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The map label for this gene is yclK [H]

Identifier: 187932625

GI number: 187932625

Start: 3114601

End: 3116058

Strand: Reverse

Name: yclK [H]

Synonym: CLL_A3015

Alternate gene names: 187932625

Gene position: 3116058-3114601 (Counterclockwise)

Preceding gene: 187933594

Following gene: 187934293

Centisome position: 81.99

GC content: 26.68

Gene sequence:

>1458_bases
ATGAAGTTATGGCAGAAAATATATTTCTTTTCTTTATTATTACTTATAGTTACTTTAAACATAGCTGGATTTATATTGAT
ACAAAAACTTCATAATAATCTATTAGAAAAGGAAGTTGAGAAATGTCTTTCAGAACAAAAAATTGTTTCTTCAGAATTCA
GAATTAATTCTCTAGCCCTGCAAAAAATCTATTATTTAAATACTGCTCCTGAAATTAATATGTCAATTAGCACTTTAATG
AGTGAATATAACAGTTTGATTGATCGTGAAGCTGGACAACATGGGGATATAGAAATTTTAGATCAGCAAAATAAAATATT
ATATTCAGATGTGAAATTTCCTGTTCCAGATGAAAAGCAGGAGTTAGAAAATCTTTCTGTGGGAAAAACTAACTACATTA
TTAAAACATTAGATGGAAAGCAGTATTTATATGTAAGTAGCTTAGTTAATGTGTATAATGTTCCAATAAAAATACATTAT
GCTAAAGATATTTCAAACATATACATTGAAAAAATGAATCAGTATGCCCTTTTTATGAAATTGGACATTTTAATCTGTTC
TCTTTTTGCCATTTTTATGTTTTTTGTAAGCAGATTAATAACAAAACCAATAAATACGTTAATAGACTCTACTCAAAAAA
TATCTTTGGGTCAGTATTCTGAAAGGGTAAGAATAAAATCAAAAGATGAATTTAACGTTCTTTCAAATCATTTTAATCTA
ATGGCTCAGACAATAGAAGATAAAATAAATGAGTTGGAAATATCGAATATTGAAAAGGAAACTTTCATAAATAACCTGAC
TCATGAGCTTAAGACACCTTTAACTTCTATAATTGGATATGCTAATTTAATAAGAACATCAAAATATAATGAAGAATTAT
TTTTCGAATCTGCAGACTACATTTACAAAGAGGGGAAAAGACTTGAGCAAATGGCTTTTAAAATGATGGATTTAATTTAT
GCTAAGACTCAGGAAATTAAATTAACACCTGAAAAAATTATGCCAATAATATATGAAGTAAAAAAATCTCTACTTGTTAA
GTTTAAAGATAAAAATATAGATTTAATTGTTGAAGAGGAAGACTGCATATTAGATGTGGACAAAGATCTAATTAAGATAG
CATTATGCAATTTAGTGGAAAATGCTATAAAAGCATCTAGGAATGATTCTAAAATATATATAAGAGTATTTGTTTTAAAT
GATAAAACTTTTATATCTGTTTTGGATTCGGGTACAGGAATTACTAAAGAACATTTGGATAAAATATGGCAGCCATTCTA
TGTAGTTGATAAAGCAAGGAGCAGAAAAAATAACGGAGCAGGTATTGGGCTTTCTATCTGCAAAAAAATAGCGGAAATTC
ATAATGCAGATATAAAAATAAATAGTGAATTAGGTAAAGGTACAGAAGTAACCATAATTTTTAATCAATCTTCTACAATT
ATAGATAAATCAATTTAA

Upstream 100 bases:

>100_bases
CAATAGATAACCATATTCAAAAGTTAAGAAAGAAGCTGGATATTGCAGATAATATAAAAACTGTATATAAAATTGGATAC
AGATTAGAGGAGTAATAGAT

Downstream 100 bases:

>100_bases
TCTATATTCTAAAATATTTATATTACAATGAGATATTTATTGTTTATAGCAAATTTTTATTATAAGTTTCTAGATTGAGA
TTGCTATTTAGCAAAATAAA

Product: sensory transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MKLWQKIYFFSLLLLIVTLNIAGFILIQKLHNNLLEKEVEKCLSEQKIVSSEFRINSLALQKIYYLNTAPEINMSISTLM
SEYNSLIDREAGQHGDIEILDQQNKILYSDVKFPVPDEKQELENLSVGKTNYIIKTLDGKQYLYVSSLVNVYNVPIKIHY
AKDISNIYIEKMNQYALFMKLDILICSLFAIFMFFVSRLITKPINTLIDSTQKISLGQYSERVRIKSKDEFNVLSNHFNL
MAQTIEDKINELEISNIEKETFINNLTHELKTPLTSIIGYANLIRTSKYNEELFFESADYIYKEGKRLEQMAFKMMDLIY
AKTQEIKLTPEKIMPIIYEVKKSLLVKFKDKNIDLIVEEEDCILDVDKDLIKIALCNLVENAIKASRNDSKIYIRVFVLN
DKTFISVLDSGTGITKEHLDKIWQPFYVVDKARSRKNNGAGIGLSICKKIAEIHNADIKINSELGKGTEVTIIFNQSSTI
IDKSI

Sequences:

>Translated_485_residues
MKLWQKIYFFSLLLLIVTLNIAGFILIQKLHNNLLEKEVEKCLSEQKIVSSEFRINSLALQKIYYLNTAPEINMSISTLM
SEYNSLIDREAGQHGDIEILDQQNKILYSDVKFPVPDEKQELENLSVGKTNYIIKTLDGKQYLYVSSLVNVYNVPIKIHY
AKDISNIYIEKMNQYALFMKLDILICSLFAIFMFFVSRLITKPINTLIDSTQKISLGQYSERVRIKSKDEFNVLSNHFNL
MAQTIEDKINELEISNIEKETFINNLTHELKTPLTSIIGYANLIRTSKYNEELFFESADYIYKEGKRLEQMAFKMMDLIY
AKTQEIKLTPEKIMPIIYEVKKSLLVKFKDKNIDLIVEEEDCILDVDKDLIKIALCNLVENAIKASRNDSKIYIRVFVLN
DKTFISVLDSGTGITKEHLDKIWQPFYVVDKARSRKNNGAGIGLSICKKIAEIHNADIKINSELGKGTEVTIIFNQSSTI
IDKSI
>Mature_485_residues
MKLWQKIYFFSLLLLIVTLNIAGFILIQKLHNNLLEKEVEKCLSEQKIVSSEFRINSLALQKIYYLNTAPEINMSISTLM
SEYNSLIDREAGQHGDIEILDQQNKILYSDVKFPVPDEKQELENLSVGKTNYIIKTLDGKQYLYVSSLVNVYNVPIKIHY
AKDISNIYIEKMNQYALFMKLDILICSLFAIFMFFVSRLITKPINTLIDSTQKISLGQYSERVRIKSKDEFNVLSNHFNL
MAQTIEDKINELEISNIEKETFINNLTHELKTPLTSIIGYANLIRTSKYNEELFFESADYIYKEGKRLEQMAFKMMDLIY
AKTQEIKLTPEKIMPIIYEVKKSLLVKFKDKNIDLIVEEEDCILDVDKDLIKIALCNLVENAIKASRNDSKIYIRVFVLN
DKTFISVLDSGTGITKEHLDKIWQPFYVVDKARSRKNNGAGIGLSICKKIAEIHNADIKINSELGKGTEVTIIFNQSSTI
IDKSI

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=467, Percent_Identity=24.6252676659529, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786600, Length=217, Percent_Identity=27.6497695852535, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788393, Length=283, Percent_Identity=25.7950530035336, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1789149, Length=335, Percent_Identity=25.3731343283582, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI145693157, Length=241, Percent_Identity=24.896265560166, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790861, Length=227, Percent_Identity=26.8722466960352, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788713, Length=242, Percent_Identity=25.2066115702479, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1790346, Length=281, Percent_Identity=27.0462633451957, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI87081816, Length=336, Percent_Identity=23.5119047619048, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI48994928, Length=239, Percent_Identity=26.3598326359833, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1787894, Length=322, Percent_Identity=24.8447204968944, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790436, Length=213, Percent_Identity=28.169014084507, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788549, Length=216, Percent_Identity=24.537037037037, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790551, Length=280, Percent_Identity=22.1428571428571, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI87082128, Length=307, Percent_Identity=21.4983713355049, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1786912, Length=207, Percent_Identity=25.6038647342995, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 55953; Mature: 55953

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLWQKIYFFSLLLLIVTLNIAGFILIQKLHNNLLEKEVEKCLSEQKIVSSEFRINSLAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKIYYLNTAPEINMSISTLMSEYNSLIDREAGQHGDIEILDQQNKILYSDVKFPVPDEKQ
HHHEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEECCCCCCCCCHH
ELENLSVGKTNYIIKTLDGKQYLYVSSLVNVYNVPIKIHYAKDISNIYIEKMNQYALFMK
HHHCCCCCCCCEEEEEECCCEEEHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHH
LDILICSLFAIFMFFVSRLITKPINTLIDSTQKISLGQYSERVRIKSKDEFNVLSNHFNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHH
MAQTIEDKINELEISNIEKETFINNLTHELKTPLTSIIGYANLIRTSKYNEELFFESADY
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHH
IYKEGKRLEQMAFKMMDLIYAKTQEIKLTPEKIMPIIYEVKKSLLVKFKDKNIDLIVEEE
HHHCCHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHEEEECCCCEEEEEECC
DCILDVDKDLIKIALCNLVENAIKASRNDSKIYIRVFVLNDKTFISVLDSGTGITKEHLD
CCEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCEEEEEECCCCCCCHHHHH
KIWQPFYVVDKARSRKNNGAGIGLSICKKIAEIHNADIKINSELGKGTEVTIIFNQSSTI
HHCCCCEEEHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCCCCC
IDKSI
CCCCC
>Mature Secondary Structure
MKLWQKIYFFSLLLLIVTLNIAGFILIQKLHNNLLEKEVEKCLSEQKIVSSEFRINSLAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKIYYLNTAPEINMSISTLMSEYNSLIDREAGQHGDIEILDQQNKILYSDVKFPVPDEKQ
HHHEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEECCCCCCCCCHH
ELENLSVGKTNYIIKTLDGKQYLYVSSLVNVYNVPIKIHYAKDISNIYIEKMNQYALFMK
HHHCCCCCCCCEEEEEECCCEEEHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHH
LDILICSLFAIFMFFVSRLITKPINTLIDSTQKISLGQYSERVRIKSKDEFNVLSNHFNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHH
MAQTIEDKINELEISNIEKETFINNLTHELKTPLTSIIGYANLIRTSKYNEELFFESADY
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHH
IYKEGKRLEQMAFKMMDLIYAKTQEIKLTPEKIMPIIYEVKKSLLVKFKDKNIDLIVEEE
HHHCCHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHEEEECCCCEEEEEECC
DCILDVDKDLIKIALCNLVENAIKASRNDSKIYIRVFVLNDKTFISVLDSGTGITKEHLD
CCEEECCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEECCCEEEEEECCCCCCCHHHHH
KIWQPFYVVDKARSRKNNGAGIGLSICKKIAEIHNADIKINSELGKGTEVTIIFNQSSTI
HHCCCCEEEHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEECCCCCC
IDKSI
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]