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The map label for this gene is thrS [H]

Identifier: 187932904

GI number: 187932904

Start: 351867

End: 353798

Strand: Reverse

Name: thrS [H]

Synonym: CLL_A0348

Alternate gene names: 187932904

Gene position: 353798-351867 (Counterclockwise)

Preceding gene: 187935189

Following gene: 187932534

Centisome position: 9.31

GC content: 30.9

Gene sequence:

>1932_bases
ATGATAAAAGTAACTTTAAAAGATGGTTCAGTTAAAGAATTTGAAGCTGGATTATCTGTATATGAAATAGCAAAATCAAT
TAGTGAAGGTTTAGCTAGAAACGCTTGTTGTGGTGTTGTTAACGGTAAGGTTTGCGACCTTAGAGAAGAAGTTAAAGAAG
ATGTTTCTTTAAGCATATGCACTTTTGATTCTCAAGAGGGTAAAGATGCTGTAAGACATAGTATATCTCATGTTTTAGCT
TATGCTGTTAAAAGATTATTCCCTGAAACAAAATTAGCTATAGGACCTTCTATTGCTACTGGTTTTTACTATGATTTTGA
TAAGGATGTTGCATTTTCAGCTCAAGATTTAGAAAAACTTGAAGCAGAAATGAAAAAAATAATCAAAGAAAATCCTTCAA
TTGAAAAATTTGAACTTCCAAGAAATGAAGCTTTAGAATTAATGAAAGATGAACCATATAAAGTAGAATTAATCAATGAT
TTAGGTGAAGATGAAATAATCTCATTCTATAAACTTGGTGAATTTACTGATTTATGTGCTGGACCTCACGTTATGTCTTT
AAAACCAATTAAAGCAATCAAACTTATTAGAAGTGCTGGTGCTTATTGGAAAGGCGACGAAAAAAATAAAATGCTTACTA
GAATATATGGTACTGCTTTCTTAAAGAAATCAGAACTTGATGAATATTTAGACGCTGTTGAAGAAGCTAAAAAAAGAGAT
CATAATAAATTAGGTAGAGAACTTAAATTATTTACTACTGATGAAAATGTAGGTCAAGGTCTTCCTTTATTAATGCCAAA
AGGAGCTAAGATTGTTCAAACTCTTCAAAGATGGGTTGAGGATGAAGAAGAAAGAAGAGGTTATGTATTAACTAAAACTC
CACTTATGGCTAAGAGCGACCTTTATAAAATTTCTGGTCACTGGGATCACTATAAAGATGGAATGTTTGTATTAGGAGAT
GAAGAAAAGGACGAAGAAGTATTTGCTTTAAGACCTATGACTTGTCCTTTCCAATATACTATATATAATGCAGAACAACA
CAGTTATAGAGATCTTCCTATAAGATACGGTGAAACTTCTACTCTATTTAGAAATGAATCTTCAGGAGAAATGCATGGAC
TTATAAGAGTTAGACAATTCACTTTAGCTGATGGCCACTTAATTGTAACTCCAGAGCAATTAGAAGAAGAATTTAAAGGT
GTACTTGAATTAATTCAATATCTAATGAAAACTTTAGGAATTGATGAAGATATAAGCTATAGATTCTCTAAATGGGATCC
AAATAATACTGAAAAATATATAAATGATCCTGAAGCTTGGAATAAAACTCAAGATACTATGAGAACTATATTAGATCATT
TAAAAATTAATTATGTTGAAGCTGATGATGAAGCTGCATTCTACGGTCCAAAGCTTGACTTACAATGTAGAAATGTTCAT
GGTAAAGAAGATACATTGTTCACAGTTCAAATCGACTTTGCTTTGGCTGAAAGATTTGATATGAGCTATATTGATAAAAA
TGGAGAAAAGAAACGTCCATATATAATTCATAGATCATCAATTGGATGCTATGAAAGAACTTTAGCAATGCTTATAGAAA
AATATGCTGGTGCATTCCCTACTTGGCTTTCTCCAGTTCAAGTAAAAGTGTTACCAATATCAGATAAATACAATGATTAT
GCTGAATCAGTAGTTAAATCATTAAGAAATAAAGGTGTTAGAATTGAAGCTGATTATAGAGCTGAAAAAATCGGTTATAA
AATCAGAGAAGCTAGACTTGAAAGAACTCCTTACATCTTAGTTGTTGGTGAAAAAGAAGCTGCTAACAATGAAGTTTCTG
TAAGAAGTAGAAAGAATGATGATGAAGGTGCTATAAAATTAGATGCCTTTACAGAAAGACTATTAAATGAAATAGCTACA
AAAGAAAGATAA

Upstream 100 bases:

>100_bases
GTGGAACCACGGATATTACTTCGTCTCTATATATTTTAGAGACGGAGTTTTTTTATTTTGTACTAAATTTTATTTTATGA
ATTTGAAAGGAGTTTTTATA

Downstream 100 bases:

>100_bases
TTTCTTTTGATTCACTGAAAATGCGATATATGCATAAGTAAATTGGACTGAGTAATTAGACTTAAGAACACTAAAATGAG
TATAGTCCCATTTTAGCTTG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 643; Mature: 643

Protein sequence:

>643_residues
MIKVTLKDGSVKEFEAGLSVYEIAKSISEGLARNACCGVVNGKVCDLREEVKEDVSLSICTFDSQEGKDAVRHSISHVLA
YAVKRLFPETKLAIGPSIATGFYYDFDKDVAFSAQDLEKLEAEMKKIIKENPSIEKFELPRNEALELMKDEPYKVELIND
LGEDEIISFYKLGEFTDLCAGPHVMSLKPIKAIKLIRSAGAYWKGDEKNKMLTRIYGTAFLKKSELDEYLDAVEEAKKRD
HNKLGRELKLFTTDENVGQGLPLLMPKGAKIVQTLQRWVEDEEERRGYVLTKTPLMAKSDLYKISGHWDHYKDGMFVLGD
EEKDEEVFALRPMTCPFQYTIYNAEQHSYRDLPIRYGETSTLFRNESSGEMHGLIRVRQFTLADGHLIVTPEQLEEEFKG
VLELIQYLMKTLGIDEDISYRFSKWDPNNTEKYINDPEAWNKTQDTMRTILDHLKINYVEADDEAAFYGPKLDLQCRNVH
GKEDTLFTVQIDFALAERFDMSYIDKNGEKKRPYIIHRSSIGCYERTLAMLIEKYAGAFPTWLSPVQVKVLPISDKYNDY
AESVVKSLRNKGVRIEADYRAEKIGYKIREARLERTPYILVVGEKEAANNEVSVRSRKNDDEGAIKLDAFTERLLNEIAT
KER

Sequences:

>Translated_643_residues
MIKVTLKDGSVKEFEAGLSVYEIAKSISEGLARNACCGVVNGKVCDLREEVKEDVSLSICTFDSQEGKDAVRHSISHVLA
YAVKRLFPETKLAIGPSIATGFYYDFDKDVAFSAQDLEKLEAEMKKIIKENPSIEKFELPRNEALELMKDEPYKVELIND
LGEDEIISFYKLGEFTDLCAGPHVMSLKPIKAIKLIRSAGAYWKGDEKNKMLTRIYGTAFLKKSELDEYLDAVEEAKKRD
HNKLGRELKLFTTDENVGQGLPLLMPKGAKIVQTLQRWVEDEEERRGYVLTKTPLMAKSDLYKISGHWDHYKDGMFVLGD
EEKDEEVFALRPMTCPFQYTIYNAEQHSYRDLPIRYGETSTLFRNESSGEMHGLIRVRQFTLADGHLIVTPEQLEEEFKG
VLELIQYLMKTLGIDEDISYRFSKWDPNNTEKYINDPEAWNKTQDTMRTILDHLKINYVEADDEAAFYGPKLDLQCRNVH
GKEDTLFTVQIDFALAERFDMSYIDKNGEKKRPYIIHRSSIGCYERTLAMLIEKYAGAFPTWLSPVQVKVLPISDKYNDY
AESVVKSLRNKGVRIEADYRAEKIGYKIREARLERTPYILVVGEKEAANNEVSVRSRKNDDEGAIKLDAFTERLLNEIAT
KER
>Mature_643_residues
MIKVTLKDGSVKEFEAGLSVYEIAKSISEGLARNACCGVVNGKVCDLREEVKEDVSLSICTFDSQEGKDAVRHSISHVLA
YAVKRLFPETKLAIGPSIATGFYYDFDKDVAFSAQDLEKLEAEMKKIIKENPSIEKFELPRNEALELMKDEPYKVELIND
LGEDEIISFYKLGEFTDLCAGPHVMSLKPIKAIKLIRSAGAYWKGDEKNKMLTRIYGTAFLKKSELDEYLDAVEEAKKRD
HNKLGRELKLFTTDENVGQGLPLLMPKGAKIVQTLQRWVEDEEERRGYVLTKTPLMAKSDLYKISGHWDHYKDGMFVLGD
EEKDEEVFALRPMTCPFQYTIYNAEQHSYRDLPIRYGETSTLFRNESSGEMHGLIRVRQFTLADGHLIVTPEQLEEEFKG
VLELIQYLMKTLGIDEDISYRFSKWDPNNTEKYINDPEAWNKTQDTMRTILDHLKINYVEADDEAAFYGPKLDLQCRNVH
GKEDTLFTVQIDFALAERFDMSYIDKNGEKKRPYIIHRSSIGCYERTLAMLIEKYAGAFPTWLSPVQVKVLPISDKYNDY
AESVVKSLRNKGVRIEADYRAEKIGYKIREARLERTPYILVVGEKEAANNEVSVRSRKNDDEGAIKLDAFTERLLNEIAT
KER

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38570111, Length=640, Percent_Identity=35.46875, Blast_Score=411, Evalue=1e-114,
Organism=Homo sapiens, GI38202255, Length=647, Percent_Identity=35.2395672333849, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI20070344, Length=652, Percent_Identity=30.9815950920245, Blast_Score=336, Evalue=3e-92,
Organism=Escherichia coli, GI1788013, Length=644, Percent_Identity=38.3540372670807, Blast_Score=479, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI71984192, Length=636, Percent_Identity=33.9622641509434, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71984184, Length=636, Percent_Identity=33.9622641509434, Blast_Score=395, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6322112, Length=636, Percent_Identity=33.1761006289308, Blast_Score=372, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6322654, Length=396, Percent_Identity=32.0707070707071, Blast_Score=229, Evalue=9e-61,
Organism=Drosophila melanogaster, GI24583842, Length=636, Percent_Identity=36.7924528301887, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI28574141, Length=636, Percent_Identity=36.7924528301887, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24583839, Length=636, Percent_Identity=36.7924528301887, Blast_Score=436, Evalue=1e-122,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 73811; Mature: 73811

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVTLKDGSVKEFEAGLSVYEIAKSISEGLARNACCGVVNGKVCDLREEVKEDVSLSIC
CEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHCCEEEEE
TFDSQEGKDAVRHSISHVLAYAVKRLFPETKLAIGPSIATGFYYDFDKDVAFSAQDLEKL
ECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHCCEEEECCCCCCCCHHHHHHH
EAEMKKIIKENPSIEKFELPRNEALELMKDEPYKVELINDLGEDEIISFYKLGEFTDLCA
HHHHHHHHHCCCCCCEEECCHHHHHHHHCCCCEEEEEEHHCCCHHHHHHHHHCCHHHHHC
GPHVMSLKPIKAIKLIRSAGAYWKGDEKNKMLTRIYGTAFLKKSELDEYLDAVEEAKKRD
CCCEECCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HNKLGRELKLFTTDENVGQGLPLLMPKGAKIVQTLQRWVEDEEERRGYVLTKTPLMAKSD
HHHCCCEEEEEECCCCCCCCCCEECCCCHHHHHHHHHHHCCHHHCCCEEEECCCCCCCCC
LYKISGHWDHYKDGMFVLGDEEKDEEVFALRPMTCPFQYTIYNAEQHSYRDLPIRYGETS
CEEECCCCCCCCCCEEEECCCCCCCCEEEECCCCCCEEEEEECCCCCCCCCCCEEECCCC
TLFRNESSGEMHGLIRVRQFTLADGHLIVTPEQLEEEFKGVLELIQYLMKTLGIDEDISY
CEEECCCCCCHHHEEEEEEEEEECCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RFSKWDPNNTEKYINDPEAWNKTQDTMRTILDHLKINYVEADDEAAFYGPKLDLQCRNVH
EEECCCCCCCHHCCCCCHHCCCHHHHHHHHHHHHEEEEEECCCCCEEECCCCCEEECCCC
GKEDTLFTVQIDFALAERFDMSYIDKNGEKKRPYIIHRSSIGCYERTLAMLIEKYAGAFP
CCCCEEEEEEEEHHHHHHHCHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCC
TWLSPVQVKVLPISDKYNDYAESVVKSLRNKGVRIEADYRAEKIGYKIREARLERTPYIL
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCCEEE
VVGEKEAANNEVSVRSRKNDDEGAIKLDAFTERLLNEIATKER
EEECCCCCCCCEEEECCCCCCCCCEEHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIKVTLKDGSVKEFEAGLSVYEIAKSISEGLARNACCGVVNGKVCDLREEVKEDVSLSIC
CEEEEECCCCHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCEECHHHHHHHCCEEEEE
TFDSQEGKDAVRHSISHVLAYAVKRLFPETKLAIGPSIATGFYYDFDKDVAFSAQDLEKL
ECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCHHCCEEEECCCCCCCCHHHHHHH
EAEMKKIIKENPSIEKFELPRNEALELMKDEPYKVELINDLGEDEIISFYKLGEFTDLCA
HHHHHHHHHCCCCCCEEECCHHHHHHHHCCCCEEEEEEHHCCCHHHHHHHHHCCHHHHHC
GPHVMSLKPIKAIKLIRSAGAYWKGDEKNKMLTRIYGTAFLKKSELDEYLDAVEEAKKRD
CCCEECCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HNKLGRELKLFTTDENVGQGLPLLMPKGAKIVQTLQRWVEDEEERRGYVLTKTPLMAKSD
HHHCCCEEEEEECCCCCCCCCCEECCCCHHHHHHHHHHHCCHHHCCCEEEECCCCCCCCC
LYKISGHWDHYKDGMFVLGDEEKDEEVFALRPMTCPFQYTIYNAEQHSYRDLPIRYGETS
CEEECCCCCCCCCCEEEECCCCCCCCEEEECCCCCCEEEEEECCCCCCCCCCCEEECCCC
TLFRNESSGEMHGLIRVRQFTLADGHLIVTPEQLEEEFKGVLELIQYLMKTLGIDEDISY
CEEECCCCCCHHHEEEEEEEEEECCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
RFSKWDPNNTEKYINDPEAWNKTQDTMRTILDHLKINYVEADDEAAFYGPKLDLQCRNVH
EEECCCCCCCHHCCCCCHHCCCHHHHHHHHHHHHEEEEEECCCCCEEECCCCCEEECCCC
GKEDTLFTVQIDFALAERFDMSYIDKNGEKKRPYIIHRSSIGCYERTLAMLIEKYAGAFP
CCCCEEEEEEEEHHHHHHHCHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCC
TWLSPVQVKVLPISDKYNDYAESVVKSLRNKGVRIEADYRAEKIGYKIREARLERTPYIL
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHCCCCEEE
VVGEKEAANNEVSVRSRKNDDEGAIKLDAFTERLLNEIATKER
EEECCCCCCCCEEEECCCCCCCCCEEHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA