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The map label for this gene is malL [H]

Identifier: 187933726

GI number: 187933726

Start: 2152633

End: 2154234

Strand: Reverse

Name: malL [H]

Synonym: CLL_A2058

Alternate gene names: 187933726

Gene position: 2154234-2152633 (Counterclockwise)

Preceding gene: 187932763

Following gene: 187934703

Centisome position: 56.69

GC content: 26.15

Gene sequence:

>1602_bases
ATGCACAAAAAATGGTGGAAAGAAAGTGTATTTTATGAAATATACATGCCAAGCTTTAAAGATGGAAACAATGATGGCAT
AGGTGACTTTAAAGGTATAACGTCAAAACTTGAATATTTAAGTGATTTAGGAATAAGAGGAATTTGGCTTACACCATTTT
ATCCATCTCCTAAAGTTGATAATGGTTATGACATATCAGATTACTATAATATTGATAAAGACTATGGAACATTAGAAGAT
TTTAACGAATTTTTAAGTAAGGCACACAGCTTAGGGATAAAAATAATAGTTGACATAGTTTTAAATCATACATCTAGTGA
ACATCCATGGTTTAAGGAATCAAGAAAATCTAAGGATAATGAAAAAAGAGATTTTTACATATGGAAAAAAGAAAAGCCAA
ATAATTGGGAGTCTTTCTTTGGTGGAGAAGCTTGGGAATATGATGAGTTAACAAAAGAATATTATTATCATGCCTTTGCT
AAAGAGCAGGTAGATTTAAATTGGTCAAATCCTAAAGTTTATGATGCTATGAAGGATGTACTAAAGTATTGGATTGACTT
AGGGGTAGATGGATTTAGATTTGATGTAATTAATTTTCTAACAATTAAAAATGATTTAGCACAAGATAATCCATATGATG
AAAAAGGTGAACAAATACATAAGTATGATAAAGACCAAGAAGGCATAATTGAAATAATAAAGACTTTAGTAAAAGATATA
AGAGAAATAAAAGAAGATGTGTTTCTTGTAGGTGAAGTTGGATCAGAAGACTTAAATGAATTAAGAGGCTATTCAGGAAA
AGATTTATTGGATGTAGTTTTTAATTTTAATTTAGGTAGTATTAATGAATTTTCAGCAGAAAAAATATATAAGGAAATTA
AAAATATGAATGATAATTATGATTCATATCAAATACCTACAATATTTTTTAATAGTCATGATATGGGGAGAAGTATCTCA
AGATTTAATCCAGATGGTAATAAAAATGGAATAGAAAAAGCTATGGCCGCTTTATTATTAATATCTTATGGTGTTCCGTT
TATGTATTTTGGTGAAGAAATAGGAATGAAAGATTTAGTTTGCCTTGATATAAATAAAATGAATGATATTCAAGGAGTCA
CTAAATATAATATAGAAATTTCAAATGGAAAAACACAAGAAGAAGCATTAATTAGTGCTAATAAAAGTTCTAGAGATAAA
TCAAGAAGCCCAATGCAATGGAATAATTCAAAGTTTTATGGATTTAGTAATACTATGCCTTGGATAAATATAGAAGATAA
GAATGATAATGAATTAGTAGAAAAACAAATTAAAGAAGAGGGTTCTTTAATTAATTTATATAAAGATTTAATAAAAATAA
GATATAAGAATGACACCTTATTATATGGTAAATATGCAAACTTATCATTTGATGATGGAGTTTTAATTATGGAAAGAGAA
TTAAATAATGAAACTATAAGAACTGTAATTAATTTTGGGGATAATGAGTATATAGAAAATAATACTGAAGAAATCATTTA
TAGGAATATAAAAGTACAAGAAAAAAGAACTTTAGGTAAATTTGATTTTATAATACAAAGGTATAAAGCAATAACTAATT
AA

Upstream 100 bases:

>100_bases
AAATAAAAGAAGATAAAGCAACATTATATGCAGGGATAAGTGATGCTGAAGCTCAATTTATAATAATTGACAATCCATTT
AAATAGAGGAGGTAAAAGCT

Downstream 100 bases:

>100_bases
TGGTTTACAGAGATTGCATTTTGAATATGATTTGTTGCATAGATTAAAACAATAATTAATGGGGCTAATGCAGAGTAATA
AGTGGATCATTAAAAATAAT

Product: trehalose-6-phosphate hydrolase

Products: NA

Alternate protein names: Dextrin 6-alpha-D-glucanohydrolase; Oligosaccharide alpha-1,6-glucosidase; Sucrase-isomaltase; Isomaltase [H]

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MHKKWWKESVFYEIYMPSFKDGNNDGIGDFKGITSKLEYLSDLGIRGIWLTPFYPSPKVDNGYDISDYYNIDKDYGTLED
FNEFLSKAHSLGIKIIVDIVLNHTSSEHPWFKESRKSKDNEKRDFYIWKKEKPNNWESFFGGEAWEYDELTKEYYYHAFA
KEQVDLNWSNPKVYDAMKDVLKYWIDLGVDGFRFDVINFLTIKNDLAQDNPYDEKGEQIHKYDKDQEGIIEIIKTLVKDI
REIKEDVFLVGEVGSEDLNELRGYSGKDLLDVVFNFNLGSINEFSAEKIYKEIKNMNDNYDSYQIPTIFFNSHDMGRSIS
RFNPDGNKNGIEKAMAALLLISYGVPFMYFGEEIGMKDLVCLDINKMNDIQGVTKYNIEISNGKTQEEALISANKSSRDK
SRSPMQWNNSKFYGFSNTMPWINIEDKNDNELVEKQIKEEGSLINLYKDLIKIRYKNDTLLYGKYANLSFDDGVLIMERE
LNNETIRTVINFGDNEYIENNTEEIIYRNIKVQEKRTLGKFDFIIQRYKAITN

Sequences:

>Translated_533_residues
MHKKWWKESVFYEIYMPSFKDGNNDGIGDFKGITSKLEYLSDLGIRGIWLTPFYPSPKVDNGYDISDYYNIDKDYGTLED
FNEFLSKAHSLGIKIIVDIVLNHTSSEHPWFKESRKSKDNEKRDFYIWKKEKPNNWESFFGGEAWEYDELTKEYYYHAFA
KEQVDLNWSNPKVYDAMKDVLKYWIDLGVDGFRFDVINFLTIKNDLAQDNPYDEKGEQIHKYDKDQEGIIEIIKTLVKDI
REIKEDVFLVGEVGSEDLNELRGYSGKDLLDVVFNFNLGSINEFSAEKIYKEIKNMNDNYDSYQIPTIFFNSHDMGRSIS
RFNPDGNKNGIEKAMAALLLISYGVPFMYFGEEIGMKDLVCLDINKMNDIQGVTKYNIEISNGKTQEEALISANKSSRDK
SRSPMQWNNSKFYGFSNTMPWINIEDKNDNELVEKQIKEEGSLINLYKDLIKIRYKNDTLLYGKYANLSFDDGVLIMERE
LNNETIRTVINFGDNEYIENNTEEIIYRNIKVQEKRTLGKFDFIIQRYKAITN
>Mature_533_residues
MHKKWWKESVFYEIYMPSFKDGNNDGIGDFKGITSKLEYLSDLGIRGIWLTPFYPSPKVDNGYDISDYYNIDKDYGTLED
FNEFLSKAHSLGIKIIVDIVLNHTSSEHPWFKESRKSKDNEKRDFYIWKKEKPNNWESFFGGEAWEYDELTKEYYYHAFA
KEQVDLNWSNPKVYDAMKDVLKYWIDLGVDGFRFDVINFLTIKNDLAQDNPYDEKGEQIHKYDKDQEGIIEIIKTLVKDI
REIKEDVFLVGEVGSEDLNELRGYSGKDLLDVVFNFNLGSINEFSAEKIYKEIKNMNDNYDSYQIPTIFFNSHDMGRSIS
RFNPDGNKNGIEKAMAALLLISYGVPFMYFGEEIGMKDLVCLDINKMNDIQGVTKYNIEISNGKTQEEALISANKSSRDK
SRSPMQWNNSKFYGFSNTMPWINIEDKNDNELVEKQIKEEGSLINLYKDLIKIRYKNDTLLYGKYANLSFDDGVLIMERE
LNNETIRTVINFGDNEYIENNTEEIIYRNIKVQEKRTLGKFDFIIQRYKAITN

Specific function: Unknown

COG id: COG0366

COG function: function code G; Glycosidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 13 family [H]

Homologues:

Organism=Homo sapiens, GI187423904, Length=522, Percent_Identity=30.8429118773946, Blast_Score=254, Evalue=1e-67,
Organism=Escherichia coli, GI1790687, Length=506, Percent_Identity=34.9802371541502, Blast_Score=320, Evalue=1e-88,
Organism=Escherichia coli, GI1786604, Length=362, Percent_Identity=23.2044198895028, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32565753, Length=516, Percent_Identity=25, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI25147709, Length=519, Percent_Identity=25.0481695568401, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321726, Length=544, Percent_Identity=36.7647058823529, Blast_Score=303, Evalue=4e-83,
Organism=Saccharomyces cerevisiae, GI6319776, Length=549, Percent_Identity=36.7941712204007, Blast_Score=296, Evalue=5e-81,
Organism=Saccharomyces cerevisiae, GI6321731, Length=549, Percent_Identity=36.6120218579235, Blast_Score=295, Evalue=9e-81,
Organism=Saccharomyces cerevisiae, GI6322245, Length=549, Percent_Identity=36.6120218579235, Blast_Score=294, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6324416, Length=544, Percent_Identity=35.1102941176471, Blast_Score=287, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6322241, Length=544, Percent_Identity=35.1102941176471, Blast_Score=287, Evalue=3e-78,
Organism=Saccharomyces cerevisiae, GI6322021, Length=544, Percent_Identity=35.1102941176471, Blast_Score=287, Evalue=3e-78,
Organism=Drosophila melanogaster, GI24586599, Length=530, Percent_Identity=34.5283018867924, Blast_Score=275, Evalue=4e-74,
Organism=Drosophila melanogaster, GI24583747, Length=530, Percent_Identity=35.0943396226415, Blast_Score=270, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24583749, Length=530, Percent_Identity=35.0943396226415, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24586597, Length=531, Percent_Identity=34.2749529190207, Blast_Score=262, Evalue=4e-70,
Organism=Drosophila melanogaster, GI45549022, Length=529, Percent_Identity=33.4593572778828, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24583745, Length=530, Percent_Identity=33.3962264150943, Blast_Score=251, Evalue=9e-67,
Organism=Drosophila melanogaster, GI24586589, Length=540, Percent_Identity=33.5185185185185, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI221330053, Length=525, Percent_Identity=33.1428571428571, Blast_Score=248, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24586593, Length=532, Percent_Identity=32.1428571428571, Blast_Score=245, Evalue=5e-65,
Organism=Drosophila melanogaster, GI24586587, Length=524, Percent_Identity=30.7251908396947, Blast_Score=228, Evalue=7e-60,
Organism=Drosophila melanogaster, GI24586591, Length=516, Percent_Identity=31.7829457364341, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI281360393, Length=477, Percent_Identity=29.769392033543, Blast_Score=177, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013780
- InterPro:   IPR006047
- InterPro:   IPR006589
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00128 Alpha-amylase [H]

EC number: =3.2.1.10 [H]

Molecular weight: Translated: 62534; Mature: 62534

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKKWWKESVFYEIYMPSFKDGNNDGIGDFKGITSKLEYLSDLGIRGIWLTPFYPSPKVD
CCCHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
NGYDISDYYNIDKDYGTLEDFNEFLSKAHSLGIKIIVDIVLNHTSSEHPWFKESRKSKDN
CCCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCHHEEEEHHHCCCCCCCCCHHHHHCCCCC
EKRDFYIWKKEKPNNWESFFGGEAWEYDELTKEYYYHAFAKEQVDLNWSNPKVYDAMKDV
CCCCEEEEECCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHCEEECCCCCCHHHHHHHHH
LKYWIDLGVDGFRFDVINFLTIKNDLAQDNPYDEKGEQIHKYDKDQEGIIEIIKTLVKDI
HHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHH
REIKEDVFLVGEVGSEDLNELRGYSGKDLLDVVFNFNLGSINEFSAEKIYKEIKNMNDNY
HHHHHHEEEEECCCCHHHHHHCCCCCCCHHHHHEECCCCCCCHHHHHHHHHHHHCCCCCC
DSYQIPTIFFNSHDMGRSISRFNPDGNKNGIEKAMAALLLISYGVPFMYFGEEIGMKDLV
CCEECCEEEECCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCEE
CLDINKMNDIQGVTKYNIEISNGKTQEEALISANKSSRDKSRSPMQWNNSKFYGFSNTMP
EEECCCCCCCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCC
WINIEDKNDNELVEKQIKEEGSLINLYKDLIKIRYKNDTLLYGKYANLSFDDGVLIMERE
EEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHEEECCCEEEEEEECCCCCCCCEEEEEEC
LNNETIRTVINFGDNEYIENNTEEIIYRNIKVQEKRTLGKFDFIIQRYKAITN
CCCHHHHHHHCCCCCCHHCCCCHHHEEECCEEHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHKKWWKESVFYEIYMPSFKDGNNDGIGDFKGITSKLEYLSDLGIRGIWLTPFYPSPKVD
CCCHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCC
NGYDISDYYNIDKDYGTLEDFNEFLSKAHSLGIKIIVDIVLNHTSSEHPWFKESRKSKDN
CCCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCHHEEEEHHHCCCCCCCCCHHHHHCCCCC
EKRDFYIWKKEKPNNWESFFGGEAWEYDELTKEYYYHAFAKEQVDLNWSNPKVYDAMKDV
CCCCEEEEECCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHCEEECCCCCCHHHHHHHHH
LKYWIDLGVDGFRFDVINFLTIKNDLAQDNPYDEKGEQIHKYDKDQEGIIEIIKTLVKDI
HHHHHHCCCCCEEEHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHHH
REIKEDVFLVGEVGSEDLNELRGYSGKDLLDVVFNFNLGSINEFSAEKIYKEIKNMNDNY
HHHHHHEEEEECCCCHHHHHHCCCCCCCHHHHHEECCCCCCCHHHHHHHHHHHHCCCCCC
DSYQIPTIFFNSHDMGRSISRFNPDGNKNGIEKAMAALLLISYGVPFMYFGEEIGMKDLV
CCEECCEEEECCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCEE
CLDINKMNDIQGVTKYNIEISNGKTQEEALISANKSSRDKSRSPMQWNNSKFYGFSNTMP
EEECCCCCCCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCC
WINIEDKNDNELVEKQIKEEGSLINLYKDLIKIRYKNDTLLYGKYANLSFDDGVLIMERE
EEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHEEECCCEEEEEEECCCCCCCCEEEEEEC
LNNETIRTVINFGDNEYIENNTEEIIYRNIKVQEKRTLGKFDFIIQRYKAITN
CCCHHHHHHHCCCCCCHHCCCCHHHEEECCEEHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1761534 [H]