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The map label for this gene is arcA

Identifier: 187733961

GI number: 187733961

Start: 4613935

End: 4614651

Strand: Reverse

Name: arcA

Synonym: SbBS512_E4949

Alternate gene names: 187733961

Gene position: 4614651-4613935 (Counterclockwise)

Preceding gene: NA

Following gene: 187732808

Centisome position: 99.97

GC content: 50.91

Gene sequence:

>717_bases
ATGCAGACCCCGCACATTCTTATCGTTGAAGACGAGTTGGTAACACGCAACGCGTTGAAAAGTATTTTCGAAGCGGAAGG
CTATGATGTTTTCGAAGCGACAGATGGCGCGGAAATGCATCAGATCCTCTCTGAATATGACATCAACCTGGTGATCATGG
ATATCAATCTGCCGGGTAAGAACGGTCTTCTGTTAGCGCGTGAACTGCGCGAGCAGGCGAATGTTGCGTTGATGTTCCTG
ACTGGCCGTGACAACGAAGTCGATAAAATTCTCGGCCTCGAAATCGGTGCAGATGACTACATCACCAAACCGTTCAACCC
GCGTGAACTGACGATTCGTGCACGCAACCTGCTGTCCCGTACCATGAATCTGGGTACTGTCAGCGAAGAACGTCGTAGCG
TTGAAAGCTACAAGTTCAATGGTTGGGAACTGGACATCAACAGCCGTTCGTTGATCAGCCCTGATGGCGAGCAGTACAAG
CTGCCGCGCAGCGAGTTCCGCGCCATGCTTCACTTCTGTGAAAACCCAGGCAAAATTCAGTCTCGTGCTGAACTGCTGAA
GAAAATGACCGGCCGTGAGCTGAAACCACACGACCGTACTGTAGACGTGACGATCCGCCGTATTCGTAAACATTTCGAAT
CTACGCCGGATACGCCGGAAATCATCGCCACCATCCACGGTGAAGGTTATCGCTTCTGTGGTGATCTGGAAGATTAA

Upstream 100 bases:

>100_bases
GTCATGTTACGCCGATCATGTTAATTTGCAGCATGCATCAGGCAGGTCAGGGACTTTTGTACTTCCTGTTTCGATTTAGT
TGGCAATTTAGGTAGCAAAC

Downstream 100 bases:

>100_bases
TCGGCTTTACCACCGTCAAAAAAAACGGCGCTTTTTAGCGCCGTTTTTATTTTTCAACCTTATTTCCAGATACGTAATTG
ATCGTCCATTGTAACTTCTT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MQTPHILIVEDELVTRNALKSIFEAEGYDVFEATDGAEMHQILSEYDINLVIMDINLPGKNGLLLARELREQANVALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLGTVSEERRSVESYKFNGWELDINSRSLISPDGEQYK
LPRSEFRAMLHFCENPGKIQSRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLED

Sequences:

>Translated_238_residues
MQTPHILIVEDELVTRNALKSIFEAEGYDVFEATDGAEMHQILSEYDINLVIMDINLPGKNGLLLARELREQANVALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLGTVSEERRSVESYKFNGWELDINSRSLISPDGEQYK
LPRSEFRAMLHFCENPGKIQSRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLED
>Mature_238_residues
MQTPHILIVEDELVTRNALKSIFEAEGYDVFEATDGAEMHQILSEYDINLVIMDINLPGKNGLLLARELREQANVALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLGTVSEERRSVESYKFNGWELDINSRSLISPDGEQYK
LPRSEFRAMLHFCENPGKIQSRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLED

Specific function: Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expres

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790863, Length=238, Percent_Identity=99.1596638655462, Blast_Score=486, Evalue=1e-139,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=42.4892703862661, Blast_Score=191, Evalue=4e-50,
Organism=Escherichia coli, GI1789809, Length=233, Percent_Identity=36.0515021459227, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1788394, Length=233, Percent_Identity=32.1888412017167, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI1786599, Length=231, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=2e-30,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=32.8888888888889, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1790860, Length=235, Percent_Identity=31.9148936170213, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1786911, Length=229, Percent_Identity=31.8777292576419, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI87082012, Length=229, Percent_Identity=31.4410480349345, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=30.7017543859649, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1786784, Length=226, Percent_Identity=28.7610619469027, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=29.646017699115, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=28.0172413793103, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI1790552, Length=234, Percent_Identity=30.3418803418803, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788550, Length=212, Percent_Identity=25.9433962264151, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27292; Mature: 27292

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTPHILIVEDELVTRNALKSIFEAEGYDVFEATDGAEMHQILSEYDINLVIMDINLPGK
CCCCCEEEEECHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCEEEEEEEECCCC
NGLLLARELREQANVALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSR
CCEEHHHHHHHHCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEHHHHHHHHH
TMNLGTVSEERRSVESYKFNGWELDINSRSLISPDGEQYKLPRSEFRAMLHFCENPGKIQ
HHCCCCCHHHHHHHHHEECCCEEEEECCCCEECCCCCCCCCCHHHHHHHHHHHCCCCCHH
SRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLED
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEECCCCCC
>Mature Secondary Structure
MQTPHILIVEDELVTRNALKSIFEAEGYDVFEATDGAEMHQILSEYDINLVIMDINLPGK
CCCCCEEEEECHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCEEEEEEEECCCC
NGLLLARELREQANVALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSR
CCEEHHHHHHHHCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEHHHHHHHHH
TMNLGTVSEERRSVESYKFNGWELDINSRSLISPDGEQYKLPRSEFRAMLHFCENPGKIQ
HHCCCCCHHHHHHHHHEECCCEEEEECCCCEECCCCCCCCCCHHHHHHHHHHHCCCCCHH
SRAELLKKMTGRELKPHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLED
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]