDYEAALEQLLAIV
CCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHH
ERDRAFRDDIARKTMVSVFDMMRDAPQAVSHWRRQLASKLN
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2492995 [H]