Click here to switch to the map view.

The map label for this gene is pyrC' [H]

Identifier: 187927719

GI number: 187927719

Start: 663269

End: 664546

Strand: Direct

Name: pyrC' [H]

Synonym: Rpic_0623

Alternate gene names: 187927719

Gene position: 663269-664546 (Clockwise)

Preceding gene: 187927718

Following gene: 187927720

Centisome position: 16.82

GC content: 65.18

Gene sequence:

>1278_bases
ATGAAACTGCATATCAAAGGCGGCCGCCTGATCGACCCGGCCAACGGTGTCGACGCACAACAGGACTTGTACATCGCGGC
AAGCAAGGTGGTCGGTGTCGGCCACGCGCCGGCGGATTTCCATGCCAACAAGACCATCGACGCGACGGGCCTGGTTGTTT
GCCCGGGTCTGATTGACTTGTCCGCGCGCCTGCGTGAGCCGGGTTTCGAATACAAGGCTACGCTCGAATCGGAAATGGCC
GCGGCCATGGCCGGCGGCGTGACCTCGCTGGTGTGCCCGCCGGACACCGATCCTGTGCTGGACGAACCCGGCCTGGTCGA
GATGCTCAAGTTTCGCGCGCGCAACCTGAACCAGGCGCATGTGTATCCGCTCGGTGCGCTCACTGTCGGCTTGAAGGGCG
CGGTGCTGACGGAGATGGCCGAATTGACTGAGTCGGGCTGCGTTGGCTTCTCGCAGACCGATGCACCGATGGCCGACACG
CAGGTGCTGATGCGCGCGCTGCAATATGCGCAGACCTTCGGCTTCACTGTCTGGCTGCGCCCCGAAGACCCGTATCTGGG
CAAGGGCGGCGTGGCCGCAAGCGGCCCGCTGGCTTCACGCCTGGGCCTCTCGGGTGTGCCGGTAATCGCCGAGACGGTGC
GCCTGCATACCATCTTCGAACTGATTCGCAGCACAGGCGCCCGCGTTCACCTGTGCCGTTTGTCGTCGGCCGCCGGCATC
GAGCTTGTACGCCGCGCAAAAGCCGAAGGCCTGCCGGTCACGTGCGATGTGAACGTCCACCATATCTCGCTGACCGACAT
CGATATCGGCTACTTCAATTCGCAGATGCGCTTTGTGCCGCCGCTGCGTTCCGGGCGCGACCGCGATGGCATCGTGCGTG
CGCTGGCGGATGGCACGATCGACGCGATCTGTTCCGACCACACGCCCGTGGATGACGACGAGAAGCTGCTACCGTTTGCC
GAGGCCACGCCGGGCGCGACCGGCCTCGAAACCCTGCTGCCGCTCACGTTGCGCTGGGCCACCGAACACAAGGTCGAGCT
TTCGAAGGCGCTGGCCCGCATCACCAGCGAGCCTGCTCGCGTGCTGGGCCTGCGTGCGGGCTCGCTGGAAGTGGGTGCGA
TGGCCGATGTGTGTGTGTTCGATCCGGCCGCGACCTGGAAACTTGAGCCTCGCGCTCTGCGCAGCCAAGGCAAGAACTCG
CCCTACCTGGGCTTTGAGCTGGCCGGCCGCGTGCGCGCCACAATGGTCGCTGGCCACCTTGCCTATGACGGGCATTGA

Upstream 100 bases:

>100_bases
ACGGTGTGCAATCGGTGATCCTGAATCAGGTGACGTTCGGCATCGCGGTGCGCATGGCGGTCATGGGCATCGTGGCTGGC
AACAACGACTAAGAAGAGCA

Downstream 100 bases:

>100_bases
TCAGCGCGTGGCAAGTGCGCCCGCCGAGGCCAGCTCGCCGCAGCGCAAGCATGTGCGGCGCAAGCTGCGCTTGCTCGTAC
ATCTGGTCGAAGGCCTGATC

Product: dihydroorotase

Products: N-carbamoyl-L-aspartate

Alternate protein names: Aspartate carbamoyltransferase 44 kDa Non-catalytic chain [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MKLHIKGGRLIDPANGVDAQQDLYIAASKVVGVGHAPADFHANKTIDATGLVVCPGLIDLSARLREPGFEYKATLESEMA
AAMAGGVTSLVCPPDTDPVLDEPGLVEMLKFRARNLNQAHVYPLGALTVGLKGAVLTEMAELTESGCVGFSQTDAPMADT
QVLMRALQYAQTFGFTVWLRPEDPYLGKGGVAASGPLASRLGLSGVPVIAETVRLHTIFELIRSTGARVHLCRLSSAAGI
ELVRRAKAEGLPVTCDVNVHHISLTDIDIGYFNSQMRFVPPLRSGRDRDGIVRALADGTIDAICSDHTPVDDDEKLLPFA
EATPGATGLETLLPLTLRWATEHKVELSKALARITSEPARVLGLRAGSLEVGAMADVCVFDPAATWKLEPRALRSQGKNS
PYLGFELAGRVRATMVAGHLAYDGH

Sequences:

>Translated_425_residues
MKLHIKGGRLIDPANGVDAQQDLYIAASKVVGVGHAPADFHANKTIDATGLVVCPGLIDLSARLREPGFEYKATLESEMA
AAMAGGVTSLVCPPDTDPVLDEPGLVEMLKFRARNLNQAHVYPLGALTVGLKGAVLTEMAELTESGCVGFSQTDAPMADT
QVLMRALQYAQTFGFTVWLRPEDPYLGKGGVAASGPLASRLGLSGVPVIAETVRLHTIFELIRSTGARVHLCRLSSAAGI
ELVRRAKAEGLPVTCDVNVHHISLTDIDIGYFNSQMRFVPPLRSGRDRDGIVRALADGTIDAICSDHTPVDDDEKLLPFA
EATPGATGLETLLPLTLRWATEHKVELSKALARITSEPARVLGLRAGSLEVGAMADVCVFDPAATWKLEPRALRSQGKNS
PYLGFELAGRVRATMVAGHLAYDGH
>Mature_425_residues
MKLHIKGGRLIDPANGVDAQQDLYIAASKVVGVGHAPADFHANKTIDATGLVVCPGLIDLSARLREPGFEYKATLESEMA
AAMAGGVTSLVCPPDTDPVLDEPGLVEMLKFRARNLNQAHVYPLGALTVGLKGAVLTEMAELTESGCVGFSQTDAPMADT
QVLMRALQYAQTFGFTVWLRPEDPYLGKGGVAASGPLASRLGLSGVPVIAETVRLHTIFELIRSTGARVHLCRLSSAAGI
ELVRRAKAEGLPVTCDVNVHHISLTDIDIGYFNSQMRFVPPLRSGRDRDGIVRALADGTIDAICSDHTPVDDDEKLLPFA
EATPGATGLETLLPLTLRWATEHKVELSKALARITSEPARVLGLRAGSLEVGAMADVCVFDPAATWKLEPRALRSQGKNS
PYLGFELAGRVRATMVAGHLAYDGH

Specific function: Non-functional DHOase [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. PyrC' subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=399, Percent_Identity=28.8220551378446, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI19923821, Length=456, Percent_Identity=25, Blast_Score=82, Evalue=7e-16,
Organism=Escherichia coli, GI1786722, Length=431, Percent_Identity=26.6821345707657, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87082175, Length=450, Percent_Identity=25.5555555555556, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI193204318, Length=417, Percent_Identity=24.7002398081535, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI86575075, Length=398, Percent_Identity=22.8643216080402, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322218, Length=388, Percent_Identity=25.7731958762887, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24642586, Length=401, Percent_Identity=26.1845386533666, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI18859883, Length=209, Percent_Identity=29.1866028708134, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.2.3

Molecular weight: Translated: 45270; Mature: 45270

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLHIKGGRLIDPANGVDAQQDLYIAASKVVGVGHAPADFHANKTIDATGLVVCPGLIDL
CEEEECCCEEECCCCCCCCCCCEEEEEEHEEECCCCCCCCCCCCEECCCCEEECCCHHHH
SARLREPGFEYKATLESEMAAAMAGGVTSLVCPPDTDPVLDEPGLVEMLKFRARNLNQAH
HHHHCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCEE
VYPLGALTVGLKGAVLTEMAELTESGCVGFSQTDAPMADTQVLMRALQYAQTFGFTVWLR
EEEEHHHEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEEC
PEDPYLGKGGVAASGPLASRLGLSGVPVIAETVRLHTIFELIRSTGARVHLCRLSSAAGI
CCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHH
ELVRRAKAEGLPVTCDVNVHHISLTDIDIGYFNSQMRFVPPLRSGRDRDGIVRALADGTI
HHHHHHHCCCCCEEEEEEEEEEEEEEEEEEEECCCEEECCCCCCCCCHHHHHHHHHCCCH
DAICSDHTPVDDDEKLLPFAEATPGATGLETLLPLTLRWATEHKVELSKALARITSEPAR
HHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEEECCHHHHHHHHHHHHHHCCCCC
VLGLRAGSLEVGAMADVCVFDPAATWKLEPRALRSQGKNSPYLGFELAGRVRATMVAGHL
EEEEECCCEECCCEECEEEECCCCCEEECHHHHHHCCCCCCEEEHEECCHHEEEEEEEEE
AYDGH
ECCCC
>Mature Secondary Structure
MKLHIKGGRLIDPANGVDAQQDLYIAASKVVGVGHAPADFHANKTIDATGLVVCPGLIDL
CEEEECCCEEECCCCCCCCCCCEEEEEEHEEECCCCCCCCCCCCEECCCCEEECCCHHHH
SARLREPGFEYKATLESEMAAAMAGGVTSLVCPPDTDPVLDEPGLVEMLKFRARNLNQAH
HHHHCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCEE
VYPLGALTVGLKGAVLTEMAELTESGCVGFSQTDAPMADTQVLMRALQYAQTFGFTVWLR
EEEEHHHEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCEEEEEC
PEDPYLGKGGVAASGPLASRLGLSGVPVIAETVRLHTIFELIRSTGARVHLCRLSSAAGI
CCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHH
ELVRRAKAEGLPVTCDVNVHHISLTDIDIGYFNSQMRFVPPLRSGRDRDGIVRALADGTI
HHHHHHHCCCCCEEEEEEEEEEEEEEEEEEEECCCEEECCCCCCCCCHHHHHHHHHCCCH
DAICSDHTPVDDDEKLLPFAEATPGATGLETLLPLTLRWATEHKVELSKALARITSEPAR
HHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEEECCHHHHHHHHHHHHHHCCCCC
VLGLRAGSLEVGAMADVCVFDPAATWKLEPRALRSQGKNSPYLGFELAGRVRATMVAGHL
EEEEECCCEECCCEECEEEECCCCCEEECHHHHHHCCCCCCEEEHEECCHHEEEEEEEEE
AYDGH
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-dihydroorotate; H2O

Specific reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]