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The map label for this gene is pcaR [H]

Identifier: 187927803

GI number: 187927803

Start: 743380

End: 744204

Strand: Direct

Name: pcaR [H]

Synonym: Rpic_0707

Alternate gene names: 187927803

Gene position: 743380-744204 (Clockwise)

Preceding gene: 187927800

Following gene: 187927807

Centisome position: 18.86

GC content: 67.39

Gene sequence:

>825_bases
ATGAGCACGACCCGTCTCCCCGATCCCGAATTCGACACCGCGCCCGCCGAGTCGAGCGACCCGAATTTCGTCACGGCGCT
CGCGCGCGGGCTGGAACTGCTGCGCGCATTCCGCCCTGGCGACACGTTGCTCGGCAACCAGGAATTCGTCCGGCGCACGG
GCTTTCCCAAGGCCACAGTCAGTCGATTGGCCGGCACGCTGGTGTCGCTCGGTTACCTGCGCTACGACGATGCGCTCGGC
AAATACGGGCTCGACGCCGGTGTGCTCGCACTCGGGTTTGCCTACCTGGCCTCAAGCGACGTGATCCAGCTCGCGCGGCC
GCATATGAGCGCATTTGCGCAGCGCTATGGGGTATCGATCTCGCTGGGCAAGCGCGATCGGCTGGACATGGTGTATCTGG
AGACGATCCGCCACGACAGCCCGTCGATGAGCGGCTCGTCGGGGCTGGGCGTGGGCTCGCGGCTCTCGCTGCTGTCGAGT
TCGATGGGACGGGCGTATCTGGCTTCGTTGCCCGCAGCGCGGCGTGAGCGCTTGTACGAAGCACTGCGCACGCAGCAGCC
GGCGCAGTGGGCGGCAGAAGGGGCCGCCGCAGATGACGCTGTCAAAGCCGGCGTACGGAATGGCTATGCCGTGTCGCTGC
GTGACTGGCATCCGGCCATCCACGCATGCGCAGTCGCGTTCTTCGCGCCAAGCCAGCGCGAGCCGTATGTCGTGAGTTGC
AGCGCGCCACACACGTCCGCCGATGCAGAGCGCATCCGCGACGAACTGGCCCCCGCGCTGCGAGAGTTCGCGGCAAGGCT
CGGCCAAGTCGCCGAGCCCGCCTGA

Upstream 100 bases:

>100_bases
GGTCGTCTCCGAGTCGTTGTTGTTCCGATATACGGAACACAGTTTCGAAATTTAGGGCTATCATAGCGCAACCGCCGACG
ATTTCCAGGGCTTTTTTGCC

Downstream 100 bases:

>100_bases
GTCGGGTCGATCAAAGATCAGTCCGCAACTTCCAAAGCTCCGGAAACAACACCACATCCAGCATCTTCCGCAGGTAACCG
ACGCCCTCGGTGCCGCCCGT

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MSTTRLPDPEFDTAPAESSDPNFVTALARGLELLRAFRPGDTLLGNQEFVRRTGFPKATVSRLAGTLVSLGYLRYDDALG
KYGLDAGVLALGFAYLASSDVIQLARPHMSAFAQRYGVSISLGKRDRLDMVYLETIRHDSPSMSGSSGLGVGSRLSLLSS
SMGRAYLASLPAARRERLYEALRTQQPAQWAAEGAAADDAVKAGVRNGYAVSLRDWHPAIHACAVAFFAPSQREPYVVSC
SAPHTSADAERIRDELAPALREFAARLGQVAEPA

Sequences:

>Translated_274_residues
MSTTRLPDPEFDTAPAESSDPNFVTALARGLELLRAFRPGDTLLGNQEFVRRTGFPKATVSRLAGTLVSLGYLRYDDALG
KYGLDAGVLALGFAYLASSDVIQLARPHMSAFAQRYGVSISLGKRDRLDMVYLETIRHDSPSMSGSSGLGVGSRLSLLSS
SMGRAYLASLPAARRERLYEALRTQQPAQWAAEGAAADDAVKAGVRNGYAVSLRDWHPAIHACAVAFFAPSQREPYVVSC
SAPHTSADAERIRDELAPALREFAARLGQVAEPA
>Mature_273_residues
STTRLPDPEFDTAPAESSDPNFVTALARGLELLRAFRPGDTLLGNQEFVRRTGFPKATVSRLAGTLVSLGYLRYDDALGK
YGLDAGVLALGFAYLASSDVIQLARPHMSAFAQRYGVSISLGKRDRLDMVYLETIRHDSPSMSGSSGLGVGSRLSLLSSS
MGRAYLASLPAARRERLYEALRTQQPAQWAAEGAAADDAVKAGVRNGYAVSLRDWHPAIHACAVAFFAPSQREPYVVSCS
APHTSADAERIRDELAPALREFAARLGQVAEPA

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=252, Percent_Identity=23.4126984126984, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29461; Mature: 29329

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTRLPDPEFDTAPAESSDPNFVTALARGLELLRAFRPGDTLLGNQEFVRRTGFPKATV
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHH
SRLAGTLVSLGYLRYDDALGKYGLDAGVLALGFAYLASSDVIQLARPHMSAFAQRYGVSI
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
SLGKRDRLDMVYLETIRHDSPSMSGSSGLGVGSRLSLLSSSMGRAYLASLPAARRERLYE
EECCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ALRTQQPAQWAAEGAAADDAVKAGVRNGYAVSLRDWHPAIHACAVAFFAPSQREPYVVSC
HHHCCCCHHHHHCCCCHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCEEEEC
SAPHTSADAERIRDELAPALREFAARLGQVAEPA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
STTRLPDPEFDTAPAESSDPNFVTALARGLELLRAFRPGDTLLGNQEFVRRTGFPKATV
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCHHHH
SRLAGTLVSLGYLRYDDALGKYGLDAGVLALGFAYLASSDVIQLARPHMSAFAQRYGVSI
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
SLGKRDRLDMVYLETIRHDSPSMSGSSGLGVGSRLSLLSSSMGRAYLASLPAARRERLYE
EECCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
ALRTQQPAQWAAEGAAADDAVKAGVRNGYAVSLRDWHPAIHACAVAFFAPSQREPYVVSC
HHHCCCCHHHHHCCCCHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCCEEEEC
SAPHTSADAERIRDELAPALREFAARLGQVAEPA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]