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The map label for this gene is pgcA [H]

Identifier: 187932543

GI number: 187932543

Start: 2546963

End: 2548690

Strand: Reverse

Name: pgcA [H]

Synonym: CLL_A2461

Alternate gene names: 187932543

Gene position: 2548690-2546963 (Counterclockwise)

Preceding gene: 187935547

Following gene: 187935614

Centisome position: 67.07

GC content: 27.55

Gene sequence:

>1728_bases
ATGGATTATAAAGAAAAATATAACTCATGGATTAATTCTGAGAGTATAAATGAAGAAACAAAGAATGAATTAAAAGCAAT
ATGTGATGAAAAAGAAATAGAAGATAGATTTTATAAAGATTTAGAATTTGGTACAGGTGGATTAAGAGGTGTAATTGGAG
CTGGAAGCAATAGAATGAATGTATATAGTGTTTCAAAAGCAACTCAAGGTTTTGCTAATTACTTAAATGAAAACTTTAAT
AAACCAGCAGTTGCAATTGCATATGATTCTAGAAATATGTCAAAAGAATTTGCTAAGGCAGCAGCACTTACATTATGCGC
TAACAATGTAAAAGTATACTTATATGAAAGTTTAAGACCAACACCAGTTTTATCTTTTGCTACAAGAGAACTAAAATGTA
GTGGTGGAATAGTTGTAACTGCTTCACATAATCCAAAACAATACAATGGATATAAGGTTTATGATGAATTTGGAGGACAA
GTTACAGATGACAAAGCTAACAAAATAATAACTTGTGTTAACCAAATTGAAGATTTTTCACAAATTAAAATTATAGATGA
AAAAGATGCGTTAGAAAAAGGTTTACTTGAATATGTAGGTGAAGAATTAGATAAAACTTATATGGAAAAAGTAAAATCTT
TAACTATTAGAAAAGAATTAGTTAGTGAAAAAGCTAATACTTTAAATGTTATATATACTCCAATTCATGGATCAGGTAAT
GTTCCAGTTAGAAGAGTATTAAAAGAATTAGGATATACAAATGTAGAAGTTGTAAAAGAACAAGAAGCTCCAGATGGAAA
CTTTCCAACAGCATCTTATCCTAATCCAGAAAATCCAGATGTATTTAAATTAGCTTTAAATATGGCACAAAGCACAAATC
CAGATATAATATTTGGAACAGATCCAGATTGTGATAGAATTGGTGTTGTTGTAAAAGACAGCAAAGGTGAATATAAAGTT
TTAACTGGTAACCAAACCGGATTATTATTAACTCATTATATATTAAGTTCATTAAAAGAAACTAATAAGTTACCTGAAAA
TGGAGTAGTTATTAAGACAATAGTAACTACGGAAGGTGCTAAAGCAATTGCTGATGATTTTAATATAGAAATATTAGATG
TACTAACTGGATTTAAATATATAGGAGAAAAGATAAGAGAATTTAAAGAATCAGGGGAATATACTTACTTATTTGGATTT
GAAGAAAGTTATGGATATCTTGCAGGAGACTTTGTTCGTGATAAAGATGCAGTAATAGCTTCAATGTTAATATGTGAAAT
GTGCTTATATTATAAAGAACATGGTAAGAGTTTATATGATGCTTTAATAGAATTATATGAAAAATATGGATACTTTAAAG
AAACTCTTGTATCTCTAGAATTAGCAGGAAAAGAAGGTCAAGAAAAAATTGCTTCTTGTATAGATGCTATGAGAAATAGT
AATATAACTGAAATTAACAATGTAAAAGTAGTTAAAAAGTTAGATTATAAATTAAGTACAGATGAGGATATTATAAATGG
TACTAAGGTAGCAATTAATTTACCAAAATCAAATGTATTAAAGTTTATACTTGAAGATGATTCTTATTTTGTAGTTAGAC
CATCAGGAACTGAGCCAAAGATGAAGGTTTATTTATCTATTAAGGGAAATAGCGTGACTGATGCAGAAAAACAAATATCA
GAATTTAAAGAAAATGTTATGAATTTAATTAATGAAAAATTAAACTAA

Upstream 100 bases:

>100_bases
TATGGTTAAGTATTGTATAATAATAGGAGTATTAAGTAAAATTTTGTTAAGTTAGTATAAATGTTTAACAAATGATTTAT
ACAAATGGGAGGGAACATAT

Downstream 100 bases:

>100_bases
ATTAATTCTACAAATAAGCTGTTTTAAGTGATATAATAATCATTTGAGACAGCTTTTGTCTTAAATACTATCAAGATAAA
ATTAGGTGGTGTAACGTAAT

Product: phosphomannomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 575; Mature: 575

Protein sequence:

>575_residues
MDYKEKYNSWINSESINEETKNELKAICDEKEIEDRFYKDLEFGTGGLRGVIGAGSNRMNVYSVSKATQGFANYLNENFN
KPAVAIAYDSRNMSKEFAKAAALTLCANNVKVYLYESLRPTPVLSFATRELKCSGGIVVTASHNPKQYNGYKVYDEFGGQ
VTDDKANKIITCVNQIEDFSQIKIIDEKDALEKGLLEYVGEELDKTYMEKVKSLTIRKELVSEKANTLNVIYTPIHGSGN
VPVRRVLKELGYTNVEVVKEQEAPDGNFPTASYPNPENPDVFKLALNMAQSTNPDIIFGTDPDCDRIGVVVKDSKGEYKV
LTGNQTGLLLTHYILSSLKETNKLPENGVVIKTIVTTEGAKAIADDFNIEILDVLTGFKYIGEKIREFKESGEYTYLFGF
EESYGYLAGDFVRDKDAVIASMLICEMCLYYKEHGKSLYDALIELYEKYGYFKETLVSLELAGKEGQEKIASCIDAMRNS
NITEINNVKVVKKLDYKLSTDEDIINGTKVAINLPKSNVLKFILEDDSYFVVRPSGTEPKMKVYLSIKGNSVTDAEKQIS
EFKENVMNLINEKLN

Sequences:

>Translated_575_residues
MDYKEKYNSWINSESINEETKNELKAICDEKEIEDRFYKDLEFGTGGLRGVIGAGSNRMNVYSVSKATQGFANYLNENFN
KPAVAIAYDSRNMSKEFAKAAALTLCANNVKVYLYESLRPTPVLSFATRELKCSGGIVVTASHNPKQYNGYKVYDEFGGQ
VTDDKANKIITCVNQIEDFSQIKIIDEKDALEKGLLEYVGEELDKTYMEKVKSLTIRKELVSEKANTLNVIYTPIHGSGN
VPVRRVLKELGYTNVEVVKEQEAPDGNFPTASYPNPENPDVFKLALNMAQSTNPDIIFGTDPDCDRIGVVVKDSKGEYKV
LTGNQTGLLLTHYILSSLKETNKLPENGVVIKTIVTTEGAKAIADDFNIEILDVLTGFKYIGEKIREFKESGEYTYLFGF
EESYGYLAGDFVRDKDAVIASMLICEMCLYYKEHGKSLYDALIELYEKYGYFKETLVSLELAGKEGQEKIASCIDAMRNS
NITEINNVKVVKKLDYKLSTDEDIINGTKVAINLPKSNVLKFILEDDSYFVVRPSGTEPKMKVYLSIKGNSVTDAEKQIS
EFKENVMNLINEKLN
>Mature_575_residues
MDYKEKYNSWINSESINEETKNELKAICDEKEIEDRFYKDLEFGTGGLRGVIGAGSNRMNVYSVSKATQGFANYLNENFN
KPAVAIAYDSRNMSKEFAKAAALTLCANNVKVYLYESLRPTPVLSFATRELKCSGGIVVTASHNPKQYNGYKVYDEFGGQ
VTDDKANKIITCVNQIEDFSQIKIIDEKDALEKGLLEYVGEELDKTYMEKVKSLTIRKELVSEKANTLNVIYTPIHGSGN
VPVRRVLKELGYTNVEVVKEQEAPDGNFPTASYPNPENPDVFKLALNMAQSTNPDIIFGTDPDCDRIGVVVKDSKGEYKV
LTGNQTGLLLTHYILSSLKETNKLPENGVVIKTIVTTEGAKAIADDFNIEILDVLTGFKYIGEKIREFKESGEYTYLFGF
EESYGYLAGDFVRDKDAVIASMLICEMCLYYKEHGKSLYDALIELYEKYGYFKETLVSLELAGKEGQEKIASCIDAMRNS
NITEINNVKVVKKLDYKLSTDEDIINGTKVAINLPKSNVLKFILEDDSYFVVRPSGTEPKMKVYLSIKGNSVTDAEKQIS
EFKENVMNLINEKLN

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=583, Percent_Identity=31.9039451114923, Blast_Score=268, Evalue=8e-72,
Organism=Homo sapiens, GI31377548, Length=560, Percent_Identity=31.6071428571429, Blast_Score=256, Evalue=4e-68,
Organism=Escherichia coli, GI1788361, Length=379, Percent_Identity=27.1767810026385, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71993870, Length=561, Percent_Identity=31.9073083778966, Blast_Score=266, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI71993878, Length=304, Percent_Identity=33.5526315789474, Blast_Score=169, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6323934, Length=584, Percent_Identity=32.0205479452055, Blast_Score=252, Evalue=9e-68,
Organism=Drosophila melanogaster, GI20129809, Length=589, Percent_Identity=29.8811544991511, Blast_Score=238, Evalue=8e-63,
Organism=Drosophila melanogaster, GI24651977, Length=458, Percent_Identity=31.0043668122271, Blast_Score=225, Evalue=7e-59,
Organism=Drosophila melanogaster, GI24653722, Length=561, Percent_Identity=28.8770053475936, Blast_Score=219, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 64549; Mature: 64549

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKEKYNSWINSESINEETKNELKAICDEKEIEDRFYKDLEFGTGGLRGVIGAGSNRMN
CCHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCEEEECCCCCEE
VYSVSKATQGFANYLNENFNKPAVAIAYDSRNMSKEFAKAAALTLCANNVKVYLYESLRP
EEEHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHEECCEEEEEEECCCC
TPVLSFATRELKCSGGIVVTASHNPKQYNGYKVYDEFGGQVTDDKANKIITCVNQIEDFS
CCCHHHHHHEEEECCCEEEEECCCCCCCCCEEEHHHHCCEECCCHHHHHHHHHHHHCCCH
QIKIIDEKDALEKGLLEYVGEELDKTYMEKVKSLTIRKELVSEKANTLNVIYTPIHGSGN
HEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCC
VPVRRVLKELGYTNVEVVKEQEAPDGNFPTASYPNPENPDVFKLALNMAQSTNPDIIFGT
CHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEECC
DPDCDRIGVVVKDSKGEYKVLTGNQTGLLLTHYILSSLKETNKLPENGVVIKTIVTTEGA
CCCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCC
KAIADDFNIEILDVLTGFKYIGEKIREFKESGEYTYLFGFEESYGYLAGDFVRDKDAVIA
HHHHCCCCEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEHHHHCCHHHHHH
SMLICEMCLYYKEHGKSLYDALIELYEKYGYFKETLVSLELAGKEGQEKIASCIDAMRNS
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHCHHHHHHHHHEECCCCCHHHHHHHHHHHHCC
NITEINNVKVVKKLDYKLSTDEDIINGTKVAINLPKSNVLKFILEDDSYFVVRPSGTEPK
CCCEECCEEEEEEECCCCCCCCHHCCCCEEEEECCHHHEEEEEEECCCEEEEECCCCCCC
MKVYLSIKGNSVTDAEKQISEFKENVMNLINEKLN
EEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDYKEKYNSWINSESINEETKNELKAICDEKEIEDRFYKDLEFGTGGLRGVIGAGSNRMN
CCHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCEEEECCCCCEE
VYSVSKATQGFANYLNENFNKPAVAIAYDSRNMSKEFAKAAALTLCANNVKVYLYESLRP
EEEHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHEECCEEEEEEECCCC
TPVLSFATRELKCSGGIVVTASHNPKQYNGYKVYDEFGGQVTDDKANKIITCVNQIEDFS
CCCHHHHHHEEEECCCEEEEECCCCCCCCCEEEHHHHCCEECCCHHHHHHHHHHHHCCCH
QIKIIDEKDALEKGLLEYVGEELDKTYMEKVKSLTIRKELVSEKANTLNVIYTPIHGSGN
HEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCC
VPVRRVLKELGYTNVEVVKEQEAPDGNFPTASYPNPENPDVFKLALNMAQSTNPDIIFGT
CHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEECC
DPDCDRIGVVVKDSKGEYKVLTGNQTGLLLTHYILSSLKETNKLPENGVVIKTIVTTEGA
CCCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCC
KAIADDFNIEILDVLTGFKYIGEKIREFKESGEYTYLFGFEESYGYLAGDFVRDKDAVIA
HHHHCCCCEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEHHHHCCHHHHHH
SMLICEMCLYYKEHGKSLYDALIELYEKYGYFKETLVSLELAGKEGQEKIASCIDAMRNS
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHCHHHHHHHHHEECCCCCHHHHHHHHHHHHCC
NITEINNVKVVKKLDYKLSTDEDIINGTKVAINLPKSNVLKFILEDDSYFVVRPSGTEPK
CCCEECCEEEEEEECCCCCCCCHHCCCCEEEEECCHHHEEEEEEECCCEEEEECCCCCCC
MKVYLSIKGNSVTDAEKQISEFKENVMNLINEKLN
EEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]