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The map label for this gene is mraW [H]

Identifier: 187934997

GI number: 187934997

Start: 2532362

End: 2533294

Strand: Reverse

Name: mraW [H]

Synonym: CLL_A2448

Alternate gene names: 187934997

Gene position: 2533294-2532362 (Counterclockwise)

Preceding gene: 187934815

Following gene: 187934253

Centisome position: 66.66

GC content: 30.76

Gene sequence:

>933_bases
ATGGAATTTAAACATATTTCAGTTTTACTAAATGAGTGCTTAGACGCATTAGATATAAAGGATAATGGAATTTATGTTGA
CTGTACACTAGGCGGAGCAGGACATTCATCTCATATATTAGAGCGTTTATCAAATGAAGGTTTATTAATAGGTATAGATC
AAGATAGAGATGCCTTAAAAGCGGCAAAAGAAAGATTGAAAAGGTTTGAAAATGTAAAATATGTTCATAGTAACTTTTAT
GACATAGATAATATTCTTCAAAATTTAGATATACCAAAAGTAGACGGTATATTAATGGATCTTGGAGTATCTTCTTATCA
ATTAGATGAGGGAGCAAGAGGCTTTAGTTATATGAAAGATGCTCCTTTAGATATGAGAATGAATAGAGATAATGATTTTT
CAGCTTATGAAATTGTAAATGAATATAGTGAGGATGAATTATATAAAATAATAAGAAATTATGGTGAAGAAAGATTTGCA
AAAAGAATCTCTAACTGTATAGTAAATAGAAGAAGCGATAAGCCTATAGAGACTACTATGGAACTAGTTGACATAATTAA
GGCAGCTATTCCGGCAAAAGCAAGAAGAGAGGGACCACACCCAGCAAAAAGAACTTTTCAAGCTATAAGAATAGAAGTGA
ATTCAGAACTAAAAATACTTAACCAAACTATTGAAGATGGTGTAAATAGATTAAAGCCTGGTGGAAGAATGGCTATAATA
ACCTTTCATTCATTAGAAGATAGAATAGTTAAGCTTAAATTTAGAGAACTTAATGATCCATGTACATGTCCAAGAGAATT
TCCAATGTGTATTTGCGGCAAAAAACCTAGCGTTAGGCTAATATCTAGAAAAGGAATAGAACCTACTAAAGAAGAGGTTG
AAGAAAATCCAAGAAGTAGAAGTGCAAAACTTAGAATAATTGAGAAATTATAA

Upstream 100 bases:

>100_bases
TTGGAGCAGGGAAAAGTGGATTAATTACAACGAATCAGATATAGATTATGATCTGATTGCAGAAAAAATGAATGATTTAG
GAATATAAGGAGTTTTTAAT

Downstream 100 bases:

>100_bases
AATTTAATTTTTATTATGTTATAAATTAAGCGGGGATGTGAATAAATTGGAAGGAAAAGAATATGATTATATTAAAGGTA
GTACAGCAGTAAAACCATCG

Product: S-adenosyl-methyltransferase MraW

Products: NA

Alternate protein names: 16S rRNA m(4)C1402 methyltransferase; rRNA (cytosine-N(4)-)-methyltransferase RsmH [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MEFKHISVLLNECLDALDIKDNGIYVDCTLGGAGHSSHILERLSNEGLLIGIDQDRDALKAAKERLKRFENVKYVHSNFY
DIDNILQNLDIPKVDGILMDLGVSSYQLDEGARGFSYMKDAPLDMRMNRDNDFSAYEIVNEYSEDELYKIIRNYGEERFA
KRISNCIVNRRSDKPIETTMELVDIIKAAIPAKARREGPHPAKRTFQAIRIEVNSELKILNQTIEDGVNRLKPGGRMAII
TFHSLEDRIVKLKFRELNDPCTCPREFPMCICGKKPSVRLISRKGIEPTKEEVEENPRSRSAKLRIIEKL

Sequences:

>Translated_310_residues
MEFKHISVLLNECLDALDIKDNGIYVDCTLGGAGHSSHILERLSNEGLLIGIDQDRDALKAAKERLKRFENVKYVHSNFY
DIDNILQNLDIPKVDGILMDLGVSSYQLDEGARGFSYMKDAPLDMRMNRDNDFSAYEIVNEYSEDELYKIIRNYGEERFA
KRISNCIVNRRSDKPIETTMELVDIIKAAIPAKARREGPHPAKRTFQAIRIEVNSELKILNQTIEDGVNRLKPGGRMAII
TFHSLEDRIVKLKFRELNDPCTCPREFPMCICGKKPSVRLISRKGIEPTKEEVEENPRSRSAKLRIIEKL
>Mature_310_residues
MEFKHISVLLNECLDALDIKDNGIYVDCTLGGAGHSSHILERLSNEGLLIGIDQDRDALKAAKERLKRFENVKYVHSNFY
DIDNILQNLDIPKVDGILMDLGVSSYQLDEGARGFSYMKDAPLDMRMNRDNDFSAYEIVNEYSEDELYKIIRNYGEERFA
KRISNCIVNRRSDKPIETTMELVDIIKAAIPAKARREGPHPAKRTFQAIRIEVNSELKILNQTIEDGVNRLKPGGRMAII
TFHSLEDRIVKLKFRELNDPCTCPREFPMCICGKKPSVRLISRKGIEPTKEEVEENPRSRSAKLRIIEKL

Specific function: Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA [H]

COG id: COG0275

COG function: function code M; Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RsmH family [H]

Homologues:

Organism=Homo sapiens, GI165377209, Length=340, Percent_Identity=35.5882352941176, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI165377202, Length=188, Percent_Identity=36.7021276595745, Blast_Score=115, Evalue=6e-26,
Organism=Escherichia coli, GI1786270, Length=316, Percent_Identity=43.9873417721519, Blast_Score=255, Evalue=2e-69,
Organism=Drosophila melanogaster, GI62472493, Length=329, Percent_Identity=35.5623100303951, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI28571637, Length=329, Percent_Identity=35.5623100303951, Blast_Score=159, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002903 [H]

Pfam domain/function: PF01795 Methyltransf_5 [H]

EC number: NA

Molecular weight: Translated: 35528; Mature: 35528

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFKHISVLLNECLDALDIKDNGIYVDCTLGGAGHSSHILERLSNEGLLIGIDQDRDALK
CCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEECCCHHHHH
AAKERLKRFENVKYVHSNFYDIDNILQNLDIPKVDGILMDLGVSSYQLDEGARGFSYMKD
HHHHHHHHHHCCHHHHHCCCCHHHHHHHCCCCCCCCCHHHCCCCCEECCCCCCCCHHHCC
APLDMRMNRDNDFSAYEIVNEYSEDELYKIIRNYGEERFAKRISNCIVNRRSDKPIETTM
CCCCEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
ELVDIIKAAIPAKARREGPHPAKRTFQAIRIEVNSELKILNQTIEDGVNRLKPGGRMAII
HHHHHHHHHCCHHHHCCCCCHHHHHHHHEEEEECCHHHHHHHHHHHHHHHCCCCCCEEEE
TFHSLEDRIVKLKFRELNDPCTCPREFPMCICGKKPSVRLISRKGIEPTKEEVEENPRSR
EEECCCCHHEEEHHHHCCCCCCCCCCCCEEEECCCCCEEEHCCCCCCCCHHHHHCCCCCC
SAKLRIIEKL
CHHHHEEECC
>Mature Secondary Structure
MEFKHISVLLNECLDALDIKDNGIYVDCTLGGAGHSSHILERLSNEGLLIGIDQDRDALK
CCCHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCEEEEECCCHHHHH
AAKERLKRFENVKYVHSNFYDIDNILQNLDIPKVDGILMDLGVSSYQLDEGARGFSYMKD
HHHHHHHHHHCCHHHHHCCCCHHHHHHHCCCCCCCCCHHHCCCCCEECCCCCCCCHHHCC
APLDMRMNRDNDFSAYEIVNEYSEDELYKIIRNYGEERFAKRISNCIVNRRSDKPIETTM
CCCCEEECCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
ELVDIIKAAIPAKARREGPHPAKRTFQAIRIEVNSELKILNQTIEDGVNRLKPGGRMAII
HHHHHHHHHCCHHHHCCCCCHHHHHHHHEEEEECCHHHHHHHHHHHHHHHCCCCCCEEEE
TFHSLEDRIVKLKFRELNDPCTCPREFPMCICGKKPSVRLISRKGIEPTKEEVEENPRSR
EEECCCCHHEEEHHHHCCCCCCCCCCCCEEEECCCCCEEEHCCCCCCCCHHHHHCCCCCC
SAKLRIIEKL
CHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA