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The map label for this gene is dxs [H]

Identifier: 187934347

GI number: 187934347

Start: 2492544

End: 2494403

Strand: Reverse

Name: dxs [H]

Synonym: CLL_A2401

Alternate gene names: 187934347

Gene position: 2494403-2492544 (Counterclockwise)

Preceding gene: 187932330

Following gene: 187933335

Centisome position: 65.64

GC content: 30.27

Gene sequence:

>1860_bases
ATGAAGTCATTATTAGATAGTTTAAATTTCCCAAAAGATTTAAATAATTTAAATGATAGTGATACAGAGAGATTAAGTAA
AGAAATAAGACAATTTTTAATAGAAAGTGTTTCAAAAACAGGAGGACACTTATCATCTAATTTAGGTGTTGTAGAGCTTA
CTTTGAGTCTTATGAAATCTTTTGATTTTGAAAAAGACAAAATAGTATGGGATGTGGGACATCAAAGTTATGTGTATAAG
ATTTTAACTGGTAGAAAAGATGGATTTAAAAATCTTAGACAATTTGATGGTTTAAGTGGATTTCCAAAGAGAAATGAAAG
CAAGTATGATTATTTTGACACAGGTCATAGTAGTACTTCAATATCAGCTGGACTTGGAATGGCAAGAGCTAGAGATTTAA
AGAAAGAAAAGTACACTGTAGTTTCTGTAATAGGAGATGGAGCTTTAACAGGTGGAATGGCATTAGAAGCTTTAAATGAT
GTTGGTTTTAGAAAAACTAAAATGGTGATAATTTTAAACGATAATCAAATGTCTATTTCACTTAATGTTGGTGGACTTTC
TAGATATTTAAATAAATTAAGAATGGGCGAAACATACAATAGATTGAAAACTAATATAAATACATCTCTTGGTTCATCTG
ATTTAGGAAAAGATATTATTTCTAAAATGTCAAAAGTAAAGGATAGTATAAAGCAATTAGTTGTACCTTCAATGTTTTTT
GAAAATATGGGAGTAAAATATATAGGTCCTATTGACGGGCATGATATAAAAGCAATGAATGAAGTATTTAGCAAGGTTAA
AGATGTGGAAGGTCCTGTTATAATACATACAGTAACTCAAAAAGGTAGAGGATATTCATTAGCAGAAAAAAGTCCATCTA
AGTATCATGCAGTACCACCTAGAGCTAATGAAAAAGAGAAACCTAGTAAACCTTGTAAGGACACATATTCTAAAGCTTTT
GGTAATGCATTAATTAATATAGCAAAAGAAGAAAAAGAAGTAGTTGCTATAACCGCAGCTATGCCAGATGGAACTGGACT
AAAAGAATTTTCTACTATTTATCCAGAAAGATTTTTTGATGTTGGAATAGCAGAGCAACATGCAGTGACTTTAGCAGCAG
GAATGGCAGCAAATGGCTTAAAACCAGTATTTGCAGTATACTCTACCTTTTTACAAAGAGGGTTTGATCAGGTAATACAT
GATGTATGTATTCAAGATTTACCTGTAACATTTGCTATAGATAGAGCTGGAATAGTAGGAGATGATGGTGAAACTCATCA
AGGAATTATGGATGTAAGCTATTTGTCAATGATGCCTAATATGACAATAGTAGCTCCTAAATGTACAGAAGAAATTCCAA
GTATGTTAAGATGGGCGATAAAAAAGAACTCCCCTGTAGCAATAAGATACCCAAGAGGTAAAGATATTGTCTGTAATTTA
CATGCTTTACAAGAGATAAGTTATGGAAAATGGGAAGTTGTAAGTGAAGGAAAGAGAATATGTATTATTGCTAGTGGAAG
AATGCTTCAACATGCATTTTTAGCAAAAGAAATACTAAAAGAAAATGGAATAGATCCTAAGATAGTAAATGCAACATTTA
TAAAACCAATAGATAAGTGTTTATTAGAAAATTTAAAAGAAGATGGATATGATATTTTGACTATTGAGGATAATATTATA
TGCGGAGGCTTAGGAATGGCTGTTCTAGAACATTTAAATTGTATAGATTATAAGGGAAATATGAAATTATTAGGATATGA
TGATGAATTTATCCCACAAGGAAATGTAGAAATACTTTATAAAACATATGGATTAGATCCTGTAAGTATAAGTAATACAA
TCCTTAAACTTTATAATTAA

Upstream 100 bases:

>100_bases
GTATAAAAATTTTAGATAATTTAAGTGTAGATGCTAGTCTATTAAAAGAATTAACGCATAATCTTTTAAATAGACTAAAT
TAAAAAAGGGAATGGTTATT

Downstream 100 bases:

>100_bases
AAGGAGAATATAATATATGGCAGAAAAAAAGGAAAGACTTGATATACTTTTAGTAGAAAAGGGTATAATTACTTCTAGGG
ATAGAGCTAAGGCTTGTATT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 619; Mature: 619

Protein sequence:

>619_residues
MKSLLDSLNFPKDLNNLNDSDTERLSKEIRQFLIESVSKTGGHLSSNLGVVELTLSLMKSFDFEKDKIVWDVGHQSYVYK
ILTGRKDGFKNLRQFDGLSGFPKRNESKYDYFDTGHSSTSISAGLGMARARDLKKEKYTVVSVIGDGALTGGMALEALND
VGFRKTKMVIILNDNQMSISLNVGGLSRYLNKLRMGETYNRLKTNINTSLGSSDLGKDIISKMSKVKDSIKQLVVPSMFF
ENMGVKYIGPIDGHDIKAMNEVFSKVKDVEGPVIIHTVTQKGRGYSLAEKSPSKYHAVPPRANEKEKPSKPCKDTYSKAF
GNALINIAKEEKEVVAITAAMPDGTGLKEFSTIYPERFFDVGIAEQHAVTLAAGMAANGLKPVFAVYSTFLQRGFDQVIH
DVCIQDLPVTFAIDRAGIVGDDGETHQGIMDVSYLSMMPNMTIVAPKCTEEIPSMLRWAIKKNSPVAIRYPRGKDIVCNL
HALQEISYGKWEVVSEGKRICIIASGRMLQHAFLAKEILKENGIDPKIVNATFIKPIDKCLLENLKEDGYDILTIEDNII
CGGLGMAVLEHLNCIDYKGNMKLLGYDDEFIPQGNVEILYKTYGLDPVSISNTILKLYN

Sequences:

>Translated_619_residues
MKSLLDSLNFPKDLNNLNDSDTERLSKEIRQFLIESVSKTGGHLSSNLGVVELTLSLMKSFDFEKDKIVWDVGHQSYVYK
ILTGRKDGFKNLRQFDGLSGFPKRNESKYDYFDTGHSSTSISAGLGMARARDLKKEKYTVVSVIGDGALTGGMALEALND
VGFRKTKMVIILNDNQMSISLNVGGLSRYLNKLRMGETYNRLKTNINTSLGSSDLGKDIISKMSKVKDSIKQLVVPSMFF
ENMGVKYIGPIDGHDIKAMNEVFSKVKDVEGPVIIHTVTQKGRGYSLAEKSPSKYHAVPPRANEKEKPSKPCKDTYSKAF
GNALINIAKEEKEVVAITAAMPDGTGLKEFSTIYPERFFDVGIAEQHAVTLAAGMAANGLKPVFAVYSTFLQRGFDQVIH
DVCIQDLPVTFAIDRAGIVGDDGETHQGIMDVSYLSMMPNMTIVAPKCTEEIPSMLRWAIKKNSPVAIRYPRGKDIVCNL
HALQEISYGKWEVVSEGKRICIIASGRMLQHAFLAKEILKENGIDPKIVNATFIKPIDKCLLENLKEDGYDILTIEDNII
CGGLGMAVLEHLNCIDYKGNMKLLGYDDEFIPQGNVEILYKTYGLDPVSISNTILKLYN
>Mature_619_residues
MKSLLDSLNFPKDLNNLNDSDTERLSKEIRQFLIESVSKTGGHLSSNLGVVELTLSLMKSFDFEKDKIVWDVGHQSYVYK
ILTGRKDGFKNLRQFDGLSGFPKRNESKYDYFDTGHSSTSISAGLGMARARDLKKEKYTVVSVIGDGALTGGMALEALND
VGFRKTKMVIILNDNQMSISLNVGGLSRYLNKLRMGETYNRLKTNINTSLGSSDLGKDIISKMSKVKDSIKQLVVPSMFF
ENMGVKYIGPIDGHDIKAMNEVFSKVKDVEGPVIIHTVTQKGRGYSLAEKSPSKYHAVPPRANEKEKPSKPCKDTYSKAF
GNALINIAKEEKEVVAITAAMPDGTGLKEFSTIYPERFFDVGIAEQHAVTLAAGMAANGLKPVFAVYSTFLQRGFDQVIH
DVCIQDLPVTFAIDRAGIVGDDGETHQGIMDVSYLSMMPNMTIVAPKCTEEIPSMLRWAIKKNSPVAIRYPRGKDIVCNL
HALQEISYGKWEVVSEGKRICIIASGRMLQHAFLAKEILKENGIDPKIVNATFIKPIDKCLLENLKEDGYDILTIEDNII
CGGLGMAVLEHLNCIDYKGNMKLLGYDDEFIPQGNVEILYKTYGLDPVSISNTILKLYN

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=605, Percent_Identity=23.9669421487603, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI4507521, Length=605, Percent_Identity=23.9669421487603, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI225637463, Length=402, Percent_Identity=24.8756218905473, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI225637461, Length=402, Percent_Identity=24.8756218905473, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI225637459, Length=402, Percent_Identity=24.8756218905473, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI133778974, Length=363, Percent_Identity=23.9669421487603, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1786622, Length=627, Percent_Identity=42.5837320574163, Blast_Score=491, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17539652, Length=653, Percent_Identity=21.2863705972435, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45551847, Length=597, Percent_Identity=23.9530988274707, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI45550715, Length=597, Percent_Identity=23.9530988274707, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24645119, Length=556, Percent_Identity=24.2805755395683, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24666278, Length=607, Percent_Identity=24.0527182866557, Blast_Score=105, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 68614; Mature: 68614

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLLDSLNFPKDLNNLNDSDTERLSKEIRQFLIESVSKTGGHLSSNLGVVELTLSLMKS
CCHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
FDFEKDKIVWDVGHQSYVYKILTGRKDGFKNLRQFDGLSGFPKRNESKYDYFDTGHSSTS
CCCCCCCEEEECCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
ISAGLGMARARDLKKEKYTVVSVIGDGALTGGMALEALNDVGFRKTKMVIILNDNQMSIS
HHHCCCHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEECCCEEEEE
LNVGGLSRYLNKLRMGETYNRLKTNINTSLGSSDLGKDIISKMSKVKDSIKQLVVPSMFF
EECCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENMGVKYIGPIDGHDIKAMNEVFSKVKDVEGPVIIHTVTQKGRGYSLAEKSPSKYHAVPP
HCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHCCCCCCEECCCC
RANEKEKPSKPCKDTYSKAFGNALINIAKEEKEVVAITAAMPDGTGLKEFSTIYPERFFD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHCCHHHHH
VGIAEQHAVTLAAGMAANGLKPVFAVYSTFLQRGFDQVIHDVCIQDLPVTFAIDRAGIVG
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEC
DDGETHQGIMDVSYLSMMPNMTIVAPKCTEEIPSMLRWAIKKNSPVAIRYPRGKDIVCNL
CCCCCCCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEH
HALQEISYGKWEVVSEGKRICIIASGRMLQHAFLAKEILKENGIDPKIVNATFIKPIDKC
HHHHHCCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHH
LLENLKEDGYDILTIEDNIICGGLGMAVLEHLNCIDYKGNMKLLGYDDEFIPQGNVEILY
HHHHHHHCCCEEEEEECCEEECHHHHHHHHHCCCEECCCCEEEECCCCCCCCCCCEEEEE
KTYGLDPVSISNTILKLYN
EEECCCCCCHHHHHHEECC
>Mature Secondary Structure
MKSLLDSLNFPKDLNNLNDSDTERLSKEIRQFLIESVSKTGGHLSSNLGVVELTLSLMKS
CCHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHH
FDFEKDKIVWDVGHQSYVYKILTGRKDGFKNLRQFDGLSGFPKRNESKYDYFDTGHSSTS
CCCCCCCEEEECCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
ISAGLGMARARDLKKEKYTVVSVIGDGALTGGMALEALNDVGFRKTKMVIILNDNQMSIS
HHHCCCHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEECCCEEEEE
LNVGGLSRYLNKLRMGETYNRLKTNINTSLGSSDLGKDIISKMSKVKDSIKQLVVPSMFF
EECCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ENMGVKYIGPIDGHDIKAMNEVFSKVKDVEGPVIIHTVTQKGRGYSLAEKSPSKYHAVPP
HCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHCCCCCCEECCCC
RANEKEKPSKPCKDTYSKAFGNALINIAKEEKEVVAITAAMPDGTGLKEFSTIYPERFFD
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHCCHHHHH
VGIAEQHAVTLAAGMAANGLKPVFAVYSTFLQRGFDQVIHDVCIQDLPVTFAIDRAGIVG
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEC
DDGETHQGIMDVSYLSMMPNMTIVAPKCTEEIPSMLRWAIKKNSPVAIRYPRGKDIVCNL
CCCCCCCCHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEH
HALQEISYGKWEVVSEGKRICIIASGRMLQHAFLAKEILKENGIDPKIVNATFIKPIDKC
HHHHHCCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHH
LLENLKEDGYDILTIEDNIICGGLGMAVLEHLNCIDYKGNMKLLGYDDEFIPQGNVEILY
HHHHHHHCCCEEEEEECCEEECHHHHHHHHHCCCEECCCCEEEECCCCCCCCCCCEEEEE
KTYGLDPVSISNTILKLYN
EEECCCCCCHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA