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The map label for this gene is blaI [H]

Identifier: 187934349

GI number: 187934349

Start: 2048247

End: 2048642

Strand: Reverse

Name: blaI [H]

Synonym: CLL_A1971

Alternate gene names: 187934349

Gene position: 2048642-2048247 (Counterclockwise)

Preceding gene: 187934353

Following gene: 187934726

Centisome position: 53.91

GC content: 25.25

Gene sequence:

>396_bases
ATGAGTGATATTCCTAAAATCTCAGAATCGGAATGGGAAGTTATGAAAACTTTATGGAAGACAAATCCATTAACCTCTGA
AGAAATAATAGATACATTGAGTTTGAAAATGAGTTGGTCAAAACAAACTATAAAAACTTTTATAACAAGACTTATAAAAA
AAGGGGTTATAGGTTTTAAAAAAGATGGTAGGGTATATAATTACTATCCTTTAATTTCTGAGGGAGATTGTATGAAGTTT
GAAAATAAATCTTTTATTAAAAAAGTATATGATGGAGCTTTAAATATTCTTTTTAGTAGCTTCTTAGAAGAGGAGGATCT
ATCTATTGATGAAATTGAAGAATTAGAAAAAATTCTTAAAGAAAAAAAGGAAAAAATCAATATAAAAGATTTTTAA

Upstream 100 bases:

>100_bases
TGGAATAAATGTAAAAATATTCTTGACGTAATTAATCTACAAGTGTAAACTTAACTTTAAGATTTACAATTGTAGATTAA
AAAGAAAGGAGCTGAATTTT

Downstream 100 bases:

>100_bases
CTATATAACGAGAAGGGGTATATTTTTATGGGGAGTTTAGAAAAGGTTTTTTTATGGTTTTTTCAAACATCTTTAACAGC
AGCTATCATTATTTTAATAA

Product: penicillinase repressor

Products: NA

Alternate protein names: Beta-lactamase repressor protein; Regulatory protein BlaI [H]

Number of amino acids: Translated: 131; Mature: 130

Protein sequence:

>131_residues
MSDIPKISESEWEVMKTLWKTNPLTSEEIIDTLSLKMSWSKQTIKTFITRLIKKGVIGFKKDGRVYNYYPLISEGDCMKF
ENKSFIKKVYDGALNILFSSFLEEEDLSIDEIEELEKILKEKKEKINIKDF

Sequences:

>Translated_131_residues
MSDIPKISESEWEVMKTLWKTNPLTSEEIIDTLSLKMSWSKQTIKTFITRLIKKGVIGFKKDGRVYNYYPLISEGDCMKF
ENKSFIKKVYDGALNILFSSFLEEEDLSIDEIEELEKILKEKKEKINIKDF
>Mature_130_residues
SDIPKISESEWEVMKTLWKTNPLTSEEIIDTLSLKMSWSKQTIKTFITRLIKKGVIGFKKDGRVYNYYPLISEGDCMKFE
NKSFIKKVYDGALNILFSSFLEEEDLSIDEIEELEKILKEKKEKINIKDF

Specific function: Transcriptional repressor that constitutively blocks expression of beta-lactamase. Regulates genes involved in antibiotic resistance. Binds DNA as a dimer [H]

COG id: COG3682

COG function: function code K; Predicted transcriptional regulator

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the BlaI transcriptional regulatory family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005650
- InterPro:   IPR011991 [H]

Pfam domain/function: PF03965 Pencillinase_R [H]

EC number: NA

Molecular weight: Translated: 15414; Mature: 15283

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIPKISESEWEVMKTLWKTNPLTSEEIIDTLSLKMSWSKQTIKTFITRLIKKGVIGFK
CCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCC
KDGRVYNYYPLISEGDCMKFENKSFIKKVYDGALNILFSSFLEEEDLSIDEIEELEKILK
CCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
EKKEKINIKDF
HHHHHCCCCCC
>Mature Secondary Structure 
SDIPKISESEWEVMKTLWKTNPLTSEEIIDTLSLKMSWSKQTIKTFITRLIKKGVIGFK
CCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCC
KDGRVYNYYPLISEGDCMKFENKSFIKKVYDGALNILFSSFLEEEDLSIDEIEELEKILK
CCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
EKKEKINIKDF
HHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096969; 3305074; 3260234; 3040663; 3498148 [H]