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The map label for this gene is deoR [H]

Identifier: 187933702

GI number: 187933702

Start: 738201

End: 738980

Strand: Reverse

Name: deoR [H]

Synonym: CLL_A0733

Alternate gene names: 187933702

Gene position: 738980-738201 (Counterclockwise)

Preceding gene: 187933192

Following gene: 187935263

Centisome position: 19.45

GC content: 27.95

Gene sequence:

>780_bases
ATGAATAAAAAACTACAACGTGCTAATAGAATTATAGAAATTTTAAAAGAAAAAAATGGTGCTTCAGTTAAAGATTTAGC
ATCTACCTTAGGGGTTTCTGAGATGACAATTAGACGAGATTTAAATCTTTTGAAATCAAATAATATAGTTAGTAATGTAT
ATGGGGCTACAATATATAATCCTTTAAATAGTATCGAAAAATTAAATAATAATTATGATATTACAGATGAAGTTATAAAA
AGAGAAAATGAAAAAATTAAAATAGGTAAAGCTGCTGCGAAATTAATACAAAATGATGATATTATCATAATAGATGCTGG
TACAACTACAGAAAAATTAGCTCAAAGCATTAGTGATGATATAAAACTAACAGCATTGTTTTATAGTATTAACATACTAA
GTTCCTTAAAAAACAGAAAAAATATTGAATTAATATTTTCTGGTGGATATTTTCACGAAAACACTCAAATGTTTGAAAGT
CCTGAAGGAATTTCTCTTATTGAAAATATGAGAGCTAATAAGGTTTTTGTGTCTGCTGCTGGAGTGCATGAAACTTTGGG
TGTTACATGTTCTAACAACTACGAGGTAGCAACTAAAAGAGCTATTATAAGTTCATCTGTTGAAAAAATATTATTAGTTG
ACTCTGATAAATTTGATTCTGTAAAATCATCTTACTTTTCAGACCTTCAAGAATTCGATATTGTAATTACAGATCACGGT
ATTCCTGATGAATGGCGTACACGCCTTGAAGATATGGAAATACAAGTTATTATCGCTTAA

Upstream 100 bases:

>100_bases
GTTAGAATATAAACAATAAGCTTTAAATTATATAAACTGTATTTTAAGCAGTATTAAAATATGAAATTGTTCACTAAAAA
ATAGAATAAGGTGATTAATA

Downstream 100 bases:

>100_bases
TTATTTAAAAATCTATAATTCTTTAAAATACATAAAGGAAATGAGTTATTTAAAAGATTATAATTCTTTGAATAACTCAT
TTTCTTTACGTTGTAACAAT

Product: deoxyribose operon repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MNKKLQRANRIIEILKEKNGASVKDLASTLGVSEMTIRRDLNLLKSNNIVSNVYGATIYNPLNSIEKLNNNYDITDEVIK
RENEKIKIGKAAAKLIQNDDIIIIDAGTTTEKLAQSISDDIKLTALFYSINILSSLKNRKNIELIFSGGYFHENTQMFES
PEGISLIENMRANKVFVSAAGVHETLGVTCSNNYEVATKRAIISSSVEKILLVDSDKFDSVKSSYFSDLQEFDIVITDHG
IPDEWRTRLEDMEIQVIIA

Sequences:

>Translated_259_residues
MNKKLQRANRIIEILKEKNGASVKDLASTLGVSEMTIRRDLNLLKSNNIVSNVYGATIYNPLNSIEKLNNNYDITDEVIK
RENEKIKIGKAAAKLIQNDDIIIIDAGTTTEKLAQSISDDIKLTALFYSINILSSLKNRKNIELIFSGGYFHENTQMFES
PEGISLIENMRANKVFVSAAGVHETLGVTCSNNYEVATKRAIISSSVEKILLVDSDKFDSVKSSYFSDLQEFDIVITDHG
IPDEWRTRLEDMEIQVIIA
>Mature_259_residues
MNKKLQRANRIIEILKEKNGASVKDLASTLGVSEMTIRRDLNLLKSNNIVSNVYGATIYNPLNSIEKLNNNYDITDEVIK
RENEKIKIGKAAAKLIQNDDIIIIDAGTTTEKLAQSISDDIKLTALFYSINILSSLKNRKNIELIFSGGYFHENTQMFES
PEGISLIENMRANKVFVSAAGVHETLGVTCSNNYEVATKRAIISSSVEKILLVDSDKFDSVKSSYFSDLQEFDIVITDHG
IPDEWRTRLEDMEIQVIIA

Specific function: This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes. It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore- forming

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787063, Length=244, Percent_Identity=32.7868852459016, Blast_Score=144, Evalue=5e-36,
Organism=Escherichia coli, GI1789519, Length=255, Percent_Identity=26.6666666666667, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI226510968, Length=256, Percent_Identity=28.125, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789059, Length=259, Percent_Identity=29.7297297297297, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI1789829, Length=254, Percent_Identity=27.9527559055118, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1787540, Length=236, Percent_Identity=26.6949152542373, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1790753, Length=259, Percent_Identity=23.9382239382239, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1788069, Length=251, Percent_Identity=25.4980079681275, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1789170, Length=237, Percent_Identity=24.8945147679325, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082344, Length=253, Percent_Identity=22.5296442687747, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 29038; Mature: 29038

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKLQRANRIIEILKEKNGASVKDLASTLGVSEMTIRRDLNLLKSNNIVSNVYGATIYN
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHCCHHHHH
PLNSIEKLNNNYDITDEVIKRENEKIKIGKAAAKLIQNDDIIIIDAGTTTEKLAQSISDD
HHHHHHHHCCCCCCCHHHHHCCCCEEEEHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCC
IKLTALFYSINILSSLKNRKNIELIFSGGYFHENTQMFESPEGISLIENMRANKVFVSAA
CEEEHHHHHHHHHHHHCCCCCEEEEEECCEEECCCHHHCCCCCHHHHHHCCCCEEEEEEC
GVHETLGVTCSNNYEVATKRAIISSSVEKILLVDSDKFDSVKSSYFSDLQEFDIVITDHG
CCHHHHEEEECCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHCEEEEECCC
IPDEWRTRLEDMEIQVIIA
CCHHHHHHHCCCEEEEEEC
>Mature Secondary Structure
MNKKLQRANRIIEILKEKNGASVKDLASTLGVSEMTIRRDLNLLKSNNIVSNVYGATIYN
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHCCHHHHH
PLNSIEKLNNNYDITDEVIKRENEKIKIGKAAAKLIQNDDIIIIDAGTTTEKLAQSISDD
HHHHHHHHCCCCCCCHHHHHCCCCEEEEHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCC
IKLTALFYSINILSSLKNRKNIELIFSGGYFHENTQMFESPEGISLIENMRANKVFVSAA
CEEEHHHHHHHHHHHHCCCCCEEEEEECCEEECCCHHHCCCCCHHHHHHCCCCEEEEEEC
GVHETLGVTCSNNYEVATKRAIISSSVEKILLVDSDKFDSVKSSYFSDLQEFDIVITDHG
CCHHHHEEEECCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHCEEEEECCC
IPDEWRTRLEDMEIQVIIA
CCHHHHHHHCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]