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The map label for this gene is bceR [H]

Identifier: 187933023

GI number: 187933023

Start: 3207985

End: 3208659

Strand: Reverse

Name: bceR [H]

Synonym: CLL_A3099

Alternate gene names: 187933023

Gene position: 3208659-3207985 (Counterclockwise)

Preceding gene: 187935522

Following gene: 187935385

Centisome position: 84.43

GC content: 26.81

Gene sequence:

>675_bases
ATGTATAAGATATTAATTGTAGAAGATGACTTAACAATAGCAAGTATTTTAAAAAATCATTTATGCAAATGGGGATATGA
GGCAGAAATTGTTTCTGACTTTAATAATGTAGTGAGTTCATTTATTGAATATGATCCACAGTTAGTAGTTTTAGATATTA
CATTACCTTTTTATAATGGGTTTCACTGGTGTACAGAAATTAGAAAGATATCTAAAGTGCCAATTATTTTTGCATCATCG
GCAAATGATAATATGAACTTAATTATGGCTATAAATATGGGGGCTGATGACTTTATAGCTAAGCCTTTCGATTTAAATGT
TATAGTTGCAAAAGTACAGGCTTTAATTAGAAGAACTTATTCATTTCAAGGACAAACTAATATTTTAGAAAGTAATGGAG
CTGTACTTAATTTAGGTGATACAACGCTTATTTATAATAATAAAAAATTAGAATTGAGCAAAAATGAATTTAAGATATTA
CAAATACTTTTAGACAATAAAAATAAGACAGTGTCTCGTGATGATATTATGACACATCTTTGGAATAGTGATAGTTTCAT
TGATGATAATACTTTAACTGTTAATGTTACTAGACTTAGAAGAAAGTTAGATGACATAAATCTTAAAAATTTTATTAAGA
CTAAAAAAGGAATCGGATATATAGTGGGGGATTAA

Upstream 100 bases:

>100_bases
ATAATTTCTAGTAAATTGTTATAATATGTTAATAAGGGAATATTTAATTGTTAATATTAGATAATAAGTAGAAAAATTTT
AAGATATAGGAGTAAGCACA

Downstream 100 bases:

>100_bases
TTATGAAGAGAGAATCTATATTATTTATGATATATTTGTACATTAAAGAAAAAATAAAGATTATTGTATCATTTTTAATA
TTTATACTTATATTTTTCAA

Product: two component transcriptional regulator, winged helix family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MYKILIVEDDLTIASILKNHLCKWGYEAEIVSDFNNVVSSFIEYDPQLVVLDITLPFYNGFHWCTEIRKISKVPIIFASS
ANDNMNLIMAINMGADDFIAKPFDLNVIVAKVQALIRRTYSFQGQTNILESNGAVLNLGDTTLIYNNKKLELSKNEFKIL
QILLDNKNKTVSRDDIMTHLWNSDSFIDDNTLTVNVTRLRRKLDDINLKNFIKTKKGIGYIVGD

Sequences:

>Translated_224_residues
MYKILIVEDDLTIASILKNHLCKWGYEAEIVSDFNNVVSSFIEYDPQLVVLDITLPFYNGFHWCTEIRKISKVPIIFASS
ANDNMNLIMAINMGADDFIAKPFDLNVIVAKVQALIRRTYSFQGQTNILESNGAVLNLGDTTLIYNNKKLELSKNEFKIL
QILLDNKNKTVSRDDIMTHLWNSDSFIDDNTLTVNVTRLRRKLDDINLKNFIKTKKGIGYIVGD
>Mature_224_residues
MYKILIVEDDLTIASILKNHLCKWGYEAEIVSDFNNVVSSFIEYDPQLVVLDITLPFYNGFHWCTEIRKISKVPIIFASS
ANDNMNLIMAINMGADDFIAKPFDLNVIVAKVQALIRRTYSFQGQTNILESNGAVLNLGDTTLIYNNKKLELSKNEFKIL
QILLDNKNKTVSRDDIMTHLWNSDSFIDDNTLTVNVTRLRRKLDDINLKNFIKTKKGIGYIVGD

Specific function: Member of the two-component regulatory system BceS/BceR involved in the regulation of bacitracin resistance. When activated by BceS, binds to the upstream region of the bceAB promoter and up-regulates the expression of these two genes [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=219, Percent_Identity=28.310502283105, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786599, Length=221, Percent_Identity=26.2443438914027, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=28.1938325991189, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=30.8035714285714, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790860, Length=219, Percent_Identity=27.3972602739726, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=27.1111111111111, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI87082012, Length=218, Percent_Identity=27.0642201834862, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI2367329, Length=229, Percent_Identity=27.9475982532751, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=30.7692307692308, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=28, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=28.2608695652174, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=25.4545454545455, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=26.7543859649123, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=26.7241379310345, Blast_Score=77, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25587; Mature: 25587

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKILIVEDDLTIASILKNHLCKWGYEAEIVSDFNNVVSSFIEYDPQLVVLDITLPFYNG
CEEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCC
FHWCTEIRKISKVPIIFASSANDNMNLIMAINMGADDFIAKPFDLNVIVAKVQALIRRTY
HHHHHHHHHHCCCCEEEEECCCCCEEEEEEEECCCHHHCCCCCCCHHHHHHHHHHHHHHH
SFQGQTNILESNGAVLNLGDTTLIYNNKKLELSKNEFKILQILLDNKNKTVSRDDIMTHL
CCCCCCEEEECCCCEEECCCEEEEECCCEEEECCCCEEEEEEEECCCCCCCCHHHHHHHH
WNSDSFIDDNTLTVNVTRLRRKLDDINLKNFIKTKKGIGYIVGD
CCCCCEECCCEEEEEHHHHHHHHHCCCHHHHHHHHCCCEEEECC
>Mature Secondary Structure
MYKILIVEDDLTIASILKNHLCKWGYEAEIVSDFNNVVSSFIEYDPQLVVLDITLPFYNG
CEEEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCC
FHWCTEIRKISKVPIIFASSANDNMNLIMAINMGADDFIAKPFDLNVIVAKVQALIRRTY
HHHHHHHHHHCCCCEEEEECCCCCEEEEEEEECCCHHHCCCCCCCHHHHHHHHHHHHHHH
SFQGQTNILESNGAVLNLGDTTLIYNNKKLELSKNEFKILQILLDNKNKTVSRDDIMTHL
CCCCCCEEEECCCCEEECCCEEEEECCCEEEECCCCEEEEEEEECCCCCCCCHHHHHHHH
WNSDSFIDDNTLTVNVTRLRRKLDDINLKNFIKTKKGIGYIVGD
CCCCCEECCCEEEEEHHHHHHHHHCCCHHHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]