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The map label for this gene is polC [H]

Identifier: 187932792

GI number: 187932792

Start: 2111346

End: 2112275

Strand: Reverse

Name: polC [H]

Synonym: CLL_A2019

Alternate gene names: 187932792

Gene position: 2112275-2111346 (Counterclockwise)

Preceding gene: 187933797

Following gene: 187934802

Centisome position: 55.58

GC content: 27.96

Gene sequence:

>930_bases
ATGAACTTTGTAGCTATAGATTTTGAAACTGCTAATGAAAAAAGGAACAGTCCATGTTCTATAGGTATTGTTGTTGTAAA
AGATGGTGAAATTATAGAAGAAGTACATCATTTAATAAAACCTAAAGAAATGAGATTTATGCCAATAAATATTGGAATTC
ATGGAATAAGACCTAGAATGGTTCAAGATGAATTAGAATTTGATAAAGTATGGGAAAAAATTAAACATTATTTTAATAAA
AATTTAGTAATAGCTCATAATGCTTCTTTTGATATATCTGTATTAAGAAATACCTTAGAACTTTATAATCTAGAAATGCC
AAGCTTTCAGTATATATGTACAATGAAGCTTTCTAGAAATTTTTATAGCAATCTTGATAATGCAAGATTAAATACAGTAA
ATAATTTTTTGGGATATGAATTTAAGCACCATGATGCGTTAGCTGATGCAATGGCATGTAGCAATATTTTACTTAATATA
TGCGAAGAATTAAATACAAGAGATATTAATGAAATATCAAAATGTGTTGGGGTTACTTTAGGATGTGTAAATGAAAATGG
ATACAAGCCATCTTCAACTAAAGGAAGAATTTTTGAAAGATCTAGTAGACAACCTGTAAGACAAAGTGAAACTACAATGA
AAAATTTTAACTTTACTGCATTTACAGATGAAGTTGTTGTATTTACTGGAGGCTTAGCATCTATGACAAGAGATGAAGCA
ATTAGACTAGTTAGAAAACTTAATGGAAGTGTGGGGAGCTCTGTAACAAAGAAAACAACATATTTGGTAACTAATACAAA
GAATATAGATGACTTACATAGAGATGAAATGAGTAATAAGCTTAGAAAAGCAGTGGATTTGAAAGATAAAGGACAAGGCA
TAAAATTTTTAAATGAAGAAGCTTTTTTAAAAAAATGTAGAGGAATTTAA

Upstream 100 bases:

>100_bases
TATTTAGAACTATTAGAAATTATAATTACACTGTTTTAATGAGTATATTCTTAGGTTATAATGTAAGAGCAAAATTAATT
GAAAATATAGGAGAAAATAA

Downstream 100 bases:

>100_bases
TTCTAGCCAATTTGTTGTAAACAAAATTATGTTAAATATAATAGCAACCTAGAAATTGATTAATCTAGGTTGCTATTATA
TTTAATTAAGTATTATTTTG

Product: DNA polymerase III subunit epsilon

Products: NA

Alternate protein names: PolIII [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MNFVAIDFETANEKRNSPCSIGIVVVKDGEIIEEVHHLIKPKEMRFMPINIGIHGIRPRMVQDELEFDKVWEKIKHYFNK
NLVIAHNASFDISVLRNTLELYNLEMPSFQYICTMKLSRNFYSNLDNARLNTVNNFLGYEFKHHDALADAMACSNILLNI
CEELNTRDINEISKCVGVTLGCVNENGYKPSSTKGRIFERSSRQPVRQSETTMKNFNFTAFTDEVVVFTGGLASMTRDEA
IRLVRKLNGSVGSSVTKKTTYLVTNTKNIDDLHRDEMSNKLRKAVDLKDKGQGIKFLNEEAFLKKCRGI

Sequences:

>Translated_309_residues
MNFVAIDFETANEKRNSPCSIGIVVVKDGEIIEEVHHLIKPKEMRFMPINIGIHGIRPRMVQDELEFDKVWEKIKHYFNK
NLVIAHNASFDISVLRNTLELYNLEMPSFQYICTMKLSRNFYSNLDNARLNTVNNFLGYEFKHHDALADAMACSNILLNI
CEELNTRDINEISKCVGVTLGCVNENGYKPSSTKGRIFERSSRQPVRQSETTMKNFNFTAFTDEVVVFTGGLASMTRDEA
IRLVRKLNGSVGSSVTKKTTYLVTNTKNIDDLHRDEMSNKLRKAVDLKDKGQGIKFLNEEAFLKKCRGI
>Mature_309_residues
MNFVAIDFETANEKRNSPCSIGIVVVKDGEIIEEVHHLIKPKEMRFMPINIGIHGIRPRMVQDELEFDKVWEKIKHYFNK
NLVIAHNASFDISVLRNTLELYNLEMPSFQYICTMKLSRNFYSNLDNARLNTVNNFLGYEFKHHDALADAMACSNILLNI
CEELNTRDINEISKCVGVTLGCVNENGYKPSSTKGRIFERSSRQPVRQSETTMKNFNFTAFTDEVVVFTGGLASMTRDEA
IRLVRKLNGSVGSSVTKKTTYLVTNTKNIDDLHRDEMSNKLRKAVDLKDKGQGIKFLNEEAFLKKCRGI

Specific function: Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0847

COG function: function code L; DNA polymerase III, epsilon subunit and related 3'-5' exonucleases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

Organism=Escherichia coli, GI1788149, Length=145, Percent_Identity=34.4827586206897, Blast_Score=72, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011708
- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR016027
- InterPro:   IPR004365
- InterPro:   IPR004013
- InterPro:   IPR003141
- InterPro:   IPR006308
- InterPro:   IPR012337 [H]

Pfam domain/function: PF07733 DNA_pol3_alpha; PF00929 Exonuc_X-T; PF02811 PHP; PF01336 tRNA_anti [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 35317; Mature: 35317

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS50172 BRCT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFVAIDFETANEKRNSPCSIGIVVVKDGEIIEEVHHLIKPKEMRFMPINIGIHGIRPRM
CCEEEEEEECCCCCCCCCCEEEEEEEECCHHHHHHHHHHCCCCCEEEEEECCEECCCCCH
VQDELEFDKVWEKIKHYFNKNLVIAHNASFDISVLRNTLELYNLEMPSFQYICTMKLSRN
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEHHHHHH
FYSNLDNARLNTVNNFLGYEFKHHDALADAMACSNILLNICEELNTRDINEISKCVGVTL
HHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEE
GCVNENGYKPSSTKGRIFERSSRQPVRQSETTMKNFNFTAFTDEVVVFTGGLASMTRDEA
EEECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHCCCEEEECCCEEEEECCHHHHHHHHH
IRLVRKLNGSVGSSVTKKTTYLVTNTKNIDDLHRDEMSNKLRKAVDLKDKGQGIKFLNEE
HHHHHHHCCCCCCCHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECHH
AFLKKCRGI
HHHHHHCCC
>Mature Secondary Structure
MNFVAIDFETANEKRNSPCSIGIVVVKDGEIIEEVHHLIKPKEMRFMPINIGIHGIRPRM
CCEEEEEEECCCCCCCCCCEEEEEEEECCHHHHHHHHHHCCCCCEEEEEECCEECCCCCH
VQDELEFDKVWEKIKHYFNKNLVIAHNASFDISVLRNTLELYNLEMPSFQYICTMKLSRN
HHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEEEHHHHHH
FYSNLDNARLNTVNNFLGYEFKHHDALADAMACSNILLNICEELNTRDINEISKCVGVTL
HHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCEE
GCVNENGYKPSSTKGRIFERSSRQPVRQSETTMKNFNFTAFTDEVVVFTGGLASMTRDEA
EEECCCCCCCCCCCCCEEECCCCCCCHHHHHHHHCCCEEEECCCEEEEECCHHHHHHHHH
IRLVRKLNGSVGSSVTKKTTYLVTNTKNIDDLHRDEMSNKLRKAVDLKDKGQGIKFLNEE
HHHHHHHCCCCCCCHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECHH
AFLKKCRGI
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]