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The map label for this gene is gabT1

Identifier: 187734236

GI number: 187734236

Start: 1407002

End: 1408267

Strand: Direct

Name: gabT1

Synonym: SbBS512_E1538

Alternate gene names: 187734236

Gene position: 1407002-1408267 (Clockwise)

Preceding gene: 187733680

Following gene: 187730683

Centisome position: 30.48

GC content: 57.35

Gene sequence:

>1266_bases
ATGAGCAACAATGAATTCCATCAGCGTCGTCTTTCTGCTACCCCACGCGGGGTTGGCGTGATGTGTAACTTCTTCGCCCA
GTCGGCAGAAAACGCTACGCTGAAGGACGTAGAGGGCAACGAATACATCGATTTCGCCGCAGGCATTGCGGTGCTGAATA
CCGGGCATCGCCACCCTGATCTGGTCGCGGCGGTGGAGCAGCAATTGCAACAGTTTACCCACACGGCGTATCAGATTGTG
CCGTACGAAAGCTACGTCACGCTGGCGGAGAAAATTAACGCCCTTGCCCCAGTGAGCGGGCAGGCTAAAACCGCATTCTT
CACTACCGGCGCGGAAGCGGTGGAAAACGCGGTGAAAATTGCTCGCGCCCATACCGGACGACCTGGCGTGATTGCGTTTA
GCGGCGGCTTCCACGGTCGTACATATATGACCATGGCGCTGACCGGAAAAGTTGCGCCGTACAAAATCGGCTTCGGCCCG
TTCCCTGGTTCGGTGTATCACGTACCTTATCCGTCAGATTTACACGGCATTTCAACACAGGACTCCCTCGACGCCATCGA
ATGCTTGTTTAAATCGGACATTGAAGCGAAGCAGGTGGCGGCCATTATTTTCGAACCGGTGCAGGGCGAGGGCGGTTTCA
ACGTTGCGCCAAAAGAGCTGGTTGCCGCCATTCGCCGCCTGTGCGACGAGCACGGTATTGTGATGATTGCCGATGAAGTG
CAAAGCGGCTTTGCGCGTACCGGTAAACTGTTTGCCATGGATCATTACGCCGATAAGCCGGACTTAATGACGATGGCGAA
AAGCCTCGCGGGCGGGATGCCGCTTTCGGGCGTGGTCGGTAACGCGAATATTATGGACGCGCCCGCGCCGGGCGGGTTGG
GTGGCACCTACGCCGGGAACCCGCTGGCGGTGGCTGCCGCGCACGCGGTGCTCAATATTATCGACAAAGAATCACTCTGC
GAACGCGCGAATCAACTGGGCCAGCGTCTCAAAAACACGTTGATTGATGCCAAAGAAAGCGTTCCGGCCATTGCTGCGGT
ACGCGGCCTGGGGTCGATGATTGCGGCAGAGTTTAACGATCCGCAAACGGGCGAGCCGTCAGCGGCGATTGCACAGAAAA
TCCAGCAACGCGCGCTGGCGCAGGGGCTGCTCCTGCTGACCTGTGGCGCATACGGCAACGTGATTCGCTTCCTGTATCCG
CTGACCATCCCGGATGCGCAATTCGATGCGGCAATGAAAATTTTGCAGGATGCGCTGAGCGATTAA

Upstream 100 bases:

>100_bases
CGCGTGCCATTTACCGCGATGGGCGCGGCTTATTACAGCCTGCGCGATCGTCTGGGCGTTTAATTTCCGATTAACAGTGA
AGAGTCAAAAGGTGTGAAAC

Downstream 100 bases:

>100_bases
TAGCCCAACGCAATAATGTCTGATGCGCTGCGCTTATCAGGCCTGCAAACGACTTATTGATTATGTATGCCGAATAAAGC
ATTCACGCCGCATCCGGCAA

Product: 4-aminobutyrate transaminase

Products: NA

Alternate protein names: GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MSNNEFHQRRLSATPRGVGVMCNFFAQSAENATLKDVEGNEYIDFAAGIAVLNTGHRHPDLVAAVEQQLQQFTHTAYQIV
PYESYVTLAEKINALAPVSGQAKTAFFTTGAEAVENAVKIARAHTGRPGVIAFSGGFHGRTYMTMALTGKVAPYKIGFGP
FPGSVYHVPYPSDLHGISTQDSLDAIECLFKSDIEAKQVAAIIFEPVQGEGGFNVAPKELVAAIRRLCDEHGIVMIADEV
QSGFARTGKLFAMDHYADKPDLMTMAKSLAGGMPLSGVVGNANIMDAPAPGGLGGTYAGNPLAVAAAHAVLNIIDKESLC
ERANQLGQRLKNTLIDAKESVPAIAAVRGLGSMIAAEFNDPQTGEPSAAIAQKIQQRALAQGLLLLTCGAYGNVIRFLYP
LTIPDAQFDAAMKILQDALSD

Sequences:

>Translated_421_residues
MSNNEFHQRRLSATPRGVGVMCNFFAQSAENATLKDVEGNEYIDFAAGIAVLNTGHRHPDLVAAVEQQLQQFTHTAYQIV
PYESYVTLAEKINALAPVSGQAKTAFFTTGAEAVENAVKIARAHTGRPGVIAFSGGFHGRTYMTMALTGKVAPYKIGFGP
FPGSVYHVPYPSDLHGISTQDSLDAIECLFKSDIEAKQVAAIIFEPVQGEGGFNVAPKELVAAIRRLCDEHGIVMIADEV
QSGFARTGKLFAMDHYADKPDLMTMAKSLAGGMPLSGVVGNANIMDAPAPGGLGGTYAGNPLAVAAAHAVLNIIDKESLC
ERANQLGQRLKNTLIDAKESVPAIAAVRGLGSMIAAEFNDPQTGEPSAAIAQKIQQRALAQGLLLLTCGAYGNVIRFLYP
LTIPDAQFDAAMKILQDALSD
>Mature_420_residues
SNNEFHQRRLSATPRGVGVMCNFFAQSAENATLKDVEGNEYIDFAAGIAVLNTGHRHPDLVAAVEQQLQQFTHTAYQIVP
YESYVTLAEKINALAPVSGQAKTAFFTTGAEAVENAVKIARAHTGRPGVIAFSGGFHGRTYMTMALTGKVAPYKIGFGPF
PGSVYHVPYPSDLHGISTQDSLDAIECLFKSDIEAKQVAAIIFEPVQGEGGFNVAPKELVAAIRRLCDEHGIVMIADEVQ
SGFARTGKLFAMDHYADKPDLMTMAKSLAGGMPLSGVVGNANIMDAPAPGGLGGTYAGNPLAVAAAHAVLNIIDKESLCE
RANQLGQRLKNTLIDAKESVPAIAAVRGLGSMIAAEFNDPQTGEPSAAIAQKIQQRALAQGLLLLTCGAYGNVIRFLYPL
TIPDAQFDAAMKILQDALSD

Specific function: Involved in the breakdown of putrescine via transamination of gamma-aminobutyrate [H]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=400, Percent_Identity=32.25, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI284507298, Length=322, Percent_Identity=32.2981366459627, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI13994255, Length=417, Percent_Identity=30.2158273381295, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI37574042, Length=448, Percent_Identity=28.5714285714286, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI188536080, Length=447, Percent_Identity=27.9642058165548, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI38679950, Length=447, Percent_Identity=27.9642058165548, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI38679946, Length=447, Percent_Identity=27.9642058165548, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI226442709, Length=389, Percent_Identity=29.5629820051414, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI226442705, Length=448, Percent_Identity=28.125, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI24119277, Length=391, Percent_Identity=26.5984654731458, Blast_Score=128, Evalue=9e-30,
Organism=Escherichia coli, GI1787560, Length=421, Percent_Identity=99.5249406175772, Blast_Score=857, Evalue=0.0,
Organism=Escherichia coli, GI1789016, Length=421, Percent_Identity=54.6318289786223, Blast_Score=454, Evalue=1e-129,
Organism=Escherichia coli, GI1789759, Length=404, Percent_Identity=33.9108910891089, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI1788044, Length=395, Percent_Identity=34.6835443037975, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI145693181, Length=403, Percent_Identity=35.2357320099256, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1786349, Length=348, Percent_Identity=31.6091954022989, Blast_Score=152, Evalue=6e-38,
Organism=Escherichia coli, GI1786991, Length=409, Percent_Identity=27.8728606356968, Blast_Score=129, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI25144271, Length=407, Percent_Identity=32.9238329238329, Blast_Score=180, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI32564660, Length=421, Percent_Identity=32.541567695962, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI71992977, Length=425, Percent_Identity=29.6470588235294, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI25144274, Length=295, Percent_Identity=32.5423728813559, Blast_Score=131, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI17541228, Length=430, Percent_Identity=26.5116279069767, Blast_Score=122, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6323470, Length=406, Percent_Identity=32.7586206896552, Blast_Score=189, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6324432, Length=406, Percent_Identity=31.2807881773399, Blast_Score=185, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6324386, Length=314, Percent_Identity=25.1592356687898, Blast_Score=93, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6321456, Length=372, Percent_Identity=26.6129032258064, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21357415, Length=404, Percent_Identity=31.6831683168317, Blast_Score=181, Evalue=7e-46,
Organism=Drosophila melanogaster, GI28574759, Length=419, Percent_Identity=30.0715990453461, Blast_Score=159, Evalue=4e-39,
Organism=Drosophila melanogaster, GI161085790, Length=418, Percent_Identity=29.6650717703349, Blast_Score=158, Evalue=6e-39,
Organism=Drosophila melanogaster, GI21356575, Length=430, Percent_Identity=28.3720930232558, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI281366494, Length=364, Percent_Identity=27.1978021978022, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24667139, Length=364, Percent_Identity=27.1978021978022, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24667143, Length=364, Percent_Identity=27.1978021978022, Blast_Score=110, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19 [H]

Molecular weight: Translated: 44648; Mature: 44517

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNNEFHQRRLSATPRGVGVMCNFFAQSAENATLKDVEGNEYIDFAAGIAVLNTGHRHPD
CCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEECCCCCCEEHHHHHHHHCCCCCCCHH
LVAAVEQQLQQFTHTAYQIVPYESYVTLAEKINALAPVSGQAKTAFFTTGAEAVENAVKI
HHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHH
ARAHTGRPGVIAFSGGFHGRTYMTMALTGKVAPYKIGFGPFPGSVYHVPYPSDLHGISTQ
HHHCCCCCCEEEECCCCCCCEEEEEEEECCCCCEEECCCCCCCCEEECCCCCCCCCCCCC
DSLDAIECLFKSDIEAKQVAAIIFEPVQGEGGFNVAPKELVAAIRRLCDEHGIVMIADEV
HHHHHHHHHHHCCCCHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEHHH
QSGFARTGKLFAMDHYADKPDLMTMAKSLAGGMPLSGVVGNANIMDAPAPGGLGGTYAGN
HCCHHHCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCEECCCCEECCCCCCCCCCCCCCC
PLAVAAAHAVLNIIDKESLCERANQLGQRLKNTLIDAKESVPAIAAVRGLGSMIAAEFND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
PQTGEPSAAIAQKIQQRALAQGLLLLTCGAYGNVIRFLYPLTIPDAQFDAAMKILQDALS
CCCCCCHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
D
C
>Mature Secondary Structure 
SNNEFHQRRLSATPRGVGVMCNFFAQSAENATLKDVEGNEYIDFAAGIAVLNTGHRHPD
CCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEECCCCCCEEHHHHHHHHCCCCCCCHH
LVAAVEQQLQQFTHTAYQIVPYESYVTLAEKINALAPVSGQAKTAFFTTGAEAVENAVKI
HHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHH
ARAHTGRPGVIAFSGGFHGRTYMTMALTGKVAPYKIGFGPFPGSVYHVPYPSDLHGISTQ
HHHCCCCCCEEEECCCCCCCEEEEEEEECCCCCEEECCCCCCCCEEECCCCCCCCCCCCC
DSLDAIECLFKSDIEAKQVAAIIFEPVQGEGGFNVAPKELVAAIRRLCDEHGIVMIADEV
HHHHHHHHHHHCCCCHHHHHHHHEECCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEHHH
QSGFARTGKLFAMDHYADKPDLMTMAKSLAGGMPLSGVVGNANIMDAPAPGGLGGTYAGN
HCCHHHCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCEECCCCEECCCCCCCCCCCCCCC
PLAVAAAHAVLNIIDKESLCERANQLGQRLKNTLIDAKESVPAIAAVRGLGSMIAAEFND
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
PQTGEPSAAIAQKIQQRALAQGLLLLTCGAYGNVIRFLYPLTIPDAQFDAAMKILQDALS
CCCCCCHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHC
D
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]