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The map label for this gene is ppnK [H]

Identifier: 187933816

GI number: 187933816

Start: 2490846

End: 2491700

Strand: Reverse

Name: ppnK [H]

Synonym: CLL_A2399

Alternate gene names: 187933816

Gene position: 2491700-2490846 (Counterclockwise)

Preceding gene: 187933335

Following gene: 187932857

Centisome position: 65.57

GC content: 27.95

Gene sequence:

>855_bases
ATGAAAAATATAGGTATTGCGATAAATCCATCAAAAGACTATAAAAATACAATTTTAAATATGGTAAAAGAAAAAATTAA
GAACATTTGCAATATTACTGATATTGAAGTATACAATAGTTTTGATATAAAAAATTTAAATTTAAGCTCATTGGATTTAC
TTATTGTTTTAGGCGGAGATGGAACTCTTCTTGGAGTAGCAAGGGAATTAGATGATGATTTTAAGGCACCTATATTAGGA
ATAAATATAGGTAATTTAGGAGTTCTATCTAGTATAGAAATATCCGATTTAGAGTTAGCACTAAAAAAATTAATGACTAA
AGATTGTAAAGTACACAAGAGAATGATGTTAAACTGTGAAGTTGATATAAATGAGTCAATAAAGAACATAAAGGCTTTAA
ATGAAGTTGCAGTAGCAAGAGGAACATTGTCAAGAATGGTAAAATTCAAGATATTTGTTGATGAAAAATTATATGCTATA
TTTAAAGGTGATGGACTTATCGTTTCAACGCCTACGGGGTCAACAGCATATTCTTTTTCAGCAGGAGGACCATTTATATG
TCCAGACTTAGAAGTTATTAGTATAGTGCCTATATGCGATCATACAAAGAGTATGCATCCAATTGTATTGAAAGGTGATA
GCACTATAAAGATAATAGCACAAAATGGCGGAGATCAAATATACTTGACAATAGATGGACAAAGAGCAATAGAAATGAAA
GATAATTCTGTTATAACTGTAAAAAAGAATCCAAAGTCATTAAAATTACTGTTATTTAATGATTATGATTATTTTAAAGT
AATAAGAAATAAGGTATTAAATAATTCTAAGGAATGTGATGGTGAAAAAAATTGA

Upstream 100 bases:

>100_bases
TTACAAAAGACGCTGAGAAAGAAAGTAATTTTGAACTTGATGATGTAGAAAGGGTTGTAGAGGAATCTCATAAAGAACTT
TAGAGATTTTCGGAGGGGTT

Downstream 100 bases:

>100_bases
AATCAAAAAGACATACTAAGATATTAGAAATTATATCATCTAAAGAAATAGAAACTCAGGAAGACTTAGCAGAAGAATTA
AAATTACAAGGTTTTGATGT

Product: NAD(+)/NADH kinase

Products: NA

Alternate protein names: Poly(P)/ATP NAD kinase [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MKNIGIAINPSKDYKNTILNMVKEKIKNICNITDIEVYNSFDIKNLNLSSLDLLIVLGGDGTLLGVARELDDDFKAPILG
INIGNLGVLSSIEISDLELALKKLMTKDCKVHKRMMLNCEVDINESIKNIKALNEVAVARGTLSRMVKFKIFVDEKLYAI
FKGDGLIVSTPTGSTAYSFSAGGPFICPDLEVISIVPICDHTKSMHPIVLKGDSTIKIIAQNGGDQIYLTIDGQRAIEMK
DNSVITVKKNPKSLKLLLFNDYDYFKVIRNKVLNNSKECDGEKN

Sequences:

>Translated_284_residues
MKNIGIAINPSKDYKNTILNMVKEKIKNICNITDIEVYNSFDIKNLNLSSLDLLIVLGGDGTLLGVARELDDDFKAPILG
INIGNLGVLSSIEISDLELALKKLMTKDCKVHKRMMLNCEVDINESIKNIKALNEVAVARGTLSRMVKFKIFVDEKLYAI
FKGDGLIVSTPTGSTAYSFSAGGPFICPDLEVISIVPICDHTKSMHPIVLKGDSTIKIIAQNGGDQIYLTIDGQRAIEMK
DNSVITVKKNPKSLKLLLFNDYDYFKVIRNKVLNNSKECDGEKN
>Mature_284_residues
MKNIGIAINPSKDYKNTILNMVKEKIKNICNITDIEVYNSFDIKNLNLSSLDLLIVLGGDGTLLGVARELDDDFKAPILG
INIGNLGVLSSIEISDLELALKKLMTKDCKVHKRMMLNCEVDINESIKNIKALNEVAVARGTLSRMVKFKIFVDEKLYAI
FKGDGLIVSTPTGSTAYSFSAGGPFICPDLEVISIVPICDHTKSMHPIVLKGDSTIKIIAQNGGDQIYLTIDGQRAIEMK
DNSVITVKKNPKSLKLLLFNDYDYFKVIRNKVLNNSKECDGEKN

Specific function: Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus [H]

COG id: COG0061

COG function: function code G; Predicted sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAD kinase family [H]

Homologues:

Organism=Homo sapiens, GI55743112, Length=255, Percent_Identity=29.0196078431373, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1788968, Length=282, Percent_Identity=31.9148936170213, Blast_Score=153, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6320794, Length=247, Percent_Identity=31.9838056680162, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322509, Length=245, Percent_Identity=29.7959183673469, Blast_Score=126, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6325068, Length=170, Percent_Identity=34.1176470588235, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28573832, Length=209, Percent_Identity=31.5789473684211, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28573830, Length=209, Percent_Identity=31.5789473684211, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28573828, Length=209, Percent_Identity=31.5789473684211, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI161077047, Length=209, Percent_Identity=31.5789473684211, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28573826, Length=209, Percent_Identity=31.5789473684211, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI20129957, Length=242, Percent_Identity=27.2727272727273, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI281363321, Length=242, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24653424, Length=234, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281363323, Length=242, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24653422, Length=242, Percent_Identity=27.2727272727273, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016064
- InterPro:   IPR017438
- InterPro:   IPR017437
- InterPro:   IPR002504 [H]

Pfam domain/function: PF01513 NAD_kinase [H]

EC number: =2.7.1.23 [H]

Molecular weight: Translated: 31402; Mature: 31402

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIGIAINPSKDYKNTILNMVKEKIKNICNITDIEVYNSFDIKNLNLSSLDLLIVLGGD
CCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEEEECCC
GTLLGVARELDDDFKAPILGINIGNLGVLSSIEISDLELALKKLMTKDCKVHKRMMLNCE
CEEEEEEHHCCCCCCCCEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHCEEEEEEEE
VDINESIKNIKALNEVAVARGTLSRMVKFKIFVDEKLYAIFKGDGLIVSTPTGSTAYSFS
ECCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCEEEEEEECCEEEEECCCCCCEEEEC
AGGPFICPDLEVISIVPICDHTKSMHPIVLKGDSTIKIIAQNGGDQIYLTIDGQRAIEMK
CCCCEECCCCEEEEEEEECCCCCCCCCEEEECCCEEEEEEECCCCEEEEEECCCEEEEEC
DNSVITVKKNPKSLKLLLFNDYDYFKVIRNKVLNNSKECDGEKN
CCCEEEEECCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKNIGIAINPSKDYKNTILNMVKEKIKNICNITDIEVYNSFDIKNLNLSSLDLLIVLGGD
CCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEEEECCC
GTLLGVARELDDDFKAPILGINIGNLGVLSSIEISDLELALKKLMTKDCKVHKRMMLNCE
CEEEEEEHHCCCCCCCCEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHHCEEEEEEEE
VDINESIKNIKALNEVAVARGTLSRMVKFKIFVDEKLYAIFKGDGLIVSTPTGSTAYSFS
ECCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCEEEEEEECCEEEEECCCCCCEEEEC
AGGPFICPDLEVISIVPICDHTKSMHPIVLKGDSTIKIIAQNGGDQIYLTIDGQRAIEMK
CCCCEECCCCEEEEEEEECCCCCCCCCEEEECCCEEEEEEECCCCEEEEEECCCEEEEEC
DNSVITVKKNPKSLKLLLFNDYDYFKVIRNKVLNNSKECDGEKN
CCCEEEEECCCCEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA