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The map label for this gene is lonC [H]

Identifier: 187933433

GI number: 187933433

Start: 3779581

End: 3781473

Strand: Reverse

Name: lonC [H]

Synonym: CLL_A3581

Alternate gene names: 187933433

Gene position: 3781473-3779581 (Counterclockwise)

Preceding gene: 187934927

Following gene: 187932892

Centisome position: 99.5

GC content: 29.69

Gene sequence:

>1893_bases
TTGAAATCAAATGAAGAAACAAATTTATTAAATAGTATAATGAGTGGGAATTTATCAATAGAAGCTCAAATAGATGCTTT
ATTTAATGTAACAAAAAATATTTTAGATAAAGGGGCGTTTAGATCTAGAGTTGTTAGATTTAAATTAGATAAATATGTAA
AATCACAAGATAATTGTGATAGAATATTTGCATTAAAGACTATATTATCTGAGGGCGAAAAAAAGGGAATTCCTAAAGAA
GAGGACTTAGAACAAGAAGTAAAAATAATTATAGAACTTATTGTAAATGAGATTGCCAAAAAGTATGTTCAAAACAAAAT
AGAAATGAAGGTTGAACAGGCAATAATGGAGAAACAAGAAAAGTATATTGATGAAGTAAGATTATCTGTAATTAAGAAGC
AAAAAGGTGTTGAAAATAACAACACTATGAGTAAATTGAATAATTTAGTTTCTTTAGATGAAAAAGTAACTAGTAAAAAT
ATTATGAGCTTTTTAAGACCAGATAGTTTTGATGAAGTAGTAGGCCAAGAACGTGCTATTAAATCATTAATATCTAAATT
ATCTTCTCCGTATCCTCAACATATTATATTATACGGACCACCTGGGGTTGGTAAAACAACTGCAGCAAGACTTGCTTTAA
AGGAAGCAAAAAAACTGAATTTTACTCCATTTGATGATGAATCAAAATTTGTTGAGGTAGATGGAACTACTTTAAGATGG
GATCCAAGAGAAATAACTAATCCTTTATTAGGATCAGTACATGATCCTATATACCAAGGAAGTAAAAGGTATCTATCAGA
GGCAGGAGTTCCTGAACCAAAGCCAGGATTAGTTACTGAAGCACACGGAGGAGTATTATTTATAGATGAAATAGGAGAAT
TAGATCATATATTACAAAATAAACTCTTAAAGGTTTTAGAAGATAAGAGAGTAGAGTTTTCATCTTCATATTATGATCCA
GATGATGAATCAACTCCTAAATATATAAAATATTTATTTGATAATGGAGCACCAGCTGATTTCGTATTAATAGGTGCTAC
GACTAAAAGTCCAAGTGAAATAAATCCAGCATTAAGATCTAGAGCTACTGAGGTTTATTTTGAACCATTATCTTCTGATG
ATATAGAGCTTATAGTTAAAAAAGCTGCTGAAAAATTAAATGTTACTTTAGAAGAAGGTGTTGCTAAGAAAATTAGTAAT
TATACTTTTGAAGGTAGAAAAGCAGTAAATATATTAACAGATGCTTATGGATATGCGCTATACATAGAAAAGCAAAGAGA
AGATAATATTGAAATAAAACTAGAATATTTAGATGAAGTATTGTCTGTTGGAAGACATGTTCCTTTCGAAATATTTGATA
ATACTGAGGAATATGAAATCGGACATATTTATGGCTTAGGAGTAAGTGGCTTTTTAGGTTCAACTATTGAAATTGAAGCG
AATGTTTTTATGGCTAAAAAGAAAGGTGCTGGAGTAGTAAGATTTAATGAAACAGCAGGTTCTATGGCTAAGGATTCAGT
ATTTAATGCAGCTTCAGTTATAAGAGCTATAACTGATAAGGATATAAAAGATTATGATATACATGTTAATGTTATAGGTG
GAGGAAAAATTGATGGCCCATCAGCAGGGGTTGCAATTACACTATGCATAATAAGTGCGTTATTAAAGAAACCTATAAAG
CAGGATATAGCAGTAACTGGTGAAATATCTTTAAGAGGAAAAGTAAAACCTGTAGGTGGAATATTTGAAAAGATATATGG
TGCTAGAAGAAAAGGAATTAAAAGAGTTTTAGTACCAAAAGATAATGAAAAAGAAATTCCGAGAGGTCTTAAAGATATAG
AAGTTAAATCAGTAAGTACCATAGAAGAAATTATGGATATTGTTTTTGAATAA

Upstream 100 bases:

>100_bases
AAAATTAGCAGGAAACTATGATATAGAAGTTAAATTATATCCTGAAGTTAGTACAAAAATGAAAGTAAATATACTTCCAC
AATAATAAGGGGGATTTGTT

Downstream 100 bases:

>100_bases
TGAAATAGGCTTCCTTGAACTAGGAAGCTTATTTTAAATTAAAGTTTAGATTGTGTTTATTAAATTAAAAAAAAGGAGGA
CTGTTTTTGGAATCACAAGT

Product: ATP-dependent protease, Lon family

Products: NA

Alternate protein names: ATP-dependent protease La 2 [H]

Number of amino acids: Translated: 630; Mature: 630

Protein sequence:

>630_residues
MKSNEETNLLNSIMSGNLSIEAQIDALFNVTKNILDKGAFRSRVVRFKLDKYVKSQDNCDRIFALKTILSEGEKKGIPKE
EDLEQEVKIIIELIVNEIAKKYVQNKIEMKVEQAIMEKQEKYIDEVRLSVIKKQKGVENNNTMSKLNNLVSLDEKVTSKN
IMSFLRPDSFDEVVGQERAIKSLISKLSSPYPQHIILYGPPGVGKTTAARLALKEAKKLNFTPFDDESKFVEVDGTTLRW
DPREITNPLLGSVHDPIYQGSKRYLSEAGVPEPKPGLVTEAHGGVLFIDEIGELDHILQNKLLKVLEDKRVEFSSSYYDP
DDESTPKYIKYLFDNGAPADFVLIGATTKSPSEINPALRSRATEVYFEPLSSDDIELIVKKAAEKLNVTLEEGVAKKISN
YTFEGRKAVNILTDAYGYALYIEKQREDNIEIKLEYLDEVLSVGRHVPFEIFDNTEEYEIGHIYGLGVSGFLGSTIEIEA
NVFMAKKKGAGVVRFNETAGSMAKDSVFNAASVIRAITDKDIKDYDIHVNVIGGGKIDGPSAGVAITLCIISALLKKPIK
QDIAVTGEISLRGKVKPVGGIFEKIYGARRKGIKRVLVPKDNEKEIPRGLKDIEVKSVSTIEEIMDIVFE

Sequences:

>Translated_630_residues
MKSNEETNLLNSIMSGNLSIEAQIDALFNVTKNILDKGAFRSRVVRFKLDKYVKSQDNCDRIFALKTILSEGEKKGIPKE
EDLEQEVKIIIELIVNEIAKKYVQNKIEMKVEQAIMEKQEKYIDEVRLSVIKKQKGVENNNTMSKLNNLVSLDEKVTSKN
IMSFLRPDSFDEVVGQERAIKSLISKLSSPYPQHIILYGPPGVGKTTAARLALKEAKKLNFTPFDDESKFVEVDGTTLRW
DPREITNPLLGSVHDPIYQGSKRYLSEAGVPEPKPGLVTEAHGGVLFIDEIGELDHILQNKLLKVLEDKRVEFSSSYYDP
DDESTPKYIKYLFDNGAPADFVLIGATTKSPSEINPALRSRATEVYFEPLSSDDIELIVKKAAEKLNVTLEEGVAKKISN
YTFEGRKAVNILTDAYGYALYIEKQREDNIEIKLEYLDEVLSVGRHVPFEIFDNTEEYEIGHIYGLGVSGFLGSTIEIEA
NVFMAKKKGAGVVRFNETAGSMAKDSVFNAASVIRAITDKDIKDYDIHVNVIGGGKIDGPSAGVAITLCIISALLKKPIK
QDIAVTGEISLRGKVKPVGGIFEKIYGARRKGIKRVLVPKDNEKEIPRGLKDIEVKSVSTIEEIMDIVFE
>Mature_630_residues
MKSNEETNLLNSIMSGNLSIEAQIDALFNVTKNILDKGAFRSRVVRFKLDKYVKSQDNCDRIFALKTILSEGEKKGIPKE
EDLEQEVKIIIELIVNEIAKKYVQNKIEMKVEQAIMEKQEKYIDEVRLSVIKKQKGVENNNTMSKLNNLVSLDEKVTSKN
IMSFLRPDSFDEVVGQERAIKSLISKLSSPYPQHIILYGPPGVGKTTAARLALKEAKKLNFTPFDDESKFVEVDGTTLRW
DPREITNPLLGSVHDPIYQGSKRYLSEAGVPEPKPGLVTEAHGGVLFIDEIGELDHILQNKLLKVLEDKRVEFSSSYYDP
DDESTPKYIKYLFDNGAPADFVLIGATTKSPSEINPALRSRATEVYFEPLSSDDIELIVKKAAEKLNVTLEEGVAKKISN
YTFEGRKAVNILTDAYGYALYIEKQREDNIEIKLEYLDEVLSVGRHVPFEIFDNTEEYEIGHIYGLGVSGFLGSTIEIEA
NVFMAKKKGAGVVRFNETAGSMAKDSVFNAASVIRAITDKDIKDYDIHVNVIGGGKIDGPSAGVAITLCIISALLKKPIK
QDIAVTGEISLRGKVKPVGGIFEKIYGARRKGIKRVLVPKDNEKEIPRGLKDIEVKSVSTIEEIMDIVFE

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG1067

COG function: function code O; Predicted ATP-dependent protease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S16 family [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=523, Percent_Identity=25.6214149139579, Blast_Score=100, Evalue=6e-21,
Organism=Homo sapiens, GI21396489, Length=668, Percent_Identity=23.6526946107784, Blast_Score=96, Evalue=1e-19,
Organism=Escherichia coli, GI1786643, Length=487, Percent_Identity=27.9260780287474, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1790850, Length=106, Percent_Identity=36.7924528301887, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17556486, Length=506, Percent_Identity=25.8893280632411, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17505831, Length=276, Percent_Identity=32.9710144927536, Blast_Score=94, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6319449, Length=90, Percent_Identity=41.1111111111111, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221513036, Length=674, Percent_Identity=24.4807121661721, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24666867, Length=674, Percent_Identity=24.4807121661721, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR020568
- InterPro:   IPR014251 [H]

Pfam domain/function: PF00004 AAA; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 70309; Mature: 70309

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS50045 SIGMA54_INTERACT_4 ; PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSNEETNLLNSIMSGNLSIEAQIDALFNVTKNILDKGAFRSRVVRFKLDKYVKSQDNCD
CCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHH
RIFALKTILSEGEKKGIPKEEDLEQEVKIIIELIVNEIAKKYVQNKIEMKVEQAIMEKQE
HHHHHHHHHHCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYIDEVRLSVIKKQKGVENNNTMSKLNNLVSLDEKVTSKNIMSFLRPDSFDEVVGQERAI
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
KSLISKLSSPYPQHIILYGPPGVGKTTAARLALKEAKKLNFTPFDDESKFVEVDGTTLRW
HHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCEEEE
DPREITNPLLGSVHDPIYQGSKRYLSEAGVPEPKPGLVTEAHGGVLFIDEIGELDHILQN
CHHHHCCHHHHHHCCHHHHCHHHHHHHCCCCCCCCCCEEECCCCEEEEHHHHHHHHHHHH
KLLKVLEDKRVEFSSSYYDPDDESTPKYIKYLFDNGAPADFVLIGATTKSPSEINPALRS
HHHHHHHHCCCHHCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCHHCCHHHHH
RATEVYFEPLSSDDIELIVKKAAEKLNVTLEEGVAKKISNYTFEGRKAVNILTDAYGYAL
CCCEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEE
YIEKQREDNIEIKLEYLDEVLSVGRHVPFEIFDNTEEYEIGHIYGLGVSGFLGSTIEIEA
EEEECCCCCCEEEHHHHHHHHHCCCCCCEEEECCCCCEEEEEEEECCCHHHCCCEEEEEE
NVFMAKKKGAGVVRFNETAGSMAKDSVFNAASVIRAITDKDIKDYDIHVNVIGGGKIDGP
EEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCC
SAGVAITLCIISALLKKPIKQDIAVTGEISLRGKVKPVGGIFEKIYGARRKGIKRVLVPK
CCHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEECCC
DNEKEIPRGLKDIEVKSVSTIEEIMDIVFE
CCCHHHCCCCHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKSNEETNLLNSIMSGNLSIEAQIDALFNVTKNILDKGAFRSRVVRFKLDKYVKSQDNCD
CCCCHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHH
RIFALKTILSEGEKKGIPKEEDLEQEVKIIIELIVNEIAKKYVQNKIEMKVEQAIMEKQE
HHHHHHHHHHCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KYIDEVRLSVIKKQKGVENNNTMSKLNNLVSLDEKVTSKNIMSFLRPDSFDEVVGQERAI
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
KSLISKLSSPYPQHIILYGPPGVGKTTAARLALKEAKKLNFTPFDDESKFVEVDGTTLRW
HHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCEEEE
DPREITNPLLGSVHDPIYQGSKRYLSEAGVPEPKPGLVTEAHGGVLFIDEIGELDHILQN
CHHHHCCHHHHHHCCHHHHCHHHHHHHCCCCCCCCCCEEECCCCEEEEHHHHHHHHHHHH
KLLKVLEDKRVEFSSSYYDPDDESTPKYIKYLFDNGAPADFVLIGATTKSPSEINPALRS
HHHHHHHHCCCHHCCCCCCCCCCCCHHHHHHHHCCCCCCCEEEEEECCCCCHHCCHHHHH
RATEVYFEPLSSDDIELIVKKAAEKLNVTLEEGVAKKISNYTFEGRKAVNILTDAYGYAL
CCCEEEECCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEE
YIEKQREDNIEIKLEYLDEVLSVGRHVPFEIFDNTEEYEIGHIYGLGVSGFLGSTIEIEA
EEEECCCCCCEEEHHHHHHHHHCCCCCCEEEECCCCCEEEEEEEECCCHHHCCCEEEEEE
NVFMAKKKGAGVVRFNETAGSMAKDSVFNAASVIRAITDKDIKDYDIHVNVIGGGKIDGP
EEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCC
SAGVAITLCIISALLKKPIKQDIAVTGEISLRGKVKPVGGIFEKIYGARRKGIKRVLVPK
CCHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHHHHHHCCEEEECCC
DNEKEIPRGLKDIEVKSVSTIEEIMDIVFE
CCCHHHCCCCHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377; 7961402; 11325926 [H]