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The map label for this gene is ilvB [H]

Identifier: 187935263

GI number: 187935263

Start: 729779

End: 731458

Strand: Reverse

Name: ilvB [H]

Synonym: CLL_A0727

Alternate gene names: 187935263

Gene position: 731458-729779 (Counterclockwise)

Preceding gene: 187933702

Following gene: 187933666

Centisome position: 19.25

GC content: 30.48

Gene sequence:

>1680_bases
ATGAAATACAATTGTGCGGAAATAGTTATTAAATTATTGGAAAATCAAGGTGTAAAATATATTGCTGGAATTCCTGGTGG
GTTTAACCTTCCAATATATGATGCTTTATATAAAAGTAATATAACTCATATCTTAGCTAGACATGAACAAGGTGCTGCTT
TTATAGCTCAAGGTATCTCAAGAAGTACAGGTAAACCCGGAGTATGCTTTGCAACATCTGGTCCGGGGGCTACAAATTTA
CTTACTGCTATTGCTGATGCTAAATTAGATTCTATTCCTCTAATTGCAATAACTGGACAAGTGCCTCTTTCCGCTATTGG
TACAGATGCTTTTCAAGAAGTTGATGCATATGGACTAACTATCCCTATTACTAAGCATAATTTTTTAGTTAGGAATTCCA
AAGATCTTTTTACTATTATCCCAGAAGCTTTTAAAATATCAATGGAAGGCCGTCCTGGCCCTGTACTGATAGATATTCCA
AAAAATATTCAAACCGAAATAATAGAAGTGGATGAAAATATTTTTAAACAAACCAAAAAAGATAATCATAAAAAAAAATC
TCCTAAAAGTTATAAACTTGAATGTATTGCTGAATTAATTAATACAGCAAAAAAGCCTATTATTTATGCTGGGGGAGGTA
TCATTAGTGCTAATGCCTCTAATAATCTATATGCATTATCTAAAAAAAGTAATATTCCAGTTGCTTTAAGCTTAATGGGA
TTAGGCGCATTTTCATCTAATGATGTTTTAAATTTAGGAATGCTTGGAATGCATGGAGCCCCTTATACAAATTATCTACT
TAACGAAGCAGATTTAATATTAGCATTTGGTGTTAGATTTGATGATAGAGCCACTGGAAATATAAATACATTTTGTCCTA
AAGCTACAATAATCCATATAGATATTGATCCTGCTGAAATTAACAAAGTTAAAATTAGTAGCCTATCTATGAATGAAAAT
ATTAAGTATTTCTTAGAGGATATTTTACCTCTTGTTAATAATAAAGAAAGAACAACCTGGATAGAACGAGTTAAATGCTT
TAAAAAAGATTATCCACTTCCTCAATTTGATAATCCTCTACATCCAACCAACATAATTTCTTTCGTAGGTAATACTGTTT
CTGATGATACGATAATTGTTACTGATGTAGGTGAACATCAAATGTGGACAGCTCAAAGATATCCTTTTAAGTATCCTAGA
ACTTTTTTGACTTCTGGTGGCTTAGGGACAATGGGATTTGGACTTCCTGCTGCAATTGGTGCTGCATTAGCAAATAAAGA
AAAACAAGTTATTTGCTTTTCTGGTGATGGTTCAATTTTAATGAATATCCAAGAACTTTCAACACTTAAAGATCTAGATT
TAAATATAAAAATAATAATATTAAATAATCATCATTTAGGATTGGTTCGCCAACAACAAGAATTATTTTATAACAAACAC
TTCATTGCATCAAAATTTATATCAAATCCCGATTTTAAATTAATTGCTAATGGCTTCGGAATAAATAGTTGTACTTTCTC
ACAAGAAAATGATTCATTTGAAAAATTAGAAGATATATTATCAAAACCTGGTCCTTATTTAATAAATATACTAATTAATG
AAACTGAAAATGTACTACCTATGGTTTATCCTGGTGGTGCAAATACAAAAATGATTGGTGGTGCAAATTTATATGATTAA

Upstream 100 bases:

>100_bases
TTAAAATAGTATCTAGGTAAGCTTCTCTTCGTCCTATTTTATTTGGATGAAGATTTTTTTATATATCTATAGGCTAATTT
TTGAAAGAGGAGTGATTTAT

Downstream 100 bases:

>100_bases
TACTGATTTTTATCTCGTTGAATTGCTTGTAAGAAATCATCCTGGAGTAATGAGTCATATAACAGGATTGTTTGCTAGAA
GAGCTTTTAATTTAGAAGGG

Product: acetolactate synthase, large subunit, biosynthetic type

Products: NA

Alternate protein names: AHAS-I; Acetohydroxy-acid synthase I large subunit; ALS-I [H]

Number of amino acids: Translated: 559; Mature: 559

Protein sequence:

>559_residues
MKYNCAEIVIKLLENQGVKYIAGIPGGFNLPIYDALYKSNITHILARHEQGAAFIAQGISRSTGKPGVCFATSGPGATNL
LTAIADAKLDSIPLIAITGQVPLSAIGTDAFQEVDAYGLTIPITKHNFLVRNSKDLFTIIPEAFKISMEGRPGPVLIDIP
KNIQTEIIEVDENIFKQTKKDNHKKKSPKSYKLECIAELINTAKKPIIYAGGGIISANASNNLYALSKKSNIPVALSLMG
LGAFSSNDVLNLGMLGMHGAPYTNYLLNEADLILAFGVRFDDRATGNINTFCPKATIIHIDIDPAEINKVKISSLSMNEN
IKYFLEDILPLVNNKERTTWIERVKCFKKDYPLPQFDNPLHPTNIISFVGNTVSDDTIIVTDVGEHQMWTAQRYPFKYPR
TFLTSGGLGTMGFGLPAAIGAALANKEKQVICFSGDGSILMNIQELSTLKDLDLNIKIIILNNHHLGLVRQQQELFYNKH
FIASKFISNPDFKLIANGFGINSCTFSQENDSFEKLEDILSKPGPYLINILINETENVLPMVYPGGANTKMIGGANLYD

Sequences:

>Translated_559_residues
MKYNCAEIVIKLLENQGVKYIAGIPGGFNLPIYDALYKSNITHILARHEQGAAFIAQGISRSTGKPGVCFATSGPGATNL
LTAIADAKLDSIPLIAITGQVPLSAIGTDAFQEVDAYGLTIPITKHNFLVRNSKDLFTIIPEAFKISMEGRPGPVLIDIP
KNIQTEIIEVDENIFKQTKKDNHKKKSPKSYKLECIAELINTAKKPIIYAGGGIISANASNNLYALSKKSNIPVALSLMG
LGAFSSNDVLNLGMLGMHGAPYTNYLLNEADLILAFGVRFDDRATGNINTFCPKATIIHIDIDPAEINKVKISSLSMNEN
IKYFLEDILPLVNNKERTTWIERVKCFKKDYPLPQFDNPLHPTNIISFVGNTVSDDTIIVTDVGEHQMWTAQRYPFKYPR
TFLTSGGLGTMGFGLPAAIGAALANKEKQVICFSGDGSILMNIQELSTLKDLDLNIKIIILNNHHLGLVRQQQELFYNKH
FIASKFISNPDFKLIANGFGINSCTFSQENDSFEKLEDILSKPGPYLINILINETENVLPMVYPGGANTKMIGGANLYD
>Mature_559_residues
MKYNCAEIVIKLLENQGVKYIAGIPGGFNLPIYDALYKSNITHILARHEQGAAFIAQGISRSTGKPGVCFATSGPGATNL
LTAIADAKLDSIPLIAITGQVPLSAIGTDAFQEVDAYGLTIPITKHNFLVRNSKDLFTIIPEAFKISMEGRPGPVLIDIP
KNIQTEIIEVDENIFKQTKKDNHKKKSPKSYKLECIAELINTAKKPIIYAGGGIISANASNNLYALSKKSNIPVALSLMG
LGAFSSNDVLNLGMLGMHGAPYTNYLLNEADLILAFGVRFDDRATGNINTFCPKATIIHIDIDPAEINKVKISSLSMNEN
IKYFLEDILPLVNNKERTTWIERVKCFKKDYPLPQFDNPLHPTNIISFVGNTVSDDTIIVTDVGEHQMWTAQRYPFKYPR
TFLTSGGLGTMGFGLPAAIGAALANKEKQVICFSGDGSILMNIQELSTLKDLDLNIKIIILNNHHLGLVRQQQELFYNKH
FIASKFISNPDFKLIANGFGINSCTFSQENDSFEKLEDILSKPGPYLINILINETENVLPMVYPGGANTKMIGGANLYD

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=581, Percent_Identity=22.7194492254733, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI93004078, Length=477, Percent_Identity=26.6247379454927, Blast_Score=132, Evalue=7e-31,
Organism=Escherichia coli, GI1790104, Length=558, Percent_Identity=51.6129032258064, Blast_Score=599, Evalue=1e-172,
Organism=Escherichia coli, GI87081685, Length=567, Percent_Identity=39.3298059964727, Blast_Score=424, Evalue=1e-120,
Organism=Escherichia coli, GI1786717, Length=564, Percent_Identity=29.2553191489362, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1787096, Length=548, Percent_Identity=25.7299270072993, Blast_Score=171, Evalue=9e-44,
Organism=Escherichia coli, GI1788716, Length=476, Percent_Identity=25.4201680672269, Blast_Score=128, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI17542570, Length=590, Percent_Identity=24.406779661017, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17531299, Length=580, Percent_Identity=25.3448275862069, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17531301, Length=580, Percent_Identity=25.3448275862069, Blast_Score=117, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323755, Length=567, Percent_Identity=40.2116402116402, Blast_Score=413, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6320588, Length=539, Percent_Identity=21.7068645640074, Blast_Score=84, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6320816, Length=570, Percent_Identity=21.4035087719298, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323163, Length=466, Percent_Identity=23.3905579399142, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323073, Length=479, Percent_Identity=22.964509394572, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321524, Length=478, Percent_Identity=21.3389121338912, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19922626, Length=481, Percent_Identity=27.2349272349272, Blast_Score=165, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 61335; Mature: 61335

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYNCAEIVIKLLENQGVKYIAGIPGGFNLPIYDALYKSNITHILARHEQGAAFIAQGIS
CCCCHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHH
RSTGKPGVCFATSGPGATNLLTAIADAKLDSIPLIAITGQVPLSAIGTDAFQEVDAYGLT
CCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHCCHHHHHHHHCCEE
IPITKHNFLVRNSKDLFTIIPEAFKISMEGRPGPVLIDIPKNIQTEIIEVDENIFKQTKK
EEEECCEEEEECCCCEEEECCCEEEEEECCCCCCEEEECCCCCCCCEEEHHHHHHHHHHH
DNHKKKSPKSYKLECIAELINTAKKPIIYAGGGIISANASNNLYALSKKSNIPVALSLMG
CCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCEEEEECCCCCCEEEEEEE
LGAFSSNDVLNLGMLGMHGAPYTNYLLNEADLILAFGVRFDDRATGNINTFCPKATIIHI
CCCCCCCCEEEEEEECCCCCCHHHHHHCCCCEEEEECCEECCCCCCCCCEECCCEEEEEE
DIDPAEINKVKISSLSMNENIKYFLEDILPLVNNKERTTWIERVKCFKKDYPLPQFDNPL
ECCHHHCCEEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCC
HPTNIISFVGNTVSDDTIIVTDVGEHQMWTAQRYPFKYPRTFLTSGGLGTMGFGLPAAIG
CHHHHHHHHCCCCCCCEEEEEECCCCCEEEECCCCCCCCHHHHCCCCCCCCCCCHHHHHH
AALANKEKQVICFSGDGSILMNIQELSTLKDLDLNIKIIILNNHHLGLVRQQQELFYNKH
HHHCCCCCEEEEECCCCCEEEEHHHHHHHHCCCCEEEEEEECCCCEEEEEHHHHHHHHHH
FIASKFISNPDFKLIANGFGINSCTFSQENDSFEKLEDILSKPGPYLINILINETENVLP
HHHHHHHCCCCEEEEECCCCCCEEECCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCEE
MVYPGGANTKMIGGANLYD
EEECCCCCCEEECCCCCCC
>Mature Secondary Structure
MKYNCAEIVIKLLENQGVKYIAGIPGGFNLPIYDALYKSNITHILARHEQGAAFIAQGIS
CCCCHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHHHH
RSTGKPGVCFATSGPGATNLLTAIADAKLDSIPLIAITGQVPLSAIGTDAFQEVDAYGLT
CCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCHHHHCCHHHHHHHHCCEE
IPITKHNFLVRNSKDLFTIIPEAFKISMEGRPGPVLIDIPKNIQTEIIEVDENIFKQTKK
EEEECCEEEEECCCCEEEECCCEEEEEECCCCCCEEEECCCCCCCCEEEHHHHHHHHHHH
DNHKKKSPKSYKLECIAELINTAKKPIIYAGGGIISANASNNLYALSKKSNIPVALSLMG
CCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCEEEECCCCCEEEEECCCCCCEEEEEEE
LGAFSSNDVLNLGMLGMHGAPYTNYLLNEADLILAFGVRFDDRATGNINTFCPKATIIHI
CCCCCCCCEEEEEEECCCCCCHHHHHHCCCCEEEEECCEECCCCCCCCCEECCCEEEEEE
DIDPAEINKVKISSLSMNENIKYFLEDILPLVNNKERTTWIERVKCFKKDYPLPQFDNPL
ECCHHHCCEEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCC
HPTNIISFVGNTVSDDTIIVTDVGEHQMWTAQRYPFKYPRTFLTSGGLGTMGFGLPAAIG
CHHHHHHHHCCCCCCCEEEEEECCCCCEEEECCCCCCCCHHHHCCCCCCCCCCCHHHHHH
AALANKEKQVICFSGDGSILMNIQELSTLKDLDLNIKIIILNNHHLGLVRQQQELFYNKH
HHHCCCCCEEEEECCCCCEEEEHHHHHHHHCCCCEEEEEEECCCCEEEEEHHHHHHHHHH
FIASKFISNPDFKLIANGFGINSCTFSQENDSFEKLEDILSKPGPYLINILINETENVLP
HHHHHHHCCCCEEEEECCCCCCEEECCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCEE
MVYPGGANTKMIGGANLYD
EEECCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2989782; 2989781; 7686882; 9278503 [H]