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The map label for this gene is adiC [H]

Identifier: 187933182

GI number: 187933182

Start: 2386972

End: 2388294

Strand: Reverse

Name: adiC [H]

Synonym: CLL_A2315

Alternate gene names: 187933182

Gene position: 2388294-2386972 (Counterclockwise)

Preceding gene: 187935606

Following gene: 187932498

Centisome position: 62.84

GC content: 30.99

Gene sequence:

>1323_bases
ATGGAGAATAACAACTTGAAAAAAGAAATTAGTCTATTTATGGCTACCATGCTTGTATGTGGAAATATGATTGGGTCAGG
AGTATTTATGTTGCCAGCAACTCTTGCACAGGTATCAGGACCGCTTGCAACAATAATAGCATGGATTATAACTACTATAG
GTTCTATATTAATAGCAATTTCATTTGCAAATTTAGGATCTAAATATCCAGCTACGGGAGGAGCATATCAATATACTAAG
GAAGCATTTGGAGAATTTACAGGTTTTTTAAGTGCATGGTTATATTGGAATGGATCTTGGATTGGAAATGCGGCTATTAT
TGTAGCTTTATCTAGTTACAGTGCATCCATTATACCTGCACTTCAAAACCCATTAGCATCAATAATATATACTAGTTCAC
TTTTATGGATTTTTACTATATTAAATATAGTGGGAGTTAAAGAAGCTGGAAAGATTCAAACTTTTGCTACTGTGTTTAAG
ATTGCATTTTTTGGAGTGTTTATAATAGCAGCTTTCTTAAATTTTGATAAAATTAATTTAATGCCACTTATGCCAGAAGG
TAAGGGATTATCTACAATTCCATTAGCAGCAACATCAACATTATGGGCATTTGTAGGATTGGAAAGCTCTACAGTTACAG
CAGGAGAAATAAGAGATCCAGAAAAAAATGTTAGAAAGAGTACAATATATGGTCTTATAATAGCATCTATTATTTACATA
TTAATAAGTGTTGGAAGCATGGGAGCAATGTCAAATTTTAAGCTTTCAAATAGTTCAGCACCGCTTACAGACATATTAAC
TAACATATTTGGACATTCAGTTGGAAAGGGACTAACTATTGCAGTTGTAATTTGTATTTTAGGAACAACAATTGGATGGT
TATTATCAACCGCTAGAGTTTCATATGCAGCAGGAATTGATGGGGTATTTCCTAAATTTTTTGGAAAGTTACATCCGAAG
TATGGAACTCCAATAAATTCATTGATAGCTGGTTCTGTATTAGTAAATATACTACTTATAATGAATTATCAAAAAAGCAT
GGTATCTGCATTTACTTTTATAACTATATTAGCAACATTATCATTTTTACCTGTTTACTTATTAACAGTGTCAGCAGAAA
TGATGCTTACATTTAGAGATGAAAAGAAGTTTGATTTTAAGATATTTATAAAAAAATCAATGATTCCTCTTTTAGCATTT
GCATATTCTATATGGACTATCTATGGTTCAGGAGCAGAAACTGTAATGTGGGGATTCATATTAATGCTTATAGGAATACC
ATTTTATATTTATAATCATTATAATAGTAAACAAACAGTTTAA

Upstream 100 bases:

>100_bases
ATTAGATAATGCATTGACAAACAATGAGAAGCTGATAAAATTATAATGTTAAAGTTAAAATTTTATATTGTAATTTCAGT
CCAATCATTAGGAGGAAAAA

Downstream 100 bases:

>100_bases
GTTGTAGATATAATTTATGTTATATCTTTATTATGTAATTAAATTAAATCTATAATATGAAATCTATAAAAGCTTATATG
CTGAAGGCGTATAAGCTTTT

Product: amino acid permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MENNNLKKEISLFMATMLVCGNMIGSGVFMLPATLAQVSGPLATIIAWIITTIGSILIAISFANLGSKYPATGGAYQYTK
EAFGEFTGFLSAWLYWNGSWIGNAAIIVALSSYSASIIPALQNPLASIIYTSSLLWIFTILNIVGVKEAGKIQTFATVFK
IAFFGVFIIAAFLNFDKINLMPLMPEGKGLSTIPLAATSTLWAFVGLESSTVTAGEIRDPEKNVRKSTIYGLIIASIIYI
LISVGSMGAMSNFKLSNSSAPLTDILTNIFGHSVGKGLTIAVVICILGTTIGWLLSTARVSYAAGIDGVFPKFFGKLHPK
YGTPINSLIAGSVLVNILLIMNYQKSMVSAFTFITILATLSFLPVYLLTVSAEMMLTFRDEKKFDFKIFIKKSMIPLLAF
AYSIWTIYGSGAETVMWGFILMLIGIPFYIYNHYNSKQTV

Sequences:

>Translated_440_residues
MENNNLKKEISLFMATMLVCGNMIGSGVFMLPATLAQVSGPLATIIAWIITTIGSILIAISFANLGSKYPATGGAYQYTK
EAFGEFTGFLSAWLYWNGSWIGNAAIIVALSSYSASIIPALQNPLASIIYTSSLLWIFTILNIVGVKEAGKIQTFATVFK
IAFFGVFIIAAFLNFDKINLMPLMPEGKGLSTIPLAATSTLWAFVGLESSTVTAGEIRDPEKNVRKSTIYGLIIASIIYI
LISVGSMGAMSNFKLSNSSAPLTDILTNIFGHSVGKGLTIAVVICILGTTIGWLLSTARVSYAAGIDGVFPKFFGKLHPK
YGTPINSLIAGSVLVNILLIMNYQKSMVSAFTFITILATLSFLPVYLLTVSAEMMLTFRDEKKFDFKIFIKKSMIPLLAF
AYSIWTIYGSGAETVMWGFILMLIGIPFYIYNHYNSKQTV
>Mature_440_residues
MENNNLKKEISLFMATMLVCGNMIGSGVFMLPATLAQVSGPLATIIAWIITTIGSILIAISFANLGSKYPATGGAYQYTK
EAFGEFTGFLSAWLYWNGSWIGNAAIIVALSSYSASIIPALQNPLASIIYTSSLLWIFTILNIVGVKEAGKIQTFATVFK
IAFFGVFIIAAFLNFDKINLMPLMPEGKGLSTIPLAATSTLWAFVGLESSTVTAGEIRDPEKNVRKSTIYGLIIASIIYI
LISVGSMGAMSNFKLSNSSAPLTDILTNIFGHSVGKGLTIAVVICILGTTIGWLLSTARVSYAAGIDGVFPKFFGKLHPK
YGTPINSLIAGSVLVNILLIMNYQKSMVSAFTFITILATLSFLPVYLLTVSAEMMLTFRDEKKFDFKIFIKKSMIPLLAF
AYSIWTIYGSGAETVMWGFILMLIGIPFYIYNHYNSKQTV

Specific function: Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular p

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI33286428, Length=450, Percent_Identity=25.7777777777778, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI115648063, Length=390, Percent_Identity=24.8717948717949, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI115648022, Length=390, Percent_Identity=24.8717948717949, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI4507047, Length=424, Percent_Identity=21.9339622641509, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI186910308, Length=362, Percent_Identity=25.1381215469613, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI186910306, Length=362, Percent_Identity=25.1381215469613, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI186910304, Length=362, Percent_Identity=25.1381215469613, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI71979932, Length=448, Percent_Identity=23.4375, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI187423910, Length=465, Percent_Identity=24.9462365591398, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI7657591, Length=465, Percent_Identity=24.9462365591398, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI258614005, Length=429, Percent_Identity=20.979020979021, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI258614003, Length=429, Percent_Identity=20.979020979021, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI9790235, Length=371, Percent_Identity=24.2587601078167, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI110347453, Length=353, Percent_Identity=26.0623229461756, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI7657683, Length=450, Percent_Identity=23.1111111111111, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI258645169, Length=429, Percent_Identity=20.2797202797203, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI114326544, Length=400, Percent_Identity=21.25, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI114326550, Length=400, Percent_Identity=21.25, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI181337167, Length=387, Percent_Identity=24.031007751938, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI2367353, Length=439, Percent_Identity=32.5740318906606, Blast_Score=224, Evalue=7e-60,
Organism=Escherichia coli, GI1786908, Length=432, Percent_Identity=27.7777777777778, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1787890, Length=453, Percent_Identity=27.3730684326711, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1790575, Length=340, Percent_Identity=29.1176470588235, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI87082250, Length=461, Percent_Identity=26.4642082429501, Blast_Score=112, Evalue=6e-26,
Organism=Escherichia coli, GI1786789, Length=393, Percent_Identity=22.9007633587786, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082023, Length=375, Percent_Identity=22.4, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1786302, Length=397, Percent_Identity=21.9143576826196, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790653, Length=404, Percent_Identity=22.2772277227723, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1788480, Length=359, Percent_Identity=21.7270194986072, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081869, Length=368, Percent_Identity=23.0978260869565, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790584, Length=383, Percent_Identity=26.8929503916449, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=413, Percent_Identity=21.7917675544794, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI32566699, Length=362, Percent_Identity=24.0331491712707, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17533459, Length=386, Percent_Identity=22.7979274611399, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17568033, Length=345, Percent_Identity=26.3768115942029, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17531343, Length=413, Percent_Identity=21.5496368038741, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17540018, Length=348, Percent_Identity=23.8505747126437, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71982612, Length=357, Percent_Identity=23.8095238095238, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71982608, Length=357, Percent_Identity=23.8095238095238, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71995382, Length=369, Percent_Identity=22.7642276422764, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71995388, Length=369, Percent_Identity=22.7642276422764, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI71993915, Length=338, Percent_Identity=24.2603550295858, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321492, Length=363, Percent_Identity=22.3140495867769, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24666159, Length=420, Percent_Identity=24.5238095238095, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI221512776, Length=420, Percent_Identity=24.5238095238095, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24641993, Length=362, Percent_Identity=25.414364640884, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24641995, Length=362, Percent_Identity=25.414364640884, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45550968, Length=438, Percent_Identity=24.8858447488584, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19921172, Length=438, Percent_Identity=24.8858447488584, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24667468, Length=414, Percent_Identity=25.1207729468599, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24668806, Length=409, Percent_Identity=22.4938875305623, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21356285, Length=409, Percent_Identity=22.4938875305623, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24668802, Length=409, Percent_Identity=22.4938875305623, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221331183, Length=370, Percent_Identity=22.972972972973, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17647653, Length=370, Percent_Identity=22.972972972973, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24664379, Length=370, Percent_Identity=22.972972972973, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281366235, Length=411, Percent_Identity=24.0875912408759, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI116007820, Length=411, Percent_Identity=24.0875912408759, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI24651635, Length=337, Percent_Identity=24.6290801186944, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24651633, Length=337, Percent_Identity=24.6290801186944, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21357367, Length=453, Percent_Identity=22.7373068432671, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI116007818, Length=382, Percent_Identity=24.6073298429319, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI85725152, Length=382, Percent_Identity=24.6073298429319, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 47769; Mature: 47769

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENNNLKKEISLFMATMLVCGNMIGSGVFMLPATLAQVSGPLATIIAWIITTIGSILIAI
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SFANLGSKYPATGGAYQYTKEAFGEFTGFLSAWLYWNGSWIGNAAIIVALSSYSASIIPA
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCEEEEEEEECCCCHHHHH
LQNPLASIIYTSSLLWIFTILNIVGVKEAGKIQTFATVFKIAFFGVFIIAAFLNFDKINL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
MPLMPEGKGLSTIPLAATSTLWAFVGLESSTVTAGEIRDPEKNVRKSTIYGLIIASIIYI
EEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHH
LISVGSMGAMSNFKLSNSSAPLTDILTNIFGHSVGKGLTIAVVICILGTTIGWLLSTARV
HHHCCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
SYAAGIDGVFPKFFGKLHPKYGTPINSLIAGSVLVNILLIMNYQKSMVSAFTFITILATL
HHHCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFLPVYLLTVSAEMMLTFRDEKKFDFKIFIKKSMIPLLAFAYSIWTIYGSGAETVMWGFI
HHHHHHHHHHHHHHHEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LMLIGIPFYIYNHYNSKQTV
HHHHHHHHHEEECCCCCCCC
>Mature Secondary Structure
MENNNLKKEISLFMATMLVCGNMIGSGVFMLPATLAQVSGPLATIIAWIITTIGSILIAI
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SFANLGSKYPATGGAYQYTKEAFGEFTGFLSAWLYWNGSWIGNAAIIVALSSYSASIIPA
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCEEEEEEEECCCCHHHHH
LQNPLASIIYTSSLLWIFTILNIVGVKEAGKIQTFATVFKIAFFGVFIIAAFLNFDKINL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
MPLMPEGKGLSTIPLAATSTLWAFVGLESSTVTAGEIRDPEKNVRKSTIYGLIIASIIYI
EEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHH
LISVGSMGAMSNFKLSNSSAPLTDILTNIFGHSVGKGLTIAVVICILGTTIGWLLSTARV
HHHCCCCCCCCCCEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
SYAAGIDGVFPKFFGKLHPKYGTPINSLIAGSVLVNILLIMNYQKSMVSAFTFITILATL
HHHCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFLPVYLLTVSAEMMLTFRDEKKFDFKIFIKKSMIPLLAFAYSIWTIYGSGAETVMWGFI
HHHHHHHHHHHHHHHEEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LMLIGIPFYIYNHYNSKQTV
HHHHHHHHHEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]